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Introducing a New Process for Methodologic and Statistical Review in Neurology.
Merino, Jose G. MD, MPhil; Schneider, Andrea L.C. MD, PhD; Ciccarelli, Olga MD, PhD, FRCP
doi : 10.1212/WNL.0000000000207356
Volume 100(16) pgs. 739-797,e1643-e1736 April 18, 2023
Genotype-Guided Dual Antiplatelet Therapy in Minor Stroke or Transient Ischemic Attack With a Single Small Subcortical Infarction.
Liu, Huihui MD, PhD *; Jing, Jing MD *; Wang, Anxin PhD; Xu, Qin PhD; Meng, Xia MD, PhD; Li, Hao PhD; Li, Zixiao MD, PhD; Wang, Yongjun MD
doi : 10.1212/WNL.0000000000206775
Single small subcortical infarction (SSSI) is an important stroke subtype. The optimal antiplatelet medication for patients with ischemic stroke with an SSSI is still unclear.
General Anesthesia Compared With Non-GA in Endovascular Thrombectomy for Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Campbell, Douglas BM; Butler, Elise MB ChB; Campbell, Ruby Blythe; Ho, Jess MB ChB; Barber, P. Alan MBChB, PhD, FRACP
doi : 10.1212/WNL.0000000000207066
Endovascular thrombectomy (EVT) for large vessel occlusion ischemic stroke is either performed under general anesthesia (GA) or with non-GA techniques such as conscious sedation or local anesthesia alone.
Changes in White Matter Microstructure Over 3 Years in People With and Without Stroke.
Egorova-Brumley, Natalia PhD; Dhollander, Thijs PhD; Khan, Wasim PhD; Khlif, Mohamed Salah PhD; Ebaid, Deena PhD; Brodtmann, Amy MBBS, PhD
doi : 10.1212/WNL.0000000000207065
Cerebral white matter health can be estimated by MRI-derived indices of microstructure. White matter dysfunction is increasingly recognized as a contributor to neurodegenerative disorders affecting cognition and to functional outcomes after stroke.
Female Hormone Therapy and Risk of Intracranial Hemorrhage From Cerebral Cavernous Malformations: A Multicenter Observational Cohort Study.
Zuurbier, Susanna M. MD, PhD *; Santos, Alejandro N. MD *; Flemming, Kelly D. MD; Schmidt, Borge PhD; Jabbarli, Ramazan MD; Lanzino, Giuseppe MD; Sure, Ulrich MD; Dammann, Philipp MD
doi : 10.1212/WNL.0000000000206888
Female hormone therapy (oral contraception in female patients of reproductive age and menopausal hormone therapy in postmenopausal patients) is not withheld from patients with cerebral cavernous malformations (CCMs), although the effects of these drugs on the risk of intracranial hemorrhage are unknown.
Updated Percentiles for the University of Pennsylvania Smell Identification Test in Adults 50 Years of Age and Older.
Brumm, Michael C. MS; Pierz, Kerri A. PhD; Lafontant, David-Erick MS; Caspell-Garcia, Chelsea MS; Coffey, Christopher S. PhD; Siderowf, Andrew MD; Marek, Kenneth MD
doi : 10.1212/WNL.0000000000207077
The University of Pennsylvania Smell Identification Test (UPSIT) is commonly used to assess olfaction and screen for early detection of disorders including Parkinson (PD) and Alzheimer disease.
Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants.
Yang, Zhirong PhD *; Wei, Chang MSc *; Li, Xiaojuan PhD; Yuan, Jinqiu PhD; Gao, Xuefeng PhD; Li, Bingyu PhD; Zhao, Ziyi MPH; Toh, Sengwee ScD; Yu, Xin MD; Brayne, Carol MD; Yang, Zuyao PhD; Sha, Feng PhD; Tang, Jinling PhD
doi : 10.1212/WNL.0000000000207081
The use of over-the-counter laxatives is common in the general population. The microbiome-gut-brain axis hypothesis suggests that the use of laxatives could be associated with dementia.
Rates of Status Epilepticus and Sudden Unexplained Death in Epilepsy in People With Genetic Developmental and Epileptic Encephalopathies.
Donnan, Alice M. BSc, MD; Schneider, Amy L. MGenCouns; Russ-Hall, Sophie BSc (Hons); Churilov, Leonid PhD; Scheffer, Ingrid E. PhD
doi : 10.1212/WNL.0000000000207080
The genetic developmental and epileptic encephalopathies (DEEs) comprise a large group of severe epilepsy syndromes, with a wide phenotypic spectrum. Currently, the rates of convulsive status epilepticus (CSE), nonconvulsive status epilepticus (NCSE), and sudden unexplained death in epilepsy (SUDEP) in these diseases are not well understood.
Genetic Causes of Cerebral Small Vessel Diseases: A Practical Guide for Neurologists.
Manini, Arianna MD; Pantoni, Leonardo MD, PhD
doi : 10.1212/WNL.0000000000201720
AB Cerebral small vessel disease (CSVD) includes various entities affecting the brain and, often, systemic small arteries, arterioles, venules, and capillaries.
What Are the Functions of the Superior Colliculus and Its Involvement in Neurologic Disorders?.
Benarroch, Eduardo MD
Pearls & Oy-sters: Salt and Pepper Sign, PLNTY for Drug-Resistant Epilepsy.
Paredes-Aragon, Elma M. MD *; AlKhaldi, Norah A. MD *; Burneo, Jorge G. MD, MSPH; Lee, Donald MD; Ang, Lee C. MD; Steven, David MD; MacDonald, Maria MD; Herrera-Aramburu, Manuel MD; Mirsattari, Seyed M. MD, PhD
doi : 10.1212/WNL.0000000000206782
AB Drug-resistant epilepsy, defined as the failure of 2 or more antiseizure medications to achieve seizure freedom, is responsible for 2/3 of epilepsy cases.
Reader Response: Prehospital Telestroke vs Paramedic Scores to Accurately Identify Stroke Reperfusion Candidates: A Cluster Randomized Controlled Trial.
Barber, Peter Alan
CYP2C19 Genotyping to Guide Antiplatelet Therapy for the Secondary Prevention of Lacunar Strokes.
Sposato, Luciano A. MD, MBA, FRCPC; Donnan, Geoffrey Alan MD
Considering the Use of Female Hormone Therapy in Women With Cerebral Cavernous Malformations: An Editorial.
Madsen, Tracy E. MD, PhD; Rexrode, Kathryn MD, MPH
Is the Eye a Window to the Peripheral Nerve?: What the Shortest Nerves Have to Say About the Longest Ones.
Smith, A. Gordon MD
Editors' Note: Prehospital Telestroke vs Paramedic Scores to Accurately Identify Stroke Reperfusion Candidates: A Cluster Randomized Controlled Trial.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Author Response: Prehospital Telestroke vs Paramedic Scores to Accurately Identify Stroke Reperfusion Candidates: A Cluster Randomized Controlled Trial.
Ranta, Anna; Scott, Imogene Mary; Manoczki, Csilla; Shyrell Tyson, Alicia Lucy; Swain, Andrew Herbert
Assessing Corneal Confocal Microscopy and Other Small Fiber Measures in Diabetic Polyneuropathy.
Gylfadottir, Sandra S. MD, PhD; Itani, Mustapha MD, PhD; Kristensen, Alexander G. MD, PhD; Nyengaard, Jens R. MD, DMSc; Sindrup, Soren Hein MD, DMSc; Jensen, Troels S. MD, DMSc; Finnerup, Nanna B. MD, DMSc; Karlsson, Pall PhD
doi : 10.1212/WNL.0000000000206902
Damage to small nerve fibers is common in diabetic polyneuropathy (DPN), and the diagnosis of DPN relies on subjective symptoms and signs in a combination with objective confirmatory tests, typically electrophysiology or intraepidermal nerve fiber density (IENFD) from skin biopsy.
Association of Employment Status With Symptom Burden and Health-Related Quality of Life in People Living With Primary CNS Tumors.
Leeper, Heather E. MD, MS; Vera, Elizabeth MS; Christ, Alexa; Acquaye, Alvina MC; Briceno, Nicole MS; Choi, Anna; Grajkowska, Ewa; Jammula, Varna; Levine, Jason MD; Lindsley, Matthew MPH, MSN, RN; Reyes, Jennifer; Roche, Kayla N.; Rogers, James L.; Timmer, Michael; Boris, Lisa MSN, CRNP; Burton, Eric MD; Lollo, Nicole MSN, CRNP; Panzer, Marissa DNP, AGNP, AONP; Penas-Prado, Marta MD; Pillai, Valentina MSN, CRNP; Polskin, Lily MSN, AGACNP-BC; Theeler, Brett J. MD; Wu, Jing MD, PhD; Gilbert, Mark R. MD; Armstrong, Terri S. PhD, ANP-BC
doi : 10.1212/WNL.0000000000207082
Financial toxicity significantly affects many patients, especially cancer survivors. We evaluated the association of unemployment as a major contributor to financial toxicity with patient-reported outcomes (PROs) assessing multiple illness experience domains in a primary CNS tumor (PCNST) cohort.
