دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Target-Catalyzed Self-Assembly of DNA-Streptavidin Nanogel for Enzyme-Free miRNA Assay (Adv. Healthcare Mater. 9/2023)
Jae Chul Park, Hyebin Na, Saehan Choi, Huiju Jeon, Yoon Sung Nam
doi : 10.1002/adhm.202370041
Volume 12, Issue 9
Egg Microneedle for Transdermal Delivery of Active Liraglutide (Adv. Healthcare Mater. 9/2023)
Jeongyun You, Seorin Juhng, Jieun Song, Jihyun Park, Mingyu Jang, Geonwoo Kang, Huisuk Yang, Hye Su Min, Jiwoo Shin, Seri Lee, Hyuk Wan Ko, Hyungil Jung
doi : 10.1002/adhm.202370042
Orally Administrable Aggregation-Induced Emission-Based Bionic Probe for Imaging and Ameliorating Dextran Sulfate Sodium-Induced Inflammatory Bowel Diseases (Adv. Healthcare Mater. 9/2023)
Wenyuan Wang, Ya Wu, Yihui Wang, Rui Wang, Cheng Deng, Luyang Yi, Lufang Wang, Mengrong He, Wuqi Zhou, Yuji Xie, Qiaofeng Jin, Yihan Chen, Tang Gao, Li Zhang, Mingxing Xie
doi : 10.1002/adhm.202370045
Design of Recombinant Spider Silk Proteins for Cell Type Specific Binding (Adv. Healthcare Mater. 9/2023)
Vanessa Tanja Trossmann, Thomas Scheibel
doi : 10.1002/adhm.202370046
Bone Tissue Engineering Scaffolds: Function of Multi-Material Hierarchically Structured Scaffolds
Tejas M. Koushik, Catherine M. Miller, Elsa Antunes
doi : 10.1002/adhm.202202766
Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, and the understanding of bone healing pathways have opened new avenues of research.
Target-Catalyzed Self-Assembly of DNA-Streptavidin Nanogel for Enzyme-Free miRNA Assay
Jae Chul Park, Hyebin Na, Saehan Choi, Huiju Jeon, Yoon Sung Nam
doi : 10.1002/adhm.202202076
Rapid, sensitive, specific, and user-friendly microRNA (miRNA) assays are in high demand for point-of-care diagnosis.
Egg Microneedle for Transdermal Delivery of Active Liraglutide
Jeongyun You, Seorin Juhng, Jieun Song, Jihyun Park, Mingyu Jang, Geonwoo Kang, Huisuk Yang, Hye Su Min, Jiwoo Shin, Seri Lee, Hyuk Wan Ko, Hyungil Jung
doi : 10.1002/adhm.202202473
Liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, is promising for safely treating type 2 diabetes mellitus (T2DM), compared to insulin, by significantly reducing the risk of glucose-dependent hypoglycemia.
Orally Administrable Aggregation-Induced Emission-Based Bionic Probe for Imaging and Ameliorating Dextran Sulfate Sodium-Induced Inflammatory Bowel Diseases
Wenyuan Wang, Ya Wu, Yihui Wang, Rui Wang, Cheng Deng, Luyang Yi, Lufang Wang, Mengrong He, Wuqi Zhou, Yuji Xie, Qiaofeng Jin, Yihan Chen, Tang Gao, Li Zhang, Mingxing Xie
doi : 10.1002/adhm.202202420
As macrophage infiltration is significantly related to the progression of inflammatory bowel disease (IBD), monitoring the macrophages is a valuable strategy for IBD diagnosis.
Design of Recombinant Spider Silk Proteins for Cell Type Specific Binding
Vanessa Tanja Trossmann, Thomas Scheibel
doi : 10.1002/adhm.202202660
Cytophilic (cell-adhesive) materials are very important for tissue engineering and regenerative medicine. However, for engineering hierarchically organized tissue structures comprising different cell types, cell-specific attachment and guidance are decisive.
Real-Time Objective Evaluation of the Ischemic Stroke through pH-Responsive Fluorescence Imaging
Shasha Yao, Chengbin He, Pengcheng Yuan, Xiaodan Xu, Xiaoxuan Zhou, Liyin Shen, Qiuhui Hu, Nigel K. H. Slater, Wenjing Sun, Youqing Shen, Hongjie Hu, Jianbin Tang
doi : 10.1002/adhm.202201981
A rapid and comprehensive assessment of ischemic stroke (IS) is critical for clinicians to take the most appropriate treatment.
Chlorogenic Acid-Conjugated Nanoparticles Suppression of Platelet Activation and Disruption to Tumor Vascular Barriers for Enhancing Drug Penetration in Tumor
Yue Ke, Zhifang Ma, Hongbo Ye, Xinghua Guan, Zehong Xiang, Yu Xia, Qiang Shi
doi : 10.1002/adhm.202202205
Hypercoagulation threatens the lives of cancer patients and cancer progression. Platelet overactivation attributes to the tumor-associated hypercoagulation and maintenance of the tumor endothelial integrity, leading to limited intratumoral perfusion of nanoagents into solid tumors in spite of the enhanced penetration and retention effect (EPR).
Defined Alginate Hydrogels Support Spinal Cord Organoid Derivation, Maturation, and Modeling of Spinal Cord Diseases
Wai Hon Chooi, Chong Yi Ng, Valerie Ow, Jasmine Harley, Winanto Ng, Jin-Hui Hor, Kay En Low, Benoit Malleret, Kun Xue, Shi-Yan Ng
doi : 10.1002/adhm.202202342
In the process of generating organoids, basement membrane extracts or Matrigel are often used to encapsulate cells but they are poorly defined and contribute to reproducibility issues.
Submicron-Sized In Situ Osmotic Pressure Sensors for In Vitro Applications in Biology
Wenbo Zhang, Luca Bertinetti, Efe Cuma Yavuzsoy, Changyou Gao, Emanuel Schneck, Peter Fratzl
doi : 10.1002/adhm.202202373
Physical forces are important cues in determining the development and the normal function of biological tissues. While forces generated by molecular motors have been widely studied, forces resulting from osmotic gradients have been less considered in this context.
Development of Mitochondria Targeting AIE-Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents
Geeta Kumari, Ajay Gupta, Raj Kumar Sah, Aryan Gautam, Monika Saini, Aashima Gupta, Akhilesh K. Kushawaha, Shailja Singh, Pijus K. Sasmal
doi : 10.1002/adhm.202202411
The emergence of resistance to conventional antimalarial treatments remains a major cause for concern. New drugs that target the distinct development stages of Plasmodium parasites are required to address this risk.
Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine-Loaded Lipid Nanoparticles
Masaki Gomi, Yu Sakurai, Minami Sato, Hiroki Tanaka, Yumi Miyatake, Koichi Fujiwara, Mizuki Watanabe, Satoshi Shuto, Yuta Nakai, Kota Tange, Hiroto Hatakeyama, Hidetaka Akita
doi : 10.1002/adhm.202202528
Lipid nanoparticles (LNPs) are one of the most successful technologies in messenger RNA (mRNA) delivery.
Calcium–Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype
Da-Wang Zhao, Chun-Miao Du, Kang-Qing Zuo, Yi-Xiang Zhao, Xiao-Qian Xu, Yi-Bo Li, Shuai Tian, Hong-Ru Yang, Yu-Peng Lu, Lei Cheng, Gui-Yong Xiao
doi : 10.1002/adhm.202202537
Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential physiological effects and promising degradation properties.
Toward 3D Bioprinting of Osseous Tissue of Predefined Shape Using Single-Matrix Cell-Bioink Constructs
Yawei Gu, Sebastien Pigeot, Lucas Ahrens, Fabian Tribukait-Riemenschneider, Melika Sarem, Francine Wolf, Andres GarcÃÂa-GarcÃÂa, Andrea Barbero, Ivan Martin, V. Prasad Shastri
doi : 10.1002/adhm.202202550
Engineering living bone tissue of defined shape on-demand has remained a challenge. 3D bioprinting (3DBP), a biofabrication process capable of yielding cell constructs of defined shape, when combined with developmental engineering can provide a possible path forward.
In Situ Regulation and Mechanisms of 3D Matrix Stiffness on the Activation and Reversion of Hepatic Stellate Cells
Guobao Chen, Yaxin Deng, Bin Xia, Yonggang Lv
doi : 10.1002/adhm.202202560
Activated hepatic stellate cells (HSCs) is a key event in the progression of liver fibrosis. HSCs transdifferentiate into myofibroblasts and secrete large amounts of extracellular matrix, resulting in increased liver stiffness.
Composite Scaffolds of Gelatin and Fe3O4 Nanoparticles for Magnetic Hyperthermia-Based Breast Cancer Treatment and Adipose Tissue Regeneration
Rui Sun, Huajian Chen, Jing Zheng, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
doi : 10.1002/adhm.202202604
Postsurgical treatment of breast cancer remains a challenge with regard to killing residual cancer cells and regenerating breast defects.
Intracellular Formation of Hemicyanine Nanoparticle Enhances Tumor-Targeting Photoacoustic Imaging and Photothermal Therapy
Lele Zhang, Minghui Wang, Fangzheng Wu, Li Liu, Xingxing Ren, Zijuan Hai
doi : 10.1002/adhm.202202676
Alkaline phosphatase (ALP) is a tumor marker for early diagnosis and treatment. Tumor targeting can recognize and fight tumor cells more accurately from healthy cells. Glycyrrhetinic acid (GA) is a targeting ligand of liver tumors.
The Epitope Basis of Embryonic Stem Cell-Induced Antitumor Immunity against Bladder Cancer
Meiling Jin, Jingchu Hu, Lili Tong, Bao-Zhong Zhang, Jian-Dong Huang
doi : 10.1002/adhm.202202691
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) share many cellular and molecular features with cancer cells. Taking advantage of these similarities, stem cells are effective vaccines against cancers in animal models.
Oxidative Stress Amplifiers as Immunogenic Cell Death Nanoinducers Disrupting Mitochondrial Redox Homeostasis for Cancer Immunotherapy
Jia Wan, Xianghong Zhang, Zhihong Li, Fuhao Mo, Dongsheng Tang, Haihua Xiao, Jingcheng Wang, Guanghua Rong, Tang Liu
doi : 10.1002/adhm.202202710
Reactive oxygen species (ROS)-induced oxidative stress in the endoplasmic reticulum (ER) is generally believed to be an important prerequisite for immunogenic cell death (ICD) which can trigger antitumor immune responses for cancer immunotherapy.
Engineered Living Oriented Electrospun Fibers Regulate Stem Cell Para-Secretion and Differentiation to Promote Spinal Cord Repair (Adv. Healthcare Mater. 9/2023)
Jingzhi Xu, Kun Xi, Jincheng Tang, Juan Wang, Yunkai Tang, Liang Wu, Yichang Xu, Zonghan Xu, Liang Chen, Wenguo Cui, Yong Gu
doi : 10.1002/adhm.202370044
Engineered Living Oriented Electrospun Fibers Regulate Stem Cell Para-Secretion and Differentiation to Promote Spinal Cord Repair
Jingzhi Xu, Kun Xi, Jincheng Tang, Juan Wang, Yunkai Tang, Liang Wu, Yichang Xu, Zonghan Xu, Liang Chen, Wenguo Cui, Yong Gu
doi : 10.1002/adhm.202202785
A Photoacoustic Contrast Nanoagent with a Distinct Spectral Signature for Ovarian Cancer Management
Anna St Lorenz, Abraham S. Moses, Babak Mamnoon, Ananiya A. Demessie, Youngrong Park, Prem Singh, Oleh Taratula, Olena R. Taratula
doi : 10.1002/adhm.202202946
Photoacoustic imaging (PAI) has tremendous potential for improving ovarian cancer detection. However, the lack of effective exogenous contrast agents that can improve PAI diagnosis accuracy significantly limits this application.
