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Aims+Scope/Editorial Board/Publication information
doi : 10.1016/S0167-8140(23)00189-5
Volume 182, May 2023, 109651
Radiotherapy dosimetry at multiple levels to improve precision, development and understanding of treatment
Dietmar Georg a,b,⇑, Marianne C Aznar c,d , Uulke van der Heide e,f , David Thwaites
doi : 10.1016/j.radonc.2023.109601
Volume 182, May 2023, 109601
State-of-the-art and potential of experimental microdosimetry in ion-beam therapy
Giulio Magrin a , Hugo Palmans a,b , Markus Stock a,c , Dietmar Georg
doi : 10.1016/j.radonc.2023.109586
Volume 182, May 2023, 109586
In radiotherapy, radiation-quality should be an expression of the biological and physical characteristics of ionizing radiation such as spatial distribution of ionization or energy deposition. Linear energy transfer (LET) and lineal energy (y) are two descriptors used to quantify the radiation quality. These two quantities are connected and exhibit similar features.
Modelling tissue specific RBE for different radiation qualities based on a multiscale characterization of energy deposition
Erik Almhagen a,b,1,⇑, Fernanda Villegas c , Nina Tilly a,d , Lars Glimelius e , Erik Traneus e , Anders Ahnesjö
doi : 10.1016/j.radonc.2023.109539
Volume 182, May 2023, 109539
We present the nanoCluE model, which uses nano- and microdosimetric quantities to model RBE for protons and carbon ions. Under the hypothesis that nano- and microdosimetric quantities correlates with the generation of complex DNA double strand breakes, we wish to investigate whether an improved accuracy in predicting LQ parameters may be achieved, compared to some of the published RBE models.
3D printed 2D range modulators preserve radiation quality on a microdosimetric scale in proton and carbon ion beams
Sandra Barna a,⇑, Cynthia Meouchi b , Andreas Franz Resch a , Giulio Magrin c , Dietmar Georg a,c , Hugo Palmans
doi : 10.1016/j.radonc.2023.109525
Volume 182, May 2023, 109525
Particle therapy using pencil beam scanning (PBS) faces large uncertain- ties related to ranges and target motion. One possibility to improve existing mitigation strategies is a 2D range modulator (2DRM). A 2DRM offers faster irradiation times by reducing the number of layers and spots needed to create a spread-out Bragg peak. We have investigated the impact of 2DRM on microdosimetric spectra measured in proton and carbon ion beams.
Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D
Johannes Soltwedel a,b,c,1 , Theresa Suckert a,d,e,1 , Elke Beyreuther a,f , Moritz Schneider a,f , Marc Boucsein g,h , Elisabeth Bodenstein a,b , Sindi Nexhipi a,b , Liane Stolz-Kieslich a,d , Mechthild Krause a,b,d,i,j , Cläre von Neubeck a,d,k , Robert Haase c , Armin Lühr a,b,l,2 , Antje Dietrich
doi : 10.1016/j.radonc.2023.109591
Volume 182, May 2023, 109591
Comprehending cellular changes of radiation-induced brain injury is crucial to prevent and treat the pathology. We provide a unique open dataset of proton-irradiated mouse brains consisting of medical imaging, radiation dose simulations, and large-scale microscopy images, all registered into a common coordinate system. This allows dose-dependent analyses on single-cell level.
Treatment plan optimisation for reirradiation
Louise Murray a,b,⇑, Christopher Thompson c , Christopher Pagett c , John Lilley c , Bashar Al-Qaisieh c , Stina Svensson d , Kjell Eriksson d , Michael Nix c , Michael Aldred c , Lynn Aspin c , Stephen Gregory c , Ane Appelt
doi : 10.1016/j.radonc.2023.109545
Volume 182, May 2023, 109545
The STRIDeR (Support Tool for Re-Irradiation Decisions guided by Radiobiology) project aims to create a clinically viable re-irradiation planning pathway within a commercial treatment planning system (TPS).
Challenges of re-irradiation: A call to arms for physicists - and radiotherapy vendors
Eliana Vasquez Osorio a,⇑, Charles Mayo b , Andrew Jackson c , Ane Appelt
doi : 10.1016/j.radonc.2023.109585
Volume 182, May 2023, 109585
Interfractional dose accumulation for MR-guided liver SBRT: Variation among algorithms is highly patient- and fraction-dependent
Isak Wahlstedt a,b,c,⇑, Abraham George Smith b,d , Claus Erik Andersen a , Claus Preibisch Behrens a,c , Susanne Nørring Bekke c , Kristian Boye b , Mette van Overeem Felter c , Mirjana Josipovic b,f , Jens Petersen b,d , Signe Lenora Risumlund b , José David Tascón-Vidarte d , Janita Elizabeth van Timmeren e , Ivan Richter Vogelius
doi : 10.1016/j.radonc.2022.109448
Volume 182, May 2023, 109448
Daily plan adaptations could take the dose delivered in previous fractions into account. Due to high dose delivered per fraction, low number of fractions, steep dose gradients, and large interfractional organ deformations, this might be particularly important for liver SBRT. This study investigates inter-algorithm variation of interfractional dose accumulation for MR-guided liver SBRT.
Applicability and usage of dose mapping/accumulation in radiotherapy
Martina Murr a,⇑, Kristy K. Brock b , Marco Fusella c , Nicholas Hardcastle d , Mohammad Hussein e , Michael G Jameson f , Isak Wahlstedt g,h,i , Johnson Yuen j,k,l , Jamie R McClelland m,1 , Eliana Vasquez Osorio
doi : 10.1016/j.radonc.2023.109527
Volume 182, May 2023, 109527
Dose mapping/accumulation (DMA) is a topic in radiotherapy (RT) for years, but has not yet found its widespread way into clinical RT routine.
Liver SBRT dose accumulation to assess the impact of anatomic variations on normal tissue doses and toxicity in patients treated with concurrent sorafenib
Jasmine Chen a , Jean-Pierre Bissonnette a,b,c,d , Tim Craig a,b , Pablo Munoz-Schuffenegger a,b , Tony Tadic a,b , Laura A. Dawson a,b , Michael Velec
doi : 10.1016/j.radonc.2023.109588
Volume 182, May 2023, 109588
Unexpected liver volume reductions occurred during trials of liver SBRT and concurrent sorafenib. The aims were to accumulate liver SBRT doses to assess the impact of these anatomic variations on normal tissue dose parameters and toxicity.
Clinical 3D/4D cumulative proton dose assessment methods for thoracic tumours with large motion
Sabine Visser ⇑, Erik W. Korevaar, Christina T. Muijs, Robin Wijsman, Johannes A. Langendijk, Pietro Pisciotta, Gabriel Gutteres Marmitt, Cássia O. Ribeiro, Stefan Both
doi : 10.1016/j.radonc.2023.109575
Volume 182, May 2023, 109575
Despite the anticipated clinical benefits of intensity-modulated proton therapy (IMPT), plan robustness may be compromised due to its sensitivity to patient treatment uncertainties, especially for tumours with large motion.
Inter- and intrafractional 4D dose accumulation for evaluating ΔNTCP robustness in lung cancer
Andreas Smolders a,b,⇑, Adriaan C. Hengeveld c , Stefan Both c , Robin Wijsman c , Johannes A. Langendijk c , Damien C. Weber a,d,e , Anthony J. Lomax a,b , Francesca Albertini a , Gabriel Guterres Marmitt
doi : 10.1016/j.radonc.2023.109488
Volume 182, May 2023, 109488
Model-based selection of proton therapy patients relies on a predefined reduction in normal tissue complication probability (NTCP) with respect to photon therapy.
Feasibility of delivered dose reconstruction for MR-guided SBRT of pancreatic tumors with fast, real-time 3D cine MRI
Guus Grimbergen a,⇑, Giulia G. Pötgens b , Hidde Eijkelenkamp a , Bas W. Raaymakers a , Martijn P.W. Intven a , Gert J. Meijer
doi : 10.1016/j.radonc.2023.109506
Volume 182, May 2023, 109506
In MR-guided SBRT of pancreatic cancer, intrafraction motion is typically monitored with (interleaved) 2D cine MRI. However, tumor surroundings are often not fully captured in these images, and motion might be distorted by through-plane movement.
Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials
Sarah M Kelly a,b,c,⇑,1 , Andrada Turcas a,b,d,1 , Coreen Corning b , Simon Bailey e , Adela Cañete f , Enrico Clementel b , Andrea di Cataldo g , Karin Dieckmann h,i , Mark N Gaze j , Gail Horan k , Meriel Jenney l , Ruth Ladenstein h , Laetitia Padovani m , Dominique Valteau-Couanet n , Tom Boterberg o , Henry Mandeville
doi : 10.1016/j.radonc.2023.109549
Volume 182, May 2023, 109549
SIOP Europe’s QUARTET project launched in 2016; aiming to improve access to high-quality radiotherapy for children and adolescents treated within clinical trials across Europe.
Prioritizing clinical trial quality assurance for photons and protons: A failure modes and effects analysis (FMEA) comparison
Paige A. Taylor a,b,⇑, Elizabeth Miles v , Lone Hoffmann c,d , Sarah M. Kelly e,f,g , Stephen F. Kry a,b , Ditte Sloth Møller c,d , Hugo Palmans h,i , Kamal Akbarov j , Marianne C. Aznar k , Enrico Clementel f , Coreen Corning f , Rachel Effeney l , Brendan Healy m , Alisha Moore n , Mitsuhiro Nakamura o , Samir Patel p , Maddison Shaw m,q , Markus Stock h,r , Joerg Lehmann n,s,t,u,1 , Catharine H. Clark
doi : 10.1016/j.radonc.2023.109494
Volume 182, May 2023, 109494
The Global Clinical Trials RTQA Harmonization Group (GHG) set out to evaluate and prioritize clinical trial quality assurance.
Tools for large-scale data analytics of an international multi-center study in radiation oncology for cervical cancer
Stefan Ecker a,⇑, Christian Kirisits a , Maximilian Schmid a , Astrid De Leeuw b , Yvette Seppenwoolde d , Johannes Knoth a , Petra Trnkova a , Gerd Heilemann a , Alina Sturdza a , Kathrin Kirchheiner a , Sofia Spampinato c , Monica Serban e , Ina Jürgenliemk-Schulz b , Supriya Chopra f , Remi Nout d , Kari Tanderup c , Richard Pötter a , Nicole Eder-Nesvacil
doi : 10.1016/j.radonc.2023.109524
Volume 182, May 2023, 109524
To develop and implement a software that enables centers, treating patients with state-of-the-art radiation oncology, to compare their patient, treatment, and outcome data to a reference cohort, and to assess the quality of their treatment approach.
Characterizing the interplay of treatment parameters and complexity and their impact on performance on an IROC IMRT phantom using machine learning
Hunter Mehrens a,b,d , Andrea Molineu a,b , Nadia Hernandez a , Laurence Court b,d , Rebecca Howell b,d , David Jaffray b , Christine B. Peterson c,d , Julianne Pollard-Larkin b,d , Stephen F. Kry
doi : 10.1016/j.radonc.2023.109577
Volume 182, May 2023, 109577
To elucidate the important factors and their interplay that drive performance on IMRT phantoms from the Imaging and Radiation Oncology Core (IROC).
Knowledge-based adaptive planning quality assurance using dosimetric indicators for stereotactic adaptive radiotherapy for pancreatic cancer
Farnoush Forghani a,⇑, John S. Ginn b , Joshua P. Schiff a , Tong Zhu a , Luke Marut a , Eric Laugeman a , Borna Maraghechi a , Shahed N. Badiyan a , Pamela P. Samson a , Hyun Kim a , Clifford G. Robinson a , Geoffrey D. Hugo a , Lauren E. Henke a , Alex T. Price
doi : 10.1016/j.radonc.2023.109603
Volume 182, May 2023, 109603
We aimed to develop knowledge-based tools for robust adaptive radiotherapy (ART) planning to determine on-table adaptive DVH metric variations or planning process errors for stereotactic pancreatic ART. We developed volume-based dosimetric identifiers to identify deviations of ART plans from simulation plans.
Multi-center dosimetric predictions to improve plan quality for brachytherapy for cervical cancer treatment
Dominique M.W. Reijtenbagh a,⇑, Jérémy Godart a , Astrid A.C. de Leeuw b , Ina M. Jürgenliemk-Schulz b , Jan-Willem M. Mens a , Michèle Huge a , Mischa S. Hoogeman
doi : 10.1016/j.radonc.2023.109518
Volume 182, May 2023, 109518
Image-guided adaptive brachytherapy (IGABT) is an important modality in the cervical cancer treatment, and plan quality is sensitive to time pressure in the workflow. Patient anatomy-based quality-assurance (QA) with overlap volume histograms (OVHs) has been demonstrated to detect suboptimal plans (outliers).
A radiomics approach for predicting acute hematologic toxicity in patients with cervical or endometrial cancer undergoing external-beam radiotherapy
Ziyu Le a,1 , Dongmei Wu b,1 , Xuming Chen a,1 , Lei Wang c , Yi Xu a , Guoqi Zhao a , Chengxiu Zhang b , Ying Chen a , Ye Hu a , Shengyu Yao a , Tingfeng Chen a , Jiangping Ren d,⇑, Guang Yang b,⇑, Yong Liu
doi : 10.1016/j.radonc.2023.109489
Volume 182, May 2023, 109489
This study is purposed to establish a predictive model for acute severe hematologic toxicity (HT) during radiotherapy in patients with cervical or endometrial cancer and investigate whether the integration of clinical features and computed tomography (CT) radiomics features of the pelvic bone marrow (BM) could define a more precise model.
Patient anatomy-specific trade-offs between sub-clinical disease coverage and normal tissue dose reduction in head-and-neck cancer
Laura Patricia Kaplan a,b,c,d,⇑, Anne Ivalu Sander Holm a , Jesper Grau Eriksen a,b , Ben J.M. Heijmen d , Stine Sofia Korreman a,b,c , Linda Rossi
doi : 10.1016/j.radonc.2023.109526
Volume 182, May 2023, 109526
Risk of subclinical disease decreases with increasing distance from the GTV in head- and-neck squamous cell carcinoma (HNSCC). Depending on individual patient anatomy, OAR sparing could be improved by reducing target coverage in regions with low risk of subclinical spread.
Evaluation of real-time tumor contour prediction using LSTM networks for MR-guided radiotherapy
Elia Lombardo a , Moritz Rabe a , Yuqing Xiong a , Lukas Nierer a , Davide Cusumano b , Lorenzo Placidi b , Luca Boldrini b , Stefanie Corradini a , Maximilian Niyazi a , Michael Reiner a , Claus Belka a,c , Christopher Kurz a , Marco Riboldi d , Guillaume Landry
doi : 10.1016/j.radonc.2023.109555
Volume 182, May 2023, 109555
Magnetic resonance imaging guided radiotherapy (MRgRT) with deformable multileaf collimator (MLC) tracking would allow to tackle both rigid displacement and tumor deformation without prolonging treatment.
Benefits of automated gross tumor volume segmentation in head and neck cancer using multi-modality information
Heleen Bollen a,⇑,1 , Siri Willems b,1 , Marilyn Wegge a , Frederik Maes b , Sandra Nuyts
doi : 10.1016/j.radonc.2023.109574
Volume 182, May 2023, 109574
Gross tumor volume (GTV) delineation for head and neck cancer (HNC) radiation therapy planning is time consuming and prone to interobserver variability (IOV).
Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study
Indra J. Das a,⇑, Poonam Yadav a , Aaron D. Andersen b , Zhe Jay Chen c , Long Huang d , Mark P. Langer e , Choonik Lee f , Lin Li g , Richard A. Popple h , Roger K. Rice i , Peter B. Schiff j , Timothy C. Zhu k , Mohamed E. Abazeed
doi : 10.1016/j.radonc.2023.109571
Volume 182, May 2023, 109571
Radiation dose prescriptions are foundational for optimizing treatment efficacy and limiting treatment-related toxicity. We sought to assess the lack of standardization of SBRT dose prescriptions across institutions.
Metrics of dose to highly ventilated lung are predictive of radiation-induced pneumonitis in lung cancer patients
Mattison J. Flakus a , Sean P. Kent b , Eric M. Wallat a , Antonia E. Wuschner a , Erica Tennant c , Poonam Yadav d , Adam Burr e , Menggang Yu f , Gary E Christensen g , Joseph M. Reinhardt h , John E. Bayouth i , Andrew M. Baschnagel
doi : 10.1016/j.radonc.2023.109553
Volume 182, May 2023, 109553
To identify metrics of radiation dose delivered to highly ventilated lung that are predictive of radiation-induced pneumonitis.
Should organs at risk (OARs) be prioritized over target volume coverage in stereotactic ablative radiotherapy (SABR) for oligometastases? a secondary analysis of the population-based phase II SABR-5 trial
Reno Eufemon Cereno a,b , Benjamin Mou a,b , Sarah Baker a,c , Nick Chng d , Gregory Arbour a , Alanah Bergman a,e , Mitchell Liu a,e , Devin Schellenberg a,c , Quinn Matthews d , Vicky Huang c , Ante Mestrovic f , Derek Hyde b , Abraham Alexander a,f , Hannah Carolan a,e , Fred Hsu a,g , Stacy Miller a,d , Siavash Atrchian a,b , Elisa Chan a,e , Clement Ho a,c , Islam Mohamed a,b , Angela Lin a,b , Tanya Berrang a,f , Andrew Bang a,e , Will Jiang a,d , Chad Lund a,c , Howard Pai a,f , Boris Valev a,f , Shilo Lefresne a,e , Scott Tyldesley a,e , Robert A. Olson
doi : 10.1016/j.radonc.2023.109576
Volume 182, May 2023, 109576
Stereotactic ablative radiotherapy (SABR) for oligometastases may improve survival, however concerns about safety remain. To mitigate risk of toxicity, target coverage was sacrificed to prioritize organs-at-risk (OARs) during SABR planning in the population-based SABR-5 trial. This study evaluated the effect of this practice on dosimetry, local recurrence (LR), and progression-free survival (PFS).
Dosimetric benefit of a library of plans versus single-plan strategy for pre-operative gastric cancer radiotherapy
Margot Bleeker a,⇑, Jorrit Visser a , Karin Goudschaal a , Arjan Bel a , Maarten C.C.M. Hulshof a , Jan-Jakob Sonke a,b , Astrid van der Horst
doi : 10.1016/j.radonc.2023.109582
Volume 182, May 2023, 109582
The stomach experiences large volume and shape changes during pre-operative gastric radiotherapy. This study evaluates the dosimetric benefit for organs-at-risk (OARs) of a library of plans (LoP) compared to the traditional single-plan (SP) strategy.
Computed tomography and radiation dose images-based deep-learning model for predicting radiation pneumonitis in lung cancer patients after radiation therapy
Zhen Zhang a,b,1 , Zhixiang Wang b,c,1 , Tianchen Luo d , Meng Yan e , Andre Dekker b , Dirk De Ruysscher b , Alberto Traverso b , Leonard Wee b,2 , Lujun Zhao
doi : 10.1016/j.radonc.2023.109581
Volume 182, May 2023, 109581
To develop a deep learning model that combines CT and radiation dose (RD) images to predict the occurrence of radiation pneumonitis (RP) in lung cancer patients who received radical (chemo)radiotherapy.
Evaluation of the four-dimensional motion of lung tumors during end-exhalation breath-hold conditions using volumetric cine computed tomography images
Tatsuya Kamima a,b,⇑, Misae Iino a , Ryohei Sakai a , Yasushi Ito a , Takeji Sakae b , Shunsuke Moriya b , Kenji Tokumasu a , Yasuo Yoshioka
doi : 10.1016/j.radonc.2023.109573
Volume 182, May 2023, 109573
This study was performed to evaluate the four-dimensional motion of lung tumors during end-exhalation (EE) breath-holding (BH) using cine computed tomography (CT) and investigate the correlation between tumor and surrogate marker motions.
Same-day adaptive palliative radiotherapy without prior CT simulation: Early outcomes in the FAST-METS study
Koen J. Nelissen a,b,⇑, Eva Versteijne a,b , Suresh Senan a,b , Barbara Rijksen a , Marjan Admiraal a , Jorrit Visser a , Sarah Barink a , Amy L. de la Fuente a , Daan Hoffmans a,b , Ben J. Slotman a,b , Wilko F.A.R. Verbakel
doi : 10.1016/j.radonc.2023.109538
Volume 182, May 2023, 109538
Standard palliative radiotherapy workflows involve waiting times or multiple clinic visits. We developed and implemented a rapid palliative workflow using diagnostic imaging (dCT) for pre-planning, with subsequent on-couch target and plan adaptation based on a synthetic computed tomography (CT) obtained from cone-beam CT imaging (CBCT).
Radiation-induced inferior brachial plexopathy after stereotactic body radiotherapy: Pooled analyses of risks
Michael T. Milano a,⇑, Panayiotis Mavroidis b , Jeff Ryckman d , Ellen Yorke c , Christopher Doucette a , Anand Mahadevan g , Irina Kapitanova e , Feng-Ming (Spring) Kong f , Lawrence B. Marks b , Jimm Grimm
doi : 10.1016/j.radonc.2023.109583
Volume 182, May 2023, 109583
Radiation-induced brachial plexopathy (RIBP), resulting in symptomatic motor or sensory deficits of the upper extremity, is a risk after exposure of the brachial plexus to therapeutic doses of radiation. We sought to model dosimetric factors associated with risks of RIBP after stereotactic body radiotherapy (SBRT).
