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Pulmonary drug delivery: an effective and convenient delivery route to combat COVID-19
Shohreh Alipour, Laleh Mahmoudi & Fatemeh Ahmadi
doi : 10.1007/s13346-022-01251-1
Volume 13, issue 3, March 2023
The recent outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China has spread rapidly around the world, leading to a widespread and urgent effort to develop and use comprehensive approaches in the treatment of COVID-19.
Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system
Hui Liu, Yu-Yan Su, Xin-Chi Jiang & Jian-Qing Gao
doi : 10.1007/s13346-022-01252-0
Recently, nanoparticle-based drug delivery systems have been widely used for the treatment, prevention, and detection of diseases. Improving the targeted delivery ability of nanoparticles has emerged as a critical issue that must be addressed as soon as possible.
A comprehensive review on the COVID-19 vaccine and drug delivery applications of interpenetrating polymer networks
Ebtisam A. Aldaais
doi : 10.1007/s13346-022-01254-y
An interpenetrating polymer network (IPNs) is a concoction of two or more polymers (natural, synthetic, and/or a combination of both) in which at least one polymer is synthesized or crosslinked in the intimate presence of the other.
Nanomedicines and nanocarriers in clinical trials: surfing through regulatory requirements and physico-chemical critical quality attributes
Diego Alejandro Dri, Federica Rinaldi, Maria Carafa & Carlotta Marianecci
doi : 10.1007/s13346-022-01262-y
Elucidation of physical-chemical characteristics of investigational medicinal products should be established with suitable methodology. Characterization of nanomedicines and nanocarriers in clinical trials may require the definition of additional specific properties depending on the nature of the nanostructures or nanomaterials composing the investigational medicinal product.
Pirfenidone-loaded hyaluronic acid methacryloyl hydrogel for preventing epidural adhesions after laminectomy
Jiawei Ji, Jiaqi Cheng, Cheng Chen, Yang Lu, Xiaoqing Chen & Feng Zhang
doi : 10.1007/s13346-022-01236-0
It is inevitable that scar formation occurs between the spinal dura and surrounding tissues after laminectomy.
Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression
Song You, Zijin Luo, Niangmei Cheng, Ming Wu, Yongping Lai, Fei Wang, Xiaoyuan Zheng, Yingchao Wang, Xiaolong Liu, Jingfeng Liu & Bixing Zhao
doi : 10.1007/s13346-022-01237-z
Circular RNAs (circRNAs) are a class of highly stable and closed-loop noncoding RNA that are involved in the occurrence and development of hepatocellular carcinoma (HCC). However, little is known about the therapeutic role of circRNAs in HCC.
Patient-friendly extemporaneous formulation of bisoprolol: application to stability and bioavailability studies
Soha M. El-Masry, Sally A. Helmy, Soha A. M. Helmy & Eman A. Mazyed
doi : 10.1007/s13346-022-01239-x
Community and hospital pharmacists always face the challenge to prepare oral liquid extemporaneous formulations to fit the needs of a specific patient population when commercial forms or the required strength is unavailable.
Efficiency of targeted delivery of streptokinase based on fibrin-specific liposomes in the in vivo experiment
Adzerikho Igor, Vladimirskaya Tatyana, Lutsik Irina, Dubatouka Katsiaryna & Agabekov Vladimir
doi : 10.1007/s13346-022-01242-2
Acute thrombosis has a narrow therapeutic window and remains the leading cause of morbidity and mortality, while thrombolytic therapy has limited efficacy and risk of side effects.
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins
Bettina Gabold, Friederike Adams, Sophie Brameyer, Kirsten Jung, Christian L. Ried, Thomas Merdan & Olivia M. Merkel
doi : 10.1007/s13346-022-01245-z
Nose-to-brain delivery presents a promising alternative route compared to classical blood–brain barrier passage, especially for the delivery of high molecular weight drugs. In general, macromolecules are rapidly degraded in physiological environment.
Self-nanoemulsifying formulation for oral delivery of sildenafil: effect on physicochemical attributes and in vivo pharmacokinetics
Sanyog Jain, Narinder Kumar, Reena Sharma, Rohan Ghadi, Tushar Date, Nallamothu Bhargavi, Dasharath Chaudhari & Sameer S. Katiyar
doi : 10.1007/s13346-022-01247-x
Sildenafil (SLD) is employed for the management of erectile dysfunction and pulmonary arterial hypertension. It exhibits meagre water solubility and is available in the form of citrate salt hydrate to improve the solubility.
Engineering of tetanus toxoid-loaded polymeric microneedle patches
Muhammad Sohail Arshad, Shafaq Gulfam, Saman Zafar, Najmusama Abdul Jalil, Nadia Ahmad, Omar Qutachi, Ming-Wei Chang, Neenu Singh & Zeeshan Ahmad
doi : 10.1007/s13346-022-01249-9
This study is aimed to fabricate tetanus toxoid laden microneedle patches by using a polymeric blend comprising of polyvinyl pyrrolidone and sodium carboxymethyl cellulose as base materials and sorbitol as a plasticizer.
Preparation, optimization, and in vitro–in vivo evaluation of sorafenib-loaded polycaprolactone and cellulose acetate nanofibers for the treatment of cutaneous leishmaniasis
Mahsa Alemomen, Somayeh Taymouri, Sedigheh Saberi & Jaleh Varshosaz
doi : 10.1007/s13346-022-01250-2
The most common form of leishmaniasis is cutaneous leishmaniasis (CL). The major difficulties in the treatment of leishmaniasis include emergence of resistance, toxicity, long-term treatment, and the high cost of the current drugs.
Precision engineering designed phospholipid-tagged pamidronate complex functionalized SNEDDS for the treatment of postmenopausal osteoporosis
Pavitra Solanki1 · Mohd. Danish Ansari1 · Mohd. Iqbal Alam2 · Mohd. Aqil1 · Farhan J. Ahmad1 · Yasmin Sultana
doi : 10.1007/s13346-022-01259-7
Disodium pamidronate, a second-generation bisphosphonate is a potent drug for the treatment of osteoporosis, which has been very well established by previous literature. It has very low oral permeability, leading to its low oral bioavailability, which restrict this drug to being administered orally.
