Acta Paediatrica, International Journal of Paediatrics




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Issue highlights

Anna Käll, Hugo Lagercrantz

doi : 10.1111/apa.16718

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Symptoms often continue for two but rarely for four weeks after onset of respiratory infection

Matti Korppi

doi : 10.1111/apa.16648

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The role of paediatrics in the abortion debate

Shannon Y. Adams, Natalia Henner, Katie Watson

doi : 10.1111/apa.16600

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It is OK to tell patients with long COVID that we don't know much about the condition yet

Danilo Buonsenso

doi : 10.1111/apa.16658

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Cooling strategies during neonatal transport for hypoxic-ischaemic encephalopathy

Greta Sibrecht, Franciszek Borys, Chiara Campone, Carlo Bellini, Peter Davis, Matteo Bruschettini

doi : 10.1111/apa.16632

We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia.

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The neurobiology of hatred: Tools of Dialogue© intervention for youth reared amidst intractable conflict impacts brain, behaviour, and peacebuilding attitudes

Ruth Feldman

doi : 10.1111/apa.16676

Myths, drama, and sacred texts have warned against the fragile nature of human love; the closer the affiliative bond, the quicker it can turn into hatred, suggesting similarities in the neurobiological underpinnings of love and hatred.

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Cerebral palsy and bisphosphonates – and what can be learned from other types of secondary osteoporosis in children: A scoping review

Jakob B. Granild-Jensen, Line K. Pedersen, Bente Langdahl, Jakob Starup-Linde, Gija Rackauskaite, Stense Farholt, Charlotte Søndergaard, Esben T. Vestergaard, Bjarne Møller-Madsen

doi : 10.1111/apa.16671

We aimed to improve bone health management of children with cerebral palsy (CP) by reviewing studies investigating bisphosphonate therapy in children with CP and other types of secondary osteoporosis.

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Valuing maternal, newborn, child and adolescent health for societal progress – Going beyond the economic orthodoxy of gross domestic product

Kiran Meka, Chandni M. Jacob, Neena Modi, Flavia Bustreo, Gian Carlo Di Renzo, Ariadne Malamitsi-Puchner, Despina Briana, Domenico G. Iaia, Helga Fogstad, Jagannadha P. Tamvada, Ivan Ochoa Moreno, Mark Hanson

doi : 10.1111/apa.16677

In view of the long-standing recognition that gross domestic product (GDP) does not capture the unremunerated work largely conducted by women upon which societal well-being depends, to discuss the implications for GDP of maternal, newborn, child and adolescent health (MNCAH), and its influences on health, well-being and prosperity across the life course and across generations.

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Hypocarbia is associated with adverse outcomes in hypoxic ischaemic encephalopathy (HIE)

Usha Devi, Abdul Kareem Pullattayil, Manigandan Chandrasekaran

doi : 10.1111/apa.16679

Hypocarbia in the early postnatal period might exacerbate brain injury in babies with hypoxic ischaemic encephalopathy following birth asphyxia. This mini-review summarised studies on pCO2 values that were monitored periodically in term newborns with moderate/severe hypoxic–ischaemic encephalopathy and correlated with short or long-term outcomes.

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Adalbert Czerny (1863–1941) and his contribution to the fight against infant mortality

Stefan Kutzsche

doi : 10.1111/apa.16627

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Norwegian paediatric residents surveyed on whether they would want life support for their own extremely preterm infant

Janicke Syltern, Trond Markestad

doi : 10.1111/apa.16631

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Improved respiratory parameters with skin-to-skin contact in premature infants with bronchopulmonary dysplasia on NIV-NAVA

Ana Serrano-Llop, Laura De-Rooy, Donovan Duffy, Anay Kulkarni, Sandeep Shetty

doi : 10.1111/apa.16638

To determine if skin-to-skin contact (SSC) improved respiratory parameters in premature infants with evolving or established bronchopulmonary dysplasia (BPD) on non-invasive neutrally adjusted ventilator assist (NIV-NAVA).

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Quantitative end-tidal carbon dioxide at initiation of resuscitation may help guide the ventilation of infants born at less than 30 weeks gestation

Dharmesh Shah, Mark Tracy, Murray Hinder, Nadia Badawi

doi : 10.1111/apa.16639

Estimation of end-tidal carbon dioxide (EtCO2) with capnography can guide mask ventilation in infants born at less than 30 weeks of gestation. Chemical-sensitive colorimetric devices to detect CO2 are widely used at resuscitation. We aimed to quantify EtCO2 in the first breaths following initiation of mask ventilation at birth and correlated need for endotracheal intubation.

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Language environment and parent-infant close contact in neonatal care and emerging lexical abilities of very preterm children–a longitudinal study

Eva Ståhlberg-Forsén, Reija Latva, Anette Aija, Liisa Lehtonen, Suvi Stolt

doi : 10.1111/apa.16647

This longitudinal study investigated associations between language environment and parent-infant close contact in the neonatal intensive care unit (NICU) and preterm children's lexical abilities.

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Low Apgar score and need for resuscitation increased the probability of receiving therapeutic hypothermia more strongly than acidosis at birth

Ida Lagerström, Dalia Daugeliene, Jenny Bolk, Sven Cnattingius, Beatrice Skiöld, Maria Altman, Stefan Johansson

doi : 10.1111/apa.16643

The aim of this study was to investigate how individual markers for birth asphyxia, so-called A criteria, were associated with the probability of receiving therapeutic hypothermia.

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Perinatal risk factors for developmental coordination disorder in children born extremely preterm

Jenny Bolk, Karin Källén, Aijaz Farooqi, Maria Hafström, Vineta Fellman, Ulrika Ã…den, Fredrik Serenius

doi : 10.1111/apa.16651

Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD.

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Vital sign-based detection of sepsis in neonates using machine learning

Antoine Honoré, David Forsberg, Katja Adolphson, Saikat Chatterjee, Kerstin Jost, Eric Herlenius

doi : 10.1111/apa.16660

Sepsis is a leading cause of morbidity and mortality in neonates. Early diagnosis is key but difficult due to non-specific signs. We investigate the predictive value of machine learning-assisted analysis of non-invasive, high frequency monitoring data and demographic factors to detect neonatal sepsis.

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Newborns requiring resuscitation: Two thirds have heart rate ≥100 beats/minute in the first minute after birth

Amalie Kibsgaard, Hege Ersdal, Jan Terje Kvaløy, Joar Eilevstjønn, Siren Rettedal

doi : 10.1111/apa.16659

The aim was to study the prevalence of bradycardia at birth in newborns requiring positive pressure ventilation (PPV), distribution of first measured heart rate (HR), changes in HR before start of PPV and HR response to PPV.

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Less invasive surfactant administration by umbilical catheter is safe and effective for treating respiratory distress syndrome in preterm infants

Thao Thuy Truong, Hoang Thi Tran, Alyson Skinner, Hassib Narchi

doi : 10.1111/apa.16650

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Psychometric testing of a Danish version of the empowerment of parents in the intensive care – Neonatology questionnaire has confirmed validity

Janne Weis, Sanne Allermann Beck, Andreas Jensen, Anne Brødsgaard, Jos M. Latour, Gorm Greisen

doi : 10.1111/apa.16661

Investigating parent satisfaction with care is important to guide quality development. In this study, we translated and validated a Danish version of the empowerment of parents in the intensive care – neonatology (EMPATHIC-N) questionnaire to determine validity in Danish contexts.

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Respiratory outcomes after delivery room stabilisation with a new respiratory support system using nasal prongs

Sonja Baldursdottir, Snorri Donaldsson, Elena Palleri, Thomas Drevhammar, Baldvin Jonsson

doi : 10.1111/apa.16665

To study if stabilisation using a new respiratory support system with nasal prongs compared to T-piece with a face mask is associated with less need for mechanical ventilation and bronchopulmonary dysplasia.

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Prediction scores based on neonatal inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates

Hidetaka Yoshimatsu, Masanori Iwai, Yasuji Kitabatake, Keiichi Ozono, Kimitoshi Nakamura

doi : 10.1111/apa.16701

The aim of the study was to examine the predictive value of inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates.

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Prolonged requirements for mechanical ventilation and tube feeding support predicted 18-month outcomes for neonatal encephalopathy

Kennosuke Tsuda, Jun Shibasaki, Akihito Takeuchi, Takeo Mukai, Yuichiro Sugiyama, Tetsuya Isayama, Tomoaki Ioroi, Akihito Takahashi, Nanae Yutaka, Osuke Iwata, the Baby Cooling Registry of Japan

doi : 10.1111/apa.16687

We evaluated the predictive ability of prolonged requirements for mechanical ventilation or tube feeding support for 18-month composite outcomes in infants with hypoxic-ischaemic encephalopathy treated with hypothermia.

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Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm

Cecilia Montgomery, Sirkku Setänen, Ylva Fredriksson Kaul, Aijaz Farooqi, Lina Broström, Ulrika Aden, Karin Källén, Fredrik Serenius

doi : 10.1111/apa.16694

To investigate the predictive ability of the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) Motor Index, in children born extremely preterm (<27 gestational weeks) without cerebral palsy.

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Visual function correlates with neurodevelopment in a population cohort of school-aged children born extremely preterm

Sigrid Hegna Ingvaldsen, Tor Ivar Hansen, Asta K. HÃ¥berg, Viggo Moholdt, Kari Anne I. Evensen, Olaf Dammann, Dordi Austeng, Tora Sund Morken

doi : 10.1111/apa.16667

To investigate visual function and neurodevelopment in a geographically defined population cohort of school-aged children born extremely preterm.

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How does stress affect maternal and paternal perceptions of relationship strain after a preterm birth? Results of a retrospective survey study

Alinda Reimer, Laura Mause, Jan Hoffmann, Anna Hagemeier, Till Dresbach, Nadine Scholten, Neo-CamCare

doi : 10.1111/apa.16664

Strain on couple relationships is associated with a lower well-being. As premature birth is known to pose stress to parents, this study explores whether interparental relationship strain comes to pass within mothers and fathers during their infant's stay in a neonatal intensive care unit.

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Breastfeeding rates fell in an Italian baby friendly hospital during the 2020 COVID-19 pandemic year and difficulties increased

Mauro Cinquetti, Carolina Marchiotto, Michele Fingerle, Marco Salani, Anna Adami, Daniela Dainese, Silvia Magaraggia, Erika Rigotti, Giorgio Piacentini

doi : 10.1111/apa.16674

Our aim was to evaluate the impact of the COVID-19 pandemic on breastfeeding at discharge in a Baby Friendly hospital in 2020.

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Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

doi : 10.1111/apa.16662

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Attention-deficit hyperactivity disorder is associated with relatively short stature among adolescents

Chen Namimi-Halevi, Chen Dor, Rita Dichtiar, Michal Bromberg, Tali Sinai

doi : 10.1111/apa.16668

To estimate the association between attention-deficit hyperactivity disorder (ADHD) and relatively short stature (RSS) among adolescents.

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Adolescent co-researchers identified the central role of social media for young people during the pandemic

Frida LygnegÃ¥rd, Maria Thell, Anna Sarkadi

doi : 10.1111/apa.16670

To test the method of engaging co-researcher adolescents in data collection and explore stated motives for their selection of social media material related to COVID-19.

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The safety of COVID-19 vaccination in immunocompromised children and young adults with immune-mediated inflammatory disease

Benjamin Sahn, Ying Lu, Joyce S. Hui-Yuen, Joanna Fishbein, Beth S. Gottlieb, Barbara A. Eberhard, Heather M. Walters

doi : 10.1111/apa.16652

To assess safety of COVID-19 vaccination in paediatric patients with immune-mediated inflammatory disease (IMID).

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High levels of antibodies 6 months after COVID-19 vaccination in children with severe chronic diseases: A prospective longitudinal case series

Ulrikka Nygaard, Nikolai Søren Kirkby, Kia Hee Schultz Dungu, Kim G. Nielsen, Tania Masmas, Klaus Juul, Peter Born, Søren Buus, Lone Graff Stensballe

doi : 10.1111/apa.16680

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IgG antispike persistence and immunophenotype in children infected by SARS-CoV-2

Alberto García-Salido, Patricia Flores-Pérez, �frica González-Murillo, Elena Sánchez-Marcos, Inés Leoz-Gordillo, Julia Cano-Fernández, Ana Castillo-Robleda, Montserrat Nieto-Moro, Raquel Jiménez-García

doi : 10.1111/apa.16705

The immune status of children recovering from SARS-CoV-2 infection is not completely understood. We describe IgG antispike persistence in children infected during the first two pandemic waves. In addition, we compared with healthy controls their leukocyte populations and CD64 expression.

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Duration of clinical symptoms in children with acute respiratory infection

Niko Paalanne, Minna Honkila, Suvi Mattila, Tytti Pokka, Marjo Renko, Terhi Tapiainen

doi : 10.1111/apa.16607

To investigate duration of clinical symptoms associated with various respiratory viruses and with the co-detection of respiratory viral and bacterial pathogens.

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Blood eosinophils during bronchiolitis: Associations with atopy, asthma and lung function in young adults

Karen Galta Sørensen, Knut Øymar, Ingvild Dalen, Thomas Halvorsen, Ingvild Bruun Mikalsen

doi : 10.1111/apa.16666

To study if blood eosinophils during bronchiolitis were associated with atopy, asthma and lung function in young adults and if these associations differed between respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis.

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Nasopharyngeal detection of atypical bacteria by multiplex polymerase chain reaction panel in acutely ill children was associated with an increased risk of pneumonia

Suvi Mattila, Suvi Sarlin, Reetta Heikkilä, Emilia Leinonen, Violetta Nurmi, Jonni Riikonen, Niko Paalanne, Minna Honkila, Heikki Huhtamäki, Tytti Pokka, Ulla Koskela, Marjo Renko, Terhi Tapiainen

doi : 10.1111/apa.16672

We aimed to assess whether detection of respiratory bacteria by multiplex polymerase chain reaction (PCR) testing associates with clinical outcomes in acutely ill children.

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A simple clinical decision rule may help to rule out severe bacterial infection and spare antibiotics in febrile young children

Cécile Feildel-Fournial, Lou Danjou, Gaëlle Hubert-Dibon, Bénédicte Vrignaud, Damien Masson, Elise Launay, Christèle Gras-Le Guen

doi : 10.1111/apa.16698

To assess the performance of a new clinical decision rule (CDR) to identify patients at a low risk of invasive bacterial infection (IBI) among febrile children and its theoretical impact on antibiotic use.

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Metabolic assessment in children with neuromuscular disorders shows risk of liver enlargement, steatosis and fibrosis

Marie Mostue Naume, Marianne Hørby Jørgensen, Christina Engel Høi-Hansen, Alfred Peter Born, John Vissing, Lise Borgwardt, Dorte Marianne Rohde Stærk, Mette Cathrine Ørngreen

doi : 10.1111/apa.16649

The aim of this study was to conduct a metabolic and nutritional assessment of children with neuromuscular disorders, including the investigation of the liver and bone mineral density.

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Pulmonary function tests for evaluating the severity of Duchenne muscular dystrophy disease

Hagit Levine, Itai Goldfarb, Julia Katz, Moriah Carmeli, Tzippy Shochat, Huda Mussaffi, Sharon Aharoni, Dario Prais, Yoram Nevo

doi : 10.1111/apa.16653

In Duchenne muscular dystrophy (DMD), lung disease contributes significantly to morbidity and mortality. This study aimed to assess the usefulness of various pulmonary function tests in evaluating DMD severity.

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Interviews with children and adolescents with epilepsy or asthma about the situation of their healthy siblings

Mathilda Charisius, Sarah Jeschke, Sarah Lange, Thilo Bertsche, Manfred Ballmann, Martina P. Neininger, Astrid Bertsche

doi : 10.1111/apa.16675

Chronic conditions can influence the situation of healthy siblings of affected children. We investigated the opinion of the affected child about the situation of their healthy sibling and the sibling relationship.

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Characteristics of intussusception among children in Hokkaido, Japan, during the pre- and post-rotavirus vaccine eras (2007–2016)

Yuya Fukuda, Yusuke Akane, Saho Honjo, Yukihiko Kawasaki, Hiroyuki Tsutsumi, Takeshi Tsugawa

doi : 10.1111/apa.16656

To analyse the epidemiology of intussusception in Hokkaido Prefecture, Japan during a 10-year period spanning the introduction of the rotavirus (RV) vaccine (2007–2016).

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Suboptimal care was frequent in severe child physical abuse cases and was mainly related to delayed diagnoses and ineffective secondary prevention

Flora Blangis, David Malorey, Christèle Gras-Le Guen, Nathalie Vabres, Georges Picherot, Patricia Ricaud, Martin Chalumeau, Elise Launay

doi : 10.1111/apa.16708

Our aim was to assess suboptimal care before a diagnosis of severe child physical abuse in western France.

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EBNEO Commentary: Early switching from intravenous to oral antibiotics in neonates with probable bacterial infection

Nehad Nasef, Islam Nour, Hesham Abdel-Hady

doi : 10.1111/apa.16642

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EBNEO Commentary: Early switching from intravenous to oral antibiotics in neonates with probable bacterial infection

Lorraine Marie Chung, Gopakumar Hariharan

doi : 10.1111/apa.16683

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