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Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac ArrestThe EXACT Randomized Clinical Trial
Stephen A. Bernard, MD1,2,3; Janet E. Bray, PhD1,3,4; Karen Smith, PhD1,2,5; Michael Stephenson, BHlthSci1,2,5; Judith Finn, PhD1,4; Hugh Grantham, MBBS4,6,7; Cindy Hein, PhD8; Stacey Masters, PhD4; Dion Stub, PhD1,2,3; Gavin D. Perkins, MD9; Natasha Dodge, MPH1; Catherine Martin, PhD10; Sarah Hopkins, MBBS2; Peter Cameron, PhD1,3; for the EXACT Investigators
doi : 10.1001/jama.2022.17701
November 8, 2022, Vol 328, No. 18, Pages 1793-1879
Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness
Shannon M. Fernando, MD, MSc1,2,3; Mary Scott, MSc2,4,5,6; Robert Talarico, MSc2,4; Eddy Fan, MD, PhD7,8,9,10; Daniel I. McIsaac, MD, MPH2,4,5,11; Manish M. Sood, MD, MSc2,4,5,12; Daniel T. Myran, MD, MPH5; Margaret S. Herridge, MD, MSc, MPH7,8,9,10; Dale M. Needham, MD, PhD13,14; Carol L. Hodgson, PhD15; Bram Rochwerg, MD, MSc16,17; Laveena Munshi, MD, MSc7,9,10; M. Elizabeth Wilcox, MD, MPH7,10; O. Joseph Bienvenu, MD, PhD18; Graeme MacLaren, MBBS, MSc19,20; Robert A. Fowler, MDCM, MSc4,7,9,21; Damon C. Scales, MD, PhD4,7,9,21,22; Niall D. Ferguson, MD, MSc7,8,9,10; Alain Combes, MD, PhD23,24; Arthur S. Slutsky, MD, MASc7,22; Daniel Brodie, MD25,26; Peter Tanuseputro, MD, MHSc2,4,5,6,27; Kwadwo Kyeremanteng, MD, MHA1,2,27,28
doi : 10.1001/jama.2022.17714
Importance Extracorporeal membrane oxygenation (ECMO) is used as temporary cardiorespiratory support in critically ill patients, but little is known regarding long-term psychiatric sequelae among survivors after ECMO.
Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease
Vikram Fielding-Singh, MD, JD1; Matthew W. Vanneman, MD1; Tristan Grogan, MS2; Jacques P. Neelankavil, MD3; Wolfgang C. Winkelmayer, MD, MPH, ScD4; Tara I. Chang, MD, MS5; Vincent X. Liu, MD, MS6; Eugene Lin, MD, MS7,8
doi : 10.1001/jama.2022.19626
Importance For patients with end-stage kidney disease treated with hemodialysis, the optimal timing of hemodialysis prior to elective surgical procedures is unknown.
Trends in Urinary Biomarkers of Exposure to Nicotine and Carcinogens Among Adult e-Cigarette Vapers vs Cigarette Smokers in the US, 2013-2019
Hongying Daisy Dai, PhD1; Adam M. Leventhal, PhD2; Ali S. Khan, MD, MPH1
doi : 10.1001/jama.2022.14847
Trends in the Association Between Diabetes and Cardiovascular Events, 1994-2019
Calvin Ke, MD, PhD1; Lorraine L. Lipscombe, MD, MSc1; Alanna Weisman, MD, PhD1; Limei Zhou, PhD2; Peter C. Austin, PhD2; Baiju R. Shah, MD, PhD1; Gillian L. Booth, MD, MSc1
doi : 10.1001/jama.2022.14914
Addressing Gaps in Research to Reduce Disparities and Advance Health EquityThe USPSTF Incorporation of the NASEM Taxonomy on Closing Evidence Gaps in Clinical Prevention
Carol M. Mangione, MD, MSPH1,2; Wanda Nicholson, MD, MPH3,4; Karina W. Davidson, PhD, MASc5,6
doi : 10.1001/jama.2022.19154
Hospital Rankings and Health Equity
Tavia Binger, MSPH1; Harold Chen, BA1; Ben Harder, BA1
doi : 10.1001/jama.2022.19001
Reforming the World Health Organization’s Essential Medicines ListEssential but Unaffordable
Thomas J. Hwang, MD1,2; Aaron S. Kesselheim, MD, JD, MPH2; Kerstin N. Vokinger, MD, JD, PhD2,3
doi : 10.1001/jama.2022.19459
Early Oxygen Supplementation After Resuscitation From Cardiac Arrest
Jonathan Elmer, MD, MS1,2,3; Francis X. Guyette, MD, MPH, MS1
doi : 10.1001/jama.2022.18620
Mental Health Outcomes Following Extracorporeal Membrane Oxygenation in Survivors of Critical Illness
Marieke Zegers, PhD1; Mark van den Boogaard, RN, PhD1; J. G. (Hans) van der Hoeven, MD, PhD1
doi : 10.1001/jama.2022.18621
Optimal Timing of Hemodialysis Before Surgery
Anthony J. Bleyer, MD, MS1
doi : 10.1001/jama.2022.19442
Treatment of HypertensionA Review
Robert M. Carey, MD1; Andrew E. Moran, MD2; Paul K. Whelton, MB, MD, MSc3
doi : 10.1001/jama.2022.19590
Importance Hypertension, defined as persistent systolic blood pressure (SBP) at least 130 mm Hg or diastolic BP (DBP) at least 80 mm Hg, affects approximately 116 million adults in the US and more than 1 billion adults worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (coronary heart disease, heart failure, and stroke) and death.
Diagnosis and Management of Hereditary Hemochromatosis
Elizabeth Cabrera, MD1; Gonzalo Crespo, MD2; Lisa B. VanWagner, MD, MSc3
doi : 10.1001/jama.2022.17727
EPA Takes Action Against Harmful “Forever Chemicals� in the US Water Supply
Melissa Suran, PhD, MSJ
doi : 10.1001/jama.2022.12678
Shifting Hepatitis A Epidemiology Requires Renewed Vaccination Efforts
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2022.18450
Second COVID-19 Booster Increases Protection for Nursing Home Patients
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2022.18451
Single Monkeypox Vaccine Dose Provides Some Protection
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2022.18452
Gene Therapy for Sickle Cell Disease, β-Thalassemia Enters Regulatory Reviews
Howard D. Larkin
doi : 10.1001/jama.2022.18448
Noninvasive Neuromodulation May Help Improve Function in Cerebral Palsy
Howard D. Larkin
doi : 10.1001/jama.2022.18447
Bionic Pancreas Outperforms Standard Care for Type 1 Diabetes in Trial
Howard D. Larkin
doi : 10.1001/jama.2022.18449
Outcomes From Intraoperative Handovers of Anesthesia Care
Philip M. Jones, MD, MSc1; Louise Y. Sun, MD, SM2; Michael J. Brenner, MD3
doi : 10.1001/jama.2022.16527
Outcomes From Intraoperative Handovers of Anesthesia Care
Andrea Vannucci, MD, MS1; Steven Greenberg, MD2; Matthew B. Weinger, MD, MS3
doi : 10.1001/jama.2022.16530
Outcomes From Intraoperative Handovers of Anesthesia Care—Reply
Melanie Meersch, MD1; Daniel I. Sessler, MD2; Alexander Zarbock, MD1
doi : 10.1001/jama.2022.16545
Racial and Ethnic Differences in Resident Selection
Daryl Turner, DO1; Murtaza Akhter, MD1
doi : 10.1001/jama.2022.16536
Racial and Ethnic Differences in Resident Selection—Reply
Randall A. Bly, MD1; Mark E. Whipple, MD, ScM1; Sarah N. Bowe, MD, EdM2
doi : 10.1001/jama.2022.16542
