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Abortion Restriction and Mental Health
Katherine L. Wisner, MD, MS1; Paul S. Appelbaum, MD2
doi : 10.1001/jamapsychiatry.2022.4962
April 2023, Vol 80, No. 4, Pages 283-402
Association of Frailty With Risk of Suicide Attempt in a National Cohort of US Veterans Aged 65 Years or Older
Randall L. Kuffel, BS; Ruth T. Morin, PhD; Kenneth E. Covinsky, MD, MPH; et al.
Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction
Kristin Köhler-Forsberg, PhD1,2,3; Vibeke H. Dam, PhD1,2; Brice Ozenne, PhD1,4; Anjali Sankar, PhD1; Vincent Beliveau, PhD1,5; Elizabeth B. Landman, MD1; Søren V. Larsen, MD1,2; Asbjørn S. Poulsen, MD1; Cheng-Teng Ip, PhD1,2,6; Anders Jørgensen, PhD2,3; Michal Meyer, BSc7; Dea S. Stenbæk, PhD1,8; Hans R. L. Eiberg, MSc9; Jacob Madsen, PhD10; Claus Svarer, PhD1; Martin B. Jørgensen, MD, DMSc1,2,3; Vibe G. Frokjaer, MD, PhD1,2,3; Gitte M. Knudsen, DMSc1,2
doi : 10.1001/jamapsychiatry.2022.4539
Importance The cerebral serotonin 4 (5-HT4) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT4 receptor has been associated with improved learning and memory in healthy individuals.
Long-term Exposure to Multiple Ambient Air Pollutants and Association With Incident Depression and Anxiety
Teng Yang, BD1; Jiawei Wang, BD1; Jing Huang, PhD1,2; Frank J. Kelly, PhD3; Guoxing Li, PhD1,3
doi : 10.1001/jamapsychiatry.2022.4812
Importance Air pollution is increasingly recognized as an important environmental risk factor for mental health. However, epidemiologic evidence on long-term exposure to low levels of air pollutants with incident depression and anxiety is still very limited.
Obsessive-Compulsive Disorder and Its Cross-Generational Familial Association With Anxiety Disorders in a National Swedish Extended Adoption Study
Kenneth S. Kendler, MD1,2; Linda Abrahamsson, PhD3; Henrik Ohlsson, PhD3; Jan Sundquist, MD, PhD3,4,5; Kristina Sundquist, MD, PhD3,4,5
doi : 10.1001/jamapsychiatry.2022.4777
Importance We know little about the transmission of obsessive-compulsive disorder (OCD) across generations.
Association of Primary Immunodeficiencies in Parents With Psychiatric Disorders and Suicidal Behavior in Their Offspring
Josef Isung, MD, PhD1,2; Kayoko Isomura, MD, PhD1,2; Kyle Williams, MD, PhD3,4; Tianyang Zhang, PhD1,2; Paul Lichtenstein, PhD5; Lorena Fernández de la Cruz, PhD1,2; Anna Sidorchuk, MD, PhD1,2; David Mataix-Cols, PhD1,2
doi : 10.1001/jamapsychiatry.2022.4786
Importance Maternal immune activation (MIA) leading to altered neurodevelopment in utero is a hypothesized risk factor for psychiatric outcomes in offspring. Primary antibody immunodeficiencies (PIDs) constitute a unique natural experiment to test the MIA hypothesis of mental disorders.
Hospitalization Associated With Comorbid Psychiatric and Substance Use Disorders Among Adults With COVID-19 Treated in US Emergency Departments From April 2020 to August 2021
Lyna Z. Schieber, MD, DPhil1; Christopher Dunphy, PhD2; Richard A. Schieber, MD, MPH3; Barbara Lopes-Cardozo, MD, MPH4; Ramal Moonesinghe, PhD5; Gery P. Guy Jr, PhD, MPH1
doi : 10.1001/jamapsychiatry.2022.5047
Importance During the COVID-19 pandemic, US emergency department (ED) visits for psychiatric disorders (PDs) and drug overdoses increased. Psychiatric disorders and substance use disorders (SUDs) independently increased the risk of COVID-19 hospitalization, yet their effect together is unknown.
Association of Cardiovascular Health With Risk of Clinically Relevant Depressive Symptoms
Thomas T. van Sloten, MD1; Eugénie Valentin, MSc2; Rachel E. Climie, PhD2,3; Xavier Jouven, MD2; Cedric Lemogne, MD4,5; Marcel Goldberg, MD6; Marie Zins, MD4; Jean-Philippe Empana, MD2
doi : 10.1001/jamapsychiatry.2022.5056
Importance Cardiovascular health may be used for prevention of depressive symptoms. However, data on the association of cardiovascular health across midlife with depressive symptoms are lacking.
Association of Familial Aggregation of Major Depression With Risk of Major Depression
Frederikke Hørdam Gronemann, PhD, Msc1; Rikke Kart Jacobsen, Msc1; Marie Kim Wium-Andersen, DMSc1; Martin Balslev Jørgensen, DMSc2; Merete Osler, DMSc1,3; Terese Sara Høj Jørgensen, PhD, Msc1,4
doi : 10.1001/jamapsychiatry.2022.4965
Importance Major depression (MD) aggregates within families, but how family history of MD confers risk of MD over the life course is unclear. Such knowledge is important to identify and prevent possible depressogenic effects of family environment.
Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric DisordersA Genome-Wide Pleiotropic Analysis
Weiming Gong, MM1,2; Ping Guo, MM1,2; Yuanming Li, BM3; Lu Liu, PhD1,2; Ran Yan, PhD1,2; Shuai Liu, MM1,2; Shukang Wang, MD, PhD1,2; Fuzhong Xue, PhD1,2; Xiang Zhou, PhD4,5; Zhongshang Yuan, PhD1,2
doi : 10.1001/jamapsychiatry.2022.4974
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) hypothesized as a potential biological basis. However, the degree to which the shared genetic determinants are involved in these associations underlying the GBA is unclear.
Clinical Recovery and Long-Term Association of Specialized Early Intervention Services vs Treatment as Usual Among Individuals With First-Episode Schizophrenia Spectrum Disorder20-Year Follow-up of the OPUS Trial
Helene Gjervig Hansen, MD1,2; Marie Starzer, MD1,2; Sandra Feodor Nilsson, PhD1; Carsten Hjorthøj, PhD1,3; Nikolai Albert, PhD1,4; Merete Nordentoft, DrMedSc1,2
doi : 10.1001/jamapsychiatry.2022.5164
Importance The OPUS 20-year follow-up is the longest follow-up of a randomized clinical trial testing early intervention services (EIS) among individuals with first-episode schizophrenia spectrum disorder.
State Cannabis Legalization and Cannabis Use Disorder in the US Veterans Health Administration, 2005 to 2019
Deborah S. Hasin, PhD1; Melanie M. Wall, PhD1; C. Jean Choi, MS2; Daniel M. Alschuler, MS2; Carol Malte, MSW3,4; Mark Olfson, MD, MPH1; Katherine M. Keyes, PhD5; Jaimie L. Gradus, DMSc, DSc6; Magdalena Cerdá, DrPH7; Charles C. Maynard, PhD8; Salomeh Keyhani, MD9; Silvia S. Martins, MD, PhD5; David S. Fink, PhD10; Ofir Livne, MD, MPH5; Zachary Mannes, PhD5; Scott Sherman, MD11; Andrew J. Saxon, MD8
doi : 10.1001/jamapsychiatry.2023.0019
Importance Cannabis use disorder (CUD) is increasing among US adults. Few national studies have addressed the role of medical cannabis laws (MCLs) and recreational cannabis laws (RCLs) in these increases, particularly in patient populations with high rates of CUD risk factors.
Dynamic Feedback Between Antidepressant Placebo Expectancies and Mood
Marta Peciña, MD, PhD1; Jiazhou Chen, BS2,3; Jordan F. Karp, MD4; Alexandre Y. Dombrovski, MD1
doi : 10.1001/jamapsychiatry.2023.0010
Importance Despite high antidepressant placebo response rates, the mechanisms underlying the persistence of antidepressant placebo effects are still poorly understood.
Performance of a Prediction Model of Suicide Attempts Across Race and Ethnicity
Santiago Papini, PhD1; Honor Hsin, MD, PhD2; Patricia Kipnis, PhD1; Vincent X. Liu, MD, MS1; Yun Lu, MD, MPH1; Stacy A. Sterling, DrPH, MSW, MPH1; Esti Iturralde, PhD1
Sex Differences in Mental Health Problems and Psychiatric Hospitalization in Autistic Young Adults
Peter Andersson, MSc1; Håkan Jarbin, PhD2; Adrian Emmanuel Desai Boström, PhD3,4
Sex Differences in Mental Health Problems and Psychiatric Hospitalization in Autistic Young Adults—Reply
Miriam I. Martini, MSc1; Agnieszka Butwicka, PhD1,2,3,4; Mark Taylor, PhD1
