دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Tocilizumab in Giant Cell Arteritis: Better Understanding the Benefits
Frank Buttgereit, Andriko Palmowski, Idil Esen, Elisabeth Brouwer
doi : 10.1002/art.42414
Concepts of Entheseal Pain
Enrico De Lorenzis, Gerlando Natalello, David Simon, Georg Schett, Maria Antonietta D'Agostino
doi : 10.1002/art.42299
Pain is the main symptom in entheseal diseases (enthesopathies) despite a paucity of nerve endings in the enthesis itself.
The Characteristics of Patients With COVID-19–Associated Pediatric Vasculitis: An International, Multicenter Study
Ezgi D. Batu, Seher Sener, Gulcan Ozomay Baykal, Elif Arslanoglu Aydin, Semanur Özdel, Alenka Gagro, Esra Esen, Merav Heshin-Bekenstein, Nilüfer Akpınar Tekgöz, Fatma G. Demirkan, Kubra Ozturk, Olga Vougiouka, H. Emine Sonmez, Maria Cristina Maggio, Ummusen Kaya Akca, Marija Jelusic, Aysenur Pac Kısaarslan, Banu Acar, Nuray Aktay Ayaz, Betül Sözeri, Seza Özen, on behalf of the Pediatric Rheumatology European Society (PReS) Vasculitis Working Party
doi : 10.1002/art.42411
COVID-19–associated pediatric vasculitis, other than Kawasaki disease (KD)–like vasculitis in multisystem inflammatory syndrome in children (MIS-C), is very rare. This study sought to analyze the characteristics, treatment, and outcomes in patients with COVID-19–associated pediatric vasculitis (excluding KD-like vasculitis in MIS-C).
Association of Antibodies to Prevotella copri in Anti–Cyclic Citrullinated Peptide-Positive Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With Early or Established Rheumatoid Arthritis
Jennifer A. Seifert, Elizabeth A. Bemis, Kristina Ramsden, Cassidy Lowell, Kristen Polinski, Marie Feser, Chelsie Fleischer, M. Kristen Demoruelle, Jane Buckner, Peter K. Gregersen, Richard M. Keating, Ted R. Mikuls, James R. O'Dell, Michael H. Weisman, Kevin D. Deane, Jill M. Norris, Allen C. Steere, V. Michael Holers
doi : 10.1002/art.42370
Prevotella copri (P copri), a gut commensal, has been reported to be an immune-relevant organism in individuals with rheumatoid arthritis (RA). This study sought to evaluate anti–P copri (anti–Pc) antibody responses in our participant cohorts and to determine when in the natural history of RA such responses develop.
Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition
Jasna Friš�ić, Christiane Reinwald, Martin Böttcher, Miranda Houtman, Maximilien Euler, Xi Chen, Kellie I. Walker, Philipp Kirchner, Honglin Zhu, Benjamin Wirth, Daniela Weidner, René Krüger, Vladimir Trajkovic, Arif B. Ekici, Kerstin Klein, Dimitrios Mougiakakos, Caroline Ospelt, Georg Schett, Markus H. Hoffmann
doi : 10.1002/art.42378
We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate epigenetic changes into transcription.
Association of Decrease in Body Mass Index With Reduced Incidence and Progression of the Structural Defects of Knee Osteoarthritis: A Prospective Multi-Cohort Study
Zubeyir Salis, Blanca Gallego, Tuan V. Nguyen, Amanda Sainsbury
doi : 10.1002/art.42307
To define the association between change in body mass index (BMI) and the incidence and progression of the structural defects of knee osteoarthritis as assessed by radiography.
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource
Unnur Styrkarsdottir, Sigrun H. Lund, Gudmar Thorleifsson, Saedis Saevarsdottir, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Kari Stefansson
doi : 10.1002/art.42376
The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population.
Dampened Inflammation and Improved Survival After CXCL5 Administration in Murine Lupus via Myeloid and Neutrophil Pathways
Xiubo Fan, Chin Teck Ng, Dianyang Guo, Frances Lim, Jia Chi Tan, Annie Law, Lim Hee Goh, Zhi Yong Poon, Alice Cheung, Say Li Kong, Michelle Tan, Shang Li, Alwin Loh, Anne James, Tony Lim, Jinmiao Chen, Julian Thumboo, William Hwang, Andrea Low
doi : 10.1002/art.42383
To determine the efficacy of CXCL5 administration in lupus-prone MRL/lpr (Faslpr) mice and elucidate its working mechanisms.
Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population-Based Study Over Four Decades Using the Lupus Midwest Network
Mehmet Hocaoǧlu, Maria O. Valenzuela-Almada, Jesse Y. Dabit, Shirley-Ann Osei-Onomah, Baptiste Chevet, Rachel E. Giblon, Ladan Zand, Fernando C. Fervenza, Charles G. Helmick, Cynthia S. Crowson, AlàDuarte-GarcÃÂa
doi : 10.1002/art.42375
There is a paucity of population-based studies investigating the epidemiology of lupus nephritis (LN) in the US and long-term secular trends of the disease and its outcomes. We aimed to examine the epidemiology of LN in a well-defined 8-county region in the US.
Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus
Guojun Hou, Tian Zhou, Ning Xu, Zhihua Yin, Xinyi Zhu, Yutong Zhang, Yange Cui, Jianyang Ma, Yuanjia Tang, Zhaorui Cheng, Yiwei Shen, Yashuo Chen, Ling-Hua Zou, Yong-fei Wang, Zihang Yin, Ya Guo, Huihua Ding, Zhizhong Ye, Nan Shen
doi : 10.1002/art.42390
IRF5 plays a crucial role in the development of lupus. Genome-wide association studies have identified several systemic lupus erythematosus (SLE) risk single-nucleotide polymorphisms (SNPs) enriched in the IRF5 locus.
The Effects of Daily Prednisone and Tocilizumab on Hemoglobin A1c During the Treatment of Giant Cell Arteritis
Naomi J. Patel, Veronica Tozzo, John M. Higgins, John H. Stone
doi : 10.1002/art.42405
To study the longitudinal effects of both glucocorticoids and tocilizumab, an interleukin-6 receptor inhibitor, on hemoglobin A1c (HbA1c) levels during glucocorticoid tapering.
Three Distinct Transcriptional Profiles of Monocytes Associate with Disease Activity in Scleroderma Patients
Hadijat-Kubura M. Makinde, Julia L. M. Dunn, Gaurav Gadhvi, Mary Carns, Kathleen Aren, Anh H. Chung, Lutfiyya N. Muhammad, Jing Song, Carla M. Cuda, Salina Dominguez, John E. Pandolfino, Jane E. Dematte D'Amico, G. Scott Budinger, Shervin Assassi, Tracy M. Frech, Dinesh Khanna, Alex Shaeffer, Harris Perlman, Monique Hinchcliff, Deborah R. Winter
doi : 10.1002/art.42380
Patients with diffuse cutaneous systemic sclerosis (dcSSc) display a complex clinical phenotype. Transcriptional profiling of whole blood or tissue from patients are affected by changes in cellular composition that drive gene expression and an inability to detect minority cell populations.
Identification of Three Different Phenotypes in Anti–Melanoma Differentiation–Associated Gene 5 Antibody–Positive Dermatomyositis Patients: Implications for Prediction of Rapidly Progressive Interstitial Lung Disease
Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, Fenghong Yuan, Ju Li, Min Wu, Zhanyun Da, Hua Wei, Wei Yan, Lei Zhou, Songlou Yin, Dongmei Zhou, Jian Wu, Yan Lu, Dinglei Su, Zhichun Liu, Lin Liu, Longxin Ma, Xiaoyan Xu, Yinshan Zang, Huijie Liu, Tianli Ren, Fang Wang, Yan Du, Jing Xue, Miaojia Zhang, Wenfeng Tan
doi : 10.1002/art.42308
There is substantial heterogeneity among the phenotypes of patients with anti–melanoma differentiation–associated gene 5 antibody–positive (anti-MDA5+) dermatomyositis (DM), hindering disease assessment and management.
Subsets of Idiopathic Inflammatory Myositis Enriched for Contemporaneous Cancer Relative to the General Population
Christopher A. Mecoli, Tak Igusa, Mengkun Chen, XingYao Wang, Jemima Albayda, Julie J. Paik, Eleni Tiniakou, Brittany Adler, Carrie Richardson, Will Kelly, Sonye Danoff, Andrew L. Mammen, Elizabeth A. Platz, Antony Rosen, Lisa Christopher-Stine, Livia Casciola-Rosen, Ami A. Shah
doi : 10.1002/art.42311
This study investigates cancer risk in idiopathic inflammatory myopathy (IIM) relative to the general population.
Reliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working Group
Silvia Sirotti, Fabio Becce, Luca M. Sconfienza, Lene Terslev, Esperanza Naredo, Pascal Zufferey, Carlos Pineda, Marwin Gutierrez, Antonella Adinolfi, Teodora Serban, Daryl MacCarter, Gael Mouterde, Anna Zanetti, Anna Scanu, Ingrid Möller, Ulrike Novo-Rivas, Raquel Largo, Piercarlo Sarzi-Puttini, Abhishek Abhishek, Hyon K. Choi, Nicola Dalbeth, Tristan Pascart, Sara K. Tedeschi, Maria-Antonietta D'Agostino, Annamaria Iagnocco, Helen I. Keen, Carlo A. Scirè, Georgios Filippou
doi : 10.1002/art.42368
To assess the reliability and diagnostic accuracy of new radiographic imaging definitions developed by an international multidisciplinary working group for identification of calcium pyrophosphate deposition (CPPD).
The ultrasonographic pseudo–double contour sign in calcium pyrophosphate deposition disease: an anatomic explanation and how to distinguish it from gout
Georgios Filippou, Maribel Miguel-Pérez, Luis Coronel, Silvia Sirotti, Giovanni Pacini, Anna Scanu, David Bong, Ingrid Möller, on behalf of the EULAR Study Group on Anatomy for the Image
doi : 10.1002/art.42397
Guide to optimizing care for Muslim patients with knee osteoarthritis
Mahfujul Z. Haque, Usman Virk, Ameen Suhrawardy, Karl C. Roberts, Marina N. Magrey
doi : 10.1002/art.42395
Walking for exercise and subsequent clinical outcomes in patients with knee osteoarthritis: comment on the article by Lo et al
Tomoyuki Kawada
doi : 10.1002/art.42310
