دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Succinic Ester-Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration (Adv. Healthcare Mater. 5/2023)
Ye Zhu, Lining Zhang, Wanglin Duan, Sergio Martin-Saldaña, Chaowei Li, Hongwen Yu, Luyao Feng, Xianpeng Zhang, Baoji Du, Guanying Li, Xifu Zheng, Yazhong Bu
doi : 10.1002/adhm.202370021
Volume 12, Issue 5
Nanostructured-Based Optical Readouts Interfaced with Machine Learning for Identification of Extracellular Vesicles (Adv. Healthcare Mater. 5/2023)
Carolina del Real Mata, Olivia Jeanne, Mahsa Jalali, Yao Lu, Sara Mahshid
doi : 10.1002/adhm.202370024
Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases (Adv. Healthcare Mater. 5/2023)
Achmad Himawan, Lalitkumar K. Vora, Andi Dian Permana, Sumarheni Sudir, Airin R. Nurdin, Ririn Nislawati, Rafikah Hasyim, Christopher J. Scott, Ryan F. Donnelly
doi : 10.1002/adhm.202370025
Nanostructured-Based Optical Readouts Interfaced with Machine Learning for Identification of Extracellular Vesicles
Carolina del Real Mata, Olivia Jeanne, Mahsa Jalali, Yao Lu, Sara Mahshid
doi : 10.1002/adhm.202202123
Extracellular vesicles (EVs) are shed from cancer cells into body fluids, enclosing molecular information about the underlying disease with the potential for being the target cancer biomarker in emerging diagnosis approaches such as liquid biopsy.
Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases
Achmad Himawan, Lalitkumar K. Vora, Andi Dian Permana, Sumarheni Sudir, Airin R. Nurdin, Ririn Nislawati, Rafikah Hasyim, Christopher J. Scott, Ryan F. Donnelly
doi : 10.1002/adhm.202202066
Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid.
Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment
Ana M. Carvalho, Rui L. Reis, Iva Pashkuleva
doi : 10.1002/adhm.202202118
The tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer-associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro-tumorigenic and carcinogenic functions.
Succinic Ester-Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration
Ye Zhu, Lining Zhang, Wanglin Duan, Sergio Martin-Saldaña, Chaowei Li, Hongwen Yu, Luyao Feng, Xianpeng Zhang, Baoji Du, Guanying Li, Xifu Zheng, Yazhong Bu
doi : 10.1002/adhm.202202122
Shape memory sponges are very promising in stopping the bleeding from noncompressible and narrow entrance wounds. However, few shape memory sponges have fast degradable properties in order to not hinder tissue healing.
Multifunctional Dual Cross-Linked Bioadhesive Patch with Low Immunogenic Response and Wet Tissues Adhesion
Yang Tang, Guidong Gong, Xianglian He, Mengyuan Dai, Mei Chen, Bo Wang, Yajie Wang, Xiaoling Wang, Junling Guo
doi : 10.1002/adhm.202201578
The development of bioadhesives is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, that is, strong adhesion, water resistance, and high biocompatibility.
Liquid Core Nanoparticle with High Deformability Enables Efficient Penetration across Biological Barriers
Chun Wang, Jian Xiao, Xinyue Hu, Qi Liu, Yadan Zheng, Ziyao Kang, Dongsheng Guo, Linqi Shi, Yang Liu
doi : 10.1002/adhm.202201889
Biological barriers significantly limit the delivery efficiency of drug delivery systems, resulting in undesired therapeutic effects.
Lipoplex-Functionalized Thin-Film Surface Coating Based on Extracellular Matrix Components as Local Gene Delivery System to Control Osteogenic Stem Cell Differentiation
Catharina Husteden, Yazmin A. Brito Barrera, Sophia Tegtmeyer, João Borges, Julia Giselbrecht, Matthias Menzel, Andreas Langner, João F. Mano, Christian E. H. Schmelzer, Christian Wölk, Thomas Groth
doi : 10.1002/adhm.202201978
A gene-activated surface coating is presented as a strategy to design smart biomaterials for bone tissue engineering. The thin-film coating is based on polyelectrolyte multilayers composed of collagen I and chondroitin sulfate, two main biopolymers of the bone extracellular matrix, which are fabricated by layer-by-layer assembly.
Selective Formation of Osteogenic and Vasculogenic Tissues for Cartilage Regeneration
Zeyang Liu, Haochen Nan, Yi Shiou Chiou, Zhen Zhan, Peter E. Lobie, Chengzhi Hu
doi : 10.1002/adhm.202202008
Tissue-engineered periosteum substitutes (TEPSs) incorporating hierarchical architecture with osteoprogenitor and vascular niches are drawing much attention as a promising tool to support functional cells in defined zones and nourish the cortical bone.
Redox Modulatory Cu(II)-Baicalein Microflowers Prepared in One Step Effectively Promote Therapeutic Angiogenesis in Diabetic Mice
Kaijing Liu, Limei Liu, Haoyang Guo, Rong Xu, Xiaoyu Liang, Youlu Chen, Huiyang Li, Xue Fu, Xiaoli Wang, Houzao Chen, Yongjun Li, Jing Yang
doi : 10.1002/adhm.202202010
Reactive oxygen species (ROS) have been implicated in multiple cellular processes, and an imbalance in redox homeostasis gives rise to diseases, therefore, reestablishing redox homeostasis is a way to cure.
Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy
Na Song, Yanqiu Song, Binbin Hu, Xin Liu, Xiunan Yu, Hao Zhou, Jiafu Long, Zhilin Yu
doi : 10.1002/adhm.202202039
Pharmacological targeting of endoplasmic reticulum (ER) stress represents one of important methods for disease therapy, which, however, is significantly suppressed by the ER homeostatic processe.
Switchable ROS Scavenger/Generator for MRI-Guided Anti-Inflammation and Anti-Tumor Therapy with Enhanced Therapeutic Efficacy and Reduced Side Effects
Muyao Li, Linlin Huo, Jie Zeng, Guifen Zhu, Xiangqing Liu, Xianglong Zhu, Guoming Huang, Yi Wang, Kaiyuan Ni, Zhenghuan Zhao
doi : 10.1002/adhm.202202043
Photosensitizer in photodynamic therapy (PDT)Â accumulates in both tumor and adjacent normal tissue due to low selective biodistribution, results in undesirable side effect with limited clinic application.
Biomimetic Nanovaccines Potentiating Dendritic Cell Internalization via CXCR4-Mediated Macropinocytosis
Chao Yang, Fan Zhang, Fangman Chen, Zhimin Chang, Yuewu Zhao, Dan Shao, Wen Sun, Wen-fei Dong, Zheng Wang
doi : 10.1002/adhm.202202064
Although targeted delivery of nanoparticulate vaccines to dendritic cells (DCs) holds tremendous potential, it still faces insufficient internalization and endosome degradation via the receptor-mediated endocytosis pathway.
Tumor Cell-Responsive Photodynamic Immunoagent for Immunogenicity-Enhanced Orthotopic and Remote Tumor Therapy
Yingchao Chen, Tao Xiong, Xueze Zhao, Jianjun Du, Wen Sun, Jiangli Fan, Xiaojun Peng
doi : 10.1002/adhm.202202085
Combining photodynamic therapy (PDT) and immune checkpoint blockades is an efficient method to maximize immunotherapeutic outcome by boosting tumor immunogenicity and modulating the immunosuppressive tumor microenvironment.
Carbon Dot@MXene Nanozymes with Triple Enzyme-Mimic Activities for Mild NIR-II Photothermal-Amplified Nanocatalytic Therapy
Bijiang Geng, Lang Yan, Yuping Zhu, Wenjing Shi, Haoneng Wang, Jingjing Mao, Lijun Ren, Jiqianzhu Zhang, Yijun Tian, Fangyuan Gao, Xiaofang Zhang, Jikuai Chen, Jiangbo Zhu
doi : 10.1002/adhm.202202154
Nanozymes have shown promising potential in disease treatment owing to the advantages of low-cost, facile fabrication, and high stability. However, the highly complex tumor microenvironment (TME) and inherent low catalytic activity severely restrict the clinical applications of nanozymes.
A Phase-Change Mediated Intelligent Nanoplatform for Chemo/Photothermal/Photodynamic Therapy of Cancer
Xiaochun Hu, Hui Li, Ruihao Li, Sufeng Qiang, Mengyao Chen, Shuo Shi, Chunyan Dong
doi : 10.1002/adhm.202202245
Up to now, chemotherapy is still the main strategy for cancer treatment. However, the emergence of chemo-resistance and systemic side effects often seriously affects the treatment and prognosis.
LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo-Inspired pH/Tactility Artificial Receptors
Renqiang Yuan, Ning Yang, Weikun Li, Zonghao Liu, Fang Feng, Qianli Zhang, Liqin Ge
doi : 10.1002/adhm.202202296
Besides barrier functions, skin possesses multiple sentiences to external stimuli (e.g., temperature, force, and humidity) for human-outside interaction. Thus, skincare should be taken very seriously, especially by patients with sensory disorders.
