دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano-Assembly to Combat Fungal Keratitis (Adv. Healthcare Mater. 10/2023)
Xiaoyan Ju, Liping Wu, Ning Gao, Ye Tian, Guojun Lu, Yichen Gao, Shaozhen Zhao, Zhongwei Niu, Ruibo Yang
doi : 10.1002/adhm.202370047
Volume 12, Issue 10
High-Performance Delivery of a CRISPR Interference System via Lipid-Polymer Hybrid Nanoparticles Combined with Ultrasound-Mediated Microbubble Destruction for Tumor-Specific Gene Repression (Adv. Healthcare Mater. 10/2023)
Yan Li, Pengying Wu, Mingting Zhu, Meiling Liang, Lei Zhang, Yujin Zong, Mingxi Wan
doi : 10.1002/adhm.202370048
Acidity-Biodegradable Iridium-Coordinated Nanosheets for Amplified Ferroptotic Cell Death Through Multiple Regulatory Pathways (Adv. Healthcare Mater. 10/2023)
Lili Huang, Tongtong Nie, Lixian Jiang, Ying Chen, Yixuan Zhou, Xiaojun Cai, Yuanyi Zheng, Longchen Wang, Jianrong Wu, Tao Ying
doi : 10.1002/adhm.202370050
Clear-Box Machine Learning for Virtual Screening of 2D Nanozymes to Target Tumor Hydrogen Peroxide (Adv. Healthcare Mater. 10/2023)
Xuejiao J. Gao, Jun Yan, Jia-Jia Zheng, Shengliang Zhong, Xingfa Gao
doi : 10.1002/adhm.202370051
Recent Advances in “Functional Engineering of Articular Cartilage Zones by Polymeric Biomaterials Mediated with Physical, Mechanical, and Biological/Chemical Cues�
Dorsa Dehghan-Baniani, Babak Mehrjou, Paul K. Chu, Wayne Yuk Wai Lee, Hongkai Wu
doi : 10.1002/adhm.202202581
Articular cartilage (AC) plays an unquestionable role in joint movements but unfortunately the healing capacity is restricted due to its avascular and acellular nature.
Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications
Ryan C. Locke, Hannah M. Zlotnick, Brendan D. Stoeckl, George W. Fryhofer, Jonathan H. Galarraga, Abhishek P. Dhand, Miltiadis H. Zgonis, James L. Carey, Jason A. Burdick, Robert L. Mauck
doi : 10.1002/adhm.202202591
The expanse of publications in tissue engineering (TE) and orthopedic TE (OTE) over the past 20 years presents an opportunity to probe emergent trends in the field to better guide future technologies that can make an impact on musculoskeletal therapies.
Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems
Dina B. Mahmoud, Michaela Schulz-Siegmund
doi : 10.1002/adhm.202202631
The breakthrough of 3D printing in biomedical research has paved the way for the next evolutionary step referred to as four dimensional (4D) printing. This new concept utilizes the time as the fourth dimension in addition to the x, y, and z axes with the idea to change the configuration of a printed construct with time usually in response to an external stimulus.
Biomaterials-Based Cell Therapy for Myocardial Tissue Regeneration
Lei Mu, Ruonan Dong, Baolin Guo
doi : 10.1002/adhm.202202699
Cardiovascular diseases (CVDs) have been the leading cause of death worldwide during the past several decades. Cell loss is the main problem that results in cardiac dysfunction and further mortality.
Drug Self-Delivery Systems: Molecule Design, Construction Strategy, and Biological Application
Chengfei Liu, Caiping Liu, Yang Bai, Jingxia Wang, Wei Tian
doi : 10.1002/adhm.202202769
Drug self-delivery systems (DSDSs) offer new ways to create novel drug delivery systems (DDSs). In typical DSDSs, therapeutic reagents are not considered passive cargos but active delivery agents of actionable targets.
Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano-Assembly to Combat Fungal Keratitis
Xiaoyan Ju, Liping Wu, Ning Gao, Ye Tian, Guojun Lu, Yichen Gao, Shaozhen Zhao, Zhongwei Niu, Ruibo Yang
doi : 10.1002/adhm.202202409
Fungal hyphae deeply invade the cornea in fungal keratitis. The corneal stroma hinders the infiltration of antifungal drugs and reduces their bioavailability. Here, this work reports a peptide conjugate nano-assembly that permeates the stroma and kills the pathogen without irritating the ocular cornea.
High-Performance Delivery of a CRISPR Interference System via Lipid-Polymer Hybrid Nanoparticles Combined with Ultrasound-Mediated Microbubble Destruction for Tumor-Specific Gene Repression
Yan Li, Pengying Wu, Mingting Zhu, Meiling Liang, Lei Zhang, Yujin Zong, Mingxi Wan
doi : 10.1002/adhm.202203082
The dCas9-based CRISPR interference (CRISPRi) system efficiently silences genes without causing detectable off-target activity, thus showing great potential for the treatment of cancer at the transcriptional level.
Acidity-Biodegradable Iridium-Coordinated Nanosheets for Amplified Ferroptotic Cell Death Through Multiple Regulatory Pathways
Lili Huang, Tongtong Nie, Lixian Jiang, Ying Chen, Yixuan Zhou, Xiaojun Cai, Yuanyi Zheng, Longchen Wang, Jianrong Wu, Tao Ying
doi : 10.1002/adhm.202202562
Ferroptosis-based treatment strategies display the potential to suppress some malignant tumors with intrinsic apoptosis resistance. However, current related cancer treatments are still hampered by insufficient intracellular reactive oxygen species (ROS) levels and Fe2+ contents, posing considerable challenges for their clinical translation.
Clear-Box Machine Learning for Virtual Screening of 2D Nanozymes to Target Tumor Hydrogen Peroxide
Xuejiao J. Gao, Jun Yan, Jia-Jia Zheng, Shengliang Zhong, Xingfa Gao
doi : 10.1002/adhm.202202925
Targeting tumor hydrogen peroxide (H2O2) with catalytic materials has provided a novel chemotherapy strategy against solid tumors. Because numerous materials have been fabricated so far, there is an urgent need for an efficient in silico method, which can automatically screen out appropriate candidates from materials libraries for further therapeutic evaluation.
A Polymer Canvas with the Stiffness of the Bone Matrix to Study and Control Mesenchymal Stem Cell Response
Alessandra Zanut, Rui Li, Ru Deng, Xiangyu Liu, Martin Rejhon, Weiqiang Chen, Marcus Weck, Giuseppe Maria de Peppo, Elisa Riedo
doi : 10.1002/adhm.202201503
Reproducing in vitro the complex multiscale physical features of human tissues creates novel biomedical opportunities and fundamental understanding of cell−environment interfaces and interactions.
Two-Dimensional Mg2Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin
Yanxia Zhu, Qi Jiang, Zhaokui Jin, Danyang Chen, Qingqing Xu, Jinchun Chen, Yue Zeng, Shengqiang Chen, Qianjun He
doi : 10.1002/adhm.202201705
Molecular hydrogen holds a high potential for wound healing owing to its anti-inflammatory effect and high biosafety, but commonly used hydrogen administration routes hardly achieve the sustained supply of high-dosage hydrogen, limiting hydrogen therapy efficacy.
Engineering Lipid Spherulites for the Sustained Release of Highly Dosed Small Hydrophilic Compounds
Elita Montanari, Hanna Krupke, Jean-Christophe Leroux
doi : 10.1002/adhm.202202249
Currently, there is a lack of parenteral sustained release formulations for the delivery of highly dosed small hydrophilic drugs. Therefore, parenteral lipid spherulites are engineered capable of entrapping large amounts of such compounds and spontaneously releasing them in a sustained fashion.
Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress
Marian Jaschke, Masina Plenge, Marius Kunkel, Tina Lehrich, Julia Schmidt, Kilian Stöckemann, Dag Heinemann, Stephan Siroky, Anaclet Ngezahayo, Sebastian Polarz
doi : 10.1002/adhm.202202290
Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here.
The Construction of Alkaline Phosphatase-Responsive Biomaterial and Its Application for In Vivo Urinary Tract Infection Therapy
Jing Zhang, Ying Fu, Rongtao Zhou, Moli Yin, Wenhe Zhu, Shunjie Yan, Huiyan Wang
doi : 10.1002/adhm.202202421
Urinary tract infections caused by urinary catheter implantations are becoming more serious. Therefore, the construction of a responsive antibacterial biomaterial that can not only provide biocompatible conditions, but also effectively prevent the growth and metabolism of bacteria, is urgently needed.
In Situ Structure Transformation of a Sprayed Gel for pH-Ultrasensitive Nano-Catalytic Antibacterial Therapy
Zhihui Niu, Mingxiao Xie, Zicheng Wei, Yang Guo, Mengxuan Han, Yingying Ding, Jianyu Huang, Kang Zheng, Yao Zhang, Yuanda Song, Dechao Niu, Yongsheng Li, Guangwu Wen, Xiaowei Li, Jianlin Shi
doi : 10.1002/adhm.202202441
Nano-catalytic bacterial killing provides new opportunities to address ever-increasing antibiotic resistance. However, the intrinsic catalytic activity usually depends on a much lower pH conditions (pH = 2–5) than that in the weakly acidic bacterial microenvironments (pH = 6–7) for reactive oxygen species production by Fenton reactions.
A Dynamic Membrane-Active Glycopeptide for Enhanced Protection of Human Red Blood Cells against Freeze-Stress
Shuhui Gao, Qingjing Niu, Yan Wang, Lixia Ren, Jinghui Chong, Kongying Zhu, Xiaoyan Yuan
doi : 10.1002/adhm.202202516
Intracellular delivery of freezing-tolerant trehalose is crucial for cryopreservation of red blood cells (RBCs) and previous strategies based on membrane-disruptive activity usually generate severe hemolysis.
Thermal-Sinterable EGaIn Nanoparticle Inks for Highly Deformable Bioelectrode Arrays
Yan Niu, Gongwei Tian, Cuiyuan Liang, Tianchi Wang, Xu Ma, Guifen Gong, Dianpeng Qi
doi : 10.1002/adhm.202202531
Liquid metal (especially eutectic gallium indium, EGaIn) nanoparticle inks overcome the poor wettability of high surface tension EGaIn to elastomer substrates and show great potential in soft electronics.
Microenvironment-Adaptive Nanozyme for Accelerating Drug-Resistant Bacteria-Infected Wound Healing
Lei Yu, Yiping Sun, Yusheng Niu, Pengfei Zhang, Jun Hu, Zhong Chen, Gong Zhang, Yuanhong Xu
doi : 10.1002/adhm.202202596
Reactive oxygen species (ROS) are favorable for antibacterial infection but their overproduction results in serious inflammatory response and aggravates the hypoxic state of the wound tissue, which is detrimental to healing stages of proliferation and remodeling.
Phase-Separated Liposomes Hijack Endogenous Lipoprotein Transport and Metabolism Pathways to Target Subsets of Endothelial Cells In Vivo
Gabriela Arias-Alpizar, Panagiota Papadopoulou, Xabier Rios, Krishna Reddy Pulagam, Mohammad-Amin Moradi, Roy Pattipeiluhu, Jeroen Bussmann, Nico Sommerdijk, Jordi Llop, Alexander Kros, Frederick Campbell
doi : 10.1002/adhm.202202709
Plasma lipid transport and metabolism are essential to ensure correct cellular function throughout the body. Dynamically regulated in time and space, the well-characterized mechanisms underpinning plasma lipid transport and metabolism offers an enticing, but as yet underexplored, rationale to design synthetic lipid nanoparticles with inherent cell/tissue selectivity.
Selective Nanoblocker of Cellular Stress Response for Improved Drug-Free Tumor Therapy
Cuimei Liu, Sihang Cheng, Xue Zhou, Jue Wang, Ping Mu, Zhongyao Wang, Lingyu Zhang, Lu Li, Chungang Wang
doi : 10.1002/adhm.202202893
Nanotechnology-based drug-free therapeutic systems using external stimuli can avoid the inherent side effects of drugs and become an attractive therapeutic strategy. However, the cellular stress responses (CSR) are activated encounter with external stimuli, which greatly weaken the efficacy of the drug-free antitumor.
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways
Zhongyin Zhang, Lichan Yuan, Yufeng Liu, Ruobing Wang, Yihong Zhang, Yan Yang, Hui Wei, Junqing Ma
doi : 10.1002/adhm.202203195
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory cytokine release, and extracellular matrix (ECM) synthesis.
pH and Thrombin Concentration Are Decisive in Synthesizing Stiff, Stable, and Open-Porous Fibrin-Collagen Hydrogel Blends without Chemical Cross-Linker
Mattis Wachendörfer, Eva Miriam Buhl, Ghazi Ben Messaoud, Walter Richtering, Horst Fischer
doi : 10.1002/adhm.202203302
Fibrin-collagen hydrogel blends exhibit high potential for tissue engineering applications. However, it is still unclear whether the underlying cross-linking mechanisms are of chemical or physical nature.
