Jindan Yu, Yao Lv, Youyou Luo, Youhong Fang & Jie Chen
doi : 10.1007/s10620-022-07801-4
Volume 68, issue 5, May 2023
Mujtaba Mubashir, Casey Carnell, Ihab Haddadin & Stefan D. Holubar
Haiming Zheng, Qian Zhuang & Xinjian Wan
Eric D. Shah
Dhruvil RadadiyaÂ
Nicholas V. CostriniÂ
Sunny Sandhu & Binu V. John
Joseph C. Yarze
Moniyka Sachar, Erick Arguetta & Grigoriy E. Gurvits
doi : 10.1007/s10620-023-07869-6
Acute esophageal necrosis (AEN) in the setting of gastric volvulus is a rare condition with only a handful of cases reported. Volvulus may contribute to AEN by limiting tissue perfusion and promoting massive reflux of gastric contents on compromised esophageal mucosa.
Gabriela Piovezani Ramos & Michael Camilleri
doi : 10.1007/s10620-022-07700-8
Irritable bowel syndrome with diarrhea and functional diarrhea are disorders of gut-brain interaction presenting with chronic diarrhea; they have significant impact on quality of life. The two conditions may exist as a continuum and their treatment may overlap.
David Y. Graham
doi : 10.1007/s10620-023-07886-5
Helicobacter pylori infects a large percentage of the world’s population and is etiologically related to gastric cancer. The U.S. Food and Drug Administration recently approved two 14-day vonoprazan-containing regimens (vonoprazan–amoxicillin with or without clarithromycin) for H. pylori infections in the United States/Europe.
Lidia Castagneto-Gissey, Loredana Gualtieri, Annalisa Diddoro, Augusto Lauro, Alfredo Genco & Giovanni Casella
doi : 10.1007/s10620-023-07874-9
Esophageal lesions ranging from erosive esophagitis to Barrett's esophagus (BE) eventually develop months—years after sleeve gastrectomy (SG), representing a significant post-surgical issue in GI practice.
Fernando S. Velayos
doi : 10.1007/s10620-023-07852-1
A 32-year-old man with a 3-month history of intermittent diarrhea was noted to have an elevated creatinine of 2.2Â mg/dL, with no prior results available. Colonoscopy revealed mucosal inflammation characterized by the loss of vascular pattern and erosions throughout the colon with sparing of the rectum.
Rahul S. Dalal, Behiye Goksel & Matthew J. Hamilton
doi : 10.1007/s10620-023-07866-9
A 32-year-old female with no significant past medical history was diagnosed with ulcerative proctitis in the setting of abdominal pain and hematochezia following a miscarriage. Index colonoscopy with biopsies demonstrated mild chronic active colitis in the rectum with normal histology throughout the remainder of the colon and terminal ileum.
Ryan Flanagan, Mayssan Muftah, Molly Perencevich, Walter Chan & Daniel J. Stein
doi : 10.1007/s10620-022-07763-7
Academic gastroenterology (GI) hospitalists are increasing, however the impacts on fellowship training and clinical care are unclear. Motivations for implementation of the GI hospitalist model are uninvestigated.
Jennifer K. Maratt, Corey A. Siegel, Alan N. Barkun, Yoram Bouhnik, Brian Bressler, Audrey H. Calderwood, James E. East, Monika Fischer, Johannes Grossmann, Joshua R. Korzenik, Stacy B. Menees, Julian Panes, Douglas K. Rex, Michael S. L. Sey, Michael K. Allio, K. Adam Baker, Leonardo Guizzetti, Julie Remillard, Rocio Sedano, Brian G. Feagan, Christopher Ma & Vipul Jairath
doi : 10.1007/s10620-022-07775-3
Despite regular need for colonoscopy in patients with Crohn’s disease (CD), the efficacy and tolerability of bowel preparation (BP) agents is rarely assessed in this population. Assessing BP quality with existing scales may be challenging in CD due to presence of inflammation, bowel resection, and strictures.
Yingjing Liu, Shenting Xu, Gulizeba Muhetaer, Hao Tang, Hongtao Guo & Hang Li
doi : 10.1007/s10620-022-07796-y
Water delivery tube reflux during gastrointestinal endoscopy examination is widespread and it is the leading cause of water injection bottle pollution.
Akiko KowadaÂ
doi : 10.1007/s10620-022-07795-z
Helicobacter pylori (HP) eradication therapy is an efficient primary prevention method to reduce gastric cancer development. In Japan, biennial endoscopic screening for individuals aged 50Â years and older is currently conducted as a national gastric cancer prevention program.
Osayande Osagiede, Frank J. Lukens, Vivek Kumbhari & Juan E. Corral
doi : 10.1007/s10620-022-07753-9
Training endoscopists to perform endoscopic retrograde cholangiopancreatography (ERCP) is critical to address the increasing patient population with pancreatobiliary diseases. Concerns remain about ERCP safety and success involving trainees. We compared the technical success and immediate adverse events between ERCP with and without trainee involvement.
Anna Evans Phillips, Gong Tang, Xianling Wang, Christopher E. Forsmark & Dhiraj Yadav
doi : 10.1007/s10620-022-07750-y
Pancreatic enzyme replacement therapy (PERT) is most commonly used to treat exocrine insufficiency related to pancreatic diseases, but can be used for non-pancreatic digestive conditions (NPDC). We aimed to determine the prevalence of PERT use and describe prescription patterns in individuals with NPDC.
Ziming Yin, Tao Chen, Yijun Shu, Qiwei Li, Zhiqing Yuan, Yijue Zhang, Xinsen Xu & Yingbin Liu
doi : 10.1007/s10620-022-07782-4
Gallbladder cancer is the sixth most common malignant gastrointestinal tumor. Radical surgery is currently the only effective treatment, but patient prognosis is poor, with a 5-year survival rate of only 5–10%. Establishing an effective survival prediction model for gallbladder cancer patients is crucial for disease status assessment, early intervention, and individualized treatment approaches.
Shohei Burns & Ma Somsouk
doi : 10.1007/s10620-022-07755-7
Organized outreach to increase CRC screening using mailed FIT tests has been shown to be effective, but durable changes to screening behavior after cessation of screening is not known.
Zhiyu Qian, Xi Chen, Daniel Pucheril, Khalid Al Khatib, Mayra Lucas, David-Dan Nguyen, Julia McNabb-Baltar, Stuart R. Lipsitz, Nelya Melnitchouk, Alexander P. Cole & Quoc-Dien Trinh
doi : 10.1007/s10620-022-07797-x
Colorectal cancer screening continuously decreased its mortality and incidence. In 2010, the Affordable Care Act extended Medicaid eligibility to low-income and childless adults. Some states elected to adopt Medicaid at different times while others chose not to. Past studies on the effects of Medicaid expansion on colorectal cancer screening showed equivocal results based on short-term data following expansion.
Sean Richard Rudnick, Judy Ugwuegbu, Stephen James Soufleris, Richa Bundy, Ajay Dharod & Mark William Russo
doi : 10.1007/s10620-022-07786-0
The coronavirus 2019 (COVID-19) pandemic required an immediate and large-scale transition to telemedicine. Telemedicine includes phone visits and video visits. Studies suggest that hepatocellular cancer (HCC) screening rates fell at the beginning of the COVID-19 pandemic. If left unaddressed, HCC morbidity/mortality may increase following the pandemic due to inadequate screening.
L. R. Caley, H. White, M. C. de Goffau, R. A. Floto, J. Parkhill, B. Marsland & D. G. Peckham
doi : 10.1007/s10620-022-07812-1
Cystic Fibrosis (CF) is associated with gut dysbiosis, local and systemic inflammation, and impaired immune function. Gut microbiota dysbiosis results from changes in the complex gut milieu in response to CF transmembrane conductance regulator (CFTR) dysfunction, pancreatic malabsorption, diet, medications, and environmental influences.
David Dahlgren, Olof Nylander & Markus Sjöblom
doi : 10.1007/s10620-022-07764-6
The role of cholinergic receptors in the regulation of duodenal mucosal permeability in vivo is currently not fully described.
Yoshihiro Akita, Masaaki Higashiyama, Chie Kurihara, Suguru Ito, Shin Nishii, Akinori Mizoguchi, Kenichi Inaba, Rina Tanemoto, Nao Sugihara, Yoshinori Hanawa, Akinori Wada, Kazuki Horiuchi, Yoshikiyo Okada, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Fumie Takei, Yasushi Satoh, Masayuki Saruta & Ryota Hokari
doi : 10.1007/s10620-022-07781-5
Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy, the mechanism of which is involved in oxidative stress, can be lethal due to hemorrhage. Thus, we aimed to investigate the effect of hydrogen-rich water (HRW), in terms of oxidative stress, on intestinal mucosal damage as well as changes in the gut microbiome and the short-chain fatty acids (SCFAs) content in feces.
Peng Liu, Xiao-ran Xie, Hao Wu, Huan Li, Jing-shu Chi, Xiao-ming Liu, Ju Luo, Yu Tang & Can-xia Xu
doi : 10.1007/s10620-022-07722-2
Mesenchymal stem cells (MSCs) are a type of adult pluripotent stem cell that has anti-inflammatory and immunomodulatory effects, and whose conditioned medium (CM) has also been found to be effective. We used MSC and CM enemas to investigate their ameliorative effects in a mouse model of colitis.
Xiaoqing Lin, Mingshu Tu, Yi Zhang, Wanzhen Zhuang, Liqing Cai, Liangming Zhang, Lili Yu, Zhenlong Zhang & Yi Huang
doi : 10.1007/s10620-022-07748-6
Neuron-specific gene family member 1 (NSG1) is a 21Â kDa endosomal protein that is specifically expressed in neurons.
Seung Young Kim, Jae Ho Park, Gabriela Leite, Mark Pimentel & Ali Rezaie
doi : 10.1007/s10620-023-07871-y
Interleukin (IL)-10 knockout (KO) mice, a model for inflammatory bowel disease (IBD), develop chronic enterocolitis due to an aberrant immune response to enteric antigens. Endoscopy, the gold standard for evaluation of human mucosal health, is not widely available for murine models.
Amber Hanif PallaÂ
Qian Niu, Lin Li, Caili Zhang, Changhai Qi, Qiufeng He & Yuanmin Zhu
doi : 10.1007/s10620-022-07772-6
5-Hydroxytryptamine (5-HT) and stem cells marker G-protein-coupled receptor 5 (LGR5) are associate with gastrointestinal inflammation and tumorigenesis. But the relationship between 5-HT and LGR5 is unclear.
Wei Liu, Chong Geng, Xiao Li, Yanni Li, Shuailing Song & Chunhui Wang
doi : 10.1007/s10620-022-07805-0
SLC9A8 has been shown to be involved in mucus layer formation, intestinal mucosal integrity, and hyperproliferation of colitis-associated tumor development. However, its effects on the epithelial–mesenchymal transition (EMT) and the metastasis of colorectal cancer (CRC) remain unknown.
Tomio Uragami, Yugo Ando, Mamiko Aoi, Toshiro Fukui, Yasushi Matsumoto, Shunsuke Horitani, Takashi Tomiyama, Kazuichi Okazaki, Koichi Tsuneyama, Hajime Tanaka & Makoto Naganuma
doi : 10.1007/s10620-022-07774-4
Chronic inflammation, such as ulcerative colitis, increases the risk of developing colitis-associated cancers. Currently, mice administered with azoxymethane/dextran sodium sulfate are well-known models for colitis-associated cancers. Although human colitis-associated cancers are often flat lesions, most azoxymethane/dextran sodium sulfate mouse cancers are raised lesions.
Xiang-Yu Gan, Jian-Di Li, Gang Chen, Rong-Quan He, Jia-Yuan Luo, Jing-Jing Zeng, Zi-Xuan Yang, Yu-Xuan Yao, Jun-Jie Zhu, Jian-Jun Li & Dan-Ming Wei
doi : 10.1007/s10620-022-07771-7
Pancreatic adenocarcinoma (PAAD) is a malignant tumor responsible for a heavy disease burden. Previously, only one pan-cancer study of Transmembrane channel-like protein 5 (TMC5) showed that TMC5 was highly expressed in PAAD, but the results lacked comprehensive verification, and the mechanism of TMC5 in PAAD was still unclear.
Jingsheng Ma, Yajun Wu, Shibao Cheng, Wentao Yang, Lin Zhong, Qigen Li & Lu Fang
doi : 10.1007/s10620-022-07780-6
Dysregulation of ubiquitin ligases plays a crucial role in the development and progression of various human tumors. F-box only protein 22 (FBXO22), an F-box E3 ubiquitin ligase, has been reported to participate in diverse aspects of cancer progression. However, the clinical significance and biological function of FBXO22 in pancreatic cancer remain poorly understood.
Haibo Wang, Wanjin Chen, Yong Qi, Deng Liu, Zhiqiang Liu, Qikun Zhang, Yujiao Yi, Juanru Wang & Wenyong Wu
doi : 10.1007/s10620-022-07810-3
miR-29-3p, an important tumor suppressor, with inhibitory effects in multiple cancers that have been studied. Its exact molecular function is in HCC, however, still not been explored clearly. The purpose of our study is to make certain how miR-29c-3p affects HCC through TPX2.
Thorsten Brechmann, Maximilian Mühlenkamp, Wolff Schmiegel & Bernd Viebahn
doi : 10.1007/s10620-022-07745-9
Argon plasma coagulation (APC) of gastric inlet patches of the cervical esophagus (GIP) has been shown to relieve the globus sensation. This study aimed to investigate the long-term effects of APC therapy on a variety of laryngopharyngeal symptoms.
Erin McDonnell, Johanna W. Lampe, Mason Nuding & Dale Lee
doi : 10.1007/s10620-022-07792-2
Gluten-free foods often contain food additives to improve palatability, but the long-term effects on the human gastrointestinal tract are not well known.
Suprabhat Giri, Shivaraj Afzalpurkar, Prajna Anirvan, Sumaswi Angadi, Sunil Kasturi, Jijo Varghese & Sridhar Sundaram
doi : 10.1007/s10620-022-07808-x
The present guidelines stratify endoscopic ultrasound-guided tissue acquisition (EUS-TA) as a high-bleeding risk procedure in patients on antithrombotics. However, the data regarding the same are conflicting. Therefore, this meta-analysis aimed to analyze the bleeding event rates associated with EUS-TA in patients receiving antithrombotic therapy.
Seokin Kang, Kee Don Choi, Yuri Kim, Hee Kyong Na, Jeong Hoon Lee, Ji Yong Ahn, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee & Hwoon-Yong Jung
doi : 10.1007/s10620-022-07776-2
Left gastric artery (LGA) pseudoaneurysm presenting with upper gastrointestinal (UGI) bleeding is rare but fatal, unless treated.
Manesh Kumar Gangwani, Muhammad Aziz, Abeer Aziz, Fnu Priyanka, Arti Patel, Umar Ghaffar, Simcha Weissman, Mahmood Asif, Wade Lee-Smith, Toseef Javaid, Ali Nawras & Benjamin Hart
doi : 10.1007/s10620-022-07804-1
Gastrostomy tube (G tube) is a commonly performed procedure for nutritional support. Current guidelines recommend discontinuation of dual antiplatelet therapy (DAPT) prior to G tube placement to reduce bleeding risk.
Hossein Haghbin, Nuruddinkhodja Zakirkhodjaev, Faiza Fatima Husain, Wade Lee-Smith & Muhammad Aziz
doi : 10.1007/s10620-022-07788-y
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used over-the-counter medications that can increase the risk of gastrointestinal (GI) bleeding through antiplatelet effects and loss of GI protection.
Gerum Gashaw Gebeyehu, Joseph Fiske, Eleanor Liu, Jimmy K. Limdi, Giacomo Broglio, Christian Selinger, Violeta Razsanskaite, Philip J. Smith, Paul K. Flanagan & Sreedhar Subramanian
doi : 10.1007/s10620-022-07770-8
Anti-tumour necrosis factor (anti-TNF) agents are associated with increased infection risk among elderly inflammatory bowel disease (IBD) patients, and thus, alternative biologics may be preferable. However, little comparative data exist on the safety and efficacy of vedolizumab and ustekinumab in elderly IBD patients.
Aaron Chung, Matthew Carroll, Patricia Almeida, Alexandra Petrova, Daniela Isaac, Diane Mould, Eytan Wine & Hien Huynh
doi : 10.1007/s10620-022-07783-3
Children with Crohn’s disease have lower response rates to infliximab, lower infliximab levels, and higher infliximab clearance on weight-based dosing than adults. We hypothesize infliximab clearance is a predictive of later outcomes on infliximab in children with Crohn’s disease.
Alexa R. Weingarden, Olivia Treiger, Lauren Ulsh, Berkeley Limketkai, David Goldenberg, Philip Okafor, Irene Sonu, Neil Stollman & Leila Neshatian
doi : 10.1007/s10620-022-07761-9
Fecal microbiota transplantation (FMT) is a highly effective treatment for recurrent Clostridioides difficile infection (CDI). However, 10–20% of patients still fail to recover following FMT. There is a need to understand why these failures occur and if there are modifiable factors that can be addressed by clinicians performing FMT.
Joshua J. Levy, Christopher M. Navas, Joan A. Chandra, Brock C. Christensen, Louis J. Vaickus, Michael Curley, William D. Chey, Jason R. Baker & Eric D. Shah
doi : 10.1007/s10620-022-07759-3
We developed a deep learning algorithm to evaluate defecatory patterns to identify dyssynergic defecation using 3-dimensional high definition anal manometry (3D-HDAM).
Rigers Cama, Neel Kapoor, Philip Sawyer, Bharat Patel & Jonathan Landy
doi : 10.1007/s10620-022-07754-8
Quantitative fecal immunochemical tests (FIT) were recommended by NICE for patients in primary care presenting with low-risk symptoms of colorectal cancer (CRC). FIT is more accurate in the detection of CRC than symptom criteria.
Naohisa Yoshida, Ken Inoue, Hikaru Hashimoto, Reo Kobayashi, Yuri Tomita, Satoshi Sugino, Ryohei Hirose, Osamu Dohi, Yukiko Morinaga, Yutaka Inada, Takaaki Murakami & Yoshito Itoh
doi : 10.1007/s10620-023-07833-4
SOUTEN (KANEKA Co., Tokyo, Japan) is a unique snare with a disk tip. We analyzed the efficacy of precutting endoscopic mucosal resection with SOUTEN (PEMR-S) for colorectal lesions.
Wenxi Jiang, Linying Xin, Shefeng Zhu, Zhaoxue Liu, Jiali Wu, Feng Ji, Chaohui Yu & Zhe Shen
doi : 10.1007/s10620-023-07848-x
Colonoscopy is regarded as the gold standard for colorectal cancer screening and surveillance. However, previous studies have reported large numbers of polyps were missed during routine colonoscopy.
So Takahashi, Waku Hatta, Kenta Watanabe, Tomoyuki Koike, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tatsuya Mikami, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Dai Hirasawa, …Katsunori Iijima
doi : 10.1007/s10620-022-07746-8
Although additional treatment is considered for patients with esophageal squamous cell carcinoma (ESCC) invading into the muscularis mucosa (pT1a-MM) or submucosa (pT1b-SM) after endoscopic submucosal dissection (ESD), the actual benefits of this method remain to be elucidated.
Hirokazu Saito, Hajime Iwasaki, Hisashi Itoshima, Yoshihiro Kadono, Takashi Shono, Kentaro Kamikawa, Atsushi Urata, Jiro Nasu, Masayoshi Uehara, Ikuo Matsushita, Tatsuyuki Kakuma & Shuji Tada
doi : 10.1007/s10620-022-07773-5
The revised American Society for Gastrointestinal Endoscopy (ASGE) guideline 2019 provides the high-risk criteria for suspected common bile duct stones (CBDSs).
Lei Yuan, Lei Shen, Mengyao Ji, Xinyu Wen, Shuo Wang, Pingxiao Huang, Yong Li & Jun Xu
doi : 10.1007/s10620-022-07768-2
The objective of this study was to develop and validate an easy-to-use risk score (APRS) to predict which patients with acute pancreatitis (AP) will need intensive care unit (ICU) treatment within 48Â h post-hospitalization on the basis of the ubiquitously available clinical records.
Jayanta Samanta, Jahnvi Dhar, Chhagan Lal Birda, Pankaj Gupta, Thakur Deen Yadav, Vikas Gupta, Saroj Kant Sinha & Rakesh Kochhar
doi : 10.1007/s10620-022-07758-4
Timely intervention can alter outcome in patients of infected pancreatic necrosis (IPN) but lacks adequate biomarker. Role of serum procalcitonin (PCT) in the management of IPN is understudied, and hence, this study was planned.
Tadahisa Inoue, Rena Kitano, Mayu Ibusuki, Kazumasa Sakamoto, Satoshi Kimoto, Yuji Kobayashi, Yoshio Sumida, Yukiomi Nakade, Kiyoaki Ito & Masashi Yoneda
doi : 10.1007/s10620-022-07749-5
Endoscopic ultrasound-guided hepaticogastrostomy with antegrade stenting (EUS-HGAS) is a promising therapeutic option for malignant distal biliary obstruction (MDBO) in the event of transpapillary approach failure. Eliminating the fistula dilation step may further decrease the incidence of adverse events (AE) and simplify the procedure.
Harshad Devarbhavi, Aarthi Sridhar, Sunu Sara Kurien, Vinod Gowda, Ksheetij Kothari, Mallikarjun Patil & Rajvir Singh
doi : 10.1007/s10620-022-07777-1
Anti-seizure drugs that cause idiosyncratic drug-induced liver injury (DILI) are an important cause of morbidity and mortality in individuals exposed to these drugs. The clinical and demographic characteristics, the liver injury pattern, the outcome, and the agents responsible for hepatotoxicity have not been thoroughly studied. We investigated the aforementioned characteristics in a large cohort of DILI registry patients.
Shanna Cheng, Elliot Yu, Zhuping Garacci, Angelika L. Erwin & Thangam Venkatesan
doi : 10.1007/s10620-022-07756-6
Acute hepatic porphyria (AHP) presents with nausea and vomiting and can mimic cyclic vomiting syndrome (CVS). The prevalence of AHP in CVS and overlap in clinical symptomatology is not known. We thus sought to determine the prevalence of pathogenic variants for AHP and characterize symptom overlap between CVS and AHP.
Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Masahide Oshita, Yasuharu Imai, Naoki Hiramatsu, Eiji Mita, Akira Kaneko, Masanori Miyazaki, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Keiji Yamamoto, Yoshinori Doi, Yuichi Yoshida, Yukinori Yamada, Takayuki Yakushijin, Tomohide Tatsumi, Tetsuo Takehara & Osaka Liver Forum
doi : 10.1007/s10620-022-07629-y
Liver function can be improved in patients with chronic hepatitis C virus (HCV) infection who achieved sustained virologic response (SVR) with direct-acting antiviral (DAA) treatment. However, to our knowledge, the impact of liver function improvement after SVR on prognosis has not been investigated.
Shelley E. Keating, Ilaria Croci, Matthew P. Wallen, Emily R. Cox, Moe Thuzar, Uyen Pham, Gregore I. Mielke, Jeff S. Coombes, Graeme A. Macdonald & Ingrid J. Hickman
doi : 10.1007/s10620-022-07779-z
High-Intensity Interval Training (HIIT) involves bursts of high-intensity exercise interspersed with lower-intensity exercise recovery. HIIT may benefit cardiometabolic health in people with nonalcoholic steatohepatitis (NASH).
Cameron Furey, Selena Zhou, Joo Hye Park, Andrew Foong, Aneesa Chowdhury, Lillian Dawit, Vivian Lee, Maria Vergara-Lluri, Rosemary She, Jeffrey Kahn, Jennifer L. Dodge & Takeshi Saito
doi : 10.1007/s10620-023-07867-8
Cirrhotic patients presenting with spontaneous bacterial peritonitis (SBP) have elevated risk of short-term mortality. While high Model for End-Stage Liver Disease-Sodium score (MELD-Na) and ascites culture yielding multi-drug resistance (MDR) bacteria are well established risk factors for further aggravating mortality, the impact of individual, causative microorganisms and their respective pathogenesis have not been previously investigated.
Ankur Jindal, Samagra Agarwal, Sanchit Sharma, Manoj Kumar, Anoop Saraya & Shiv Kumar Sarin
doi : 10.1007/s10620-022-07778-0
Assessment of clinically significant portal hypertension (CSPH) non-invasively using a combination of liver stiffness measurement (LSM) and platelet counts is proposed as an alternative to hepatic venous pressure gradient (HVPG) estimation. Utility of these criteria in compensated advanced chronic liver disease (cACLD) patients of different etiologies including nonalcoholic steatohepatitis (NASH) with BMI  >  30 kg/m2 was studied in a large cohort.
Trevor L. Schell, Miguel A. Mailig, Mazen Almasry, Sarah Lazarus, Luke J. Richard, Katharine Tippins, Jennifer Weiss, Mary S. Hayney & Freddy Caldera
Jie Xu, Yujia Wang, Huifen Feng, Fang Liu & Haiyan Yang
Shao-ce Zhi, Shi-zuan Chen, Yan-yan Li, Jun-jian Li, Yi-hu Zheng & Fu-xiang Yu
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