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Ralph L. Sacco, 65, Dies: Stroke Expert With a Talent for Architectural Design.
Avitzur, Orly MD, MBA
doi : 10.1161/STR.0000000000000423
Volume 54(3) pgs. 639-908,e52-e125 March 2023
Stroke: Dissemination of Exceptional Science to Impact Stroke Care Globally.
Hillis, Argye Elizabeth MD, MA
Vascular Biology of Dementia.
Cipolla, Marilyn J. PhD; Alkayed, Nabil J. MD, PhD
Cerebral Small Vessel Disease-Related Dementia: More Questions Than Answers.
Elahi, Fanny M. MD, PhD; Wang, Michael M. MD, PhD; Meschia, James F. MD
doi : 10.1161/STROKEAHA.122.038265
AB Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-dependent diseases, including stroke and dementia. CSVD-related dementia will affect a growing fraction of the aging population, requiring improved recognition, understanding, and treatments.
Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments.
Andjelkovic, Anuska V. MD, PhD; Situ, Muyu BS; Citalan-Madrid, Ali Francisco PhD; Stamatovic, Svetlana M. MD, PhD; Xiang, Jianming MD; Keep, Richard F. PhD
doi : 10.1161/STROKEAHA.122.040578
AB Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional interface, the blood-brain barrier (BBB). The endothelium is regulated by perivascular cells and components forming the neurovascular unit.
Hippocampal Vascular Supply and Its Role in Vascular Cognitive Impairment.
Johnson, Abbie C. PhD
doi : 10.1161/STROKEAHA.122.038263
AB The incidence of age-related dementia is increasing as the world population ages and due to lack of effective treatments for dementia. Vascular contributions to cognitive impairment and dementia are increasing as the prevalence of pathologies associated with cerebrovascular disease rise, including chronic hypertension, diabetes, and ischemic stroke.
Emerging Roles of Endothelial Nitric Oxide in Preservation of Cognitive Health.
Katusic, Zvonimir S. MD, PhD; d'Uscio, Livius V. PhD; He, Tongrong MD, PhD
doi : 10.1161/STROKEAHA.122.041444
AB eNOS (endothelial nitric oxide synthase) is critically important enzyme responsible for regulation of cardiovascular homeostasis. Under physiological conditions, constitutive eNOS activity and production of endothelial nitric oxide (NO) exert essential neurovascular protective functions.
Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial.
Nishiyama, Yasuhiro MD; Kimura, Kazumi MD; Otsuka, Toshiaki MD; Toyoda, Kazunori MD; Uchiyama, Shinichiro MD; Hoshino, Haruhiko MD; Sakai, Nobuyuki MD; Okada, Yasushi MD; Origasa, Hideki PhD; Naritomi, Hiroaki MD; Houkin, Kiyohiro MD; Yamaguchi, Keiji MD; Minematsu, Kazuo MD; Matsumoto, Masayasu MD; Tominaga, Teiji MD; Tomimoto, Hidekazu MD; Terayama, Yasuo MD; Yasuda, Satoshi MD; Yamaguchi, Takenori MD; for the CSPS.com Trial Investigators
doi : 10.1161/STROKEAHA.122.039900
The effectiveness of long-term dual antiplatelet therapy (DAPT) to prevent recurrent strokes in patients with lacunar stroke remains unclarified. Therefore, this study aimed to compare and to elucidate the safety and effectiveness of DAPT and single antiplatelet therapy (SAPT) in preventing recurrence in chronic lacunar stroke.
Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion: An EXTEND-IA TNK Trials Analysis.
Yogendrakumar, Vignan MD; Churilov, Leonid PhD; Guha, Prodipta BSc; Beharry, James MBChB; Mitchell, Peter J. MMed; Kleinig, Timothy J. PhD; Yassi, Nawaf PhD; Thijs, Vincent PhD; Wu, Teddy Y. PhD; Brown, Helen MPhil; Dewey, Helen M. PhD; Wijeratne, Tissa PhD; Yan, Bernard DMedSc; Sharma, Gagan MCA; Desmond, Patricia M. MD; Parsons, Mark W. PhD; Donnan, Geoffrey A. MD; Davis, Stephen M. MD; Campbell, Bruce C.V. PhD; for the EXTEND-IA TNK Investigators; Dowling, Richard; Bush, Steven; Scroop, Rebecca; Brooks, Mark; Asadi, Hamed; Ang, Timothy; Miteff, Ferdinand; Levi, Christopher; Zhao, Henry; Ng, Felix; Alemseged, Fana; Rice, Henry; de Villiers, Laetitia; Redmond, Kendal; Leggett, David
doi : 10.1161/STROKEAHA.122.041061
Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that influence alteplase-associated reperfusion. In this study, we assessed the reperfusion efficacy of tenecteplase and alteplase in subgroups based on these characteristics in a pooled analysis of the EXTEND-IA TNK trial (Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke).
Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial.
Al-Ajlan, Fahad S. MD; Gladstone, David J. MD, PhD; Song, Dongbeom MD, PhD; Thorpe, Kevin E. MMath; Swartz, Rick H. MD, PhD; Butcher, Kenneth S. MD, PhD; del Campo, Martin MD; Dowlatshahi, Dar MD, PhD; Gensicke, Henrik MD; Lee, Gloria Jooyoung BSc; Flaherty, Matthew L. MD; Hill, Michael D. MD, MSc; Aviv, Richard I. MD; Demchuk, Andrew M. MD; SPOTLIGHT Investigators; Swartz, Richard H. MD; Gladstone, David J. MD; Boyle, Karl MD.; Braganza, Maria; Fedasko, Nadia; Golob, Dolores; Bardi, Edith; Senyshyn, Samantha; Cayley, Megan; Colavecchia, Connie; Demchuk, Andrew M. MD; Hill, Michael D. MD; Coutts, Shelagh MD; Klein, Gary MD; Menon, Bijoy MD; Watson, Tim MD; Smith, Eric MD; Subramaniam, Suresh MD; Bal, Simerpreet MD; Barber, Philip MD; Camden, Marie-Christine MD; Horton, Myles MD; Mishra, Sachin MD; Nambiar, Vivek MD; Torres, Andres Venegas MD; Adatia, Sweta MD; Alseraya, Amjad MD; Desai, Jamsheed MD; Mandzia, Jennifer MD; Shamy, Michel MD; Trivedi, Anurag MD; Choi, Philip MD; Dubuc, Veronique MD; Klourfeld, Evgenia MD; Field, Thalia MD; Singh, Dilip MD; Musuka, Tapuwa MD; Bloujney, Sarah MD; Nikneshan, Davar MD; Imoukhuede, Oje MD; Yu, Amy MD; Appireddy, Ramana MD; Evans, Jamie MD.; Ryckborst, Karla; Calvert, Carly; Dowlatshahi, Dariush MD; Stotts, Grant MD; Sharma, Mukul MD.; Robert, Sohail; Mortensen, Melodie; Shamloul, Rany; Campo, Martin Del MD; Silver, Frank L. MD; Casaubon, Leanne MD; Jaigobin, Cheryl MD; Perez, Yael MD.; Kalman, Libby; Abraham, Jemini; Wiegner, Relu; Cayley, Anne; Riediger, Victoria; Butcher, Ken MD; Kate, Mahesh MD; Jeerakathil, Thomas MD; Shuaib, Ashfaq MD.; Gaucher, Sylvia; Sivakumar, Leka; Yip, Samuel MD; Teal, Philip MD; Woolfenden, Andrew MD; Benavente, Oscar MD; Beckman, Jeff MD; Murphy, Colleen MD; Field, Thalia MD; Asdaghi, Negar MD.; Villaluna-MurrVay, Karina; Sahlas, Demetrios J. MD; Algird, Almunder MD.; Knapman, Jordan; Macmillan, Sue; Sancan, Janice; Mehdiratta, Manu MD; Perez, Yael MD; John, Verity MD; Dhanani, AlNoor MD; Temple, Bryan MD; Douen, Andre MD.; Selchen, Daniel MD; Saposnik, Gustavo MD.; Kostyrko, Pawel; Chan, Richard MD; Young, Bryan MD; Kumar, Balagopal MD; Soros, Peter MD.; Hesser, Kimberley; Wright, Mary; Frank, Connie; Amato-Marziali, Belinda; Deschaintre, Yan MD; Poppe, Alexandre; Lapierre, Marlene; Boulanger, Jean-Martin MD; Berger, Leo MD.; Blais, Lise; Simard, Christel; Teitelbaum, Jeanne MD; Campbell, Natasha; Jin, Al MD; Breen, Adriana; Bickford, Suzanne
doi : 10.1161/STROKEAHA.121.038475
: In the SPOTLIGHT trial (Spot Sign Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy), patients with a computed tomography (CT) angiography spot-sign positive acute intracerebral hemorrhage were randomized to rFVIIa (recombinant activated factor VIIa; 80 [mu]g/kg) or placebo within 6 hours of onset, aiming to limit hematoma expansion. Administration of rFVIIa did not significantly reduce hematoma expansion.
Mechanical Thrombectomy Versus Best Medical Treatment in the Late Time Window in Non-DEFUSE-Non-DAWN Patients: A Multicenter Cohort Study.
Dittrich, Tolga D. MD ,*; Sporns, Peter B. MD, MHBA ,,*; Kriemler, Lilian F. MD; Rudin, Salome MD; Nguyen, Anh MD; Zietz, Annaelle MD; Polymeris, Alexandros A. MD, PhD; Tranka, Christopher MD; Thilemann, Sebastian MD, BSc; Wagner, Benjamin MD; Altersberger, Valerian L. MD; Piot, Ines MD; Barinka, Filip MD; Muller, Susanne PhD; Hansel, Martin MD; Gensicke, Henrik MD; Engelter, Stefan T. MD; Lyrer, Philippe A. MD; Sutter, Raoul MD; Nickel, Christian H. MD; Katan, Mira MD, MSc; Peters, Nils MD; Kulcsar, Zsolt MD; Karwacki, Grzegorz M. MD; Pileggi, Marco MD; Cereda, Carlo MD; Wegener, Susanne MD; Bonati, Leo H. MD; Fischer, Urs MD; Psychogios, Marios MD ,+; De Marchis, Gian Marco MD, MSc ,+
doi : 10.1161/STROKEAHA.122.039793
We assessed the efficacy and safety of mechanical thrombectomy (MT) in adult stroke patients with anterior circulation large vessel occlusion presenting in the late time window not fulfilling the DEFUSE-3 (Thrombectomy for Stroke at 6 to 16 Hours With Selection by Perfusion Imaging trial) and DAWN (Thrombectomy 6 to 24 Hours After Stroke With a Mismatch Between Deficit and Infarct trial) inclusion criteria.
Mechanical Thrombectomy in Late-Time Windows: Time to Treat More Patients.
Turc, Guillaume MD, PhD
Impact of Time to Treatment on Endovascular Thrombectomy Outcomes in the Early Versus Late Treatment Time Windows.
Asdaghi, Negar MD, MSc; Wang, Kefeng MSc; Gardener, Hannah ScD; Jameson, Angus MD, MPH; Rose, David Z. MD; Alkhachroum, Ayham MD; Gutierrez, Carolina M. PhD; Ying, Hao MSc; Mueller-Kronast, Nils MD; Sur, Nicole B. MD; Dong, Chuanhui PhD; Gordon Perue, Gillian MD; LePain, Marissa MBA, RN; Koch, Sebastian MD; Krementz, Nastajjia MD; Marulanda-Londono, Erika MD, MSc; Hanel, Ricardo MD, PhD; Mehta, Brijesh MD; Yavagal, Dileep R. MD; Rundek, Tatjana MD, PhD; Sacco, Ralph L. MD, MSc; Romano, Jose G. MD; for the Florida Stroke Registry
doi : 10.1161/STROKEAHA.122.040352
The impact of time to treatment on outcomes of endovascular thrombectomy (EVT) especially in patients presenting after 6 hours from symptom onset is not well characterized. We studied the differences in characteristics and treatment timelines of EVT-treated patients participating in the Florida Stroke Registry and aimed to characterize the extent to which time impacts EVT outcomes in the early and late time windows.
Reperfusion Treatments in Disabling Versus Nondisabling Mild Stroke due to Anterior Circulation Vessel Occlusion.
Schwarz, Ghil MD; Cascio Rizzo, Angelo MD; Matusevicius, Marius MD, PhD; Giussani, Giuditta MD; Invernizzi, Paolo MD; Melis, Fabio MD; Lesko, Norbert MD; Toni, Danilo MD; Agostoni, Elio Clemente MD; Ahmed, Niaz MD
doi : 10.1161/STROKEAHA.122.041772
The benefit of distinguishing between disabling versus nondisabling deficit in mild acute ischemic stroke due to endovascular thrombectomy-targetable vessel occlusion (EVT-tVO; including anterior circulation large and medium-vessel occlusion) is unknown.
Nomogram to Predict Good Collateral Formation After the STA-MCA Bypass Surgery in Adult Patients With Moyamoya Disease.
Sun, Haogeng MD; Li, Yue MM; Xiao, Anqi MD; Li, Wanjiang MM; Xia, Chao MD; You, Chao MD; Ma, Lu MD; Liu, Yi MD ,*; Xia, Chunchao MD ,*
doi : 10.1161/STROKEAHA.122.039975
Collateral formation from the extracranial carotid artery to ischemic brain tissue determines the clinical success of superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery in adult patients with moyamoya disease, but postoperative collateral formation (PCF) after STA-MCA bypass surgery is unpredictable.
Mediation of Systemic Inflammation on Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke.
Jin, Aoming PhD ,,*; Wang, Shukun PhD ,*; Li, Jiejie MD, PhD; Wang, Mengxing BS; Lin, Jinxi MD, PhD; Li, Hao PhD; Meng, Xia MD, PhD; Wang, Yongjun MD; Pan, Yuesong PhD
doi : 10.1161/STROKEAHA.122.039542
Insulin resistance is associated with stroke recurrence and poor functional outcomes of nondiabetic patients with ischemic stroke. The study aimed to investigate whether the association between insulin resistance and the prognosis of nondiabetic patients with ischemic stroke was mediated by systematic inflammation.
Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia.
Garcia-Tornel, Alvaro MD, PhD; Flores, Alan MD, PhD; Terceno, Mikel MD, PhD; Cardona, Pedro MD, PhD; Amaro, Sergi MD, PhD; Gomis, Meritxell MD, PhD; Zaragoza, Josep MD; Krupinski, Jerzy MD; Gomez-Choco, Manuel MD, PhD; Mas, Natalia MD; Cocho, Dolores MD, PhD; Catena, Esther MD; Purroy, Francesc MD, PhD; Deck, Matias MD; Rubiera, Marta MD, PhD; Pagola, Jorge MD, PhD; Rodriguez-Luna, David MD, PhD;
doi : 10.1161/STROKEAHA.122.041013
We aim to assess whether time of day modified the treatment effect in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion Trial), a cluster-randomized trial that did not demonstrate the benefit of direct transportation to a thrombectomy-capable center versus nearest local stroke center for patients with a suspected large vessel stroke triaged in nonurban Catalonia between March 2017 and June 2020.
Lack of Statin Therapy and Outcomes After Ischemic Stroke: A Population-Based Study.
Aivo, Julia MD, PhD; Ruuskanen, Jori O. MD, PhD; Tornio, Aleksi MD, PhD; Rautava, Paivi MD, PhD; Kyto, Ville MD, PhD
doi : 10.1161/STROKEAHA.122.040536
Statin treatment is effective at preventing adverse vascular events after ischemic stroke (IS). However, many patients fail to use statins after IS. We studied the impact of not using statins after IS on adverse outcomes.
Genetic Risk Score Improves Risk Stratification for Anticoagulation-Related Intracerebral Hemorrhage.
Mayerhofer, Ernst MD; Parodi, Livia PhD; Prapiadou, Savvina; Malik, Rainer PhD; Rosand, Jonathan MD, MSc; Georgakis, Marios K. MD, PhD ,,,,*; Anderson, Christopher D. MD, MMSc ,,,,*
doi : 10.1161/STROKEAHA.122.041764
Intracerebral hemorrhage (ICH) is the most devastating adverse outcome for patients on anticoagulants. Clinical risk scores that quantify bleeding risk can guide decision-making in situations when indication or duration for anticoagulation is uncertain.
Whole-Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke.
Xie, Yuhan MPhil ,*; Acosta, Julian N. MD ,*; Ye, Yixuan PhD; Demarais, Zachariah S. BS; Conlon, Carolyn J. MS; Chen, Ming PhD; Zhao, Hongyu PhD; Falcone, Guido J. MD, ScD, MPH
doi : 10.1161/STROKEAHA.122.040883
Ischemic stroke (IS) is a highly heritable trait, and genome-wide association studies have identified several commonly occurring susceptibility risk loci for this condition. However, there are limited data on the contribution of rare genetic variation to IS.
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.
Bakker, Mark K. PhD; Kanning, Jos P. MSc; Abraham, Gad PhD; Martinsen, Amy E. MSc; Winsvold, Bendik S. MD, PhD; Zwart, John-Anker MD, PhD; Bourcier, Romain MD, PhD; Sawada, Tomonobu MD, PhD; Koido, Masaru PhD; Kamatani, Yoichiro MD, PhD; Morel, Sandrine PhD; Amouyel, Philippe MD, PhD; Debette, Stephanie MD, PhD; Bijlenga, Philippe MD, PhD; Berrandou, Takiy PhD
doi : 10.1161/STROKEAHA.122.040715
Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction.
Novel Polygenic Risk Score for Intracranial Aneurysms.
Frerich, Simon MSc; Cole, John W. MD, MS
Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke: Results From the ENCLOSE Study.
Kauw, Frans MD; Velthuis, Birgitta K. MD, PhD; Takx, Richard A.P. MD, PhD; Guglielmo, Marco MD; Cramer, Maarten J. MD, PhD; van Ommen, Fasco MSc, PhD; Bos, Anneloes BSc; Bennink, Edwin PhD; Kappelle, L. Jaap MD, PhD; de Jong, Hugo W.A.M. PhD; Dankbaar, Jan W. MD, PhD
doi : 10.1161/STROKEAHA.122.041018
Identifying cardioembolic sources in patients with acute ischemic stroke is important for the choice of secondary prevention strategies. We prospectively investigated the yield of admission (spectral) nongated cardiac computed tomography angiography (CTA) to detect cardioembolic sources in stroke.
Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors.
Young, Brittany M. MD, PhD; Holman, E. Alison PhD, FNP; Cramer, Steven C. MD, MMSc; on behalf of the STRONG Study Investigators; Shah, Shreyansh MD; Griessenauer, Christoph J. MD; Patel, Nirav MD; Lin, David J. MD; Gee, Joey DO; Moon, Johnson MD; Schwertfeger, Julie PT, PhD, DPT, MBA; Jayaraman, Arun PT, PhD; Lee, Robert MD; Lansberg, Maarten MD, PhD; Payne, Jeremy MD, PhD; Patten, Carolynn PhD, PT; Cramer, Steven C. MD, MMSc; Holman, E. Alison PhD, FNP; Agrawal, Kunal MD; Kissela, Brett MD, MS; DeJong, Stacey PT, PhD; Cole, John MD, MS; Silver, Brian MD; Cucchiara, Brett MD; Busza, Ania MD, PhD; Liew, Sook-Lei PhD, OTR/L; Alderman, Susan PhD, RN; Hayes, Heather PT, PhD, DPT; Majersik, Jennifer J. MD, MS; Worrall, Brad MD; Tirschwell, David MD, MSc; Bushnell, Cheryl MD, MHS; El Husseini, Nadia MD, MHS; Lee, Jin-Moo MD, PhD; Falcone, Guido J. MD, ScD, MPH
doi : 10.1161/STROKEAHA.122.041098
Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predict rehabilitation therapy dose.
Nationally Certified Stroke Centers Outperform Self-Attested Stroke Centers in the Florida Stroke Registry.
Marulanda, Erika MD, MS; Bustillo, Antonio MSPH; Gutierrez, Carolina M. PhD; Rose, David Z. MD; Jameson, Angus MD, MPH; Gardener, Hannah ScD; Alkhachroum, Ayham MD; Zhou, Lili MS; Ying, Hao MS; Dong, Chuanhui PhD; Foster, Dianne MBA; Hanel, Ricardo MD; Mehta, Brijesh MD; Mokin, Maxim MD, PhD; Mueller-Kronast, Nils MD; Landreth, Mark CPE; Sand, Charles MD; Romano, Jose G. MD; Rundek, Tatjana MD, PhD; Asdaghi, Negar MD, MSc; Sacco, Ralph L. MD, MS
doi : 10.1161/STROKEAHA.122.038869
The Florida Stroke Act, signed into law in 2004, set criteria for Comprehensive Stroke Centers (CSC). For a set time period, Florida hospitals were permitted to either receive national certification (NC) or could self-attest (SA) as fulfilling CSC criteria.
Comparison of Stroke Care Costs in Urban and Nonurban Hospitals and Its Association With Outcomes in New Zealand: A Nationwide Economic Evaluation.
Kim, Joosup PhD; Cadilhac, Dominique A. PhD; Thompson, Stephanie PhD; Gommans, John FRACP; Davis, Alan FRACP; Barber, P. Alan PhD; Fink, John FRACP; Harwood, Matire PhD; Levack, William PhD; McNaughton, Harry PhD; Abernethy, Virginia Dip OT; Girvan, Jacqueline BSN; Feigin, Valery MD, PhD; Denison, Hayley PhD; Corbin, Marine PhD; Wilson, Andrew MBChB; Douwes, Jeroen PhD; Ranta, Anna MD, PhD
doi : 10.1161/STROKEAHA.122.040869
Although geographical differences in treatment and outcomes after stroke have been described, we lack evidence on differences in the costs of treatment between urban and nonurban regions. Additionally, it is unclear whether greater costs in one setting are justified given the outcomes achieved.
MicroRNA-210 Downregulates TET2 (Ten-Eleven Translocation Methylcytosine Dioxygenase 2) and Contributes to Neuroinflammation in Ischemic Stroke of Adult Mice.
Li, Yong PhD; Song, Rui PhD; Shen, Guofang PhD; Huang, Lei PhD; Xiao, DaLiao PhD; Ma, Qingyi PhD; Zhang, Lubo PhD
doi : 10.1161/STROKEAHA.122.041651
Stroke is a leading cause of morbidity and mortality worldwide. Neuroinflammation plays a key role in acute brain injury of ischemic stroke. MicroRNA-210 (miR210) is the master hypoxamir and regulates microglial activation and inflammation in a variety of diseases.
Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit.
Kowalski, Robert G. MBBCh, MS; Ledreux, Aurelie MS, PhD; Violette, John E. RT(R)(CT); Neumann, Robert T. MD, PhD; Ornelas, David BSN, RN; Yu, Xiaoli PhD; Griffiths, Steven G. PhD; Lewis, Scott BS; Nash, Priscilla MS; Monte, Andrew A. MD, PhD; Coughlan, Christina M. PhD, MSCS; Deighan, Clayton PhD; Grotta, James C. MD ,*; Jones, William J. MD ,*; Graner, Michael W. PhD ,*
doi : 10.1161/STROKEAHA.122.041422
Neuroinflammation is ubiquitous in acute stroke and worsens outcome. However, the precise timing of the inflammatory response is unknown, hindering the design of acute anti-inflammatory therapeutic interventions.
Acute Microbleeds and Microinfarcts Within the Perihematomal Area After Intracerebral Hemorrhage.
Puy, Laurent MD, PhD; Rauch, Antoine MD, PhD; Deramecourt, Vincent MD, PhD; Cordonnier, Charlotte MD, PhD; Berezowski, Vincent PhD
doi : 10.1161/STROKEAHA.122.040908
To further our understanding of the pathophysiology of spontaneous intracerebral hemorrhage (ICH) and related injury, we provided a postmortem neuropathological examination of acute microvascular lesions (microbleeds and microinfarcts) within the perihematomal area.
Smoking-Cessation Pharmacotherapy After Stroke and Transient Ischemic Attack: A Get With The Guidelines-Stroke Analysis.
Parikh, Neal S. MD, MS; Zhang, Cenai MS; Salehi Omran, Setareh MD; Restifo, Daniel MA; Carpenter, Matthew J. PhD; Schwamm, Lee MD; Kamel, Hooman MD, MS
Influenza-Like Illness as a Short-Term Risk Factor for Arterial Dissection.
Witsch, Jens MD ,,*; Rutrick, Stephanie B. MD ,*; Lansdale, Kelsey N. BA; Seitz, Alison MD; Kamel, Hooman MD, MS; Parikh, Neal S. MD, MS; Segal, Alan Z. MD; Mir, Saad A. MD; Murthy, Santosh B. MD, MPH; Niogi, Sumit N. MD, PhD; Gaudino, Mario MD; Girardi, Leonard N. MD; Kim, Jiwon MD; Devereux, Richard B. MD; Roman, Mary J. MD; Iadecola, Costantino MD; Kasner, Scott E. MD; Zhang, Cenai MS; Merkler, Alexander E. MD, MS
Dural Arteriovenous Fistula Presenting With Decreased Arterial-Spin-Labeling on Magnetic Resonance Imaging.
Thatikunta, Prateek B. MD; Zhou, Lily W. MD, MS; Lee, Sarah MD
Ischemic Stroke 3 Months After Wrapping of an Incidental Aneurysm.
Poltrum, Birgit MD; Beitzke, Markus MD; Fazekas, Franz MD; Gattringer, Thomas MD, PhD
Three-Dimensional Maps of the Anterior Choroidal Artery Territory.
Antoniello, Daniel MD; Patel, Neil R. MD; Ladsaria, Sally S. MD
Advances in Stroke: Treatments-Preventive.
Charlotte Sandset, Else MD, PhD; Goldstein, Larry B. MD
Advances in Digital Health.
Schwamm, Lee H. MD; Silva, Gisele Sampaio MD, MPH, PhD
Clinically Ineffective Reperfusion After Endovascular Therapy in Acute Ischemic Stroke.
Nie, Ximing MD, PhD; Leng, Xinyi MD, PhD; Miao, Zhongrong MD, PhD; Fisher, Marc MD; Liu, Liping MD, PhD
doi : 10.1161/STROKEAHA.122.038466
AB Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large vessel occlusion. However, in clinical practice, nearly half of the patients do not have favorable outcomes despite successful recanalization of the occluded artery.
Ambient Air Pollution and Stroke: An Updated Review.
Kulick, Erin R. PhD, MPH; Kaufman, Joel D. MD, MPH; Sack, Coralynn MD, MPH
doi : 10.1161/STROKEAHA.122.035498
AB Despite recent advances in treatment and prevention, stroke remains a leading cause of morbidity and mortality. There is a critical need to identify novel modifiable risk factors for disease, including environmental agents.
Caring for Patients With Diabetes in Stroke Neurology.
Kernan, Walter N. MD; Forman, Rachel MD; Inzucchi, Silvio E. MD
doi : 10.1161/STROKEAHA.122.038163
AB Diabetes is a heterogeneous disease that affects 9% of the world's population (11% in the United States). The consequences of diabetes for the brain are severe; it nearly doubles a person's risk of stroke and is a major contributor to risk for cerebral small vessel disease and dementia.
Research Opportunities in Stroke Prevention for Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop.
Go, Alan S. MD; Al-Khatib, Sana M. MD, MHS; Desvigne-Nickens, Patrice MD; Bansal, Nisha MD, MAS; Bushnell, Cheryl D. MD; Fang, Margaret C. MD, MPH; Freeman, James V. MD, MPH, MS; Gage, Brian F. MD, MSc; Hanke, Thorsten MD; Hylek, Elaine M. MD, MPH; Lopes, Renato D. MD, MHS; Noseworthy, Peter A. MD; Reddy, Vivek Y. MD; Singer, Daniel E. MD; Thomas, Kevin L. MD; True Hills, Mellanie BS; Turakhia, Mintu P. MD, MAS; Zieman, Susan J. MD, PhD; Cooper, Lawton S. MD, MPH; Benjamin, Emelia J. MD, ScM
doi : 10.1161/STROKEAHA.121.038273
AB Atrial fibrillation (AF) is one of the strongest risk factors for ischemic stroke, which is a leading cause of disability and death. Given the aging population, increasing prevalence of AF risk factors, and improved survival in those with cardiovascular disease, the number of individuals affected by AF will continue increasing over time.
Domain-Specific Outcome Measures in Clinical Trials of Therapies Promoting Stroke Recovery: A Suggested Blueprint.
Cramer, Steven C. MD, MMSc; Lin, David J. MD; Finklestein, Seth P. MD
doi : 10.1161/STROKEAHA.122.042313
AB Different deficits recover to different degrees and with different time courses after stroke, indicating that plasticity differs across the brain's neural systems after stroke. To capture these differences, domain-specific outcome measures have received increased attention.
Endovascular Therapy for Basilar Artery Occlusion: Among the First to Conceptualize, Last to Prove.
Puetz, Volker MD; Lutsep, Helmi L. MD; Nguyen, Thanh N. MD
doi : 10.1161/STROKEAHA.122.041645
AB In 1981, the dismal outcomes of patients with basilar artery occlusion (BAO) inspired the first reports of intra-arterial thrombolytic treatment in BAO. These reports were among the first to conceptualize that opening an artery could help patients with large vessel occlusion stroke.
Antifibrinolytic Therapy for Aneurysmal Subarachnoid Hemorrhage: An Update of a Cochrane Systematic Review.
Germans, Menno R. MD, PhD; Dronkers, Wouter J. MD, LLM, MA; Baharoglu, M. Irem MD, PhD; Post, Rene MD, PhD; Verbaan, Dagmar PhD; Rinkel, Gabriel J.E. MD, PhD; Roos, Yvo B.W.E.M. MD, PhD
Stroke Literature Synopsis (Clinical).
Kancheva, Angelina MSc; Quinn, Terence J. MD
Understanding Medical Malpractice Lawsuits.
Liang, Bryan A. MD, PhD, JD; Maroulis, James MAS, JD; Mackey, Tim K. MAS, PhD
Advice for Early Career Clinical Stroke Researchers Applying for National Institutes of Health Funding.
Miller, Eliza C. MD, MS; Pemberton, Victoria RNC, MS
Computed Tomography Perfusion Imaging in Acute Ischemic Stroke: Accurate Interpretation Matters.
Kargiotis, Odysseas MD; Psychogios, Klearchos MD; Safouris, Apostolos MD; Andrikopoulou, Athina MD; Eleftheriou, Andreas MD; Spiliopoulos, Stavros MD; Magoufis, Georgios MD ,*; Tsivgoulis, Georgios MD ,*
Diagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association.
Amin, Hardik P. MD, Chair; Madsen, Tracy E. MD, PhD, Vice Chair; Bravata, Dawn M. MD; Wira, Charles R. MD; Johnston, S. Claiborne MD, PhD; Ashcraft, Susan DNP; Burrus, Tamika M. MD; Panagos, Peter D. MD; Wintermark, Max MD, MAS; Esenwa, Charles MD, MS; on behalf of the American Heart Association Emergency Neurovascular Care Committee of the Stroke Council and Council on Peripheral Vascular Disease
doi : 10.1161/STR.0000000000000418
AB At least 240 000 individuals experience a transient ischemic attack each year in the United States. Transient ischemic attack is a strong predictor of subsequent stroke. The 90-day stroke risk after transient ischemic attack can be as high as 17.8%, with almost half occurring within 2 days of the index event.
Correction to: Carotid Stenting Versus Endarterectomy for Asymptomatic Carotid Artery Stenosis: A Systematic Review and Meta-Analysis.
Correction to: Racial Inequities Across Rural Strata in Acute Stroke Care and In-Hospital Mortality: National Trends Over 6 Years.
Correction to: Ultra-Long Transfers for Endovascular Thrombectomy-Mission Impossible?: The Australia-New Zealand Experience.
Correction to: Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke.
