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The ‘scientist’, the ‘analyst’ and the ‘novelist’: science or metrics?
Enzo Bonora
doi : 10.1007/s00125-022-05808-0
An overwhelming number of meta-analyses and reviews are published by scientific journals. In part this may reflect some preference of editors and publishers for these types of papers, which are more frequently cited and can increase the impact factor of their journals.
Missing the forest-plot for the trees
Deirdre K. TobiasÂ
doi : 10.1007/s00125-022-05862-8
Systematic reviews and meta-analyses are methods increasingly used in biomedical research since their introduction in the 1970s. They serve to replace other non-systematic and cherry-picked narrative reviews, which are highly variable in their approach, structure and content.
Do sex differences in paediatric type 1 diabetes care exist? A systematic review
Silvia A. G. de Vries, Carianne L. Verheugt, Dick Mul, Max Nieuwdorp & Theo C. J. Sas
doi : 10.1007/s00125-022-05866-4
Sex differences are present in cardiovascular care and in outcomes among adults with type 1 diabetes mellitus, which typically commences in childhood. Whether sex influences care and outcomes in childhood is not known. This systematic review provides an overview of sex differences in children with type 1 diabetes, focusing on patient and disease characteristics, treatment, comorbidities and complications.
Changes in attitudes to awareness of hypoglycaemia during a hypoglycaemia awareness restoration programme are associated with avoidance of further severe hypoglycaemia episodes within 24 months: the A2A in HypoCOMPaSS study
Eduardo Sepúlveda, Peter Jacob, Rui PoÃnhos, Davide Carvalho, Selene G. Vicente, Emma L. Smith, James A. M. Shaw, Jane Speight, Pratik Choudhary, Nicole de Zoysa & Stephanie A. Amiel on behalf of the HypoCOMPaSS Study Group
doi : 10.1007/s00125-022-05847-7
The aims of this study were to assess cognitions relating to hypoglycaemia in adults with type 1 diabetes and impaired awareness of hypoglycaemia before and after the multimodal HypoCOMPaSS intervention, and to determine cognitive predictors of incomplete response (one or more severe hypoglycaemic episodes over 24 months).
Projecting the incidence and costs of major cardiovascular and kidney complications of type 2 diabetes with widespread SGLT2i and GLP-1 RA use: a cost-effectiveness analysis
Jedidiah I. Morton, Clara Marquina, Jonathan E. Shaw, Danny Liew, Kevan R. Polkinghorne, Zanfina Ademi & Dianna J. Magliano
doi : 10.1007/s00125-022-05832-0
Whether sodium–glucose co-transporter 2 inhibitors (SGLT2is) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are cost-effective based solely on their cardiovascular and kidney benefits is unknown.
Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England
Suping Ling, Francesco Zaccardi, Eyad Issa, Melanie J. Davies, Kamlesh Khunti & Karen Brown
doi : 10.1007/s00125-022-05854-8
The aim of this study was to describe the long-term trends in cancer mortality rates in people with type 2 diabetes based on subgroups defined by sociodemographic characteristics and risk factors.
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F. Spigelman, Han Sun, Jennifer M. Ikle, Swaraj Thaman, Antje K. Rottner, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E. Manning Fox, Jason M. Torres, Agata Wesolowska-Andersen, Grace Z. Yu, Anubha Mahajan, Anders Larsson, Patrick E. MacDonald, Benjamin Davies, Marcel den Hoed & Anna L. Gloyn
doi : 10.1007/s00125-022-05856-6
Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. However, little is known about the function of the zinc finger transcription factor Ras-responsive element binding protein 1 (RREB1) in glucose homeostasis or how changes in its expression and/or function influence diabetes risk.
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Paola Carrera, Ilaria Marzinotto, Riccardo Bonfanti, Luca Massimino, Silvia Calzavara, Μariagrazia Favellato, Tatiana Jofra, Valeria De Giglio, Clara Bonura, Angela Stabilini, Valeria Favalli, Simone Bondesan, Maria Pia Cicalese, Andrea Laurenzi, Amelia Caretto, Giulio Frontino, Andrea Rigamonti, Chiara Molinari, Marina Scavini, Federica Sandullo, Ettore Zapparoli, Nicoletta Caridi, Silvia Bonfiglio, Valeria Castorani, …Georgia Fousteri
doi : 10.1007/s00125-022-05865-5
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at disease onset. A single AAb, sometimes at low titre, is often detected in some individuals, making their diagnosis uncertain.
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
Mohammad Tariq, Arnaldo H. de Souza, Mohammed Bensellam, Heeyoung Chae, Manon Jaffredo, Anne-Françoise Close, Jean-Philippe Deglasse, Laila R. B. Santos, Antoine Buemi, Nizar I. Mourad, Anne Wojtusciszyn, Matthieu Raoux, Patrick Gilon, Christophe Broca & Jean-Christophe Jonas
doi : 10.1007/s00125-022-05842-y
The rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin secretion (GSIS), emphasising the role of beta cell dysfunction in the early stages of the disease.
Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice
Qi Fu, Hemin Jiang, Yu Qian, Hui Lv, Hao Dai, Yuncai Zhou, Yang Chen, Yunqiang He, Rui Gao, Shuai Zheng, Yucheng Liang, Siqi Li, Xinyu Xu, Kuanfeng Xu & Tao Yang
doi : 10.1007/s00125-022-05849-5
Islets have complex heterogeneity and subpopulations. Cell surface markers representing alpha, beta and delta cell subpopulations are urgently needed for investigations to explore the compositional changes of each subpopulation in obesity progress and diabetes onset, and the adaptation mechanism of islet metabolism induced by a high-fat diet (HFD).
Counter-regulatory responses to postprandial hypoglycaemia in patients with post-bariatric hypoglycaemia vs surgical and non-surgical control individuals
Afroditi Tripyla, David Herzig, Gemma Reverter-Branchat, Jacopo Pavan, Michele Schiavon, Philippe J. Eugster, Eric Grouzmann, Christos T. Nakas, Valérie Sauvinet, Laure Meiller, Joerg Zehetner, Daniel Giachino, Philipp Nett, Joanna Gawinecka, Simone Del Favero, Andreas Thomas, Mario Thevis, Chiara Dalla Man & Lia Bally
doi : 10.1007/s00125-022-05861-9
Post-bariatric hypoglycaemia is an increasingly recognised complication of bariatric surgery, manifesting particularly after Roux-en-Y gastric bypass. While hyperinsulinaemia is an established pathophysiological feature, the role of counter-regulation remains unclear.
Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
Bernhard Radlinger, Claudia Ress, Sabrina Folie, Karin Salzmann, Ana Lechuga, Bernhard Weiss, Willi Salvenmoser, Michael Graber, Jakob Hirsch, Johannes Holfeld, Christian Kremser, Patrizia Moser, Gabriele Staudacher, Tomas Jelenik, Michael Roden, Herbert Tilg & Susanne Kaser
doi : 10.1007/s00125-022-05851-x
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are widely used in the treatment of type 2 diabetes, heart failure and chronic kidney disease. Their role in the prevention of diet-induced metabolic deteriorations, such as obesity, insulin resistance and fatty liver disease, has not been defined yet.
Prospective randomised placebo-controlled trial assessing the efficacy of silver dressings to enhance healing of acute diabetes-related foot ulcers
Nicole Lafontaine, Jane Jolley, Mervyn Kyi, Sophie King, Laura Iacobaccio, Eva Staunton, Brent Wilson, Catherine Seymour, Sonja Rogasch & Paul Wraight
doi : 10.1007/s00125-022-05855-7
Silver dressings are used for their antimicrobial properties but there is limited evidence of clinical benefit when managing diabetes-related foot ulcers (DFUs). We aimed to assess whether silver dressings in acute DFUs increased the proportion of ulcers healed compared with non-silver dressings.
Environmental exposures are important for type 2 diabetes pathophysiology in sub-Saharan African populations
Dirk L. Christensen, Line Hjort, Stellah G. Mpagama & Kaushik L. Ramaiya
Environmental exposures are important for type 2 diabetes pathophysiology in sub-Saharan African populations. Reply to Christensen D, Hjort L, Mpagama S et al [letter]
Julia H. Goedecke, Carmen Pheiffer & Amy E. Mendham
