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On the Way to Self-sufficiency: Improving Deceased Organ Donation in India
Kute, Vivek B.; Ramesh, Vasanthi; Rela, Mohamed
doi : 10.1097/TP.0000000000003677
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1625-1630
Organ transplantation in India to date relies predominantly (80.3%) on living donor procedures for kidney and liver transplantation. Heart, lung, pancreas, and small bowel transplants are therefore less frequent.1-4 There is also a pronounced gender inequality with a majority of male transplant recipients (81%), whereas most donors (78%) are female. At this time, there are limited living donor follow-up and variable recipient results. Most transplants take place in private sector hospitals with costs that nearly twice compared with those in the public sector.
Health System Building Blocks and Organ Transplantation in India
Divyaveer, Smita; Nagral, Sanjay; Prasad, K.T.; Sharma, Ashish; Jha, Vivekanand
doi : 10.1097/TP.0000000000003685
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1631-1634
Research Highlights
Kempkes, Rosalie W.M.; Issa, Fadi
doi : 10.1097/TP.0000000000003874
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1635-1636
B Cells Break Maternal T-Cell Tolerance of Fetal Antigen
Nellore, Anoma; Porrett, Paige M.
doi : 10.1097/TP.0000000000003727
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1637-1638
Dr Andreas Gerasimos Tzakis, MD, PhD, Dhc (mult), Professor of Surgery, Emeritus Director of Transplantation, Cleveland Clinic
doi : 10.1097/TP.0000000000003807
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1639-1642
Early Allograft Dysfunction and Complications in DCD Liver Transplantation: Expert Consensus Statements From the International Liver Transplantation Society
Quintini, Cristiano; Muiesan, Paolo; Detry, Olivier; Gastaca, Mikel; de Jonge, Jeroen; Clavien, Pierre-Alain; Del Prete, Luca; Fondevila, Constantino
doi : 10.1097/TP.0000000000003877
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1643-1652
Cytomegalovirus: Another Source of Antibody-mediated Graft Injury?
Cook, Charles H.
doi : 10.1097/TP.0000000000003549
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1653-1654
Urine the Right Direction: The Consensus Statement From the Committee on Transplant Anesthesia of the American Society of Anesthesiologists on Fluid Management During Kidney Transplantation
Weinberg, Laurence; Collins, Michael G.; Peyton, Philip
doi : 10.1097/TP.0000000000003582
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1655-1657
Immunosuppression for Liver Retransplantation: Babel Revisited
Peters, Anna L.; Tremblay, Simon; Alloway, Rita R.; Woodle, E. Steve
doi : 10.1097/TP.0000000000003418
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1658-1659
Imlifidase Shows Promise for the Most Disadvantaged Sensitized Transplant Candidates
Schinstock, Carrie A.
doi : 10.1097/TP.0000000000003497
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1660-1661
Outfoxing Rejection: Urinary FOXP3 mRNA, TCMR, and the Fate of Allografts
Tedla, Fasika M.; Sanchez Russo, Luis; Menon, Madhav C.
doi : 10.1097/TP.0000000000003479
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1662-1663
Oxygen-sensitive Magnetic Resonance Imaging: A Noninvasive Step Forward for Diagnosing Vasculopathy in the Cardiac Allograft
van Heeswijk, Ruud B.; Hullin, Roger
doi : 10.1097/TP.0000000000003420
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1664-1665
Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation
Cunningham, Kyle T.; Mills, Kingston H.G.
doi : 10.1097/TP.0000000000003673
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1666-1676
Fluid Management During Kidney Transplantation: A Consensus Statement of the Committee on Transplant Anesthesia of the American Society of Anesthesiologists
Wagener, Gebhard; Bezinover, Dmitri; Wang, Cynthia; Kroepfl, Elizabeth; Diaz, Geraldine; Giordano, Chris; West, James; Kindscher, James D.; Moguilevitch, Marina; Nicolau-Raducu, Ramona; Planinsic, Raymond M.; Rosenfeld, David M.; Lindberg, Scott; Schumann, Roman; Pivalizza, Evan G.
doi : 10.1097/TP.0000000000003581
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1677-1684
Frailty in Pancreas Transplantation
Parajuli, Sandesh; Aziz, Fahad; Garg, Neetika; Wallschlaeger, Rebecca E.; Lorden, Heather M.; Al-Qaoud, Talal; Mandelbrot, Didier A.; Odorico, and Jon S.
doi : 10.1097/TP.0000000000003586
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1685-1694
There are a variety of definitions and criteria used in clinical practice to define frailty. In the absence of a gold-standard definition, frailty has been operationally defined as meeting 3 out of 5 phenotypic criteria indicating compromised function: low grip strength, low energy, slowed walking speed, low physical activity, and unintentional weight loss. Frailty is a common problem in solid organ transplant candidates who are in the process of being listed for a transplant, as well as after transplantation.
Uterine Transplantation: Review of Livebirths and Reproductive Implications
Jones, Benjamin P.; Kasaven, Lorraine; Vali, Saaliha; Saso, Srdjan; Jalmbrant, Maria; Bracewell-Milnes, Timothy; Thum, Meen-Yau; Quiroga, Isabel; Friend, Peter; Diaz-Garcia, Cesar; Ghaem-Maghami, Sadaf; Yazbek, Joseph; Lees, Christoph; Testa, Giuliano; Johannesson, Liza; Jones, Bryony; Smith, J. Richard
doi : 10.1097/TP.0000000000003578
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1695-1707
Uterine transplantation (UTx) is a fertility restoring treatment for women with absolute uterine factor infertility. At a time when there is no question of the procedure’s feasibility, and as the number of livebirths begins to increase exponentially, various important reproductive, fetal, and maternal medicine implications have emerged.
Reporting and Handling of Missing Participant Data in Systematic Reviews of Kidney Transplant Studies
Budhiraja, Pooja; Kalot, Mohamad A.; Alayli, Abdallah El; Dimassi, Ahmad; Kaplan, Bruce; Chakkera, Harini A.; Mustafa, Reem A.
doi : 10.1097/TP.0000000000003503
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1708-1717
Participant withdrawal from clinical trials occurs for various reasons, predominantly adverse effects or intervention inefficacy. Because these missing participant data can have implications for the validity, reproducibility, and generalizability of study results, when conducting a systematic review, it is important to collect and appropriately analyze missing data information to assess its effects on the robustness of the study results.
Murine Cytomegalovirus–induced Complement-fixing Antibodies Deposit in Murine Renal Allografts During Acute Rejection
Saunders, Ute; Li, Mao; Boddeda, Srinivasa R.; Maher, Sonya; Ghere, Jessica; Kaptsan, Irina; Dhital, Ravi; Velazquez, Victoria; Guo, Lingling; Chen, Bo; Zeng, Qiang; Schoeb, Trenton R.; Cianciolo, Rachel; Shimamura, Masako
doi : 10.1097/TP.0000000000003548
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1718-1729
Human cytomegalovirus (CMV) infection is associated with renal allograft dysfunction and loss, particularly in combination with acute rejection. Emerging literature suggests that non-HLA antibodies may contribute to antibody-mediated rejection, but pathogen-induced antibodies have not been investigated in this context. This study examines the presence of CMV-induced antibodies in murine CMV (MCMV)–infected renal allografts during acute rejection.
Imaging Tolerance Induction in Neonatal Mice: Hierarchical Interplay Between Allogeneic Adult and Neonatal Immune Cells
Bascom, Roger A.; Tao, KeSheng; West, Lori J.
doi : 10.1097/TP.0000000000003566
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1730-1746
In Medawar’s murine neonatal tolerance model, injection of adult semiallogeneic lymphohematopoietic cells (spleen cells [SC] and bone marrow cells [BMC]) tolerizes the neonatal immune system. An eventual clinical application would require fully allogeneic (allo) cells, yet little is known about the complex in vivo/in situ interplay between those cells and the nonconditioned neonatal immune system.
Presence of Donor Lymph Nodes Within Vascularized Composite Allotransplantation Ameliorates VEGF-C-mediated Lymphangiogenesis and Delays the Onset of Acute Rejection
Olariu, Radu; Tsai, Catherine; Abd El Hafez, Mai; Milusev, Anastasia; Banz, Yara; Lese, Ioana; Leckenby, Jonathan I.; Constantinescu, Mihai; Rieben, Robert; V?gelin, Esther; Taddeo, Adriano
doi : 10.1097/TP.0000000000003601
Transplantation: August 2021 - Volume 105 - Issue 8 - p 1747-1759
The lymphatic system plays an active role in modulating inflammation in autoimmune diseases and organ rejection. In this work, we hypothesized that the transfer of donor lymph node (LN) might be used to promote lymphangiogenesis and influence rejection in vascularized composite allotransplantation (VCA).
A Comparison of Pulsatile Hypothermic and Normothermic Ex Vivo Machine Perfusion in a Porcine Kidney Model
Vallant, Natalie; Wolfhagen, Nienke; Sandhu, Bynvant; Hamaoui, Karim; Cook, Terence; Pusey, Charles; Papalois, Vassilios
doi : 10.1097/TP.0000000000003599
Transplantation. 105(8):1760-1770, August 2021
Hypothermic machine perfusion (HMP) is a well-established method for deceased donor kidney preservation. Normothermic machine perfusion (NMP) might offer similar or greater advantages. We compared the 2 methods in an ex vivo perfusion model using 34 porcine kidneys.
Major Thromboembolic Complications in Liver Transplantation: The Role of Rotational Thromboelastometry and Cryoprecipitate Transfusion
Nguyen-Buckley, Christine; Gao, Wei; Agopian, Vatche; Wray, Christopher; Steadman, Randolph H.; Xia, Victor W.
doi : 10.1097/TP.0000000000003427
Transplantation. 105(8):1771-1777, August 2021
Although hemorrhage is a major concern during liver transplantation (LT), the risk for thromboembolism is well recognized. Implementation of rotational thromboelastometry (ROTEM) has been associated with the increased use of cryoprecipitate; however, the role of ROTEM-guided transfusion strategy and cryoprecipitate administration in the development of major thromboembolic complications (MTCs) has never been documented.
Early Versus Late Hepatocellular Carcinoma Recurrence After Transplantation: Predictive Factors, Patterns, and Long-term Outcome
El-domiaty, Nada; Saliba, Faouzi; Vibert, Eric; Karam, Vincent; Sobesky, Rodolphe; Ibrahim, Wafaa; Pittau, Gabriella; Ciacio, Oriana; Salloum, Chady; Amer, Khaled; Saeed, Maysaa A.; Shawky, Jihan A.; Sa Cunha, Antonio; Rosmorduc, Olivier; Cherqui, Daniel; Adam, René; Samuel, Didier
doi : 10.1097/TP.0000000000003434
Transplantation. 105(8):1778-1790, August 2021
Hepatocellular carcinoma (HCC) is currently the first indication of liver transplantation (LT) in Europe and Asia-Pacific region and the third in the United States. HCC recurrence is the main complication affecting short- and medium-term outcomes after LT.
A Novel Technique for Bile Duct Division During Laparoscopic Living Donor Hepatectomy to Overcome Biliary Complications in Liver Transplantation Recipients: “Cut and Clip” Rather Than “Clip and Cut”
Rhu, Jinsoo; Kim, Mi Seung; Choi, Gyu-Seong; Jeong, Woo Kyoung; Kim, Jong Man; Joh, Jae-Won
doi : 10.1097/TP.0000000000003423
Transplantation. 105(8):1791-1799, August 2021
This study was designed to analyze the clinical impact of a new bile duct division technique during laparoscopic living donor hepatectomy.
Differences in Early Immunosuppressive Therapy Among Liver Retransplantation Recipients in a National Cohort
Mezochow, Alyssa K.; Abt, Peter L.; Bittermann, Therese
doi : 10.1097/TP.0000000000003417
Transplantation. 105(8):1800-1807, August 2021
There is no unified consensus as to the preferred immunosuppression (IS) strategy following liver retransplantation (reLT).
Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)
Jordan, Stanley C.; Legendre, Christophe; Desai, Niraj M.; Lorant, Tomas; Bengtsson, Mats; Lonze, Bonnie E.; Vo, Ashley A.; Runstr?m, Anna; Laxmyr, Lena; Sj?holm, Kristoffer; Schi?tt, ?sa; Sonesson, Elisabeth; Wood, Kathryn; Winstedt, Lena; Kjellman, Christian; Montgomery, Robert A.
doi : 10.1097/TP.0000000000003496
Transplantation. 105(8):1808-1817, August 2021
Highly HLA sensitized patients have limited access to life-saving kidney transplantation because of a paucity of immunologically suitable donors. Imlifidase is a cysteine protease that cleaves IgG leading to a rapid decrease in antibody level and inhibition of IgG-mediated injury. This study investigates the efficacy and safety of imlifidase in converting a positive crossmatch test to negative, allowing highly sensitized patients to be transplanted with a living or deceased donor kidney
Infectious Complications in Tocilizumab-treated Kidney Transplant Recipients
Sethi, Supreet; Peng, Alice; Najjar, Reiad; Vo, Ashley; Jordan, Stanley C.; Huang, Edmund
doi : 10.1097/TP.0000000000003512
Transplantation. 105(8):1818-1824, August 2021
Tocilizumab is an interleukin-6 receptor antagonist recently described as a promising treatment for antibody-mediated rejection. We compared infectious complications among tocilizumab-treated kidney transplant patients with those receiving intravenous immunoglobulin (IVIG)/rituximab.
FOXP3 mRNA Profile Prognostic of Acute T Cell–mediated Rejection and Human Kidney Allograft Survival
Luan, Danny; Dadhania, Darshana M.; Ding, Ruchuang; Muthukumar, Thangamani; Lubetzky, Michelle; Lee, John R.; Sharma, Vijay K.; August, Phyllis; Mueller, Franco B.; Schwartz, Joseph E.; Suthanthiran, Manikkam
doi : 10.1097/TP.0000000000003478
Transplantation. 105(8):1825-1839, August 2021
T cell–mediated rejection (TCMR) is the most frequent type of acute rejection and is associated with kidney allograft failure. Almost 40% of TCMR episodes are nonresponsive to therapy, and molecular mechanisms for the nonresponsiveness are unknown. Our single-center study identified that urinary cell FOXP3 mRNA abundance predicts TCMR reversibility and allograft survival.
Immunosuppression Regimen Use and Outcomes in Older and Younger Adult Kidney Transplant Recipients: A National Registry Analysis
Lentine, Krista L.; Cheungpasitporn, Wisit; Xiao, Huiling; McAdams-DeMarco, Mara; Lam, Ngan N.; Segev, Dorry L.; Bae, Sunjae; Ahn, JiYoon B.; Hess, Gregory P.; Caliskan, Yasar; Randall, Henry B.; Kasiske, Bertram L.; Schnitzler, Mark A.; Axelrod, David A.
doi : 10.1097/TP.0000000000003547
Transplantation. 105(8):1840-1849, August 2021
Although the population of older transplant recipients has increased dramatically, there are limited data describing the impact of immunosuppression regimen choice on outcomes in this recipient group.
Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors
Nguyen, Tiffany; Sise, Meghan E.; Delgado, Cindy; Williams, Winfred; Reese, Peter; Goldberg, David
doi : 10.1097/TP.0000000000003511
Transplantation. 105(8):1850-1857, August 2021
Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups.
Characteristics of T- and NK-cell Lymphomas After Renal Transplantation: A French National Multicentric Cohort Study
Barba, Thomas; Bachy, Emmanuel; Maarek, Alizée; Fossard, Gaëlle; Genestier, Laurent; Anglicheau, Dany; Moal, Valérie; Dantal, Jacques; Rieu, Philippe; Chemouny, Jonathan; Charrier, Manon; Durrbach, Antoine; Provot, François; Ducloux, Didier; Westeel, Pierre-François; Heng, Anne-Elisabeth; Rerolle, Jean-Philippe; Barrou, Benoit; Grimbert, Philippe; Chatelet, Valérie; Mousson, Christiane; Janbon, Bénédicte; Pernin, Vincent; Frimat, Luc; Ouali, Nacera; Glotz, Denis; Thierry, Antoine; Mariat, Christophe; Büchler, Mathias; Gaulard, Philippe; Leblond, Véronique; Morelon, Emmanuel; Dubois, Valérie; Salles, Gilles; Caillard, Sophie; Thaunat, Olivier
doi : 10.1097/TP.0000000000003568
Transplantation. 105(8):1858-1868, August 2021
Posttransplant lymphoproliferative disorders (PTLDs) encompass a spectrum of heterogeneous entities. Because the vast majority of cases PTLD arise from B cells, available data on PTLD of T or NK phenotype (T/NK-cell PTLD) are scarce, which limits the quality of the management of these patients.
Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature
Tchiloemba, Bianief; Kauke, Martin; Haug, Valentin; Abdulrazzak, Obada; Safi, Ali-Farid; Kollar, Branislav; Pomahac, Bohdan
doi : 10.1097/TP.0000000000003513
Transplantation. 105(8):1869-1880, August 2021
Facial vascularized composite allotransplantation (fVCA) represents a reconstructive approach that enables superior improvements in functional and esthetic restoration compared with conventional craniomaxillofacial reconstruction. Outcome reports of fVCA are usually limited to short-term follow-up or single-center experiences. We merge scientific literature on reported long-term outcome data to better define the risks and benefits of fVCA.
The First Successfully Performed LDLT in the UAE: 13 Years of Follow-up
Obed, Aiman; Al Shaikh, Saeed; Bashir, Abdullah; Jarrad, Anwar
doi : 10.1097/TP.0000000000003749
Transplantation. 105(8):e79, August 2021
Low Immunization Rate in Kidney Transplant Recipients Also After Dose 2 of the BNT162b2 Vaccine: Continue to Keep Your Guard up!
Midtvedt, Karsten; Tran, Trung; Parker, Krystina; Marti, Hans-Peter; Stenehjem, Aud-E.; G?ransson, Lasse Gunnar; M?rkve Soldal, Kari; Madsen, Camilla; Smedbr?ten, Julia; Vaage, Eline Benno; Lund-Johansen, Fridtjof; ?sberg, Anders
doi : 10.1097/TP.0000000000003856
Transplantation. 105(8):e80-e81, August 2021
Antibody Response to the Janssen COVID-19 Vaccine in Solid Organ Transplant Recipients
Boyarsky, Brian J.; Chiang, Teresa P.-Y.; Ou, Michael T.; Werbel, William A.; Massie, Allan B.; Segev, Dorry L.; Garonzik-Wang, Jacqueline M.
doi : 10.1097/TP.0000000000003850
Transplantation. 105(8):e82-e83, August 2021
Transplantation Outcome in Recipients Engrafted With Organs Recovered From the First French Deceased Donor With a SARS-COV-2 Vaccine-induced Thrombotic Thrombocytopenia
Jamme, Matthieu; Elalamy, Ismail; d’Izarny Gargas, Thibaut; Pettenati, Caroline; Desire, Eva; Tissot, Adrien; Rabant, Marion; Lefebvre, Mathilde; Soorojebally, Yanish; Vourc’h, Mickael; Conti, Filomena; Ferlicot, Sophie; Delahousse, Michel; Sartorius-Brodin, Albane; Hertig, Alexandre
doi : 10.1097/TP.0000000000003847
Transplantation. 105(8):e84-e86, August 2021
Training Experiences of American Society of Transplant Surgeons Fellows in Deceased Donor Organ Procurement
Connelly, Christopher R.; Quillin, Ralph Cutler; Biesterveld, Ben E.; Highet, Alexandra; Schenk, Austin D.; Syed, Shareef; Bongu, Advaith; Waits, Seth A.
doi : 10.1097/TP.0000000000003711
Transplantation. 105(8):e87-e88, August 2021
Ex Vivo Liver Splitting and Hypothermic Oxygenated Machine Perfusion: Technical Refinements of a Promising Preservation Strategy in Split Liver Transplantation
Mabrut, Jean-Yves; Lesurtel, Mickaël; Muller, Xavier; Dubois, Rémi; Ducerf, Christian; Rossignol, Guillaume; Mohkam, Kayvan
doi : 10.1097/TP.0000000000003775
Transplantation. 105(8):e89-e90, August 2021
Simultaneous Pancreas-kidney Transplantation for Type 2 Diabetes Mellitus
Singh, Neeraj; Parsons, Ronald; Lentine, Krista; Woodside, Kenneth J.; Basu, Arpita; Cheungpasitporn, Wisit; Kensinger, Clark; Parajuli, Sandesh; Rivera, Franco H. Cabeza; Sultan, Samuel; Tantisattamo, Ekamol; Zibari, Gazi; Pavlakis, Martha; Cooper, Matthew
doi : 10.1097/TP.0000000000003752
Transplantation. 105(8):e91-e92, August 2021
The Authors’ Reply: Type 2 Diabetes and Simultaneous Pancreas-kidney Transplantation
Chadban, Steve J.; Knoll, Greg A.
doi : 10.1097/TP.0000000000003753
Transplantation. 105(8):e93, August 2021
