Prospective Randomized Control Trial to Compare the Role of Injection Cerebrolysin for 10 Days Duration Against Placebo in Operated Cases of Degenerative Cervical Myelopathy.

Sharma, Ayush DNB, MS a; Agrawal, Harsh MS a; Naseem, Atif MS a; Marathe, Nandan MS, MRCS b; Gajbhiye, Komalchand MS a; Subramanian, Santhoshkumar MBBS a; Rocos, Brett BSc (Hons), MBChB, MD, FRCS (Tr & Orth) c

doi : 10.1097/BRS.0000000000004542

Volume 48(5) pgs. 295-370,E54-E69 March 1, 2023

AB Study Design. Prospective randomized control trial. Objective. To analyze outcomes following the injection of cerebrolysin in surgically treated patients with degenerative cervical myelopathy (DCM). Summary of Background Data.

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Management of Anticoagulation/Antiplatelet Medication and Venous Thromboembolism Prophylaxis in Elective Spine Surgery: Concise Clinical Recommendations Based on a Modified Delphi Process.

Zuckerman, Scott L. MD, MPH a; Berven, Sigurd MD b; Streiff, Michael B. MD c; Kerolus, Mena MD d; Buchanan, Ian A. MD d; Ha, Alex MD d; Bonfield, Christopher M. MD a; Buchholz, Avery L. MD e; Buchowski, Jacob M. MD, MS f; Burch, Shane MD g; Devin, Clinton J. MD h; Dimar, John R. MD i; Gum, Jeffrey L. MD i; Good, Christopher MD j; Kim, Han Jo MD k; Kim, Jun S. MD l; Lombardi, Joseph M. MD d; Mandigo, Christopher E. MD m; Bydon, Mohamad MD n; Oppenlander, Mark E. MD o; Polly, David W. Jr MD p; Poulter, Gregory MD q; Shah, Suken A. MD r; Singh, Kern MD s; Than, Khoi D. MD t; Spyropoulos, Alex C. MD u; Kaatz, Scott MD v; Jain, Amit MD w; Schutzer, Richard W. MD x; Wang, Tina Z. MD y; Mazique, Derek C. MD z; Lenke, Lawrence G. MD d; Lehman, Ronald A. MD d

doi : 10.1097/BRS.0000000000004540

Delphi method. Objective. To gain consensus on the following questions: (1) When should anticoagulation/antiplatelet (AC/AP) medication be stopped before elective spine surgery?; (2) When should AC/AP medication be restarted after elective spine surgery?; (3) When, how, and in whom should venous thromboembolism (VTE) chemoprophylaxis be started after elective spinal surgery? Summary of Background Data.

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Deterioration After Surgery for Degenerative Cervical Myelopathy: An Observational Study From the Canadian Spine Outcomes and Research Network.

Evaniew, Nathan MD, PhD a,b; Burger, Lukas D. MD a; Dea, Nicolas MD, MSc c; Cadotte, David W. MD, PhD a; Bailey, Christopher S. MD, MSc d; Christie, Sean D. MD e; Fisher, Charles G. MD, MHSc c; Rampersaud, Y Raja MD f; Paquet, Je[Combining Acute Accent]ro[Combining Circumflex Accent]me MD g; Singh, Supriya MD, MSc d; Weber, Michael H. MD, PhD h; Attabib, Najmedden MBBCH i; Johnson, Michael G. MD j; Manson, Neil MD i; Phan, Philippe MD, PhD k; Nataraj, Andrew MD, MSc l; Wilson, Jefferson R. MD, PhD f; Hall, Hamilton MD f; McIntosh, Greg MSc m; Jacobs, W. Bradley MD a; On behalf of the Canadian Spine Outcomes and Research Network (CSORN)

doi : 10.1097/BRS.0000000000004552

A Prospective cohort study. Objective. To investigate the incidence, etiology, and outcomes of patients who experience neurological deterioration after surgery for Degenerative Cervical Myelopathy (DCM). Summary of Background Data.

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Clinical Improvements in Myelopathy Result in Improved Patient-Reported Outcomes Following Anterior Cervical Discectomy and Fusion.

Lambrechts, Mark J. MD; Toci, Gregory R. MD; Karamian, Brian A. MD; Siniakowicz, Claudia BS; Canseco, Jose A. MD, PhD; Woods, Barrett I. MD; Hilibrand, Alan S. MD; Schroeder, Gregory D. MD; Vaccaro, Alexander R. MD, MBA, PhD; Kepler, Christopher K. MD, MBA

doi : 10.1097/BRS.0000000000004518

Retrospective cohort study. Objective. To determine if myelopathy severity predicted the magnitude of improvement in health-related quality of life metrics following anterior cervical discectomy and fusion (ACDF).

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A Five-Year Cost-Utility Analysis Comparing Synthetic Cage Versus Allograft Use in Anterior Cervical Discectomy and Fusion Surgery for Cervical Spondylotic Myelopathy.

Raad, Micheal MD a; Xu, Amy L. BS a; Ortiz-Babilonia, Carlos BS a,b; Marrache, Majd MD a; Durand, Wesley M. MD a; Greenberg, Marc MD a; Jain, Amit MD, MBA a

doi : 10.1097/BRS.0000000000004526

Retrospective cost-utility analysis. Objective. To conduct a cost-analysis comparing synthetic cage (SC) versus allograft (Allo) over a five-year time horizon. Summary of Background Data. SC and Allo are two commonly used interbody choices for anterior cervical discectomy and fusion (ACDF) surgery.

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Long-Term Clinical, Radiographic, and Cost Analysis of Corrective Spine Surgery for Adult Symptomatic Lumbar Deformity With a Mean of 7.5 years Follow-Up.

Yagi, Mitsuru MD, PhD a,b; Shimizu, Toshiyuki MD b; Suzuki, Satoshi MD, PhD a; Takahashi, Yohei MD, PhD a; Ozaki, Masahiro MD, PhD a; Tsuji, Osahiko MD, PhD a; Nagoshi, Narihito MD, PhD a; Yato, Yoshiyuki MD, PhD b; Matsumoto, Morio MD, PhD a; Nakamura, Masaya MD, PhD a; Watanabe, Kota MD, PhD a; Keio Spine Research Group

doi : 10.1097/BRS.0000000000004551

Multicenter retrospective study. Objective. This study reports long-term clinical and radiographic outcomes in surgically treated patients with adult symptomatic lumbar deformity (ASLD). Summary of Background Data.

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Neurological Safety of Endoscopic Transforaminal Lumbar Interbody Fusion: A Magnetic Resonance Neurography Study.

Yang, Xinyu MD a,b; Wang, Lianlei MD a; Yang, Qing BMed a; Su, Junxiao MM a,b; Qiu, Cheng MM a,b; Ibrahim, Yakubu MM a,b; Yuan, Suomao MD a; Tian, Yonghao MD a; Liu, Xinyu MD, PhD a,b

doi : 10.1097/BRS.0000000000004496

A magnetic resonance neurography (MRN) study was conducted to assess the neurological safety of endoscopic transforaminal lumbar intervertebral fusion (endo-TLIF). Materials and Methods. A total of 56 healthy volunteers (29 men, 27 women; average age, 44 yr; age range, 21-60 yr) were included in the study.

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Patient-Reported Outcomes and Reoperation Rates Following Lumbar Tubular Microdecompression: Six-year Follow-Up.

Bullock, Garrett PT; DPT, DPhil a,b; Sangio, Christian A. BS, BA a; Beck, Edward C. MD, MS a; Gowd, Anirudh K. MD a; Miller, Evan MD a; Danelson, Kerry PhD a; James O'Gara, Tadhg MD a,c

doi : 10.1097/BRS.0000000000004538

Prospective cohort study Objective. To report reoperation rates after lumbar tubular microdecompression (LTM) and to compare patient-reported outcomes (PROs) six years after surgery between those who did and did not need revision at the index level. Summary of Background Data.

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Patterns of Vertebral Bone Marrow Edema in the Normal Healing Process of Lumbar Interbody Fusion: Baseline Data for Diagnosis of Pathological Events.

Hasegawa, Yuichi MD a; Kanayama, Masahiro MD a; Oha, Fumihiro MD a; Shimamura, Yukitoshi MD a; Tsujimoto, Takeru MD a; Hashimoto, Tomoyuki MD a; Iwasaki, Norimasa MD b

doi : 10.1097/BRS.0000000000004534

Retrospective investigation using a prospectively collected database. Objective. To examine the appearance and characteristics of vertebral bone marrow edema (BME) in the normal healing of lumbar interbody fusion. Summary of Background Data.

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Cross-cultural Adaptation and Validation of Hindi Version of Roland Morris Disability Questionnaire for Chronic Low Back Pain in Indian Population.

Mohan, Anjali MD a; Sharma, Rajni PhD b; Ghai, Babita MD, DNB, MNAMS a; Kumar, Vishal MS c; Makkar, Jeetinder K. MD, DNB, MNAMS, FRCPC a; Jain, Aditi DM d

doi : 10.1097/BRS.0000000000004472

A cross-cultural adaptation, validation, and psychometric analysis. Objective. The main aim was to assess the validity and reliability of the Hindi version of the Roland Morris Disability Questionnaire (Hi-RMDQ) for chronic low back pain.

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miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.

Zhang, Jiafang a,b; Liu, Ruiduan c; Mo, Ling d; Liu, Caijun d; Jiang, Jianming PhD a

doi : 10.1097/BRS.0000000000004486

Low back pain is the leading cause of disability in the elderly population and is strongly associated with intervertebral disk degeneration (IVDD). However, the precise molecular mechanisms regulating IVDD remain elusive.

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