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Migraine-Not Just a Numbers Game: Aim to Improve Quality of Life.
Kopel, David MD; Gottschalk, Christopher H. MD, FAHS
doi : 10.1212/WNL.0000000000201566
Volume 100(8) pgs. 357-400,e764-e883 February 21, 2023
The Significance of the Increased Incidence of New Onset Seizures and Epilepsy After a COVID-19 Infection.
Bensken, Wyatt P. PhD; O'Brien, Terence J. MD
What Do Parents of Seriously Ill Infants With Neurologic Conditions Want From Their Medical Team?: Starting Out With Care.
Treat, Lauren MD; Dingman, Andra MD
Effect of Atogepant for Preventive Migraine Treatment on Patient-Reported Outcomes in the Randomized, Double-blind, Phase 3 ADVANCE Trial.
Lipton, Richard B. MD; Pozo-Rosich, Patricia MD, PhD; Blumenfeld, Andrew M. MD; Li, Ye PhD; Severt, Lawrence MD, PhD; Stokes, Jonathan T. MBA; Creutz, Lela PhD; Gandhi, Pranav PhD; Dodick, David MD
doi : 10.1212/WNL.0000000000201568
The oral calcitonin gene-related peptide receptor antagonist atogepant is indicated for the preventive treatment of episodic migraine. We evaluated changes in patient-reported outcomes with atogepant in adults with migraine.
Sensitivity of the NIH Toolbox to Detect Cognitive Change in Individuals With Intellectual and Developmental Disability.
Shields, Rebecca H. MS; Kaat, Aaron PhD; Sansone, Stephanie M. PhD; Michalak, Claire; Coleman, Jeanine PhD; Thompson, Talia PhD; McKenzie, Forrest J. BS; Dakopolos, Andrew PhD; Riley, Karen PhD; Berry-Kravis, Elizabeth MD; Widaman, Keith F. PhD; Gershon, Richard C. PhD; Hessl, David PhD
doi : 10.1212/WNL.0000000000201528
Individuals with intellectual disability (ID) experience protracted cognitive development compared with typical youth. Sensitive measurement of cognitive change in this population is a critical need for clinical trials and other intervention studies, but well-validated outcome measures are scarce.
Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis: A Retrospective Cohort Study.
Taquet, Maxime MD, PhD; Devinsky, Orrin MD, PhD; Cross, J. Helen MD, PhD; Harrison, Paul J. DM, FRCPsych; Sen, Arjune MD, PhD
doi : 10.1212/WNL.0000000000201595
The relationship between COVID-19 and epilepsy is uncertain. We studied the potential association between COVID-19 and seizures or epilepsy in the 6 months after infection.
The ALIGN Framework: A Parent-Informed Approach to Prognostic Communication for Infants With Neurologic Conditions.
Lemmon, Monica E. MD; Barks, Mary C. MA; Bansal, Simran; Bernstein, Sarah MD, MHA; Kaye, Erica C. MD, MPH; Glass, Hannah C. MD; Ubel, Peter A. MD; Brandon, Debra PhD; Pollak, Kathryn I. PhD
doi : 10.1212/WNL.0000000000201600
Clinicians often communicate complex, uncertain, and distressing information about neurologic prognosis to parents of critically ill infants. Although communication tools have been developed in other disciplines and settings, none address the unique needs of the neonatal and pediatric neurology context. We aimed to develop a parent-informed framework to guide clinicians in communicating information about neurologic prognosis.
Patient-Reported Impact of Symptoms in Friedreich Ataxia.
Seabury, Jamison BS; Alexandrou, Danae BS; Dilek, Nuran MS; Cohen, Brittany CCRA-PM; Heatwole, John; Larkindale, Jane PhD; Lynch, David R. MD, PhD; Park, Courtney BS; Rosero, Spencer BS; Subramony, Sub H. MD; Varma, Anika BS; Wagner, Ellen MS; Walther, Susan MS, CGC; Weinstein, Jennifer MS; Wells, McKenzie MS, LCGC, CCRP; Zizzi, Christine BA; Heatwole, Chad MD, MS-CI
doi : 10.1212/WNL.0000000000201598
To determine the prevalence and relative importance of symptoms experienced by children and adults with Friedreich ataxia (FA) and to identify factors associated with a higher burden of disease.
Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke.
Bretzner, Martin MD; Bonkhoff, Anna K. MD; Schirmer, Markus D. PhD; Hong, Sungmin PhD; Dalca, Adrian PhD; Donahue, Kathleen BS; Giese, Anne-Katrin MD; Etherton, Mark R. MD, PhD; Rist, Pamela M. ScD; Nardin, Marco BS; Regenhardt, Robert W. MD, PhD; Leclerc, Xavier MD, PhD; Lopes, Renaud PhD; Gautherot, Morgan PhD; Wang, Clinton PhD; Benavente, Oscar R. MD; Cole, John W. MD, MS; Donatti, Amanda PhD; Griessenauer, Christoph MD; Heitsch, Laura MD; Holmegaard, Lukas MD; Jood, Katarina MD; Jimenez-Conde, Jordi MD; Kittner, Steven J. MD; Lemmens, Robin MD; Levi, Christopher R. PhD; McArdle, Patrick F. PhD; McDonough, Caitrin W. PhD; Meschia, James F. MD; Phuah, Chia-Ling MD; Rolfs, Arndt MD; Ropele, Stefan MD; Rosand, Jonathan MD, MSc; Roquer, Jaume MD; Rundek, Tatjana MD, PhD; Sacco, Ralph L. MD, MS; Schmidt, Reinhold MD; Sharma, Pankaj MD, PhD, FRCP; Slowik, Agnieszka MD, PhD; Sousa, Alessandro MD; Stanne, Tara M. MD; Strbian, Daniel MD; Tatlisumak, Turgut MD; Thijs, Vincent PhD; Vagal, Achala MD; Wasselius, Johan MD, PhD; Woo, Daniel MD; Wu, Ona PhD; Zand, Ramin MD; Worrall, Bradford B. MD, MSc; Maguire, Jane PhD; Lindgren, Arne G. MD, PhD; Jern, Christina MD; Golland, Polina PhD; Kuchcinski, Gregory MD, PhD; Rost, Natalia S. MD, MPH; and the MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium
doi : 10.1212/WNL.0000000000201596
While chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age."
Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration.
Prosser, Lloyd BSc, MSc; Macdougall, Amy PhD; Sudre, Carole H.; Manning, Emily N. PhD; Malone, Ian B.; Walsh, Phoebe PhD; Goodkin, Olivia PhD; Pemberton, Hugh PhD; Barkhof, Frederik MD, PhD; Biessels, Geert Jan MD, PhD; Cash, David M.; Barnes, Josephine; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000201572
Dementia is a growing socioeconomic challenge that requires early intervention. Identifying biomarkers that reliably predict clinical progression early in the disease process would better aid selection of individuals for future trial participation.
Cross-sectional Associations of [beta]-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies.
Ferreira, Daniel PhD; Przybelski, Scott A. BS; Lesnick, Timothy G. MS; Schwarz, Christopher G. PhD; Diaz-Galvan, Patricia PhD; Graff-Radford, Jonathan MD; Senjem, Matthew L. MS; Fields, Julie A. PhD; Knopman, David S. MD; Jones, David T. MD; Savica, Rodolfo MD, PhD; Ferman, Tanis J. PhD; Graff-Radford, Neill MBBCh; Lowe, Val J. MD; Jack, Clifford R. MD; Petersen, Ronald C. MD, PhD; Westman, Eric PhD; Boeve, Brad F. MD; Kantarci, Kejal MD
doi : 10.1212/WNL.0000000000201579
Although alpha-synuclein-related pathology is the hallmark of dementia with Lewy bodies (DLB), cerebrovascular and Alzheimer disease pathologies are common in patients with DLB. Little is known about the contribution of these pathologies to neurodegeneration in DLB.
Diagnostic Performance and Clinical Applicability of Blood-Based Biomarkers in a Prospective Memory Clinic Cohort.
Sarto, Jordi MD; Ruiz-Garcia, Raquel MD, PhD; Guillen, Nuria MD; Ramos-Campoy, Oscar MD; Falgas, Neus MD, PhD; Esteller, Diana MD; Contador, Jose MD; Fernandez, Guadalupe BSc; Gonzalez, Yolanda BSc; Tort-Merino, Adria BSc, PhD; Junca-Parella, Jordi BSc; Bosch, Bea BSc, PhD; Borrego-Ecija, Sergi MD, PhD; Molina-Porcel, Laura MD, PhD; Castellvi, Magda BSc; Vergara, Miguel BSc; Antonell, Anna BSc, PhD; Auge, Josep Maria MD, PhD; Naranjo, Laura BSc; Sanchez-Valle, Raquel MD, PhD *; Llado, Albert MD, PhD *; Balasa, Mircea MD, PhD *
doi : 10.1212/WNL.0000000000201597
Blood-based biomarkers have emerged as minimally invasive options for evaluating cognitive impairment. Most studies to date have assessed them in research cohorts, limiting their generalization to everyday clinical practice.
Longitudinal Changes in Blood Biomarkers of Clinical Alzheimer Disease in a Biracial Population Sample.
Rajan, Kumar B. PhD; McAninch, Elizabeth A. MD; Aggarwal, Neelum T. MD; Barnes, Lisa L. PhD; Wilson, Robert S.; Weuve, Jennifer ScD; DeCarli, Charles S. MD; Evans, Denis A. MD
doi : 10.1212/WNL.0000000000201289
Recent studies suggest the utility of blood biomarkers in detecting changes in neurodegenerative disorders. The objective of our research was to test the hypothesis that the longitudinal changes in total tau (t-tau), neurofilament light chain (Nf-L), and glial fibrillary acidic protein (GFAP) are associated with structural MRI and the development of clinical Alzheimer disease (AD) and cognitive decline.
What Is the Role of Norepinephrine in Cerebellar Modulation and Stress-Induced Episodic Ataxia?.
Benarroch, Eduardo MD
Diffuse Leptomeningeal Glioneuronal Tumor Involving Circle of Willis and Spinal Nerve Roots.
Lei, XiaoYang MS *; Liu, Ying MS *; Han, Feng MD; Yu, Hui PhD; Deng, ChaoNan PhD; He, Dian MD
Clinical Reasoning: A 37-Year-Old Man Presenting With Intermittent Dizziness and Brief Choreiform Movements.
Wu, Bin MD, PhD; Zhang, Wenli Msc; Peng, Fangqiang Msc; Zhang, Miaoyi Msc; Shen, Bo MD; Shi, Xin Msc; Zhang, Yue MD
doi : 10.1212/WNL.0000000000201653
AB In this report, we describe the case of a 37-year-old man presenting with intermittent episodes of dizziness and choreiform movements. MRI of the head showed an acute infarction in the left cerebellar hemisphere and multiple chronic infarctions in the cerebellum and pons
Teaching NeuroImage: Brain Calcification in a Young Woman With Seizures: Explore the Rare Differentials.
Menon, Bindu MD; Manam, Gayatri MD; Reddy, Pramesh MD; Mandalapu, Harsha MD; Sudarsana, A. Pharm D
Editors' Note: Cognitive-Driven Activities of Daily Living Impairment as a Predictor for Dementia in Parkinson Disease: A Longitudinal Cohort Study.
Lewis, Ariane MD; Ganesh, Aravind MD; Galetta, Steven MDLewis, Ariane MD; Ganesh, Aravind MD; Galetta, Steven MD
Reader Response: Cognitive-Driven Activities of Daily Living Impairment as a Predictor for Dementia in Parkinson Disease: A Longitudinal Cohort Study.
Kasten, Meike
Author Response: Cognitive-Driven Activities of Daily Living Impairment as a Predictor for Dementia in Parkinson Disease: A Longitudinal Cohort Study.
Becker, Sara; Bode, Merle; Liepelt-Scarfone, Inga
