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Ageing meets kidney disease
Alberto Ortiz, Francesco Mattace-Raso, Maria José Soler, Denis Fouque
doi : 10.1093/ndt/gfac199
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 523–526
Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for ˃3 months, with implications for health.
Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association
Alberto Ortiz, Christoph Wanner, Ron Gansevoort, the ERA Council
doi : 10.1093/ndt/gfac257
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 527–531
Overcoming barriers to implementing new guideline-directed therapies for chronic kidney disease
Robert Nee, Christina M Yuan, Andrew S Narva, Guofen Yan, Keith C Norris
doi : 10.1093/ndt/gfac283
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 532–541
For the first time in many years, guideline-directed drug therapies have emerged that offer substantial cardiorenal benefits, improved quality of life and longevity in patients with chronic kidney disease (CKD) and type 2 diabetes. These treatment options include sodium-glucose cotransporter-2 inhibitors, nonsteroidal mineralocorticoid receptor antagonists and glucagon-like peptide-1 receptor agonists.
Clinical implications and guidelines for CKD in type 2 diabetes
Rong M Zhang, Frederik Persson, Janet B McGill, Peter Rossing
doi : 10.1093/ndt/gfac285
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 542–550
Chronic kidney disease (CKD) is a complication of type 2 diabetes (T2D) with high morbidity and mortality. The prevalence of CKD in T2D is increasing due to rising numbers of persons with T2D.
The management of lupus nephritis as proposed by EULAR/ERA 2019 versus KDIGO 2021
Hans-Joachim Anders, Jerome Loutan, Annette Bruchfeld, Gema M Fernández-Juárez, Jürgen Floege, Dimitrios Goumenos, Kultigin Turkmen, Cees van Kooten, Eleni Frangou, Kate I Stevens, Andreas Kronbichler, Mårten Segelmark, Vladimir Tesar
doi : 10.1093/ndt/gfab351
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 551–561
In 2019 and 2021, the European League for Rheumatism (EULAR) jointly with the European Renal Association (ERA) and the Kidney Disease: Improving Global Outcomes (KDIGO), respectively, released updated guidelines on the management of lupus nephritis (LN).
Vaptans or voluntary increased hydration to protect the kidney: how do they compare?
Lise Bankir, Dominique Guerrot, Daniel G Bichet
doi : 10.1093/ndt/gfab278
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 562–574
The adverse effects of vasopressin (AVP) in diverse forms of chronic kidney disease have been well described. They depend on the antidiuretic action of AVP mediated by V2 receptors (V2R).
Preparing European Nephrology for the next pandemic: lessons from the ERACODA collaboration
Priya Vart, Raphaël Duivenvoorden, Casper F M Franssen, Marc H Hemmelder, Kitty J Jager, Luuk B Hilbrands, Marlies Noordzij, Daniel Abramowicz, Carlo Basile, Adrian Covic, Marta Crespo, Ziad A Massy, Alberto Ortiz, J Emilio Sanchez, Emily Petridou, Colin White, Ron T Gansevoort
doi : 10.1093/ndt/gfac306
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 575–582
Owing to the vulnerability of patients with chronic kidney disease to infectious diseases, the coronavirus disease 2019 (COVID-19) pandemic has been particularly devastating for the nephrology community.
Bioimpedance in CKD: an untapped resource?
Kaitlin J Mayne, Jennifer S Lees, William G Herrington
doi : 10.1093/ndt/gfac275
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 583–585
miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt-induced hypertensive rats
Patrizia Lombari, Massimo Mallardo, Oriana Petrazzuolo, Joseph Amruthraj Nagoth, Giuseppe Fiume, Roberto Scanni, Anna Iervolino, Sara Damiano, Annapaola Coppola, Margherita Borriello, Diego Ingrosso, Alessandra F Perna, Miriam Zacchia, Francesco Trepiccione, Giovambattista Capasso
doi : 10.1093/ndt/gfac232
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 586–598
The kidney is the main organ in the pathophysiology of essential hypertension. Although most bicarbonate reabsorption occurs in the proximal tubule, the medullary thick ascending limb (mTAL) of the nephron also maintains acid–base balance by contributing to 25% of bicarbonate reabsorption.
Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes
Noël Knops, Yasaman Ramazani, Henriëtte De Loor, Roel Goldschmeding, Tri Q Nguyen, Lambert P van den Heuvel, Elena Levtchenko, Dirk J Kuypers
doi : 10.1093/ndt/gfac237
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 599–609
Common genetic variants of the enzymes and efflux pump involved in tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but their importance is unclear because of the multifactorial background of renal fibrosis.
Electronic alerts and a care bundle for acute kidney injury—an Australian cohort study
Sradha Kotwal, Sanjeeva Herath, Jonathan Erlich, Sally Boardman, Jennifer Qian, Paul Lawton, Craig Campbell, Andrew Whatnall, Su Teo, A Rita Horvath, Zoltán H Endre
doi : 10.1093/ndt/gfac155
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 610–617
Early recognition of hospital-acquired acute kidney injury (AKI) may improve patient management and outcomes.
Multidisciplinary management of chronic refractory pain in autosomal dominant polycystic kidney disease
Franka van Luijk, Ron T Gansevoort, Hans Blokzijl, Gerbrand J Groen, Robbert J de Haas, Anna M Leliveld, Esther Meijer, Joke M Perdok, Ruud Stellema, Andreas P Wolff, Niek F Casteleijn
doi : 10.1093/ndt/gfac158
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 618–629
Chronic pain is often difficult to manage in autosomal dominant polycystic kidney disease (ADPKD) patients and sometimes even leads to nephrectomy.
High unmet treatment needs in patients with chronic kidney disease and type 2 diabetes: real-world evidence from a US claims database
Linda Fried, Niklas Schmedt, Kerstin Folkerts, Kevin Bowrin, Hanaya Raad, Michael Batech, Csaba Kovesdy
doi : 10.1093/ndt/gfac140
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 630–643
Chronic kidney disease (CKD), a serious complication of type 2 diabetes (T2D) increases the comorbid risk of cardiovascular disease (CVD) and end-stage kidney disease
Early biomarkers for kidney injury in heat-related illness patients: a prospective observational study at Japanese Self-Defense Force Fuji Hospital
Hiroyasu Goto, Shinichi Shoda, Hiroyuki Nakashima, Midori Noguchi, Toshihiko Imakiire, Naoki Ohshima, Manabu Kinoshita, Soichi Tomimatsu, Hiroo Kumagai
doi : 10.1093/ndt/gfac166
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 644–654
Since heatstroke-induced acute kidney injury (AKI) can progress to chronic kidney disease, it would be useful to detect heatstroke-induced AKI and severe heat-related illness in the early phase.
The risks associated with percutaneous native kidney biopsies: a prospective study
Simeone Andrulli, Michele Rossini, Giuseppe Gigliotti, Gaetano La Manna, Sandro Feriozzi, Filippo Aucella, Antonio Granata, Elisabetta Moggia, Domenico Santoro, Lucio Manenti, Barbara Infante, Angelo Ferrantelli, Rosario Cianci, Mario Giordano, Domenico Giannese, Giuseppe Seminara, Marina Di Luca, Mario Bonomini, Leonardo Spatola, Francesca Bruno, Olga Baraldi, David Micarelli, Matteo Piemontese, Giulio Distefano, Francesca Mattozzi, Paola De Giovanni, Davide Penna, Maurizio Garozzo, Luigi Vernaglione, Cataldo Abaterusso, Fulvia Zanchelli, Rachele Brugnano, Enrica Gintoli, Laura Sottini, Marco Quaglia, Gioacchino Li Cavoli, Marco De Fabritiis, Maria Maddalena Conte, Massimo Manes, Yuri Battaglia, Francesco Fontana, Loreto Gesualdo, ITA-KID-BIO-Group
doi : 10.1093/ndt/gfac177
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 655–663
The known risks and benefits of native kidney biopsies are mainly based on the findings of retrospective studies. The aim of this multicentre prospective study was to evaluate the safety of percutaneous renal biopsies and quantify biopsy-related complication rates in Italy.
Kidney function at 3 months after acute kidney injury is an unreliable indicator of subsequent kidney dysfunction: the NARA-AKI Cohort Study
Masatoshi Nishimoto, Miho Murashima, Maiko Kokubu, Masaru Matsui, Masahiro Eriguchi, Ken-Ichi Samejima, Yasuhiro Akai, Kazuhiko Tsuruya
doi : 10.1093/ndt/gfac172
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 664–670
The relationship between kidney function at 3 months after acute kidney injury (AKI) and kidney function prognosis has not been characterized.
End-proximal tubule phosphate concentration increases as GFR falls in humans: measurement by means of a lithium clearance-based methodology
Giacomo Colussi, Alberto Menegotto, Marialuisa Querques, Federica Ravera, Simona Verdesca, Valeriana Colombo, Enrico E Minetti
doi : 10.1093/ndt/gfac179
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 671–678
Microscopic nephrocalcinosis secondary to intratubular calcium phosphate (CaP) precipitation is thought to accelerate progression to end-stage renal failure in chronic kidney diseases.
Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia
Rosa Vargas-Poussou, Felix Claverie-Martin, Caroline Prot-Bertoye, Valentina Carotti, Jenny van der Wijst, Ana Perdomo-Ramirez, Gloria M Fraga-Rodriguez, Marguerite Hureaux, Caro Bos, Femke Latta, Pascal Houillier, Joost G J Hoenderop, Jeroen H F de Baaij
doi : 10.1093/ndt/gfac182
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 679–690
Hypomagnesaemia with secondary hypocal-caemia (HSH) is a rare autosomal recessive disorder caused by pathogenic variants in TRPM6, encoding the channel-kinase transient receptor potential melastatin type 6.
Evaluation of renal oxygenation by BOLD–MRI in high-risk patients with type 2 diabetes and matched controls
Steffen S Sørensen, Søren Gullaksen, Liv Vernstrøm, Steffen Ringgaard, Christoffer Laustsen, Kristian L Funck, Esben Laugesen, Per L Poulsen
doi : 10.1093/ndt/gfac186
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 691–699
Diabetic kidney disease (DKD) accounts for ∼50% of end-stage kidney disease. Renal hypoxia is suggested as a main driver in the pathophysiology underlying chronic DKD.
Metabolic dysfunction–associated fatty liver disease predicts new onset of chronic kidney disease better than fatty liver or nonalcoholic fatty liver disease
Marenao Tanaka, Kazuma Mori, Satoko Takahashi, Yukimura Higashiura, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi
doi : 10.1093/ndt/gfac188
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 700–711
Possible associations of chronic kidney disease (CKD) with fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) have recently been focused on.
Association of coronary artery calcium with adverse cardiovascular outcomes and death in patients with chronic kidney disease: results from the KNOW-CKD
Chan-Young Jung, Hae-Ryong Yun, Jung Tak Park, Young Su Joo, Hyung Woo Kim, Tae-Hyun Yoo, Shin-Wook Kang, Joongyub Lee, Dong-Wan Chae, Wookyung Chung, Yong-Soo Kim, Kook-Hwan Oh, Seung Hyeok Han
doi : 10.1093/ndt/gfac194
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 712–721
In East Asian countries, patients with chronic kidney disease (CKD) have lower cardiovascular risk profiles and experience fewer cardiovascular events (CVEs) than those in Western countries. Thus the clinical predictive performance of well-known risk factors warrants further testing in this population.
Comorbidity, life-style factors and healthcare utilization in incident chronic kidney disease: sex-specific analyses of claims data
Miriam Giovanna Colombo, Christian Förster, Stephanie Wallwiener, Kathrin Hassdenteufel, Sabine Hawighorst-Knapstein, Gudula Kirtschig, Ariane Chaudhuri, Simon Dally, Stefanie Joos
doi : 10.1093/ndt/gfac245
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 722–732
Chronic kidney disease (CKD) is common in aging men and women. In contrast to other European countries, Germany lacks CKD registries. The aim of this study was to determine the incidence of CKD stages 2–5 in men and women in Germany.
Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients—a systematic review and meta-analysis
Wen Wen, Ignacio Portales-Castillo, Rituvanthikaa Seethapathy, Scott Krinsky, Daniela Kroshinsky, Sahir Kalim, Jeremy Goverman, Rosalynn M Nazarian, Vipul Chitalia, Rajeev Malhotra, Rafael Kramann, Cindy K Malhotra, Sagar U Nigwekar
doi : 10.1093/ndt/gfac171
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 733–745
Vascular calcification (VC) is a common comorbidity among patients with chronic kidney disease (CKD), indicating major cardiovascular events. This study aimed to evaluate the effects and safety of intravenous sodium thiosulphate (STS) for VC in CKD patients.
Inhibit progression of coronary artery calcification with vitamin K in hemodialysis patients (the iPACK-HD study): a randomized, placebo-controlled multi-center, pilot trial
Rachel M Holden, Sarah L Booth, Deborah Zimmerman, Louise Moist, Patrick A Norman, Andrew G Day, Alex Menard, Xueyan Fu, M Kyla Shea, Corinne S Babiolakis, Robert Nolan, Mandy E Turner, Emilie Ward, Martin Kaufmann, Michael A Adams, Daren K Heyland
doi : 10.1093/ndt/gfac191
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 746–756
Vitamin K activates matrix Gla protein (MGP), a key inhibitor of vascular calcification. There is a high prevalence of sub-clinical vitamin K deficiency in patients with end-stage kidney disease.
Salivary potassium measured by genetically encoded potassium ion indicators as a surrogate for plasma potassium levels in hemodialysis patients—a proof-of-concept study
Andras T Deak, Katarina Belić, Anna-Maria Meissl, Katharina Artinger, Kathrin Eller, Bernd Rechberger, Tobias Niedrist, Wolfgang F Graier, Roland Malli, Helmut Bischof, Sandra Burgstaller, Sandra Blass, Alexander Avian, Alexander R Rosenkranz, Alexander H Kirsch
doi : 10.1093/ndt/gfac195
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 757–763
Hyperkalemia is a common complication in cardiorenal patients treated with agents interfering with renal potassium (K+) excretion. It frequently leads to discontinuation of potentially life-saving medication, which has increased the importance of K+ monitoring.
Identification of a serum and urine extracellular vesicle signature predicting renal outcome after kidney transplant
Jacopo Burrello, Silvia Monticone, Alessio Burrello, Sara Bolis, Carlotta Pia Cristalli, Giorgia Comai, Valeria Corradetti, Cristina Grange, Giuseppe Orlando, Massimiliano Bonafè, Gaetano La Manna, Lucio Barile, Benedetta Bussolati
doi : 10.1093/ndt/gfac259
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 764–777
A long-standing effort is dedicated towards the identification of biomarkers allowing the prediction of graft outcome after kidney transplant. Extracellular vesicles (EVs) circulating in body fluids represent an attractive candidate, as their cargo mirrors the originating cell and its pathophysiological status.
Pretransplant evaluation and the risk of glucose metabolic alterations after renal transplantation: a prospective study
Arminda Fariña-Hernández, Domingo Marrero-Miranda, Estefania Perez-Carreño, Antonia De Vera-Gonzalez, Alejandra González, Cristian Acosta-Sorensen, Ana Elena RodrÃguez-RodrÃguez, Tatiana Collantes, Marta del Pino GarcÃa, Ana Isabel RodrÃguez-Muñoz, Carla Rodriguez-Alvarez, Antonio Rivero, Manuel MacÃa, Elena Teran, Nuria V Sanchez-Dorta, Lourdes Perez-Tamajón, Alejandra Alvarez-González, Ana González-Rinne, Aurelio RodrÃguez-Hernández, Eduardo De Bonis-Redondo, Concepción Rodriguez-Adanero, Domingo Hernández, Esteban Porrini, Armando Torres
doi : 10.1093/ndt/gfac256
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 778–786
Post-transplant prediabetes (PreDM) and diabetes (PTDM) are common and have an impact on cardiovascular events. We sought to investigate the pathogenesis and best approach for prediction.
Kidney utilization in the Netherlands – do we optimally use our donor organs?
Rianne Schutter, Willemijn A L Vrijlandt, Gelske M Weima, Robert A Pol, Jan-Stephan F Sanders, Meindert J Crop, Henri G D Leuvenink, Cyril Moers
doi : 10.1093/ndt/gfac300
Nephrology Dialysis Transplantation, Volume 38, Issue 3, March 2023, Pages 787–796
To ensure optimal utilization of deceased donor kidneys, it is important to understand the precise reasons why kidneys are discarded. In this study we aimed to obtain a comprehensive overview of kidney utilization and discard during the entire donation process in the Netherlands.
