دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes
Nita G. Forouhi
doi : 10.1007/s00125-023-05873-z
Nutrition therapy has been emphasised for decades for people with type 2 diabetes, and the vital importance of diet and nutrition is now also recognised for type 2 diabetes prevention.
Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Shuai Yuan, Jordi Merino & Susanna C. Larsson
doi : 10.1007/s00125-023-05879-7
Diabetes and its complications cause a heavy disease burden globally. Identifying exposures, risk factors and molecular processes causally associated with the development of diabetes can provide important evidence bases for disease prevention and spur novel therapeutic strategies.
Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial
Søren Gullaksen, Liv Vernstrøm, Steffen S. Sørensen, Steffen Ringgaard, Christoffer Laustsen, Kristian L. Funck, Per L. Poulsen & Esben Laugesen
doi : 10.1007/s00125-023-05876-w
Glucagon-like peptide-1 receptor agonists (GLP-1ras) and sodium–glucose cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects. Improved kidney oxygenation and haemodynamic changes are suggested mechanisms; however, human data are scarce.
Congenital malformations among offspring of women with type 1 diabetes who use insulin pumps: a prospective cohort study
Ida H. Thorius, Lise Lotte N. Husemoen, Rikke B. Nordsborg, Amra C. Alibegovic, Mari-Anne Gall, Janne Petersen & Elisabeth R. Mathiesen
doi : 10.1007/s00125-022-05864-6
Continuous subcutaneous insulin infusion by insulin pump is often superior in improving glycaemic control compared with conventional multiple daily insulin injection (MDI). However, whether pump treatment leads to improved pregnancy outcomes in terms of congenital malformations and perinatal death remains unknown.
Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia
Matthew J. L. Hare, Louise J. Maple-Brown, Jonathan E. Shaw, Jacqueline A. Boyle, Paul D. Lawton, Elizabeth L. M. Barr, Steven Guthridge, Vanya Webster, Denella Hampton, Gurmeet Singh, Roland F. Dyck & Federica Barzi
doi : 10.1007/s00125-023-05868-w
The aim of this work was to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern Territory (NT), Australia.
The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population
Lauren E. Wedekind, Anubha Mahajan, Wen-Chi Hsueh, Peng Chen, Muideen T. Olaiya, Sayuko Kobes, Madhumita Sinha, Leslie J. Baier, William C. Knowler, Mark I. McCarthy & Robert L. Hanson
doi : 10.1007/s00125-023-05870-2
There is limited information on how polygenic scores (PSs), based on variants from genome-wide association studies (GWASs) of type 2 diabetes, add to clinical variables in predicting type 2 diabetes incidence, particularly in non-European-ancestry populations.
Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study
Rianneke de Ritter, Simone J. S. Sep, Marleen M. J. van Greevenbroek, Yvo H. A. M. Kusters, Rimke C. Vos, Michiel L. Bots, M. Eline Kooi, Pieter C. Dagnelie, Simone J. P. M. Eussen, Miranda T. Schram, Annemarie Koster, Martijn C. G. Brouwers, Niels M. R. van der Sangen, Sanne A. E. Peters, Carla J. H. van der Kallen & Coen D. A. Stehouwer
doi : 10.1007/s00125-023-05880-0
Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the association between diabetes status and body composition and whether this association is moderated by sex.
Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response
Dominik Lutter, Stephan Sachs, Marc Walter, Anna Kerege, Leigh Perreault, Darcy E. Kahn, Amare D. Wolide, Maximilian Kleinert, Bryan C. Bergman & Susanna M. Hofmann
doi : 10.1007/s00125-023-05874-y
Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual. We used gene expression profiles from a cross-sectional study to identify potential candidate genes for the prediction of diabetes risk and intervention response.
Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
René van Tienhoven, Maria J. L. Kracht, Arno R. van der Slik, Sofia Thomaidou, Anouk H. G. Wolters, Ben N. G. Giepmans, Juan Pablo Romero Riojas, Michael S. Nelson, Françoise Carlotti, Eelco J. P. de Koning, Rob C. Hoeben, Arnaud Zaldumbide & Bart O. Roep
doi : 10.1007/s00125-023-05882-y
Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets.
Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops
Ilaria Marzinotto, David L. Pittman, Alistair J. K. Williams, Anna E. Long, Peter Achenbach, Michael Schlosser, Beena Akolkar, William E. Winter, Vito Lampasona & participating laboratories
doi : 10.1007/s00125-023-05877-9
The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring autoantibodies in type 1 diabetes and the concordance of results across laboratories.
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
Shao-Wen Weng, Jian-Ching Wu, Feng-Chih Shen, Yen-Hsiang Chang, Yu-Jih Su, Wei-Shiung Lian, Ming-Hong Tai, Chia-Hao Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Tian-Huei Chu, Ying-Hsien Kao, Feng-Sheng Wang & Pei-Wen Wang
doi : 10.1007/s00125-023-05869-9
The mitochondrial chaperonin heat shock protein (HSP) 60 is indispensable in protein folding and the mitochondrial stress response; however, its role in nutrient metabolism remains uncertain. This study investigated the role of HSP60 in diet-induced non-alcoholic fatty liver disease (NAFLD).
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
Da Som Lee, Tae Hyeon An, Hyunmi Kim, Eunsun Jung, Gyeonghun Kim, Seung Yeon Oh, Jun Seok Kim, Hye Jin Chun, Jaeeun Jung, Eun-Woo Lee, Baek-Soo Han, Dai Hoon Han, Yong-Ho Lee, Tae-Su Han, Keun Hur, Chul-Ho Lee, Dae-Soo Kim, Won Kon Kim, Jun Won Park, Seung-Hoi Koo, Je Kyung Seong, Sang Chul Lee, Hail Kim, Kwang-Hee Bae & Kyoung-Jin Oh
doi : 10.1007/s00125-023-05878-8
Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like 2 (TCF7L2) is closely associated with type 2 diabetes risk, the role of TCF7L2 in NAFLD development remains unclear.
Determination of autoantibodies in type 2 diabetes: one simple way to improve classification
Johnny LudvigssonÂ
doi : 10.1007/s00125-022-05858-4
This letter aims to increase interest in better classification of type 2 diabetes. This can be done in a simple and cheap way via determination of autoantibodies. Autoantibody analysis can be used to detect the 7–12% of people with diabetes that is phenotypic of type 2 diabetes but is, in fact, latent autoimmune diabetes in adults (LADA), which may be regarded as a variant of type 1 diabetes.
Determination of autoantibodies in type 2 diabetes: one simple way to improve classification. Reply by Lean et al to Ludvigsson J [letter]
Michael E. J. Lean, Roy Taylor & Naveed Sattar
Determination of autoantibodies in type 2 diabetes: one simple way to improve classification. Reply by Laferrère to Ludvigsson J [letter]
Blandine LaferrèreÂ
