دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Modern Neurology Training Is Failing Outpatients
Louise M. Klebanoff, MD1; Joseph E. Safdieh, MD1
doi : 10.1001/jamaneurol.2022.5490
April 2023, Vol 80, No. 4, Pages 331-422
It’s Time to Rebrand “Mommy Brain�
Clare McCormack, PhD1; Bridget L. Callaghan, PhD2; Jodi L. Pawluski, PhD, HDR3
Stepping Closer to Precision Rehabilitation
David J. Lin, MD1,2; Joel Stein, MD3,4
Optimal Intensity and Duration of Walking Rehabilitation in Patients With Chronic StrokeA Randomized Clinical Trial
Pierce Boyne, PT, DPT, PhD, NCS1; Sandra A. Billinger, PT, PhD2,3,4,5; Darcy S. Reisman, PT, PhD6; Oluwole O. Awosika, MD, MS7; Sofia Buckley1; Jamiah Burson, BS1; Daniel Carl, PhD1; Matthew DeLange, PT, DPT1; Sarah Doren, PT, DPT1; Melinda Earnest, PT, DPT, ATC1; Myron Gerson, MD8,9; Madison Henry, PT, DPT10; Alli Horning, BS1; Jane C. Khoury, PhD11,12; Brett M. Kissela, MD, MS7; Abigail Laughlin, BS1; Kiersten McCartney, PT, DPT6; Thomas McQuaid, BS1; Allison Miller, PT, DPT, PhD, NCS6; Alexandra Moores, MS2; Jacqueline A. Palmer, PT, DPT, PhD2; Heidi Sucharew, PhD11,12; Elizabeth D. Thompson, PT, PhD, NCS6; Erin Wagner, MS1; Jaimie Ward, MS2; Emily Patton Wasik, PT, DPT1; Alicen A. Whitaker, PT, DPT10; Henry Wright, PT, DPT6; Kari Dunning, PT, PhD1
doi : 10.1001/jamaneurol.2023.0033
Importance For walking rehabilitation after stroke, training intensity and duration are critical dosing parameters that lack optimization.
State-Level Indicators of Childhood Educational Quality and Incident Dementia in Older Black and White Adults
Yenee Soh, ScD1; Rachel A. Whitmer, PhD2,3; Elizabeth Rose Mayeda, PhD, MPH4; M. Maria Glymour, ScD5; Rachel L. Peterson, PhD, MPH6; Chloe W. Eng, MSPH5,7; Charles P. Quesenberry, PhD1; Jennifer J. Manly, PhD8; Paola Gilsanz, ScD1,5
doi : 10.1001/jamaneurol.2022.5337
Importance Higher educational attainment is associated with reduced dementia risk, but the role of educational quality is understudied, presenting a major evidence gap, especially as it may contribute to racial inequities.
Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers
Niklas Mattsson-Carlgren, MD, PhD1,2,3; Gemma Salvadó, PhD1; Nicholas J. Ashton, PhD4,5,6,7; Pontus Tideman, MSc1,8; Erik Stomrud, MD, PhD1,8; Henrik Zetterberg, MD, PhD4,9,10,11,12; Rik Ossenkoppele, PhD1,13,14; Tobey J. Betthauser, PhD15,16; Karly Alex Cody, BS15,16; Erin M. Jonaitis, MS, PhD15,16; Rebecca Langhough, PhD15,16; Sebastian Palmqvist, MD, PhD1,8; Kaj Blennow, MD, PhD4,9; Shorena Janelidze, PhD1; Sterling C. Johnson, PhD15,16; Oskar Hansson, MD, PhD1,8
doi : 10.1001/jamaneurol.2022.5272
Importance Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid (Aβ) accumulation without symptoms. The duration of this phase differs greatly among individuals. While this disease phase has high relevance for clinical trial designs, it is currently unclear how to best predict the onset of clinical progression.
Trends in Postmortem Neurodegenerative and Cerebrovascular Neuropathologies Over 25 Years
Francine Grodstein, ScD1,2; Sue E. Leurgans, PhD1,3; Ana W. Capuano, PhD1,3; Julie A. Schneider, MD1,3,4; David A. Bennett, MD1,3
doi : 10.1001/jamaneurol.2022.5416
Importance With rapid aging of the US population, understanding trends over time in dementia occurrence is essential to public health planning and intervention; this understanding includes trends in neuropathologies underlying clinical dementia.
Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia
Adit Friedberg, MD1,3; Lorenzo Pasquini, PhD1,2; Ryan Diggs, BA1; Erika A. Glaubitz, BA1; Lucia Lopez, BS1; Ignacio Illán-Gala, MD, PhD3,4,5; Leonardo Iaccarino, PhD1,6; Renaud La Joie, PhD1; Nidhi Mundada, BS1; Marguerite Knudtson, MS1; Kyra Neylan, BS1; Jesse Brown, PhD1; Isabel Elaine Allen, PhD1,3; Katherine P. Rankin, PhD1,3; Luke W. Bonham, MD1,7; Jennifer S. Yokoyama, PhD1,7; Eliana M. Ramos, PhD8; Daniel H. Geschwind, MD, PhD9,10,11; Salvatore Spina, MD, PhD1; Lea T. Grinberg, MD, PhD1,12; Zachary A. Miller, MD1; Joel H. Kramer, PsyD1; Howard Rosen, MD1; Maria Luisa Gorno-Tempini, MD, PhD1; Gil Rabinovici, MD1,13; William W. Seeley, MD1,12; Bruce L. Miller, MD1,3
doi : 10.1001/jamaneurol.2023.0001
Importance The neurological substrates of visual artistic creativity (VAC) are unknown. VAC is demonstrated here to occur early in frontotemporal dementia (FTD), and multimodal neuroimaging is used to generate a novel mechanistic hypothesis involving dorsomedial occipital cortex enhancement. These findings may illuminate a novel mechanism underlying human visual creativity.
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest
Nicholas J. Ashton, PhD1,2,3,4; Marion Moseby-Knappe, PhD5; Andrea L. Benedet, PhD1; Lana Grötschel, MSc1; Juan Lantero-Rodriguez, PhD1; Thomas K. Karikari, PhD1,6; Christian Hassager, PhD7; Matt P. Wise, PhD8; Pascal Stammet, PhD9,10; Jesper Kjaergaard, PhD7; Hans Friberg, PhD11; Niklas Nielsen, PhD11; Tobias Cronberg, PhD5; Henrik Zetterberg, PhD1,12,13,14,15; Kaj Blennow, PhD1,12
doi : 10.1001/jamaneurol.2023.0050
Importance Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known.
Association of Serum Neurofilament Light Chain Levels at Disease Onset With Disability Worsening in Patients With a First Demyelinating Multiple Sclerosis Event Not Treated With High-Efficacy Drugs
Enric Monreal, MD1; José Ignacio Fernández-Velasco, MSc2; MarÃa Isabel GarcÃa-Sánchez, MSc3; Susana Sainz de la Maza, MD1; Sara Llufriu, MD, PhD4; Roberto Ã�lvarez-Lafuente, MSc, PhD5; Bonaventura Casanova, MD, PhD6; Manuel Comabella, MD, PhD7; LluÃs Ramió-Torrentà , MD, PhD8,9,10; José Enrique MartÃnez-RodrÃguez, MD, PhD11; Luis Brieva, MD, PhD12; Albert Saiz, MD, PhD4; Sara Eichau, MD, PhD13; José MarÃa Cabrera-Maqueda, MD4; Noelia Villarrubia, PhD2; Mercedes Espiño, PhD2; Francisco Pérez-Miralles, MD, PhD6; Xavier Montalbán, MD, PhD7; Mar Tintoré, MD, PhD7; Ana Quiroga-Varela, MSc, PhD8,9,10; MarÃa Inmaculada DomÃnguez-Mozo, MSc, PhD5; Fernando RodrÃguez-Jorge, MD1; Juan LuÃs Chico-GarcÃa, MD1; Daniel Lourido, MD14; José Carlos Ã�lvarez-Cermeño, MD, PhD1; Jaime Masjuan, MD, PhD1; Lucienne Costa-Frossard, MD1; Luisa MarÃa Villar, PhD2
doi : 10.1001/jamaneurol.2023.0010
Importance The value of serum neurofilament light chain (sNfL) levels for predicting long-term disability in patients with multiple sclerosis (MS) remains controversial.
Targeting B Cells and Microglia in Multiple Sclerosis With Bruton Tyrosine Kinase Inhibitors
Sarah Dybowski, MSc1; Sebastian Torke, PhD1,2,3; Martin S. Weber, MD1,4,5
doi : 10.1001/jamaneurol.2022.5332
Importance Currently, disease-modifying therapies for multiple sclerosis (MS) use 4 mechanisms of action: immune modulation, suppressing immune cell proliferation, inhibiting immune cell migration, or cellular depletion.
Magnetic Resonance Imaging Features of GABA-A Receptor Antibody-Mediated Encephalitis
Omar Baqal, MBBS1; Aimen Vanood, MD2; Ehab Harahsheh, MBBS2
Bibrachial Amyotrophy Due to Spontaneous Spinal Cerebrospinal Fluid Leak
Wouter I. Schievink, MD1; Marcel M. Maya, MD2
Changes in the Rate of Leucine-Rich Glioma-Inactivated 1 Seropositivity During the COVID-19 Lockdown
Adam E. Handel, DPhil1,2; Jacqueline Palace, MD1; Elizabeth Bateman, PhD3; Patrick Waters, DPhil1,2; Sarosh R. Irani, DPhil1,2
Benefits and Risks of Periconceptional Folic Acid Supplementation
P. Emanuela Voinescu, MD, PhD1; Page B. Pennell, MD2; Kimford Meador, MD3
Benefits and Risks of Periconceptional Folic Acid Supplementation—Reply
Håkon Magne Vegrim, MD1; Torbjörn Tomson, MD, PhD2; Marte-Helene Bjørk, MD, PhD1,3,4
Updates to Table 1, the Institutional Review Board Statement, the Additional Information Section, and References
