Laura P. Cohen, MD, MPP1,2,3; Nicolas Isaza, MD2,4; Inmaculada Hernandez, PharmD, PhD5; Gregory D. Lewis, MD1,2; Jennifer E. Ho, MD2,4; Gregg C. Fonarow, MD6,7; Dhruv S. Kazi, MD, MSc, MS2,4,8; Brandon K. Bellows, PharmD, MS9
doi : 10.1001/jamacardio.2023.0077
Importance Adding a sodium-glucose cotransporter-2 inhibitor (SGLT2-I) to standard-of-care treatment in patients with heart failure with preserved ejection fraction (HFpEF) reduces the risk of a composite outcome of worsening heart failure or cardiovascular mortality, but the cost-effectiveness in US patients with HFpEF is uncertain.
Catherine O. Johnson, PhD, MPH1; Nicole K. DeCleene, BS1; Brigette F. Blacker, MPH1; Matthew W. Cunningham, MS1; Aleksandr Aravkin, PhD1,2; Joseph L. Dieleman, PhD1,2; Emmanuela Gakidou, PhD1,2; Mohsen Naghavi, MD, PhD1,2; Modele O. Ogunniyi, MD, MPH3; Peng Zheng, PhD1,2; Gregory A. Roth, MD, MPH1,2,4
doi : 10.1001/jamacardio.2023.0112
Importance Cardiovascular disease (CVD) is the leading cause of death in the US, with considerable variation by both state and race and ethnicity group. Consistent, comparable measures of mortality by specific CVD cause at the state level and by race and ethnicity have not previously been available and are necessary for supporting policy decisions aimed at reducing health inequities.
Joshua A. Jacobs, PharmD1; Daniel K. Addo, MS1; Alexander R. Zheutlin, MD, MS2; Catherine G. Derington, PharmD, MS1; Utibe R. Essien, MD, MPH3,4; Ann Marie Navar, MD, PhD5,10; Inmaculada Hernandez, PharmD, PhD6; Donald M. Lloyd-Jones, MD, ScM7; Jordan B. King, PharmD, MS1,8; Shreya Rao, MD, MPH5; Jennifer S. Herrick, MS9; Adam P. Bress, PharmD, MS1; Ambarish Pandey, MD, MSCS5
doi : 10.1001/jamacardio.2023.0228
Importance The burden of atherosclerotic cardiovascular disease (ASCVD) in the US is higher among Black and Hispanic vs White adults. Inclusion of race in guidance for statin indication may lead to decreased disparities in statin use.
Jenica N. Upshaw, MD, MS1,2; Jason Nelson, MPH2; Angie Mae Rodday, PhD2; Anita J. Kumar, MD2,3; Andreas K. Klein, MD3; Marvin A. Konstam, MD1; John B. Wong, MD2; Iris Z. Jaffe, MD, PhD1,4; Bonnie Ky, MD5; Jonathan W. Friedberg, MD6; Matthew Maurer, PhD7; David M. Kent, MD2; Susan K. Parsons, MD2,3
doi : 10.1001/jamacardio.2023.0303
Importance Anthracycline-containing regimens are highly effective for diffuse large B-cell lymphoma (DLBCL); however, patients with preexisting heart failure (HF) may be less likely to receive anthracyclines and may be at higher risk of lymphoma mortality.
Ajay J. Kirtane, MD, SM1,2; Andrew S. P. Sharp, MD3; Felix Mahfoud, MD, MA4,5; Naomi D. L. Fisher, MD6; Roland E. Schmieder, MD7; Joost Daemen, MD, PhD8; Melvin D. Lobo, PhD9; Philipp Lurz, MD, PhD10; Jan Basile, MD11; Michael J. Bloch, MD12; Michael A. Weber, MD13; Manish Saxena, MBBS, MSc9; Yale Wang, MD14; Kintur Sanghvi, MD15; J. Stephen Jenkins, MD16; Chandan Devireddy, MD17; Florian Rader, MD, MSc18; Philippe Gosse, MD19; Marc Sapoval, MD20,21,22; Neil C. Barman, MD23; Lisa Claude, MS23; Dimitri Augustin, MD23; Lisa Thackeray, MS24; Christopher M. Mullin, MS24; Michel Azizi, MD, PhD20,21,22; for the RADIANCE Investigators and Collaborators
doi : 10.1001/jamacardio.2023.0338
Importance Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP) in patients with uncontrolled hypertension (HTN). Establishing the magnitude and consistency of the uRDN effect across the HTN spectrum is clinically important.
Girish M. Nair, MBBS, MSc1; David H. Birnie, MB, ChB1; Pablo B. Nery, MD1; Calum J. Redpath, MB, ChB, PhD1; Jean-Francois Sarrazin, MD2; Jean-Francois Roux, MD3; Ratika Parkash, MD4; Martin Bernier, MD5; Laurence D. Sterns, MD6; John Sapp, MD4; Paul Novak, MD6; George Veenhuyzen, MD7; Carlos A. Morillo, MD7; Sheldon M. Singh, MD8; Mouhannad M. Sadek, MD1; Mehrdad Golian, MD1; Andres Klein, MD1; Marcio Sturmer, MD9; Vijay S. Chauhan, MD10; Paul Angaran, MD11; Martin S. Green, MD1; Jordan Bernick, MSc1; George A. Wells, PhD1; Vidal Essebag, MD, PhD5,9
doi : 10.1001/jamacardio.2023.0212
Importance Recurrent atrial fibrillation (AF) commonly occurs after catheter ablation and is associated with patient morbidity and health care costs.
Hui-Chen Han, MBBS, PhD1,2; Jia Wang, MSc3; David H. Birnie, MD4; Marco Alings, MD, PhD5; François Philippon, MD6; Ratika Parkash, MD, MSc7; Jaimie Manlucu, MD8; Paul Angaran, MD9; Claus Rinne, MD10; Benoit Coutu, MD11; R. Aaron Low, MD12; Vidal Essebag, MD, PhD13,14; Carlos Morillo, MD15; Jeffrey S. Healey, MD16; Damian Redfearn, MD17; Satish Toal, MD18; Giuliano Becker, MD14; Michel DeGrâce, MD19; Bernard Thibault, MD20; Eugene Crystal, MD21; Stanley Tung, MD22; John LeMaitre, MD23; Omar Sultan, MD24; Matthew Bennett, MD25; Jamil Bashir, MD1; Felix Ayala-Paredes, MD, PhD26; Philippe Gervais, MD6; Leon Rioux, MD27; Martin E. W. Hemels, MD, PhD28,29; Leon H. R. Bouwels, MD30; Derek V. Exner, MD14; Paul Dorian, MD9; Stuart J. Connolly, MD3; Yves Longtin, MD31; Andrew D. Krahn, MD1
doi : 10.1001/jamacardio.2023.0467
Importance Cardiac implantable electronic device (CIED) infection is a potentially devastating complication with an estimated 12-month mortality of 15% to 30%. The association of the extent (localized or systemic) and timing of infection with all-cause mortality has not been established.
Adam J. Nelson, MBBS, MBA, MPH, PhD1; Zachary K. Wegermann, MD1; Dianne Gallup, MS1; Sean O’Brien, PhD1; Andrzej S. Kosinski, PhD1; Vinod H. Thourani, MD2; Dharam J. Kumbhani, MD, SM3; Ajay Kirtane, MD, SM4,5,6; Joseph Allen, MSc7; John D. Carroll, MD8; David M. Shahian, MD9; Nimesh D. Desai, MD, PhD10; Ralph G. Brindis, MD, MPH11; Eric D. Peterson, MD, MPH3; David J. Cohen, MD, MSc5,12; Sreekanth Vemulapalli, MD1
doi : 10.1001/jamacardio.2023.0477
Importance Professional societies and the Centers for Medicare & Medicaid Services suggest volume thresholds to ensure quality in transcatheter aortic valve implantation (TAVI).
Thomas A. Zelniker, MD, MSc1; Stephen D. Wiviott, MD2; Ofri Mosenzon, MD, MSc3; Erica L. Goodrich, MS2; Petr Jarolim, MD, PhD4; Avivit Cahn, MD3; Deepak L. Bhatt, MD, MPH5; Lawrence A. Leiter, MD6; Darren K. McGuire, MD, MHSc7; John Wilding, MD8; Oleg Averkov, MD9; Andrzej Budaj, MD10; Alexander Parkhomenko, MD11; Kausik K. Ray, MBChB12; Ingrid Gause-Nilsson, MD, PhD13; Anna Maria Langkilde, MD, PhD13; Martin Fredriksson, PhD13; Itamar Raz, MD3; Marc S. Sabatine, MD, MPH2,14; David A. Morrow, MD, MPH2
doi : 10.1001/jamacardio.2023.0019
Importance Dapagliflozin reduces the risk of hospitalizations for heart failure and the progression of chronic kidney disease in patients with and without type 2 diabetes (T2D), whereas the effects on reducing atherosclerotic events appear less clear.
Sara S. Inglis, MB, BCh, BAO1
Alexander T. Sandhu, MD, MS1,2; David J. Cohen, MD, MSc3,4
Robert O. Bonow, MD, MS1,2
Ana Barac, MD, PhD1
Joseph M. Kim, MD1; Bradley A. Maron, MD2
Christopher C. Cheung, MD, MPH1; Edward P. Gerstenfeld, MD, MS1
Mohammad A. Zafar, MBBS1; John A. Elefteriades, MD1
Matthew D. Solomon, MD, PhD1,2; David H. Liang, MD, PhD3; Alan S. Go, MD2
Shichu Liang, MD1; Min Ma, MD, PhD1,2; Yong He, MD1
Shamir R. Mehta, MD, MSc1; Natalia Pinilla-Echeverri, MD1; John A. Cairns, MD2
Clyde W. Yancy, MD, MSc1,2; Gregg C. Fonarow, MD3,4; Patrick T. O’Gara, MD2,5
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