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Adolescent raloxifene treatment in females prevents cognitive deficits in a neurodevelopmental rodent model of schizophrenia
Viktoria Felgel-Farnholz a,*, Elizabeth Barroeta Hlusicka a, Henriette Edemann-Callesen b, Alexander Garthe c, Christine Winter b, Ravit Hadar
doi : 10.1016/j.bbr.2022.114276
Volume 441, 12 March 2023, 114276
The existence of sex differences in schizophrenia is a well documented phenomenon which led to the hypothesis that female sex hormones are neuroprotective and hence responsible for the more favorable disease characteristics seen in women.
The effectiveness of extinction training in male rats: Temporal considerations and brain mechanisms
Pedro Correia a,b,d,1, Korn �el Demeter a,c,1, J �anos Varga a, Eszter Urb �an a, Bibi �ana T ̈or ̈ok a,b,d, Di �ana Bal �azsfi a, Nikoletta Bakos a, J �ozsef Haller a, D �ora Zelena
doi : 10.1016/j.bbr.2023.114285
Volume 441, 12 March 2023, 114285
The extinction of conditioned fear is frequently used in laboratories as a model for human exposure therapy and is crucial for studies of posttraumatic stress disorder (PTSD).
A Chinese pedigree with Perry disease caused by the p.Y78H mutation in DCTN1: A 6-year clinical follow-up
Xingyuan Pan, Qian Hong, Xucong Lu, Zhengzheng Li, Luxi Wang, Weian Chen *,1, Sipei Pan
doi : 10.1016/j.bbr.2023.114284
Volume 441, 12 March 2023, 114284
Perry disease is a rare autosomal dominant neurodegenerative disorder with core features of parkinsonism, depression, apathy, weight loss, and central hyperventilation. To date, few cases of Perry disease have been reported worldwide, and they are all due to mutations in the DCTN1 gene. We report a case of a Chinese pedigree.
Reversal of cold intolerance by testosterone in orchiectomized mice after tibial nerve transection
Emad Khalilzadeh a,c,*, Mohammadhassan Aliyoldashi a, Babak Abdkarimi a, Farzin Azarpey a,c, Gholamreza Vafaei Saiah a, Reza Hazrati b, Ombretta Caspani
doi : 10.1016/j.bbr.2022.114269
Volume 441, 12 March 2023, 114269
Cold intolerance is a debilitating effect of nerve injury, has a strong impact on the life of patients and no advisable treatment exists against it. Testosterone influences pain pathways and has analgesic effects.
Behavioral context improves optogenetic stimulation of transplanted dopaminergic cells in unilateral 6-OHDA rats☆
Kevin A. Anderson a,1, Bailey J. Whitehead a,e, Eric D. Petersen b,c,d, Madison R. Kemme a,f, Anna Wedster b, Ute Hochgeschwender b,c,d, Michael I. Sandstrom a
doi : 10.1016/j.bbr.2022.114279
Volume 441, 12 March 2023, 114279
Stem cell therapy has long been a popular method of treatment for Parkinson’s disease currently being researched in both preclinical and clinical settings. While early clinical results are based upon fetal tissue transplants rather than stem cell transplants, the lack of successful integration in some patients and gradual loss of effect in others suggests a more robust protocol is needed.
Predicting insomnia severity using structure-function coupling in female chronic insomnia patients
Dongyan Wu a,1, Xinzhi Wang b,1, Shiqi Lin b, Guang Xu c, Junzhang Tian b, Xiaofen Ma
doi : 10.1016/j.bbr.2023.114283
Volume 441, 12 March 2023, 114283
Functional connectivity between brain regions is constrained by the underlying structural pathways. However, how this structure-function coupling is disrupted in female patients with insomnia disorder is unclear.
Maternal separation increased memory function and anxiety without effects of environmental enrichment in male rats
Ozge Selin Cevik a,*, Kenan Cevik b, Gulhan Orekici Temel c, Leyla Sahin
doi : 10.1016/j.bbr.2022.114280
Volume 441, 12 March 2023, 114280
Maternal separation is a detrimental postnatal influence, whereas environmental enrichment is a therapeutic and protective agent. It is unclear if long-term environmental enrichment can compensate for the effects of maternal separation stress on memory-related alterations.
The “eye� in imagination: The role of eye movements in a reciprocal aiming task
Aarohi Pathak a,*, Shikha Patel a, April Karlinsky a,b, Saba Taravati a, Timothy N. Welsh
doi : 10.1016/j.bbr.2022.114261
Volume 441, 12 March 2023, 114261
Humans not only perform a variety of actions, but they also simulate or imagine themselves performing those actions. When individuals physically execute goal-directed hand movements, eye movements typically precede the hand movements to the target to enhance movement accuracy.
Active vs passive novelty-related strategies: Sex differences in exploratory behaviour and monoaminergic systems
Kristi Liiver a, Sophie Imbeault a, Marianna ˇSkolnaja a,b, Tanel Kaart c, Margus Kanarik d, Karita Laugus d, Jade De Wettinck a, Aleksander Pulver a, Ruth Shimmo a, Jaanus Harro
doi : 10.1016/j.bbr.2023.114297
Volume 441, 12 March 2023, 114297
Sex differences are apparent in numerous behavioural characteristics. In order to compare and characterise male and female variability of exploratory behaviour, 365 male and 401 female rats were assessed in a task where a bimodal response distribution had previously been established in males.
Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway
Zhongxuan Ma a,*, Dingding Feng b, Wenjuan Rui c, Zhiqing Wang
doi : 10.1016/j.bbr.2023.114299
Volume 441, 12 March 2023, 114299
Baicalin (BA), a flavonoid glycoside extracts from Scutellaria baicalensis Georgi, has been reported to exert antidepressant effects. Emerging evidence indicates that neuronal apoptosis plays a crucial role in the pathogenesis of depression. Poly (ADP-ribose) polymerase-1 (PARP1) is established as a key regulator of the cellular apoptosis.
Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2
Akbar Hajizadeh Moghaddam a,*, Ali Eslami a, Sedigheh khanjani Jelodar a, Mojtaba Ranjbar b, Vahid Hasantabar
doi : 10.1016/j.bbr.2023.114300
Volume 441, 12 March 2023, 114300
Akbar Hajizadeh Moghaddam a,*, Ali Eslami a, Sedigheh khanjani Jelodar a, Mojtaba Ranjbar b, Vahid Hasantabar
Activation of D1R signaling in the medial prefrontal cortex rescues maternal separation-induced behavioral deficits through restoration of excitatory neurotransmission
Youjun Yang a,b,*, Zhanqiong Zhong a, Baojia Wang a, Yili Wang c, Weijun Ding
doi : 10.1016/j.bbr.2023.114287
Volume 441, 12 March 2023, 114287
Neural activation to infant cry among Latina and non-Latina White mothers
Ozlü Aran a,*,1, Tiffany Phu a,*,1, Andrew Erhart a,b, Sarah Watamura a, Pilyoung Kim
doi : 10.1016/j.bbr.2023.114298
Volume 441, 12 March 2023, 114298
Cultural neuroscience is an emerging framework positing that culture (for example, values, beliefs, practices, and modes of emotional expression) critically informs socialization goals and desired behaviors, which are perhaps accompanied by differential patterns of brain activation.
Behavior, BDNF and epigenetic mechanisms in response to social isolation and social support in middle aged rats exposed to chronic stress
Juliano Viana Borges a,1, Vivian Naziaseno Pires a,c,1, Betˆania Souza de Freitas a, Gabriel Rübensam b, Vit �oria Corrˆea Vieira a, Cristophod de Souza dos Santos a, Nadja Schr ̈oder d,e, Elke Bromberg a,
doi : 10.1016/j.bbr.2023.114303
Volume 441, 12 March 2023, 114303
Social deprivation can be stressful for group-living mammals. On the other hand, an amazing response of these animals to stress is seeking social contact to give and receive joint protection in threatening situations.
Minocycline treatment improves cognitive and functional plasticity in a preclinical mouse model of major depressive disorder
Silvia Poggini a,1, Maria Banqueri Lopez b,1, Naomi Ciano Albanese a,c, Maria Teresa Golia d, Fernando Gonz �alez Ib �a ̃nez e,f, Cristina Limatola d,i, Martin Furhmann g, Maciej Lalowski h, Marie-Eve Tremblay e,f, Laura Maggi d, Bozena Kaminska b,2, Igor Branchi
doi : 10.1016/j.bbr.2023.114295
Volume 441, 12 March 2023, 114295
Major depressive disorder (MDD) is a chronic, recurring, and potentially life-threatening illness, which affects over 300 million people worldwide. MDD affects not only the emotional and social domains but also cognition.
Sleep behaviors and Parkinson's disease: A bidirectional Mendelian randomization analysis
Yuxiao Ling a, Jiahao Zhu b, Feng Yan c, Lap Ah TSE d, Sanjay Kinra e, MinMin Jiang
doi : 10.1016/j.bbr.2022.114281
Volume 441, 12 March 2023, 114281
Whether the quantity and quality of sleep are the risk factors for the development of Parkinson's disease remains unclear though it has now been confirmed that the quality of sleep among patients with Parkinson's disease is affected at the prodromal and clinical stages.
Corrigendum to: “Inhibition of Piezo1/Ca(2+)/calpain signaling in the rat basal forebrain reverses sleep deprivation-induced fear memory impairments� [Behav. Brain Res. 417 (2022) 113594]
Tao Ma a,1, Ying-Ying Wang b,1, Yan Lu c, Long Feng d, Yi-Tian Yang e, Guan-Hua Li a, Chi Li a, Yang Chu a, Wei Wang a,*, Hao Zhang
doi : 10.1016/j.bbr.2023.114302
Volume 441, 12 March 2023, 114302
