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Speckled Pigment of Upper GI Tract Mucosa on Endoscopy: A Case of Pseudomelanosis of the Stomach and Proximal Small Bowel
Kian Abdul-Baki, Obada Hisham Saeed Tayyem, Paul Young, Suimin Qiu & Jose Aguirre
doi : 10.1007/s10620-022-07757-5
Volume 68, issue 4, April 2023
Ischemic Jejunal Stricture Secondary to Polycythemia Vera
Ashley McFarquhar, Firas Bahdi, Ya Xu & Lee B. Lu
Does Sharpening the Focus Broaden the Depth of the Field? Defining the Scope of the GI Hospitalist Model
Ryan F. Flanagan & Daniel J. Stein
SALL4 Expression in Epithelial Gastric Cancer: Epigenetic or Epiphenomenon?
Trinath JammaÂ
Non-celiac Gluten Intolerance: A Call to Clarify
Jacqueline Jossen & Benjamin Lebwohl
Untangling the Link Between Gastroparesis, Micronutrient Deficiency, and Hair Loss
Ryan F. Flanagan & Jennifer X. Cai
Muscle Mass Effect: The Importance of Diagnosing and Treating Sarcopenia in Patients with Advanced Chronic Liver Disease
Rafael PaternostroÂ
Transplant Hepatology Fellowship Websites: The Good, the Bad, and the Unhelpful
Faraz I. Jafri, Alexis de Montfort Shepherd, Pralahad Raman, Thomas C. Varkey, Charles Hyman & Deepak Agrawal
Relationship Between Esophageal Disease and Pulmonary Fibrosis
Joyce C. Zhou, Sravanya Gavini, Walter W. Chan & Wai-Kit Lo
doi : 10.1007/s10620-023-07908-2
Esophageal disorders are prevalent among patients with chronic lung diseases, including idiopathic pulmonary fibrosis (IPF).
Une Liaison Dangereuse: Spontaneous Pyeloduodenal Fistula
Patrizia Alba Gentile, Loredana Gualtieri, Silvia Izzo, Klaudia Luka, Augusto Lauro & Bruno Salvati
doi : 10.1007/s10620-023-07828-1
We describe the case of a 76-year-old woman with a spontaneous nephroduodenal fistula. The patient was initially evaluated for gastrointestinal and urinary symptoms associated with fever and anemia, after which she was admitted with the diagnosis of right chronic pyelonephritis, hydronephrosis, and renal lithiasis.
On a Knife’s Edge: Management of Vulvar Cutaneous Crohn’s Disease
Nicole S. Evans & Fernando S. Velayos
Besting the Biologics: Vancomycin Monotherapy for Ulcerative Colitis Management in Patients with Primary Sclerosing Cholangitis
Taqwa Ahmed, Maia Kayal, Dana Hashem & Ryan C. Ungaro
A Single-Center Experience with Dupilumab for Atopic or Psoriasiform Dermatitis in Patients with Inflammatory Bowel Disease
Elizabeth A. Spencer, Michael T. Dolinger & Marla C. Dubinsky
doi : 10.1007/s10620-022-07684-5
Dupilumab blocks IL4/IL13 and is used in atopic disease. There are concerns that blockade may lead to inflammatory bowel disease (IBD) inception or activity. Limited data exist on the use of this therapy in patients with IBD; we aimed to describe our experience using dupilumab in IBD to treat concomitant atopic dermatitis (AD) or anti-TNF-induced dermatitis.
Best Practices in Treatment of Laryngopharyngeal Reflux Disease: A Multidisciplinary Modified Delphi Study
Afrin N. Kamal, Shumon I. Dhar, Jonathan M. Bock, John O. Clarke, Jerome R. Lechien, Jacqueline Allen, Peter C. Belafsky, Joel H. Blumin, Walter W. Chan, Ronnie Fass, P. Marco Fisichella, Michael Marohn, Ashli K. O’Rourke, Gregory Postma, Edoardo V. Savarino, Michael F. Vaezi, Thomas L. Carroll & Lee M. Akst
doi : 10.1007/s10620-022-07672-9
Laryngopharyngeal reflux (LPR) is a common otolaryngologic diagnosis. Treatment of presumed LPR remains challenging, and limited frameworks exist to guide treatment.
Clinical Outcomes of Inside Stents and Conventional Plastic Stents as Bridge-to-Surgery Options for Malignant Hilar Biliary Obstruction
Hirotoshi Ishiwatari, Takanori Kawabata, Hiroki Kawashima, Yousuke Nakai, Shin Miura, Hironari Kato, Hideyuki Shiomi, Nao Fujimori, Takeshi Ogura, Osamu Inatomi, Kensuke Kubota, Toshio Fujisawa, Mamoru Takenaka, Hiroshi Mori, Kensaku Noguchi, Yuki Fujii, Teiichi Sugiura, Noboru Ideno, Tomoki Nakafusa, Atsushi Masamune, Hiroyuki Isayama & Naoki Sasahira
doi : 10.1007/s10620-022-07718-y
The appropriate method of preoperative endoscopic biliary drainage (EBD) for cholangiocarcinoma with hilar biliary obstruction remains controversial. The inside-stent technique is a method of placing plastic stents entirely inside the bile duct.
A National Survey of the Infrastructure and Scope of Practice for Gastroenterology Hospitalists
David W. Wan, Melissa Latorre, Edward Sun, Michelle L. Hughes, Adam Buckholz & Darrick K. Li
doi : 10.1007/s10620-023-07831-6
Hospital-based specialty-trained physicians have become more prevalent with emerging data suggesting benefit in consult and procedure volume, reduced complication rates, and increased practice productivity. Interest in gastroenterology (GI) hospitalist programs has increased in recent years. However, little is known regarding the types of GI hospitalist models that currently exist.
Impact of Disease Activity and Inflammatory Bowel Disease Subtype on Quality of Life in Preconception and Pregnant Patients
Grace Wang, Parul Tandon, Nicole Rodriguez, Lindsy Ambrosio, Reed T. Sutton, Levinus A. Dieleman, Karen I. Kroeker & Vivian Huang
doi : 10.1007/s10620-022-07638-x
Inflammatory bowel disease (IBD) and pregnancy both impact health-related quality of life (HRQoL). However, little is known about IBD-related HRQoL around pregnancy.
Endoscopic Ultrasound-Directed Transgastric ERCP (EDGE) Utilization of Trends Among Interventional Endoscopists
Sardar M. Shah-Khan, Eric Zhao, Amy Tyberg, Sardar Sarkar, Haroon M. Shahid, Rodrigo Duarte-Chavez, Monica Gaidhane & Michel Kahaleh
doi : 10.1007/s10620-022-07650-1
Endoscopic ultrasound-directed transgastric ERCP (EDGE) has become standard-of-care therapy at many centers for pancreaticobiliary disease in patients with Roux-en-Y Gastric Bypass. In this study, we aimed to evaluate the opinions and practices of endoscopists who perform EDGE.
Impact of Medicaid Expansion on Incidence and Mortality from Gastric and Esophageal Cancer
Elaheh Niroomand, Smriti Rajita Kumar, David Goldberg & Shria Kumar
doi : 10.1007/s10620-022-07659-6
Individuals in Medicaid expanded states have increased access to treatment for medical conditions and other health care resources. Esophageal and gastric cancer are associated with several modifiable risk factors (e.g. smoking, drinking, Helicobacter pylori infection). The impact of Medicaid expansion on these cancers incidence and mortality remains uninvestigated.
Gastroesophageal Balloon Tamponade Simulation Training with 3D Printed Model Improves Knowledge, Skill, and Confidence
Christopher Mowry, Ruhail Kohli, Courtney Bhat, Aimee Truesdale, Paul Menard-Katcher, Andrew Scallon & Michael Kriss
doi : 10.1007/s10620-022-07665-8
Gastroesophageal balloon tamponade (BT) tube placement is a life-saving procedure for refractory bleeding from gastroesophageal varices performed by gastroenterologists, intensivists, internists, and emergency medicine physicians.
Existing Bowel Preparation Quality Scales Are Reliable in the Setting of Centralized Endoscopy Reading
Jurij Hanzel, Michael Sey, Christopher Ma, Guangyong Zou, James E. East, Corey A. Siegel, Mahmoud Mosli, Walter Reinisch, John W. D. McDonald, Mark S. Silverberg, Tanja Van Viegen, Lisa M. Shackelton, Lucy B. Clayton, Robert Enns, Ian Epstein, Robert J. Hilsden, Lawrence Hookey, Dana C. Moffatt, Richard Ng Kwet Shing, Jennifer J. Telford, Daniel von Renteln, Brian G. Feagan, Alan Barkun & Vipul Jairath
doi : 10.1007/s10620-022-07729-9
Development of bowel preparation products has been based upon colon cleansing rating by a local endoscopist. It is unclear how bowel preparation scales perform when centrally evaluated.
COVID-19 Pandemic Had Minimal Impact on Colonoscopy Completion After Colorectal Cancer Red Flag Sign or Symptoms in US Veterans
Joshua Demb, Lin Liu, Ranier Bustamante, Jason A. Dominitz, Ashley Earles, Shailja C. Shah, Andrew J. Gawron, Maria Elena Martinez & Samir Gupta
doi : 10.1007/s10620-022-07685-4
Delays in colonoscopy work-up for red flag signs or symptoms of colorectal cancer (CRC) during the COVID-19 pandemic are not well characterized.
Electronic Health Record Work Demands for Gastroenterology and Hepatology Providers: A Prospective Use Analysis and Survey Study
Mark Benson, Deepak Gopal & Patrick Pfau
doi : 10.1007/s10620-022-07691-6
There is a paucity of research on the use of the electronic health record (EHR) by gastroenterology and hepatology providers and its effect on work–life balance. Our aim was to study the after-hour EHR work completed among providers within a multispecialty academic practice.
Crohn’s Disease Among the Poorest Billion: Burden of Crohn’s Disease in Low- and Lower-Middle-Income Countries
Ruma Rajbhandari, Samantha Blakemore, Neil Gupta, Sara Mannan, Klejda Nikolli, Alison Yih, Laura Drown & Gene Bukhman
doi : 10.1007/s10620-022-07675-6
To establish the epidemiology and patterns of care of Crohn’s Disease in low- and lower-middle-income countries.
Prepandemic Prevalence Estimates of Fatty Liver Disease and Fibrosis Defined by Liver Elastography in the United States
Aynur Unalp-Arida & Constance E. Ruhl
doi : 10.1007/s10620-022-07707-1
Fatty liver disease is a growing public health burden. We estimated prepandemic fatty liver disease prevalence determined by transient elastography-assessed hepatic steatosis and fibrosis, and examined associations with lifestyle and other factors in a United States population sample.
Hydrogen Availability Is Dependent on the Actions of Both Hydrogen-Producing and Hydrogen-Consuming Microbes
Aleksandr Birg, Nathaniel Ritz, Larry L. Barton & Henry C. Lin
doi : 10.1007/s10620-022-07743-x
Hydrogen gas (H2) is produced by H2-producing microbes in the gut during polysaccharide fermentation. Gut microbiome also includes H2-consuming microbes utilizing H2 for metabolism: methanogens producing methane, CH4, and sulfate-reducing bacteria producing hydrogen sulfide, H2S.
“M1/M2� Muscularis Macrophages Are Associated with Reduction of Interstitial Cells of Cajal and Glial Cells in Achalasia
Haisheng Qian, Yanjuan Wang, Xiaosu Chen, Lin Lin, Weifeng Zhang, Yun Wang, Nana Tang, Xinmin Si, Chunhua Jiao, Guoxin Zhang & Bixing Ye
doi : 10.1007/s10620-022-07734-y
Several studies showed muscularis macrophages (MMφ) are associated with GI motility disorders. The purpose of this study was to preliminary explore the association between MMφ and achalasia.
Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via IRF5-Mediated Macrophage Polarization
Chang Liang, Yu Tang, Xin Gao, Na Lei, Ying Luo, Pingrun Chen, Shihao Duan, Yubin Cao, Yi Yang & Yan Zhang
doi : 10.1007/s10620-022-07679-2
Patients with inflammatory bowel disease (IBD) and concurrent depression are predisposed to severer disease activity and a worse prognosis. Macrophage polarization toward the M1 phenotype may contribute to the exacerbation of IBD with comorbid depression. Moreover, interferon regulatory factor 5 (IRF5) is involved in the pathogenesis of IBD. The aim of this study was to explore the role of IRF5 in macrophage polarization in the impact of depression upon colitis.
Nintedanib Induces the Autophagy-Dependent Death of Gastric Cancer Cells by Inhibiting the STAT3/Beclin1 Pathway
Hui Zhu, Min-Ming Xia, Ke-Hui Tong & Wen-Biao Duan
doi : 10.1007/s10620-022-07653-y
Tyrosine kinase inhibitors are currently the most widely studied targeted therapies for gastric cancer. As a triple tyrosine inhibitor, nintedanib can alleviate the progression of a variety of cancers, but it is poorly studied in gastric cancer.
Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer
Lei Ren, Hong Deng, Yu Jiang & Chunfeng Liu
doi : 10.1007/s10620-022-07790-4
SALL4 has been demonstrated in many cancers and participated in tumorigenesis and tumor progression, however, its expression and function still remain ambiguous in GC, especially its upstream mechanistic modulators.
Chromosome 12 Open Reading Frame 49 Promotes Tumor Growth and Predicts Poor Prognosis in Colorectal Cancer
Yiming Tao, Jia Luo, Hongyi Zhu, Yi Chu & Lei Pei
doi : 10.1007/s10620-022-07751-x
Little is known about the role of chromosome 12 open reading frame 49 (C12ORF49)-induced metabolic signal transduction in tumor growth. We investigated the relationship between C12ORF49 expression and prognosis in colorectal cancer (CRC) patients.
Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma
Zhiming Dong, Guoqiang Zhang, Juntao Lu, Yanli Guo, Jia Liang, Supeng Shen & Wei Guo
doi : 10.1007/s10620-022-07664-9
TOB1, a member of the transducer of erbB-2 /B-cell translocation gene family, was detected to be down-regulated in ESCC by RNA sequencing. TOB1-AS1, a head-to-head antisense lncRNA with TOB1, was down-regulated in several cancers. However, the roles of them in esophageal squamous cell carcinoma (ESCC) remained unclarified.
Liver Cirrhosis Patients Homozygous for MTHFR C677T Develop Portal Vein Thrombosis 8 Years Earlier Than Wild Type
Paul R. J. Ames, Giovanna D’Andrea, Alessia Arcaro, Vincenzo Marottoli, Luigi Iannaccone, Maurizio Maraglione & Fabrizio Gentile
doi : 10.1007/s10620-022-07666-7
Age at portal vein thrombosis (PVT) in liver cirrhosis (LC) carriers of the methylene tetrahydrofolate reductase (MTHFR) rs1801133 (C → T667 transition) polymorphism has never been addressed; we compared age at PVT in LC patients genotyped for the MTHFR and explored the interrelated clinical and laboratory factors predicting age at PVT.
P-element-Induced Wimpy-Testis-Like Protein 1 Regulates the Activation of Pancreatic Stellate Cells Through the PI3K/AKT/mTOR Signaling Pathway
Ran Xue, Jun Zhou, Jing Wu, Qinghua Meng, Jifang Gong & Lin Shen
doi : 10.1007/s10620-022-07605-6
Pancreatic fibrosis is the main pathological characteristic of chronic pancreatitis (CP) and pancreatic cancer. Pancreatic stellate cells (PSCs) play a critical role in pancreatic fibrosis. Any targets that may have an impact on the activation of PSCs could become potential treatment candidates for CP and pancreatic cancer. Our goal was to investigate the effect of P-element-induced wimpy-testis (PIWI) protein 1 (PIWIL1) on PSC activation.
NEDD8-Activating Enzyme Inhibitor MLN4924 Inhibits Both the Tumor Stroma and Angiogenesis in Pancreatic Cancer via Gli1 and REDD1
Weilin Mao, Lei Zhang, Yefei Rong, Tiantao Kuang, Dansong Wang, Xuefeng Xu, Wenhui Lou & Jianang Li
doi : 10.1007/s10620-022-07671-w
Pancreatic cancer is characterized by a dense desmoplasia stroma, which hinders efficient drug delivery and plays a critical role in tumor progression and metastasis.
Self-Reported Gluten Intolerance Is Prevalent, but Not All Gluten-Containing Foods Are Equal
Claire L. Jansson-Knodell, Mattie White, Carolyn Lockett, Huiping Xu, Alberto Rubio-Tapia & Andrea Shin
doi : 10.1007/s10620-022-07800-5
Celiac disease prevalence approaches 1%; more suffer from non-celiac gluten sensitivity.
Bi-directional Relationship Between Celiac Disease and Liver Chemistries: A Systematic Review and Meta-Analysis
Manik Aggarwal, Rajat Garg, Prabhat Kumar, Christina C. Lindenmeyer, Jamile Wakim-Fleming, Claire Jansson-Knodell & Alberto Rubio-Tapia
doi : 10.1007/s10620-022-07663-w
Previous studies have reported conflicting results regarding prevalence of elevated LC (2–70%) in celiac disease (CD). This systematic review and meta-analysis assessed the prevalence of elevated LC at time of CD diagnosis and associated response to GFD. We also report the prevalence of CD in patients with unexplained elevation of LC.
Band Ligation Can Be Used to Treat Barrett’s Esophagus and Concurrent Esophageal Varices: A Case Series
Colin Hartgerink, Faisal M. Nimri, Tobias Zuchelli, Syed-Mohammed Jafri & Cyrus Piraka
doi : 10.1007/s10620-022-07696-1
Patients with Barrett’s esophagus (BE) and esophageal varices present a unique management dilemma. Endoscopic ablation and endoscopic resection are not suitable treatment options due to bleeding risk. Data are limited on successful eradication of BE and esophageal varices utilizing band ligation.
Mid-Term and Long-Term Outcomes of Peroral Endoscopic Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis
Han Zhang, Xinyi Zeng, Shu Huang, Lei Shi, Huifang Xia, Jiao Jiang, Wensen Ren, Yan Peng, Muhan Lü & Xiaowei Tang
doi : 10.1007/s10620-022-07720-4
Peroral endoscopic myotomy (POEM) achieves a satisfactory short-term clinical response in patients with achalasia. However, data on mid- and long-term clinical outcomes are limited. We aimed to assess the mid- and long-term efficacy and safety of POEM in achalasia patients.
Hair Loss in Patients with Gastroparesis: A Sign of Nutritional Deficiency in Gastroparesis?
Paul J. Silver, Michael J. Coles, Candrice R. Heath & Henry P. Parkman
doi : 10.1007/s10620-022-07803-2
Some patients with gastroparesis (Gp) report hair loss. The aim of this study was to investigate the prevalence of patient-reported hair loss in Gp patients, analyze hair loss association to severity of Gp and nutritional deficiencies, and study effects of multivitamin treatment on hair loss.
Age- and Gender-Based Differences in Anorectal Function, Gastrointestinal Symptoms, and Constipation-Specific Quality of Life in Patients with Chronic Constipation
Borko Nojkov, Jason R. Baker, William D. Chey, Richard Saad, Lydia Watts, Moira Armstrong, Kristen Collins, Gabrielle Ezell, Cari Phillips & Stacy Menees
doi : 10.1007/s10620-022-07709-z
The effect of age and gender differences on anorectal function, symptoms severity, and quality of life (QoL) in patients with chronic constipation (CC) is not well studied. This study examines the impact of age and gender on anorectal function testing (AFT) characteristics, symptoms burden, and QoL in patients with CC.
Cap-Assisted Endoscopic Esophageal Foreign Body Removal Is Safe and Efficacious Compared to Conventional Methods
Zohaib Ahmed, Syeda Faiza Arif, Stephanie Lin Ong, Joyce Badal, Wade Lee-Smith, Anas Renno, Yaseen Alastal, Ali Nawras & Muhammad Aziz
doi : 10.1007/s10620-022-07741-z
Esophageal foreign body impaction (FBI) is a commonly encountered gastrointestinal emergency requiring immediate intervention. Foreign bodies can be composed of food, commonly referred to as a "food bolus" (FB), or other matter (non-food). We aim to conduct systematic review and meta-analysis to compare cap-assisted and conventional endoscopic techniques for removal of esophageal FBI.
Safety and Efficacy of Sedation During Emergency Endoscopy for Upper Gastrointestinal Bleeding: A Propensity Score Matching Analysis
Daisuke Yamaguchi, Goshi Nagatsuma, Yasuhisa Sakata, Yumi Mizuta, Tadahiro Nomura, Azuki Jinnouchi, Kasumi Gondo, Ryosuke Asahi, Satoshi Ishida, Shunichiro Kimura, Shun Fujimoto, Akane Shimakura, Amane Jubashi, Yuki Takeuchi, Kei Ikeda, Yuichiro Tanaka, Wataru Yoshioka, Naoyuki Hino, Tomohito Morisaki, Keisuke Ario, Seiji Tsunada & Motohiro Esaki
doi : 10.1007/s10620-022-07740-0
This study aimed to compare patients with and without sedation during emergency endoscopy for upper gastrointestinal bleeding (UGIB) and to clarify the safety and efficacy of sedation in emergency endoscopy.
Erythromycin Improves the Quality of Esophagogastroduodenoscopy in Upper Gastrointestinal Bleeding: A Network Meta-Analysis
Muhammad Aziz, Hossein Haghbin, Manesh Kumar Gangwani, Simcha Weissman, Arti R. Patel, Manraj K. Randhawa, Luke B. Samikanu, Zakaria Abdullah Alyousif, Wade Lee-Smith, Faisal Kamal, Ali Nawras & Colin W. Howden
doi : 10.1007/s10620-022-07698-z
Upper gastrointestinal bleeding (UGIB) usually requires esophagogastroduodenoscopy (EGD) for diagnostic and—potentially—therapeutic purposes. However, blood within the gastric lumen may hinder the procedure. Administration of prokinetics like erythromycin has shown efficacy. This network meta-analysis investigates the efficacy of this intervention prior to EGD.
Motorized Spiral Enteroscopy Is Effective in Patients with Prior Abdominal Surgery
Antonio Giordano, Gherzon Casanova, Miriam Escapa, Gloria Fernández-Esparrach, Àngels Ginès, Oriol Sendino, Isis K. Araujo, Andrés Cárdenas, Henry Córdova, Julia MartÃnez-Ocon, Graciela MartÃnez-Palli, Francesc Balaguer, Josep Llach, Elena Ricart & Begoña González-Suárez
doi : 10.1007/s10620-022-07688-1
Motorized Spiral Enteroscopy (MSE) reduces procedure time and increases insertion depth into the small bowel; however, there is scarce evidence on factors affecting MSE efficacy.
Similar Time Trends of Hodgkin Lymphoma, Multiple Sclerosis, and Inflammatory Bowel Disease
Amnon Sonnenberg
doi : 10.1007/s10620-022-07705-3
The Epstein-Barr virus (EBV) plays a role in the causation of Hodgkin lymphoma (HL) and multiple sclerosis (MS). A previous study showed that the time trends of mortality from Crohn’s disease (CD) and MS shared striking similarities. It was hypothesized that such similarities would also involve the time trends of ulcerative colitis and HL.
Endo-histologic Normalization Is Achievable with Tofacitinib and Is Associated with Improved Clinical Outcomes
Nathaniel A. Cohen, Joshua M. Steinberg, Alexa Silfen, Cindy Traboulsi, Tina G. Rodriguez, Jorie M. Singer, Shivani Patel, Russell D. Cohen, Sushila R. Dalal, Atsushi Sakuraba, Joel Pekow, Dejan Micic & David T. Rubin
doi : 10.1007/s10620-022-07716-0
Recent real-world effectiveness studies investigating tofacitinib have been encouraging. Questions remain regarding the long-term effectiveness and safety of tofacitinib, effect on endoscopic remission rates, histologic changes, and alterations in fecal calprotectin levels.
Computed Tomography-Based Deep Learning Nomogram Can Accurately Predict Lymph Node Metastasis in Gastric Cancer
Xiao Guan, Na Lu & Jianping Zhang
doi : 10.1007/s10620-022-07640-3
Computed tomography is the most commonly used imaging modality for preoperative assessment of lymph node status, but the reported accuracy is unsatisfactory.
Underwater Versus Conventional Endoscopic Mucosal Resection for Superficial Non-ampullary Duodenal Epithelial Tumors: A Systematic Review and Meta-Analysis
Jae Gon Lee, Sang Pyo Lee, Hyun Joo Jang & Sea Hyub Kae
doi : 10.1007/s10620-022-07715-1
Duodenal underwater endoscopic mucosal resection (UEMR) has been suggested as a feasible treatment option for superficial non-ampullary duodenal epithelial tumors (SNADETs). However, its efficacy and safety have not been fully established yet.
Fecal Microbiome Associated with Both Colon Adenomas and Lifetime Colorectal Cancer Risk
Sarah Alharfi, Nancy Furey, Hilmi Al-Shakhshir, Mahmoud Ghannoum & Gregory S. Cooper
doi : 10.1007/s10620-022-07673-8
Increasing data indicates the gut flora including bacteria and fungi combined with environmental factors are important in the pathogenesis of colorectal cancer (CRC). Understanding differences in the microbiome in patients with colon neoplasia will foster the development of biomarkers for early detection.
Efficacy and Predictors of Pain Response to Combined Antioxidants in Children with Chronic Pancreatitis
Amrit Gopan, Anshu Srivastava, Amrita Mathias, Surender Kumar Yachha, Sunil Kumar Jain, Prabhakar Mishra, Moinak Sen Sarma & Ujjal Poddar
doi : 10.1007/s10620-022-07676-5
Pain is a major problem in 90% of patients with chronic pancreatitis (CP). Studies evaluating response to antioxidants (AO) are conflicting and no pediatric studies are available.
Stratification Based on Risk Factors at Diagnosis Could Predict Progression in Patients with Pancreatic Cysts
Ryo Sugio, Tsutomu Nishida, Kengo Matsumoto, Kosuke Kawamura, Miyoung Park, Tomoya Hamabe, Kana Hosokawa, Shinji Kuriki, Li-sa Chang, Yoshifumi Fujii, Naoto Osugi, Aya Sugimoto, Kaori Mukai, Dai Nakamatsu, Shiro Hayashi, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui & Masami Inada
doi : 10.1007/s10620-022-07699-y
Predicting the risk of malignant transformation in pancreatic cyst patients is challenging.
Pre-existing, Concurrent/Early-Onset, and Late-Onset Diabetes in Chronic Pancreatitis: Do Outcomes Differ?
Shaharyar A. Zuberi, Ishani Shah, Rachel L. Bocchino, Awais Ahmed, Steven D. Freedman, Darshan J. Kothari & Sunil G. Sheth
doi : 10.1007/s10620-022-07742-y
Diabetes secondary to endocrine insufficiency in chronic pancreatitis (CP) may develop at any time during the disease course. We sought to evaluate the differences in clinical characteristics and outcomes in CP patients with pre-existing, early-onset, and late-onset diabetes.
The Frequency of Germline BRCA and Non-BRCA HR-Gene-Variants in a Cohort of Pancreatic Cancer Patients
M. Baz, V. Gondran-Teiller, B. Bressac, O. Cabaret, A. Fievet, M. Dimaria, V. Goldbarg, C. Colas, M. N. Bonnet-Dupeyron, J. Tinat, M. Lebrun, V. Mari, J. M. Limacher, C. Corsini, E. Ginglinger, J. C. Saurin, A. Brahimi, C. Rouzier, S. Giraud, H. Schuster, A. Hollebecque, V. Boige, E. Cauchin, D. Malka, O. Caron & E. Rouleau
doi : 10.1007/s10620-022-07733-z
Germline DNA alterations affecting homologous recombination pathway genes have been associated with pancreatic cancer (PC) risk. BRCA2 is the most studied gene and affects the management of PC patients and their families.
Long-Term Impact of Endoscopic Gallbladder Stenting for Calculous Cholecystitis in Poor Surgical Candidates: A Multi-center Comparative Study
Tadahisa Inoue, Yuta Suzuki, Michihiro Yoshida, Itaru Naitoh, Fumihiro Okumura, Rena Kitano, Kenichi Haneda, Kazuki Hayashi & Masashi Yoneda
doi : 10.1007/s10620-022-07651-0
Although long-term stent placement using endoscopic gallbladder stenting (EGBS) reportedly reduces cholecystitis recurrence in patients unfit to undergo cholecystectomy, its efficacy and safety remain uncertain.
Clinical Outcomes of Patients with Benign Peptic Ulcer Bleeding After an Emergency Endoscopy Based on Patient Location
Boram Cha, Jin Hee Noh, Ji Yong Ahn, Jun Su Lee, Ga Hee Kim, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee & Hwoon-Yong Jung
doi : 10.1007/s10620-022-07708-0
In the efforts toward reducing bleeding-related mortality, it is crucial to determine the risk factors for rebleeding after endoscopic hemostasis in benign peptic ulcer (BPU).
Endoscopic Ultrasound-Guided Antegrade Stent Placement in Patients with Failed ERCP as a Modality of Preoperative and Palliative Biliary Drainage
Sridhar Sundaram, Kiran Mane, Prachi Patil, Raosaheb Rathod, Aadish Kumar Jain, Unique Tyagi & Shaesta Mehta
doi : 10.1007/s10620-022-07655-w
No large studies have addressed the role of endoscopic-ultrasound biliary drainage (EUS-BD) as preoperative biliary drainage (PBD) for malignant extrahepatic biliary obstruction (MEBO). We aimed to discuss the outcomes of EUS antegrade stent placement (EUS-AG) in the preoperative and palliative setting.
Efficacy and Safety of Bezafibrate Alone or in Combination with Ursodeoxycholic Acid in Primary Biliary Cholangitis: Systematic Review and Meta-Analysis
Nidah Shabbir Khakoo, Shahnaz Sultan, John M. Reynolds & Cynthia Levy
doi : 10.1007/s10620-022-07704-4
Bezafibrate (BZF) alone or in combination with ursodeoxycholic acid (UDCA) has been used to slow disease progression in patients with primary biliary cholangitis (PBC). We performed a systematic review and meta-analysis to assess the efficacy and harms of BZF monotherapy or combination therapy.
A Risk Prediction Model for Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis After Stent Insertion for Malignant Biliary Obstruction: Development and Validation
Zhifeng Fu, Jitao Song, Yilin Pi, Xianxin Sun, Maoning Liu, Zunlong Xiao & Jing Chen
doi : 10.1007/s10620-022-07649-8
Pancreatitis is the most common complication of post-endoscopic retrograde cholangiopancreatography (ERCP). There are currently no prediction models, particularly for post-ERCP pancreatitis (PEP) after biliary stent placement due to malignant biliary obstruction (MBO). To that end, we aim to develop and validate a predictive model for PEP.
Missing Causality and Heritability of Autoimmune Hepatitis
Albert J. Czaja
doi : 10.1007/s10620-022-07728-w
Autoimmune hepatitis has an unknown cause and genetic associations that are not disease-specific or always present. Clarification of its missing causality and heritability could improve prevention and management strategies.
Concomitant Diseases and Co-contribution on Progression of Liver Stiffness in Patients with Hepatitis B Virus Infection
Chang-Hai Liu, Wei Jiang, Dong-Bo Wu, Qing-Min Zeng, You-Juan Wang & Hong Tang
doi : 10.1007/s10620-022-07695-2
The association between hepatitis B and concomitant diseases, such as fatty liver, T2DM, MetS, and Hp infection, remains unclear.
Effects of Hepatitis B Virus Infection on Patients with COVID-19: A Meta-Analysis
Yang Yu, Xingzhao Li & Taihu Wan
doi : 10.1007/s10620-022-07687-2
The COVID-19 pandemic has brought new problems to patients infected with hepatitis B virus (HBV).
Type of Infection Is Associated with Prognosis in Acute-on-Chronic Liver Failure: A National Veterans Health Administration Study
Nadim Mahmud, K. Rajender Reddy, Tamar H. Taddei & David E. Kaplan
doi : 10.1007/s10620-022-07680-9
Acute-on-chronic liver failure (ACLF) is a syndrome in patients with cirrhosis with high short-term mortality. Infection is a frequent precipitant of ACLF; however, it is unclear if prognosis varies by difference infectious sources. To address this knowledge gap, we utilized a large national database of patients with cirrhosis.
Sarcopenia Defined by Psoas Muscle Thickness Predicts Mortality After Transjugular Intrahepatic Portosystemic Shunt
Tongqiang Li, Jiacheng Liu, Jianbo Zhao, Yaowei Bai, Songjiang Huang, Chongtu Yang, Yingliang Wang, Chen Zhou, Chaoyang Wang, Shuguang Ju, Yang Chen, Wei Yao & Bin Xiong
doi : 10.1007/s10620-022-07806-z
To assess and compare the value of psoas muscle thickness at the level of the third lumbar (L3) vertebra (TPML) or umbilicus (TPMU) and skeletal muscle index (SMI) for diagnosing sarcopenia and predicting mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS).
