دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
ANA Investigates Disruptive Technologies: Neuroethics Role in Advancing Innovation
Rohini D. Samudralwar MD, Amanda Jagolino-Cole MD, Adeline Goss MD, Karen S. Rommelfanger PhD
doi : 10.1002/ana.26607
Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus
Cloé A. Payet PhD, Axel You MSc, Odessa-Maud Fayet MSc, Edouard Hemery MSc, Frederique Truffault MSc, Vincent Bondet PhD, Darragh Duffy PhD, Frédérique Michel PhD, Elie Fadel MD, Julien Guihaire MD, Sophie Demeret MD, Sonia Berrih-Aknin PhD, Rozen Le Panse PhD
doi : 10.1002/ana.26590
Myasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR-MG and is characterized by a type I interferon (IFN) signature linked to IFN-β. We investigated if AChR-MG was characterized by an IFN-I signature in the blood, and further investigated the chronic thymic IFN-I signature.
Limbic Connectivity Underlies Pain Treatment Response in Small-Fiber Neuropathy
Chi-Chao Chao MD, PhD, Paul-Chen Hsieh MD, Chien-Ho (Janice) Lin PhD, Shin-Leh Huang MD, Sung-Tsang Hsieh MD, PhD, Ming-Chang Chiang MD, PhD
doi : 10.1002/ana.26577
Small-fiber neuropathy (SFN) is characterized by neuropathic pain due to degeneration of small-diameter nerves in the skin. Given that brain reorganization occurs following chronic neuropathic pain, this study investigated the structural and functional basis of pain-related brain changes after skin nerve degeneration.
Longitudinal Effects of Asymptomatic C9orf72 Carriership on Brain Morphology
Kevin van Veenhuijzen MD, Henk-Jan Westeneng MD, Harold H. G. Tan MD, Abram D. Nitert MD, Hannelore K. van der Burgh PhD, Isabel Gosselt MSc, Michael A. van Es MD, PhD, Tanja C. W. Nijboer PhD, Jan H. Veldink MD, PhD, Leonard H. van den Berg MD, PhD
doi : 10.1002/ana.26572
We investigated effects of C9orf72 repeat expansion and gene expression on longitudinal cerebral changes before symptom onset.
An Apple a Day to Keep the Parkinson's Disease Doctor Away?
Bastiaan R. Bloem MD, PhD, FRCPE, Erik Post MSc, Deborah A. Hall MD PhD
doi : 10.1002/ana.26612
It is challenging to reliably assess the motor features of Parkinson's disease in real-time. This has motivated the search for new digital outcomes that can objectively and remotely measure the severity of parkinsonian motor impairments over an extended period of time.
Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3
Jayashree Chandrasekaran MS, Emilien Petit MSc, Young Woo Park PhD, Sophie Tezenas du Montcel MD, PhD, James M. Joers PhD, Dinesh K. Deelchand PhD, Michal Považan PhD, Guita Banan PhD, Romain Valabregue PhD, Philipp Ehses PhD, Jennifer Faber MD, Pierrick Coupé PhD, Chiadi U. Onyike MBBS, MD, Peter B. Barker PhD, Jeremy D. Schmahmann MD, Eva-Maria Ratai PhD, S. H. Subramony MD, Thomas H. Mareci PhD, Khalaf O. Bushara MD, Henry Paulson MD, PhD, Alexandra Durr MD, PhD, Thomas Klockgether MD, Tetsuo Ashizawa MD, Christophe Lenglet PhD, Gülin Öz PhD, for the READISCA Consortium
doi : 10.1002/ana.26573
This study was undertaken to identify magnetic resonance (MR) metrics that are most sensitive to early changes in the brain in spinocerebellar ataxia type 1 (SCA1) and type 3 (SCA3) using an advanced multimodal MR imaging (MRI) protocol in the multisite trial setting.
Illusory Responses across the Lewy Body Disease Spectrum
Marian Shahid MSc, Ashley Rawls MD, Veronica Ramirez BS, Sephira Ryman PhD, Veronica E. Santini MD, Laurice Yang MD, Sharon J. Sha MD, Jacob N. Hall MD, Thomas J. Montine MD, PhD, Amy Lin MPH, Lu Tian PhD, Victor W. Henderson MD, MS, Brenna Cholerton PhD, Maya Yutsis PhD, Kathleen L. Poston MD, MS
doi : 10.1002/ana.26574
This study was undertaken to study pareidolias, or perceived meaningful objects in a meaningless stimulus, in patients across the Lewy body (LB) disease spectrum, where most do not report hallucinations or delusions.
Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine
Gerrit L. J. Onderwater MD, PhD, Robin M. van Dongen MD, PhD, Amy C. Harms PhD, Ronald Zielman MD, PhD, Willebrordus P. J. van Oosterhout MD, PhD, Jan B. van Klinken PhD, Jelle J. Goeman PhD, Gisela M. Terwindt MD, PhD, Arn M. J. M. van den Maagdenberg PhD, Thomas Hankemeier PhD, Michel D. Ferrari MD, PhD, FANA, FRCP
doi : 10.1002/ana.26576
Impaired amine metabolism has been associated with the etiology of migraine, that is, why patients continue to get migraine attacks. However, evidence from cerebrospinal fluid (CSF) is lacking. Here, we evaluated individual amine levels, global amine profiles, and amine pathways in CSF and plasma of interictal migraine patients and healthy controls.
Biomarkers of Migraine and Cluster Headache: Differences and Similarities
Roberta Messina, Carole H. Sudre, Diana Y. Wei, Massimo Filippi, Sebastien Ourselin, Peter J. Goadsby
doi : 10.1002/ana.26583
This study was undertaken to identify magnetic resonance imaging (MRI) biomarkers that differentiate migraine from cluster headache patients and imaging features that are shared.
Seasonal Variation in Neurologic Hospitalizations in the United States
Ali G. Hamedani MD MHS, Dylan Thibault MS, Allison W. Willis MD MSCI
doi : 10.1002/ana.26579
Certain neurologic diseases have been noted to vary by season, and this is important for understanding disease mechanisms and risk factors, but seasonality has not been systematically examined across the spectrum of neurologic disease, and methodologic guidance is also lacking.
Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy
Piero Perucca MD, PhD, Kate Stanley MSc, Natasha Harris MS, Anne M. McIntosh PhD, Ali A. Asadi-Pooya MD, Mohamad A. Mikati MD, Danielle M. Andrade MD, MSc, Patricia Dugan MD, Chantal Depondt MD, PhD, Hyunmi Choi MD, MS, Erin L. Heinzen PharmD, PhD, Gianpiero L. Cavalleri PhD, Russell J. Buono PhD, Orrin Devinsky MD, Michael R. Sperling MD, Samuel F. Berkovic MD, Norman Delanty MD, David B. Goldstein PhD, Terence J. O'Brien MD, the EPIGEN Consortium
doi : 10.1002/ana.26581
Genetic factors have long been debated as a cause of failure of surgery for mesial temporal lobe epilepsy (MTLE). We investigated whether rare genetic variation influences seizure outcomes of MTLE surgery.
EEG lexicality effect predicts clinical outcome in disorders of consciousness
Amina Ben Salah MD, Clémence Marois MD, MSc, Aude Sangare MD, PhD, Mélanie Valente, Jacobo Sitt MD, PhD, Benjamin Rohaut MD, PhD, Lionel Naccache MD, PhD
doi : 10.1002/ana.26614
This study aimed at probing covert language processing in patients with disorders of consciousness. An auditory paradigm contrasting words to pronounceable pseudowords was designed, while recording bedside electroencephalogram and computing the two main correlates of lexicality: N400 and late positive component (LPC).
Prevalence of Mutations in Mendelian Stroke Genes in Early Onset Stroke Patients
Hong-Kyun Park MD, MSc, Keon-Joo Lee MD, MSc, Jong-Moo Park MD, PhD, Kyusik Kang MD, PhD, Soo Joo Lee MD, PhD, Jae Guk Kim MD, MSc, Jae-Kwan Cha MD, PhD, Dae-Hyun Kim MD, PhD, Moon-Ku Han MD, PhD, Jihoon Kang MD, PhD, Beom Joon Kim MD, PhD, Tai Hwan Park MD, PhD, Moo-Seok Park MD, Kyung Bok Lee MD, PhD, Jun Lee MD, PhD, Keun-Sik Hong MD, PhD, Yong-Jin Cho MD, PhD, Byung-Chul Lee MD, PhD, Kyung-Ho Yu MD, PhD, Mi Sun Oh MD, PhD, Joon-Tae Kim MD, PhD, Kang-Ho Choi MD, PhD, Dong-Eog Kim MD, PhD, Wi-Sun Ryu MD, PhD, Jay Chol Choi MD, PhD, Jee-Hyun Kwon MD, PhD, Wook-Joo Kim MD, PhD, Dong-Ick Shin MD, PhD, Sung Il Sohn MD, PhD, Jeong-Ho Hong MD, PhD, Juneyoung Lee PhD, Kyunghoon Lee MD, Junghan Song MD, PhD, Joon Seol Bae PhD, Hyun Sub Cheong PhD, Stéphanie Debette MD, PhD, Hee-Joon Bae MD, PhD
doi : 10.1002/ana.26575
Heritability of stroke is assumed not to be low, especially in the young stroke population. However, most genetic studies have been performed in highly selected patients with typical clinical or neuroimaging characteristics. We investigated the prevalence of 15 Mendelian stroke genes and explored the relationships between variants and the clinical and neuroimaging characteristics in a large, unselected, young stroke population.
Genotype-Guided Dual Antiplatelet Use for Transient Ischemic Attack and Minor Stroke by Imaging Status: Subgroup Analysis of the CHANCE-2 Trial
Jing Jing MD, PhD, Xuewei Xie MD, PhD, S. Claiborne Johnston MD, PhD, Philip M. Bath DSc, FMedSci, Zixiao Li MD, PhD, Xingquan Zhao MD, PhD, Liping Liu MD, PhD, Yilong Wang MD, PhD, Qin Xu PhD, Anxin Wang PhD, Yong Jiang MD, PhD, Hao Li MD, PhD, Xia Meng MD, Yongjun Wang MD, for the CHANCE-2 Investigators
doi : 10.1002/ana.26589
This study was performed to investigate whether ticagrelor/aspirin versus clopidogrel/aspirin can further reduce the residual risk of stroke recurrence in patients with positive diffusion-weighted imaging (DWI) in the High-Risk Patients with Acute Nondisabling Cerebrovascular Events II (CHANCE-2) trial.
Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient-Level Analysis of EXTEND-IA Trials and SELECT Prospective Cohort
Amrou Sarraj MD, Deep K. Pujara MBBS, MPH, MS, Leonid Churilov PhD, Clark W. Sitton MD, Felix Ng MD, Ameer E. Hassan DO, Michael G. Abraham MD, Spiros L. Blackburn MD, Gagan Sharma MS, Nawaf Yassi PhD, Timothy Kleinig PhD, Darshan Shah MBBS, Teddy Y. Wu PhD, Wondwossen G. Tekle MD, Ronald F. Budzik MD, William J. Hicks II MD, Nirav Vora MD, Randall C. Edgell MD, Diogo Haussen MD, Santiago Ortega-Gutierrez MD, Gabor Toth MD, Laith Maali MD, Mohammad Ammar Abdulrazzak MD, Faisal Al-Shaibi MD, Tareq AlMaghrabi MD, Vignan Yogendrakumar MD, Faris Shaker MBChB, Osman Mir MD, Ashish Arora MD, Kelsey Duncan MD, Sophia Sundararajan MD, PhD, Amanda Opaskar MD, Yin Hu MD, Abhishek Ray MD, Jeffrey Sunshine MD, Nicholas Bambakidis MD, Sheryl Martin-Schild MD, M. Shazam Hussain MD, Raul Nogueira MD, Anthony Furlan MD, Cathy A. Sila MD, MS, James C. Grotta MD, Mark Parsons BMed, PhD, Peter J. Mitchell MMed, Geoffrey A. Donnan MD, Stephen M. Davis MD, Gregory W. Albers MD, Bruce C. V. Campbell MBBS, PhD, on behalf of the SELECT, EXTEND-IA, EXTEND-IA TNK, and EXTEND-IA TNK Part II Investigators
doi : 10.1002/ana.26587
Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both infarct growth and edema are plausible mediators of clinical benefit with reperfusion. We aimed to quantify these mediators and their interrelationship.
Health Conditions Associated with Alzheimer's Disease and Vascular Dementia
Lori L. Beason-Held PhD, Cailey I. Kerley PhD, Shikha Chaganti PhD, Abhay Moghekar MBBS, Madhav Thambisetty MD, PhD, Luigi Ferrucci MD, PhD, Susan M. Resnick PhD, Bennett A. Landman PhD
doi : 10.1002/ana.26584
We examined medical records to determine health conditions associated with dementia at varied intervals prior to dementia diagnosis in participants from the Baltimore Longitudinal Study of Aging (BLSA).
Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease
Anna Rubinski PhD, Simon Frerich MSc, Rainer Malik PhD, Nicolai Franzmeier PhD, Alfredo Ramirez PhD, Martin Dichgans PhD, Michael Ewers PhD, Alzheimer's Disease Neuroimaging Initiative (ADNI)
doi : 10.1002/ana.26588
Polygenic variation accounts for a substantial portion of the risk of Alzheimer's disease (AD), but its effect on the rate of fibrillar-tau accumulation as a key driver of dementia symptoms is unclear.
APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology
Axel D. Meneses BS, Shunsuke Koga MD, PhD, Zonghua Li PhD, Justin O'Leary BS, Fuyao Li BS, Kai Chen MS, Aya Murakami MD, PhD, Wenhui Qiao PhD, Aishe Kurti BS, Michael G. Heckman MS, Launia White BS, Manling Xie PhD, Yixing Chen BS, Nicole A. Finch MS, Melina J. Lim BS, Marion Delenclos PhD, Michael A. DeTure PhD, Cynthia Linares BS, Nicholas B. Martin BS, Tadafumi C. Ikezu MS, Marka M. van Blitterswijk MD, PhD, Long-Jun Wu PhD, Pamela J. McLean PhD, Rosa Rademakers PhD, Owen A. Ross PhD, Dennis W. Dickson MD, Guojun Bu PhD, Na Zhao MD, PhD
doi : 10.1002/ana.26580
Recent evidence supports a link between increased TDP-43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct effect of APOE on TDP-43 pathology due to the presence of mixed AD pathologies. The goal of this study is to address how APOE isoforms impact TDP-43 pathology and related neurodegeneration in the absence of typical AD pathologies.
Social Health and Cognitive Change in Old Age: Role of Brain Reserve
Anna Marseglia PhD, Grégoria Kalpouzos PhD, Erika J. Laukka PhD, Jane Maddock PhD, Praveetha Patalay PhD, Hui-Xin Wang, Lars Bäckman, Eric Westman, Anna-Karin Welmer PhD, Serhiy Dekhtyar PhD, on behalf of the SHARED Consortium
doi : 10.1002/ana.26591
Individual aspects of social health (SH; eg, network, engagement, support) have been linked to cognitive health. However, their combined effect and the role of the structural properties of the brain (brain reserve [BR]) remain unclear. We investigated the interplay of SH and BR on cognitive change in older adults.
Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation
Aletta M. R. van den Bosch MSc, Sophie Hümmert MSc, Anna Steyer PhD, Torben Ruhwedel, Jörg Hamann PhD, Joost Smolders MD, PhD, Klaus-Armin Nave PhD, Christine Stadelmann MD, PhD, Maarten H. P. Kole PhD, Wiebke Möbius PhD, Inge Huitinga PhD
doi : 10.1002/ana.26585
Changes in the normal-appearing white matter (NAWM) in multiple sclerosis (MS) may contribute to disease progression. Here, we systematically quantified ultrastructural and subcellular characteristics of the axon–myelin unit in MS NAWM and determined how this correlates with low-grade inflammation.
