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Women in Transplant Surgery in Italy.
Franchi, Eloisa MD 1,2; Parini, Sara MD 3; Capelli, Giulia MD 4; Perali, Carolina MD 1; Lombardi, Ilaria 5; Amoroso, Antonio MD 6; Feltrin, Giuseppe MD 7; Gringeri, Enrico MD 8; Maggiore, Umberto MD 9; Amarelli, Cristiano MD 10; Ferraresso, Mariano MD 11; Biancofiore, Giandomenico 12; Gruttadauria, Salvatore 13,14; Cardillo, Massimo MD 5; Boggi, Ugo MD 15; Spolverato, Gaya MD 4
doi : 10.1097/TP.0000000000004381
Volume 107(4) pgs. 793-1003,e88-e124 April 2023
Research Highlights.
Short, Sarah MBBS 1; Lewik, Guido MD 1; Issa, Fadi DPhil, FRCS 1
The Future Is Now: OrganEx Technology and Its Implications for Transplant Medicine.
Duarte, Sergio PhD 1; Carpenter, Anne-Marie MD 1; Zarrinpar, Ali MD, PhD 1
The Impact of Selection Bias in Transplant Research Intended to Inform Patient Selection: An Example and Potential Solutions.
Ross-Driscoll, Katie PhD, MPH 1,2,3; Harding, Jessica L. PhD, MPH 1,2,3; Labgold, Katie PhD, MPH 2; Gunasti, Jonathan MSPH 2; Lynch, Raymond J. MD, MS 1; Patzer, Rachel E. PhD, MPH 1,2,3,4
What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2022? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society.
Bhat, Mamatha MD, PhD 1,2; Dondossola, Daniele MD 3,4; Varghese, Rhea BHSc 5; Czigany, Zoltan MD, PhD 6; Emamaullee, Juliet MD, PhD 7; Ghinolfi, Davide MD, PhD 8; Al-Adra, David MD, PhD 9; Bonaccorsi-Riani, Eliano MD, PhD 10,11; Pang, Li MD 12; Boteon, Yuri L. MD, PhD 13; Bruggenwirth, Isabel MD, PhD 14,15; Pavan-Guimaraes, Juliana MD 16; Ho, Cheng-Maw MD 17; Yuksel, Muhammed MD 18; Zarrinpar, Ali MD, PhD 19; Abdelrahim, Maen MD, PhD 20; Barbas, Andrew S. MD, PhD 21; Mas, Valeria PhD 22; Selzner, Markus MD, PhD 1,2; Martins, Paulo N. MD, PhD 16
Simultaneous Pancreas-kidney Transplantation Candidates With Type 2 Diabetes Mellitus: Elevated C-peptide Levels Warrant Scrutiny, May Portend Worse Outcomes.
Matar, Abraham MD 1; Parsons, Ronald F. MD 1
Is ABO Compatibility Important in Islet Transplantation?.
Cowan, Peter J. PhD 1,2
Assessing the Reversibility of Renal Impairment in Patients Awaiting Heart Transplantation.
Macdonald, Peter FRACP, MD, PhD 1
Many a Slip Twixt the Intake Form and the Living Donation.
Mejia, Christina D. MD 1; Brennan, Daniel C. MD 1
Clinical Integration of Genomic Testing in Kidney Transplantation Clinics.
Nestor, Jordan G. MD 1
When the Guest Meets the Host: Assessing the Immune Reconstitution of the Liver Graft One Cell at a Time.
McDaniels, Jennifer M. PhD 1; Maluf, Daniel G. MD 2; Mas, Valeria R. MSc, PhD 1
Preexisting Coronary Artery Disease in Liver Transplant Candidates: Risk Factor or Risk Marker?.
Meurer, Lindsay MD 1; VanWagner, Lisa B. MD, MSc 1
Pathways of Antigen Recognition by T Cells in Allograft Rejection.
Carnel, Natacha PharmD 1; Lancia, Hyshem H. MS 1; Guinier, Claire MD 1; Benichou, Gilles PhD 1
doi : 10.1097/TP.0000000000004420
AB The adaptive immune response leading to the rejection of allogeneic transplants is initiated and orchestrated by recipient T cells recognizing donor antigens.
Health-related Quality of Life Outcomes Following Single or Bilateral Lung Transplantation: A Systematic Review.
Raguragavan, Aarohanan BBiomedSc 1; Jayabalan, Dujinthan BMedSc 1; Saxena, Akshat MBBS, BMedSc, MS, PhD 2
Liver Paired Exchange: Programmatic Hopes and Fears.
Khan, Afshin A. MD, MPH 1; Hashimoto, Koji MD, PhD 2; Kwon, Choon H. David MD, PhD 3; Fujiki, Masato MD 4; Ahmad, Mahwish MD, MPH 5; Esfeh, Jamak Modaresi MD 6
doi : 10.1097/TP.0000000000004397
AB The dearth of deceased liver donors has created a supply demand gap, necessitating creation of living donor liver transplantation.
Balancing the Risks and Benefits of Pet Ownership in Pediatric Transplant Recipients.
Garcia Sanchez, Paula MD 1; Iglesias, Irene VMD, PhD 2; Falces-Romero, Iker MD 3; Serrano-Villar, Maria PhD 4; Calvo, Cristina MD, PhD 5,6; Alcolea, Sonia BSN 5,7; Sainz, Talia MD, PhD 5,6; Mendez-Echevarria, Ana MD, PhD 5,6
doi : 10.1097/TP.0000000000004419
AB In recent decades, the number of pediatric transplantations and their survival rates have increased. Psychological problems and poorer quality of life are notable among children undergoing transplantation and can have long-lasting consequences and affect immunosuppressive therapy adherence.
Addressing Risks Derived From the Commodification of Substances of Human Origin: A European Proposal Applicable Worldwide.
Cuende, Natividad MD, MPH, PhD 1; Vilarrodona, Anna MD 2; Vuelta, Elena PhD 3; Marazuela, Rosario MD, PhD 4; Herrera, Concha MD, PhD 5; Querol, Sergi MD, PhD 2; Sanchez-Ibanez, Jacinto MD 6; Carmona, Mar Pharm 4; Gaya, Antonio MD, PhD 7; Tort, Jaume MD 8; Hernandez, Dolores MD, PhD 4; Dominguez-Gil, Beatriz MD, PhD 4
doi : 10.1097/TP.0000000000004527
AB In view of the public consultation recently launched by the World Health Organization on Regulatory Convergence of Cell and Gene Therapy Products and the Proposal for a Regulation on substances of human origin (SoHO) repealing the European Union Directives on Blood and on Tissues and Cells, an opportunity arises to define an ethical and transparent framework of collaboration between industry and authorities responsible for SoHO-derived products, comprising medicines, medical devices, transfusion, and transplantation.
Renal Ischemia-reperfusion Injury Attenuated by Exosomes Extracted From Splenic Ischemic Preconditioning Models.
Liu, Hongtao MM 1; Shen, Ye MD 2
doi : 10.1097/TP.0000000000004514
To investigate the protective effects of exosomes extracted from splenic ischemic preconditioning (sIPC) models on renal ischemia-reperfusion injury (IRI).
Evaluating the Potential for ABO-incompatible Islet Transplantation: Expression of ABH Antigens on Human Pancreata, Isolated Islets, and Embryonic Stem Cell-derived Islets.
Verhoeff, Kevin MD 1,2; Cuesta-Gomez, Nerea PhD 1,2; Albers, Patrick MD 2; Pawlick, Rena BSc 1; Marfil-Garza, Braulio A. MD 1,2,3,4,5; Jasra, Ila PhD 1,2; Dadheech, Nidheesh PhD 1,2,3; O'Gorman, Doug 3; Kin, Tatsuya PhD 3; Halpin, Anne MSc 6; West, Lori J. MD, DPhil 2,6,7,8,9; Shapiro, A.M. James MD, PhD 1,2,3
doi : 10.1097/TP.0000000000004347
ABO-incompatible transplantation has improved accessibility of kidney, heart, and liver transplantation. Pancreatic islet transplantation continues to be ABO-matched, yet ABH antigen expression within isolated human islets or novel human embryonic stem cell (hESC)-derived islets remain uncharacterized.
Transcription Factor YY1 Ameliorates Liver Ischemia-reperfusion Injury Through Modulating the miR-181a-5p/ESR1/ERBB2 Axis.
Wu, Kun MD 1,2; Ma, Long MB 3; Xu, Ting PhD 4,5; Cao, Jun MD 1,2; Zhou, Chengming MM 1,2; Yu, Xiangyou MD 3; Wang, Yi MD 3; Wen, Hao PhD 1,2
doi : 10.1097/TP.0000000000004356
Liver ischemia/reperfusion injury (I/RI) is characterized by inflammatory actions. Understanding the mechanistic insights underpinning inflammation is critical to developing treatment strategies. In this study, we illustrated the mechanistic insights of transcription factor Yin-Yang 1 (YY1)-mediated microRNA (miR)-181a-5p/estrogen receptor alpha (ESR1)/epidermal growth factor receptor 2 (ERBB2) axis in liver I/RI.
Decoding Single-cell Landscape and Intercellular Crosstalk in the Transplanted Liver.
Huang, Haitao MD 1,2; Chen, Ruihan MM 1,2; Lin, Yimou MM 1,2; Jiang, Jingyu MM 1,2; Feng, Shi MD 3; Zhang, Xueyou MM 4; Zhang, Cheng MD 1,2; Ji, Qinghua MD 5; Chen, Hui BS 2; Xie, Haiyang MD 1,2; Zheng, Shusen MD, PhD 1,2,4; Ling, Qi MD, PhD 1,2,6
doi : 10.1097/TP.0000000000004365
Liver transplantation (LT) is the most effective treatment for various end-stage liver diseases. However, the cellular complexity and intercellular crosstalk of the transplanted liver have constrained analyses of graft reconstruction after LT.
Feasibility and Potential of Transcriptomic Analysis Using the NanoString nCounter Technology to Aid the Classification of Rejection in Kidney Transplant Biopsies.
Varol, Hilal MD 1,2; Ernst, Angela MSc 3; Cristoferi, Iacopo MD 2,4,5; Arns, Wolfgang MD, PhD 6; Baan, Carla C. PhD 2,7; van Baardwijk, Myrthe MSc 2,4,5; van den Bosch, Thierry PhD 1; Eckhoff, Jennifer MD, PhD 8; Harth, Ana MD, PhD 6; Hesselink, Dennis A. MD, PhD 2,7; van Kemenade, Folkert J. MD, PhD 1; de Koning, Willem MSc 4,9; Kurschat, Christine MD, PhD 10; Minnee, Robert C. MD, PhD 2,5; Mustafa, Dana A. PhD 9; Reinders, Marlies E.J. MD, PhD 2,7; Shahzad-Arshad, Shazia P. ING 1; Snijders, Malou L.H. MD, PhD 11; Stippel, Dirk MD, PhD 8; Stubbs, Andrew P. PhD 2,4; von der Thusen, Jan MD, PhD 1,2; Wirths, Katharina MD 12; Becker, Jan U. MD 13; Clahsen-van Groningen, Marian C. MD, PhD 1,2,14
doi : 10.1097/TP.0000000000004372
Transcriptome analysis could be an additional diagnostic parameter in diagnosing kidney transplant (KTx) rejection. Here, we assessed feasibility and potential of NanoString nCounter analysis of KTx biopsies to aid the classification of rejection in clinical practice using both the Banff-Human Organ Transplant (B-HOT) panel and a customized antibody-mediated rejection (AMR)-specific NanoString nCounter Elements (Elements) panel. Additionally, we explored the potential for the classification of KTx rejection building and testing a classifier within our dataset.
Clinical Impact of Spontaneous Portosystemic Shunts in Liver Transplantation: A Comprehensive Assessment Through Total Shunt Area Measurement.
Centonze, Leonardo MD 1,2; Gorga, Giovanna MD 3; De Carlis, Riccardo MD 1,4; Bernasconi, Davide PhD 5; Lauterio, Andrea MD, FEBS 1,6; Carbonaro, Luca MD 3; Vella, Ivan MD 1; Sgrazzutti, Cristiano MD 3; Incarbone, Niccolo MD 1; Rizzetto, Francesco MD 3; Valsecchi, Maria Grazia PhD 5; Vanzulli, Angelo MD 3,7,*; De Carlis, Luciano MD, FEBS 1,6,*
doi : 10.1097/TP.0000000000004391
The impact of spontaneous portosystemic shunts (SPSSs) on natural history of cirrhotic patients was recently evaluated through the measurement of total shunt area (TSA), a novel tool that allows a comprehensive assessment of SPSSs extension, identifying a direct correlation of higher TSA with lower patient survival.
Utility of Digital Single-operator Video Cholangioscopy for the Endoscopic Management of Biliary Complications After Liver Transplantation-A Single-center Experience.
Bokemeyer, Arne MD 1,2; Lenze, Frank MD 2,3; Stoica, Viorelia MD 2; Selcuk Sensoy, Timur MD 1; Huesing-Kabar, Anna MD 2; Kabar, Iyad MD 2; Schmidt, Hartmut MD 1; Ullerich, Hansjoerg MD 2
doi : 10.1097/TP.0000000000004388
Liver transplant recipients (LTRs) frequently develop biliary complications, and endoscopy is crucial for their subsequent management. Recently, single-operator video cholangioscopy (SOVC) with digital imaging quality was introduced.
Outcomes of Liver Transplantation in Patients With Preexisting Coronary Artery Disease.
Reznicek, Emily DO 1; Sasaki, Kazunari MD 2; Montane, Bryce MD 1; Sims, Ariel MD 1; Beard, Jonathan MD 1; Fares, Maan MD 3; Sharma, Vikram MD 2; Cywinski, Jacek MD 4; Quintini, Christiano MD 5; Aucejo, Federico N. MD 6; Eghtesad, Bijan MD, FAASLD 6; Miller, Charles M. MD 5; Menon, K.V. Narayanan MD, FRCP, FAASLD 6
doi : 10.1097/TP.0000000000004402
Advances in surgical and medical technology over the years has made liver transplantation possible for older and higher risk patients.
Higher Fasting Pretransplant C-peptide Levels in Type 2 Diabetics Undergoing Simultaneous Pancreas-kidney Transplantation Are Associated With Posttransplant Pancreatic Graft Dysfunction.
Parajuli, Sandesh MD 1; Mandelbrot, Didier MD 1; Aufhauser, David MD 2; Kaufman, Dixon MD, PhD 2; Odorico, Jon MD 2
doi : 10.1097/TP.0000000000004489
Among selected patients with type 2 diabetes mellitus (T2DM), simultaneous pancreas and kidney (SPK) transplants can be an effective option.
Characteristics of Potential and Actual Living Kidney Donors: A Single-center Experience.
Cholin, Liza K. MD 1; Schold, Jesse D. PhD, MStat, Med 2; Arrigain, Susana MA 2; Poggio, Emilio D. MD 1,3; Sedor, John R. MD 1; O'Toole, John F. MD 1; Augustine, Joshua J. MD 1,3; Wee, Alvin C. MD 3; Huml, Anne M. MD 1,3
doi : 10.1097/TP.0000000000004357
There are limited data and no national capture of barriers associated with initiating and completing the donation process for potential living kidney donors (LKDs).
Incorporation of Genetic Studies in the Kidney Transplant Evaluation Clinic: The Value of a Multidisciplinary Approach.
El Ters, Mireille MD 1,2; Pinto e Vairo, Filippo PhD 3,4; Prochnow, Carri BSc 4; Schinstock, Carrie MD 1,2; Dean, Patrick MD 2; Kemppainen, Jennifer MS 4; Lazaridis, Konstantinos MD 4; Cosio, Fernando MD 1,2; Fervenza, Fernando C. MD, PhD 1; Cornell, Lynn MD 5; Amer, Hatem MD 1,2; Hogan, Marie C. MD, PhD 1
The Cost-effectiveness of Transplanting Hearts From Hepatitis C-infected Donors Into Uninfected Recipients.
Woolley, Ann E. MD, MPH 1,2; Gandhi, Aditya R. BA 3; Jones, Michelle L. BS 3; Kim, Jane J. PhD 4; Mallidi, Hari R. MD 2,5; Givertz, Michael M. MD 2,6; Baden, Lindsey R. MD, MSc 1,2; Mehra, Mandeep R. MD 2,6; Neilan, and Anne M. MD, MPH 2,3,7,8
doi : 10.1097/TP.0000000000004378
The DONATE HCV trial demonstrated the safety and efficacy of transplanting hearts from hepatitis C viremic (HCV+) donors. In this report, we examine the cost-effectiveness and impact of universal HCV+ heart donor eligibility in the United States on transplant waitlist time and life expectancy.
Financial Impact of a Culturally Sensitive Hispanic Kidney Transplant Program on Increasing Living Donation.
Wang, Andrew PhD, MPH 1,2; Caicedo, Juan Carlos MD 3; Mathur, Amit K. MD, MS 4; Ruiz, Richard M. MD 5; Gordon, Elisa J. PhD, MPH 1,3
Severely Reduced Kidney Function Assessed by a Single eGFR Determination at the Time of an Isolated Heart Transplant Does Not Predict Inevitable Posttransplant ESKD.
Kumar, Abhishek MD 1; Bonnell, Levi N. MPH 2; Thomas, Christie P. MD 3,4
doi : 10.1097/TP.0000000000004350
Consensus guidelines advise simultaneous heart kidney transplantation (SHK) in heart candidates with an estimated glomerular filtration rate (eGFR) of <30 mL/min/1.73 m2. We hypothesize that a significant fraction of such patients would not need an SHK, even though a graded increase in mortality and end-stage kidney disease (ESKD) would be seen with decrements in eGFR.
Increasing Proportion of High-risk Cytomegalovirus Donor-positive/Recipient-negative Serostatus in Solid Organ Transplant Recipients.
Imlay, Hannah MD, MS 1; Wagener, Marilyn M. MPH 2; Vutien, Philip MD 3; Perkins, James MD 3; Singh, Nina MD 2; Limaye, Ajit P. MD 4
Assessing the Impact of Prophylactic Eculizumab on Renal Graft Survival in Atypical Hemolytic Uremic Syndrome.
Glover, Emily K. MBBS 1,2; Smith-Jackson, Kate MBChB 1,2,3; Brocklebank, Vicky MBBS 1,2,3; Wilson, Valerie PhD 1; Walsh, Patrick R. MBChB 1,2; Montgomery, Emma K. MBBS, FRCP 1; Wong, Edwin K.S. PhD 1,2; Johnson, Sally PhD 1,2,3,4; Malina, Michal PhD 1,2,4; Kavanagh, David PhD 1,2,3; Sheerin, Neil S. PhD 1,2,3; UK aHUS Transplant Consortium; Ahmed, Aimun; Ashby, Damien; Awan, Atif; Baker, Richard; Bhandari, Sunil; Bingham, Coralie; Bommayya, Girish; Border, David; Breen, Cormac; Brown, Henry; Brown, Alison; Carmichael, Paul; Chowdhury, Paramit; Curran, Simon; Donne, Rosie; Dudley, Chris; Dutt, Tina; Eardley, Kevin; Eblamo-Abad, Elinor; Gale, Daniel; Griffin, Sian; Harty, John; Hewins, Peter; Holt, Richard; Ingham, Victoria; Kilbride, Hannah; Kingdon, Ed; Lewis, Robert; Mansfield, Nicholas; Marks, Stephen D; Mason, Phil; Mead, Paul; Morton, Muir; Muniraju, Thalakunte; Nagaraja, Pramod; Padmanabhan, Neal; Plant, Nicholas; Raftery, Tara; Rowe, Peter; Salama, Alan; Shenbagaraman, Packiam; Taylor, Alison; Tomlinson, Kerry; Torpey, Nick; Uniacke, Mark; Walbaum, David; Webb, Michelle; Williams, Matt; Woodman, Alastair; Shah, Sapna; Saif, Imran
Donor Simvastatin Treatment in Liver Transplantation: Post Hoc Analysis of a Randomized Placebo-controlled Trial With Long-term Follow-up.
Aberg, Fredrik MD, PhD 1; Nykanen, Antti I. MD, PhD 2,3; Helantera, Ilkka MD, PhD 1; Lemstrom, Karl 2,3
Comment to "Donor Simvastatin Treatment in Liver Transplantation: Post-hoc Analysis of a Randomized Placebo-controlled Trial With Long-term Follow-up".
Pagano, Duilio MD, PhD 1; Gruttadauria, Salvatore MD, PhD 1,2
