The Lancet




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Generation coronavirus?

The Lancet

doi : 10.1016/S0140-6736(20)31445-8

p1949

The catastrophic elements that have perpetuated the COVID-19 pandemic—global interconnectedness, climate change due to human activity, vast economic inequality, and deep veins of antiscience—have resulted in more than 9 million infections and almost 500 000 deaths worldwide. Although children might be less susceptible to infection by severe acute respiratory syndrome coronavirus 2 and generally have better outcomes than adults, COVID-19 as a phenomenon weighs heavily on their health and wellbeing. Today's children are digital natives born after the turn of the 21st century, who inhabit a planet in crisis and now will inherit the unknowns of a pandemic aftermath. This roiling milieu offers a moment in which a new agenda for health could emerge with children and adolescents at the centre, which could determine if this generation—Gen C—will be defined and confined by the losses from COVID-19.

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Physical distancing, face masks, and eye protection for prevention of COVID-19

C Raina MacIntyre,Quanyi Wang

doi : 10.1016/S0140-6736(20)31183-1

p1950

The choice of various respiratory protection mechanisms, including face masks and respirators, has been a vexed issue, from the 2009 H1N1 pandemic to the west African Ebola epidemic of 2014,1 to the current COVID-19 pandemic.

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Biomarkers in Down syndrome can help us understand Alzheimer's disease

Elizabeth Head,Beau Ances

doi : 10.1016/S0140-6736(20)30916-8

p1951

Down syndrome is associated with increased risk of developing early-onset Alzheimer's disease, primarily because of the overexpression of the APP gene on chromosome 21. People with Down syndrome, as a form of genetically determined Alzheimer's disease, represent one of the largest cohorts at risk of early-onset Alzheimer's disease because virtually all adults with Down syndrome will develop Alzheimer's disease by age 40 years. 1 However, the age range for the onset of cognitive decline is wide (from <50 years to >70 years). 2 The characterisation of the preclinical phases of Alzheimer's disease is crucial for early diagnosis in this susceptible group of people.

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Vaccinating against mosquitoes: anticipating the unexpected

Pat Nuttall

doi : 10.1016/S0140-6736(20)31319-2

p1953

Mosquitoes act as vectors of a remarkable number of viruses and some parasites, which they transmit in their saliva while they feed on blood. Among these mosquito-borne agents are pathogens that cause some of the most medically devastating infectious diseases—malaria, lymphatic filariasis, dengue, yellow fever, Zika virus disease, chikungunya, Japanese encephalitis, and West Nile fever. Although some of these diseases have been around for centuries, in the past few decades epidemics caused by viruses such as West Nile, chikungunya, and Zika took many regions by surprise, overwhelming health systems.

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COVID-19 and ethnicity: who will research results apply to?

Shaun Treweek,Nita G Forouhi,K M Venkat Narayan,Kamlesh Khunti

doi : 10.1016/S0140-6736(20)31380-5

p1955

The toll of COVID-19 is not equal. Evidence globally shows a greater COVID-19 burden with older age, male sex, obesity, comorbidities, and poverty.

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Informal home care providers: the forgotten health-care workers during the COVID-19 pandemic

Emily Ying Yang Chan,Nina Gobat,Jean H Kim,Elizabeth A Newnham,Zhe Huang,Heidi Hung,Caroline Dubois,Kevin Kei Ching Hung,Eliza Lai Yi Wong,Samuel Yeung Shan Wong

doi : 10.1016/S0140-6736(20)31254-X

p1957

The COVID-19 pandemic has placed pressure on many national health-care systems worldwide. Due to the rapid surge in caseloads and resource constraints in health systems, in many high-income settings, the focus has been on disease screening, with those who have severe disease prioritised for hospitalisation.

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Offline: The second wave

Richard Horton

doi : 10.1016/S0140-6736(20)31451-3

p1960

The spectre of a second wave of COVID-19 hangs over us. Some infectious disease specialists believe that SARS-CoV-2 might be losing virulence. Most are less sanguine.

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LGBTQ discrimination in US health care under scrutiny

Susan Jaffe

doi : 10.1016/S0140-6736(20)31446-X

p1961

A US Supreme Court ruling could undermine the Trump administration's plan to roll back some protections against sex discrimination. Susan Jaffe reports.

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Access to health care under threat in Afghanistan

Sharmila Devi

doi : 10.1016/S0140-6736(20)31447-1

p1962

Attacks on hospitals and high numbers of COVID-19 cases among health workers could hamper access to health care. Sharmila Devi reports. Millions of people are at risk from rising violence in Afghanistan including attacks on health-care facilities amid the COVID-19 pandemic, the International Committee of the Red Cross (ICRC) warned on June 17.

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Aletha Maybank: AMA's Chief Health Equity Officer

Susan Jaffe

doi : 10.1016/S0140-6736(20)31408-2

p1963

The world has changed in the year since the American Medical Association (AMA) named Aletha Maybank as its first Chief Health Equity Officer and founder of the AMA's Center for Health Equity, dedicated to eliminating the barriers to optimal health for all patients.

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Nature and nowness under lockdown

Rachel Clarke

doi : 10.1016/S0140-6736(20)31409-4

p1964

“Death”, wrote Saul Bellow in his acclaimed novel Humboldt's Gift, “is the dark backing a mirror needs if we are to see anything”. 45 years have elapsed since he wrote these words, but they have surely never carried more weight. As we reel, stunned and awestruck, through the COVID-19 pandemic, the menace of death has inspired a profound attentiveness to—and gratitude for—the simplest moments of life. Amid the soaring death tolls, it has felt at times as though nothing—not least the natural world on our doorstep—will ever be taken for granted again.

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James Learmonth Gowans

Geoff Watts

doi : 10.1016/S0140-6736(20)31410-0

p1966

Immunologist and science administrator. He was born in Sheffield, UK, on May 7, 1924, and died in Oxford, UK, on April 1, 2020, aged 95 years.

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What we need is a sustainable politics of life

Tony Joakim Sandset,Kristin Heggen,Eivind Engebretsen

doi : 10.1016/S0140-6736(20)31378-7

p1967

Richard Horton1 provides us with an important comment on the ongoing COVID-19 pandemic. By refracting the ongoing pandemic through the scholarship of the anthropologist and physician Didier Fassin,2 Horton alerts us to the fact that COVID-19 is much more than a global health crisis: it is a crisis of life itself.

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COVID-19, nuclear war, and global warming: lessons for our vulnerable world

James E Muller,David G Nathan

doi : 10.1016/S0140-6736(20)31379-9

p1967

The COVID-19 pandemic teaches lessons we must embrace to overcome two additional existential threats: nuclear war and global warming. Health professionals need to send a message to those whose lives we have vowed to protect: all three threats result from forces of nature made dangerous by triumphs of human intelligence, and all three can be solved by human intelligence

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Gendered effects of school closures during the COVID-19 pandemic

Katarzyna Burzynska,Gabriela Contreras

doi : 10.1016/S0140-6736(20)31377-5

p1968

Governments worldwide have implemented school closures as a preventive measure to the spread of COVID-19. According to UNESCO, school closures have sent about 90% of all students out of school, among them more than 800 million girls. A substantial number of these girls live in the world's least developed countries where getting an education is already a struggle. We agree with Hall and colleagues1 who recognise girls as a vulnerable group in the COVID-19 pandemic, stress two issues hindering girls' education in developing countries, and challenge progress and commitment toward gender equality, girl empowerment, and the Sustainable Development Goals.

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Challenges for the female academic during the COVID-19 pandemic

Brooke Peterson Gabster,Kim van Daalen,Roopa Dhatt,Michele Barry

doi : 10.1016/S0140-6736(20)31412-4

p1968

Science and innovation benefit from diversity. However, as the global community fights COVID-19, the productivity and scientific output of female academics are disproportionately affected, leading to loss of women's scientific expertise from the public realm.

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Overcoming fragmentation of health research in Europe: lessons from COVID-19

Karin R Sipido,Fernando Antoñanzas,Julio Celis,Laurent Degos,Richard Frackowiak,...

doi : 10.1016/S0140-6736(20)31411-2

p1970

We face an unprecedented crisis in our interconnected world where health and wellbeing, security, and economy affect populations across borders. Individual and societal health is valued widely, with care for the planet and health top priorities for European citizens. Europe's answer to COVID-19 comes with long-term geopolitical and economic consequences and, in this intense spotlight, EU health policy weaknesses are starkly apparent.

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Primaquine for Plasmodium vivax malaria treatment

Harin Karunajeewa,Robert James

doi : 10.1016/S0140-6736(20)30242-7

p1971

The main reason conventional primaquine regimens last 14 days is because this was the time taken to repatriate US military personnel by ship following active service in the Korean War.1 We therefore congratulate Walter Taylor and colleagues2 for finally upending an absurdly impractical 60-year-old legacy and setting a new standard of care. However, convincing policy makers and practitioners to implement this new standard of care presents challenges relating to how risk is perceived and managed.

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Primaquine for Plasmodium vivax malaria treatment – Authors' reply

Richard N Price,Walter R J Taylor,Kamala Thriemer,Nicholas J White,Nicholas P Day

doi : 10.1016/S0140-6736(20)30217-8

p1972

We agree with Harin Karunajeewa and Robert James that radical cure of Plasmodium vivax malaria needs to be deployed more widely. The question is, how do we achieve this? Shortening the treatment course and thereby improving adherence is an important step in the right direction.1 Primaquine regimens are usually extended over 14 days to reduce the daily dose and thereby improve tolerability and safety.

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Racism, the public health crisis we can no longer ignore

Delan Devakumar,Sujitha Selvarajah,Geordan Shannon,Kui Muraya,Sarah Lasoye,Susanna Corona,Yin Paradies,Ibrahim Abubakar,E Tendayi Achiume

doi : 10.1016/S0140-6736(20)31371-4

e112

Extraordinary times call for extraordinary measures. We are facing a global pandemic, a climate catastrophe, an imminent recession, and possibly depression. The health of the most vulnerable and all of humanity is at stake. Yet there is nothing new, extraordinary, or unprecedented about racism, xenophobia, and discrimination.

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Faced with today's crisis, what would Gandhi do?

Abhay Bang

doi : 10.1016/S0140-6736(20)31413-6

e114

The current global crisis is multi-layered. The COVID-19 pandemic, economic recession, and global warming are compounded by the void of political and moral leadership. Faced with the present crisis, what would Gandhi do?

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Department of Error

-

doi : 10.1016/S0140-6736(20)30892-8

p1972

Naci H, Salcher-Konrad M, Kesselheim AS, et al. Generating comparative evidence on new drugs and devices before approval. Lancet 2020; 395: 986–97—In this Series paper, Professor Lise Rochaix's affiliations should have been University of Paris 1, Panthéon-Sorbonne, Paris, France and Hospinnomics, Assistance Publique—Hôpitaux de Paris and Paris School of Economics, Paris, France. These corrections have been made to the online version as of June 25, 2020.

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Department of Error

-

doi : 10.1016/S0140-6736(20)31419-7

p1972

Sawitzki B, Harden PN, Reinke P, et al. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet 2020; 395: 1627–39—In this Article, the Acknowledgments have been updated. This correction has been made to the online version as of June 25, 2020.

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Department of Error

-

doi : 10.1016/S0140-6736(20)31323-4

p1972

MacIntyre CR, Wang Q. Physical distancing, face masks, and eye protection for prevention of COVID-19. Lancet 2020; published online June 1. https://doi.org/10.1016/S0140-6736(20)31183-1—In this Comment, the second sentence of the fourth paragraph should read “. . . in a subanalysis, respirators were 96% effective (aOR 0·04, 95% CI 0·004–0·30) compared with other masks, which were 67% effective (aOR 0·33, 95% CI 0·17–0·61; pinteraction=0·090).” This correction has been made to the online version as of June 5, 2020, and will be made to the printed Comment.

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