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Tocotrienols-enriched Self-nanoemulsifying Drug Delivery System Enhances the Antileukemic Activity of All-trans Retinoic Acid but not Electrocardiogram Alterations Evoked by Its Combination with Arsenic Trioxide
Gabriel Silva Marques Borges, Pierre Sicard, Cristina de Mello Gomides Loures, Fernanda Gontijo Cristina Evangelista, Camila Campos Sales, Adriano de Paula Sabino, Christian Fernandes, Lucas Antônio Miranda Ferreira & Sylvain Richard
doi : 10.1208/s12249-023-02531-w
Volume 24, issue 3, March 2023
All-trans retinoic acid and arsenic trioxide are the leading choices for the treatment of acute promyelocytic leukemia. Notwithstanding the impressive differentiative properties of all-trans retinoic acid and the apoptotic properties of arsenic trioxide, some problems still occur in acute promyelocytic leukemia treatment.
Impact of Solid-State Properties on the Aerosolization Performance of Spray-Dried Curcumin Powders
Qian Zhang, Yongquan Li, Linghui Li, Yushan Cheng, Fangkun Yu, Rui Li & Shuguang Hou
doi : 10.1208/s12249-023-02536-5
Amorphous and crystalline active pharmaceutical ingredients (APIs) are both widely studied for pulmonary delivery.
99mTc-Labeled, Colistin Encapsulated, Theranostic Liposomes for Pseudomonas aeruginosa Infection
Merve Karpuz, Aybala Temel, Emre Ozgenc, Yamac Tekintas, Gulsah Erel-Akbaba, Zeynep Senyigit & Evren Atlihan-Gundogdu
doi : 10.1208/s12249-023-02533-8
Infectious diseases are still the major issue not only due to antibiotic resistance but also causing deaths if not diagnosed at early-stages.
Continuous Manufacturing of Oil in Water (O/W) Emulgel by Extrusion Process
V. Anusha Echanur, Anusha V. Matadh, S. G. Pragathi, S. Sarasija, Yeoh Thean, Abu Zayed Badruddoza, Jaymin Shah, Vijay Kulkarni, Srinivas Ajjarapu, N. M. Reena, H. N. Shivakumar & S. Narasimha Murthy
doi : 10.1208/s12249-023-02530-x
Pharmaceutical industries and drug regulatory agencies are inclining towards continuous manufacturing due to better control over the processing conditions and in view to improve product quality.
Correction to: Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: a Comprehensive Review
Derick Muhindo1 · Rasha Elkanayati 1 · Priyanka Srinivasan1 · Michael A. Repka1,2 · Eman A. Ashour1
Antibacterial-Anti-Inflammatory-Bone Restoration Procedure Achieved by MIN-Loaded PLGA Microsphere for Efficient Treatment of Periodontitis
Jiansong Zhao, Ying Wei, Jian Xiong, Hongbing Liu, Gaoshuai Lv, Jingyi Zhao, Haibing He, Jingxin Gou, Tian Yin, Xing Tang & Yu Zhang
doi : 10.1208/s12249-023-02538-3
The main development process of periodontitis involves periodontal pathogenic bacteria as the initiating factor causing the onset of destructive inflammation, which in turn stimulates the destruction of periodontal tissue.
Good Practices for the Laboratory Performance Testing of Aqueous Oral Inhaled Products (OIPs): an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS)
Jolyon P. Mitchell, I. Carter, J. D. Christopher, M. Copley, W. H. Doub, A. Goodey, C. J. Gruenloh, B. B. Larson, S. Lyapustina, R. B. Patel, S. W. Stein & J. D. Suman
doi : 10.1208/s12249-023-02528-5
Multiple sources must be consulted to determine the most appropriate procedures for the laboratory-based performance evaluation of aqueous oral inhaled products (OIPs) for the primary measures, dose uniformity/delivery, and aerodynamic particle (droplet) size distribution (APSD).
Formulation and Characterization of Buccal Films Containing Valsartan with Additional Support from Image Analysis
Blaž Grilc, Tjaša Felicijan, Timeja Planinšek Parfant & Odon Planinšek
doi : 10.1208/s12249-023-02537-4
The present study was aimed to the development and characterization of valsartan-containing buccal films with an introduction to a novel technique of image analysis. Visual inspection of the film provided a wealth of information that was difficult to quantify objectively.
Enhanced Transdermal Delivery of N-Acetylcysteine and 4-Phenylbutyric Acid for Potential Use as Antidotes to Lewisite
Amruta A. Dandekar, Deepal Vora, Jihee Stephanie Yeh, Ritesh Kumar Srivastava, Mohammad Athar & Ajay K. Banga
doi : 10.1208/s12249-023-02527-6
Lewisite is a highly toxic chemical warfare agent that leads to cutaneous and systemic damage. N-acetylcysteine (NAC) and 4-phenylbutryic acid (4-PBA) are two novel antidotes developed to treat toxicity caused by lewisite and similar arsenicals.
Direct Tableting on a Continuous Manufacturing Line—Impact of Mixing Parameters, Material Densities, and Drug Load on Subsequent Process Parameters and Tablet Quality
Marius J. Kreiser, Christoph Wabel & Karl G. Wagner
doi : 10.1208/s12249-023-02525-8
The continuous manufacturing (CM) of solid oral dosage forms has received increased attention in recent years and has become a leading technology in the pharmaceutical industry.
