دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma
Josbert Metselaar, Twan Lammers, Amelie Boquoi, Roland Fenk, Fabio Testaquadra, Mirle Schemionek, Fabian Kiessling, Susanne Isfort, Stefan Wilop & Martina Crysandt
doi : 10.1007/s13346-022-01268-6
Volume 13, issue 4, April 2023
Despite the introduction of multiple new drugs and combination therapies, conventional dexamethasone remains a cornerstone in the treatment of multiple myeloma (MM). Its application is, however, limited by frequent adverse effects of which the increased infection rate may have the strongest clinical impact.
Nanoclays for wound management applications
Filipa Mascarenhas-Melo, Diana Peixoto, Carolina Aleixo, Maria Beatriz S. Gonçalves, Faisal Raza, Kiran D. Pawar, Francisco Veiga, Mingxian Liu & Ana Cláudia Paiva-Santos
doi : 10.1007/s13346-022-01279-3
Nanotechnology has been comprehensively applied as a new approach to managing wound healing. Particularly, nanoclays are being used to improve traditional wound healing approaches or new therapies.
Particle preparation of pharmaceutical compounds using supercritical antisolvent process: current status and future perspectives
Rahul Kumar, Amit K. Thakur, Gergely Kali, Kancharlapalli Chinaraga Pitchaiah, Raj Kumar Arya & Anurag Kulabhi
doi : 10.1007/s13346-022-01283-7
The low aqueous solubility and subsequently slow dissolution rate, as well as the poor bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in the pharmaceutical industry.
Machine learning in accelerating microsphere formulation development
Jiayin Deng, Zhuyifan Ye, Wenwen Zheng, Jian Chen, Haoshi Gao, Zheng Wu, Ging Chan, Yongjun Wang, Dongsheng Cao, Yanqing Wang, Simon Ming-Yuen Lee & Defang Ouyang
doi : 10.1007/s13346-022-01253-z
Microspheres have gained much attention from pharmaceutical and medical industry due to the excellent biodegradable and long controlled-release characteristics. However, the drug release behavior of microspheres is influenced by complicated formulation and manufacturing factors.
A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism
Le Tong, ZeYang Zhou, Gang Wang & Chao Wu
doi : 10.1007/s13346-022-01255-x
Oral absorption of docetaxel was limited by drug efflux pump p-glycoprotein (P-gp) and cytochrome P450 enzyme (CYP 450). Therefore, co-loading agent that inhibits P-gp and CYP450 in self-nanoemulsifying drug delivery systems (SMEs) is considered a promising strategy for oral delivery of docetaxel.
Central composite design–based optimization, fabrication, and pharmacodynamic assessment of sulfasalazine-loaded lipoidal nanoparticle-based hydrogel for the management of rheumatoid arthritis
Ritu Mishra, Neha Jain, Shreya Kaul & Upendra Nagaich
doi : 10.1007/s13346-022-01260-0
Rheumatoid arthritis is a progressive, chronic, immunological, and inflammatory disorder that is distinguished by joint inflammation, joint tenderness, and synovial joint destruction. The study aimed to fabricate sulfasalazine-loaded solid lipid nanoparticle (SLN)–based gels for rheumatoid arthritis management.
Long-acting injectable in situ gel of rasagiline: a patented product development
Dongyang Zhao, Ping Chen, Yuanbin Hao, Jing Dong, Yu Dai, Qingqing Lu, Xin Zhang & Chia-Wen Liu
doi : 10.1007/s13346-022-01261-z
Rasagiline has a certain potential in neuroprotection and delaying the progression of Parkinson’s disease (PD). However, the poor pharmacokinetics (PK) characteristics of conventional oral tablets and poor medication compliance limit the optimal efficacy of rasagiline.
Encapsulation and release of hydrocortisone from proliposomes govern vaginal delivery
Marc-Phillip Mast, LetÃcia Mesquita, Kennard Gan, Svetlana Gelperina, José das Neves & Matthias G. Wacker
doi : 10.1007/s13346-022-01263-x
Topical preparations of hydrocortisone can be used for the anti-inflammatory treatment of the female genital area. Although the drug is a low-strength corticosteroid, systemic absorption and distribution of the drug are the most common safety risks associated with this therapy.
Cationic liposomes as promising vehicles for timolol/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro/in vivo evaluation
Ali bigdeli, Behzad Sharif Makhmalzadeh, Mostafa Feghhi & Emad SoleimaniBiatiani
doi : 10.1007/s13346-022-01266-8
Glaucoma is a chronic eye disease in which the pressure inside the eye increases and leads to damage to the optic nerve, and eventually causes blindness. In this disease, it is often necessary to use a multi-drug treatment system.
Development and evaluation of transdermal delivery system of tranylcypromine for the treatment of depression
Nisha Shrestha & Ajay K. Banga
doi : 10.1007/s13346-022-01269-5
Tranylcypromine (logP = 1.34, MW = 133.19 g/mol) is a monoamine oxidase inhibitor used in treating major depressive disorder and is available only as oral tablets.
Harnessing immunotherapy to enhance the systemic anti-tumor effects of thermosensitive liposomes
Maximilian Regenold, Xuehan Wang, Kan Kaneko, Pauric Bannigan & Christine Allen
doi : 10.1007/s13346-022-01272-w
Chemotherapy plays an important role in debulking tumors in advance of surgery and/or radiotherapy, tackling residual disease, and treating metastatic disease. In recent years many promising advanced drug delivery strategies have emerged that offer more targeted delivery approaches to chemotherapy treatment.
Exploring paclitaxel-loaded adenosine-conjugated PEGylated PLGA nanoparticles for targeting triple-negative breast cancer
Dasharath Chaudhari, Kaushik Kuche, Vivek Yadav, Rohan Ghadi, Tushar Date, Nallamothu Bhargavi & Sanyog Jain
doi : 10.1007/s13346-022-01273-9
In present investigation, we developed paclitaxel (PTX)-loaded adenosine (ADN)-conjugated PLGA nanoparticles for combating triple-negative breast cancer (TNBC), where ADN acts as a substrate for adenosine receptors (AR) that are overexpressed in TNBC.
A membrane-free microfluidic approach to mucus permeation for efficient differentiation of mucoadhesive and mucopermeating nanoparticulate systems
Leah Wright, Anthony Wignall, Silver Jõemetsa, Paul Joyce & Clive A. Prestidge
doi : 10.1007/s13346-022-01274-8
The gastrointestinal mucus barrier is a widely overlooked yet essential component of the intestinal epithelium, responsible for the body’s protection against harmful pathogens and particulates.
Cholecalciferol-load films for the treatment of nasal burns caused by cauterization of the hypertrophied inferior turbinate: formulation, in vivo study, and clinical assessment
Soad A. Mohamad, Ahmed M. Badwi, Mahmoud Elrehany, Sherif Ali & Abdelrahman M. Helmy
doi : 10.1007/s13346-022-01275-7
Nasal turbinate hypertrophy is among the most common nasal obstruction disorders, affecting the patient’s quality of life significantly. Endoscopic submucosal diathermy is a prevalent cauterization procedure for treating turbinate hypertrophy.
In vitro–in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
Ana F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones & Carmen Alvarez-Lorenzo
doi : 10.1007/s13346-022-01276-6
There is still a paucity of information on how in vitro release profiles from drug-loaded contact lenses (CLs) recorded in 3D printed eye models correlate with in vivo profiles. This work aims to evaluate the release profiles of two drug-loaded CLs in a 3D in vitro eye blink model and compare the obtained results with the release in a vial and the drug levels in tear fluid previously obtained from an animal in vivo study.
Improving in vivo oral bioavailability of a poorly soluble drug: a case study on polymeric versus lipid nanoparticles
Giovanna Rassu, Antonella Obinu, Carla Serri, Sandra Piras, Antonio Carta, Luca Ferraro, Elisabetta Gavini, Paolo Giunchedi & Alessandro Dalpiaz
doi : 10.1007/s13346-022-01278-4
Poorly soluble drugs must be appropriately formulated for clinical use to increase the solubility, dissolution rate, and permeation across the intestinal epithelium. Polymeric and lipid nanocarriers have been successfully investigated for this aim, and their physicochemical properties, and in particular, the surface chemistry, significantly affect the pharmacokinetics of the drugs after oral administration.
Cyclodextrin inclusion complex of a multi-component natural product by hot-melt extrusion
Rhayssa de Oliveira Nonato, Anna Paula Krawczyk-Santos, Gleidson Cardoso, Ana Carolina Kogawa, Karina Ricommini, Ã�dley Antonini Neves de Lima, Luana Heimfarth, Lucindo José Quintans-Júnior, MarcÃlio Cunha-Filho, Stephania Fleury Taveira & Ricardo Neves Marreto
doi : 10.1007/s13346-022-01280-w
This study aimed to investigate whether hot-melt extrusion (HME) processing can promote molecular encapsulation of a multi-component natural product composed of volatile and pungent hydrophobic substances (ginger oleoresin (OR)) with cyclodextrins
Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation
Mohamed Mahmoud Ali, Raguia Aly Shoukri & Carol Yousry
doi : 10.1007/s13346-022-01285-5
Rasagiline mesylate (RM) is a monoamine oxidase inhibitor that is commonly used to alleviate the symptoms of Parkinson’s disease.
