Dose Response in Antivascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Is It Only the Number of Injections?

Maguire, Maureen G. PhD

doi : 10.1097/IAE.0000000000003117

Retina: June 2021 - Volume 41 - Issue 6 - p 1141-1142

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FOVEA-SPARING VERSUS COMPLETE INTERNAL LIMITING MEMBRANE PEELING IN VITRECTOMY FOR VITREOMACULAR INTERFACE DISEASES

Wang, Yuelin MD*,†; Zhao, Xinyu MD*,†; Zhang, Wenfei MD*,†; Yang, Jingyuan MD*,†; Chen, Youxin MD, PhD

doi : 10.1097/IAE.0000000000003140

Retina: June 2021 - Volume 41 - Issue 6 - p 1143-1152

To evaluate fovea-sparing internal limiting membrane (ILM) peeling in vitrectomy compared with traditional complete ILM peeling in vitreomacular interface diseases, including macular hole (MH), epiretinal membrane, macular foveoschisis, myopic traction maculopathy, and the like.

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ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR DOSING AND EXPECTED ACUITY OUTCOME AT 1 YEAR

Spaide, Richard F. MD

doi : 10.1097/IAE.0000000000003116

Retina: June 2021 - Volume 41 - Issue 6 - p 1153-1163

To determine the dose–response characteristics of the antivascular endothelial growth factor agents ranibizumab and aflibercept in neovascular age-related macular degeneration using published randomized trials and observational series.

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SIX MONTHS PRIMARY SUCCESS RATE FOR RETINAL DETACHMENT BETWEEN VITRECTOMY AND SCLERAL BUCKLING

Koto, Takashi MD, PhD*; Kawasaki, Ryo MD, PhD†; Yamakiri, Keita MD, PhD‡; Baba, Takayuki MD, PhD§; Nishitsuka, Koichi MD, PhD¶; Hirakata, Akito MD, PhD*; Sakamoto, Taiji MD, PhD‡; on behalf of the Japan-Retinal Detachment Registry Group

doi : 10.1097/IAE.0000000000002994

Retina: June 2021 - Volume 41 - Issue 6 - p 1164-1173

To compare clinical outcomes between pars plana vitrectomy (PPV), scleral buckling (SB), and PPV+SB for rhegmatogenous retinal detachment in the Japan-RD Registry.

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COMPARING VITRECTOMY, SILICONE OIL ENDOTAMPONADE WITH/WITHOUT CYCLOPEXY TO TREAT CYCLODIALYSIS CLEFTS WITH SEVERE OCULAR TRAUMA

Wang, Anan MD*; Zhao, Zhenquan MD†

doi : 10.1097/IAE.0000000000002996

Retina: June 2021 - Volume 41 - Issue 6 - p 1174-1181

Comparing the anatomical and functional outcomes of vitrectomy, silicone oil endotamponade without cyclopexy (VEWOC) and with cyclopexy (VEWC) in patients with traumatic cyclodialysis clefts and severe ocular comorbidities.

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SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN SMALL CHOROIDAL MELANOMAS AND CHOROIDAL NEVI

Greig, Eugenia Custo BA*,†; Laver, Nora V. MD*; Mendonca, Luisa S.M. MD*,‡; Levine, Emily S. BS*; Baumal, Caroline R.*; Waheed, Nadia K. MD, MPH*; Duker, Jay S. MD*

doi : 10.1097/IAE.0000000000003053

Retina: June 2021 - Volume 41 - Issue 6 - p 1182-1192

To evaluate the use of swept-source optical coherence tomography angiography to detect distinct vascular features in small choroidal melanomas and choroidal nevi.

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SERUM LEVELS OF ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES ARE DECREASED IN PATIENTS WITH RETINAL VEIN OCCLUSION

Posch-Pertl, Laura MD*; Weger, Martin MD*; Pinter-Hausberger, Silke MD*; List, Wolfgang MD*; Posch, Florian MD, PhD, MSc†; Wedrich, Andreas MD*; Michelitsch, Katharina MD*; Kozma, Maria O. Msc‡; Woltsche, Nora MD*; Binder, Christoph J. MD, PhD‡

doi : 10.1097/IAE.0000000000003001

Retina: June 2021 - Volume 41 - Issue 6 - p 1193-1201

Oxidative stress and inflammation have been implicated in the development of retinal vein occlusion (RVO). Oxidation-specific epitopes (OSEs) represent products of oxidative stress that can trigger vascular inflammation and thrombosis. Natural occurring antibodies have been shown to bind oxidation-specific epitopes thereby inhibiting their inflammatory potential and promoting their removal.

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NONPERFUSION ASSESSMENT IN RETINAL VEIN OCCLUSION

Glacet-Bernard, Agnès MD; Miere, Alexandra MD, MSc; Houmane, Badreddine MD; Tilleul, Julien MD; Souied, Eric MD, PhD

doi : 10.1097/IAE.0000000000002993

Retina: June 2021 - Volume 41 - Issue 6 - p 1202-1209

To compare widefield optical coherence tomography angiography (OCTA) to ultra-widefield fluorescein angiography (UWFA) in the assessment of nonperfusion in retinal vein occlusion (RVO).

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NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION

Kadomoto, Shin MD; Muraoka, Yuki MD; Uji, Akihito MD, PhD; Tamiya, Ryosuke MD; Oritani, Yasuyuki MD; Kawai, Kentaro MD; Ooto, Sotaro MD, PhD; Murakami, Tomoaki MD, PhD; Iida-Miwa, Yuko MD, PhD; Tsujikawa, Akitaka MD, PhD

doi : 10.1097/IAE.0000000000002999

Retina: June 2021 - Volume 41 - Issue 6 - p 1210-1218

To precisely quantify retinal nonperfusion areas (NPAs) in branch retinal vein occlusion using widefield optical coherence tomography angiography (OCTA) and examine their association with neovascular complications.

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ANGIOGRAPHIC RISK FACTORS FOR RECURRENCE OF MACULAR EDEMA ASSOCIATED WITH BRANCH RETINAL VEIN OCCLUSION

Kogo, Takahiro MD; Muraoka, Yuki MD, PhD; Uji, Akihito MD, PhD; Ooto, Sotaro MD, PhD; Murakami, TOMOAKI MD, PhD; Kadomoto, Shin MD; Iida-Miwa, Yuko MD, PhD; Miyake, Masahiro MD, PhD, MPH; Miyata, Manabu MD, PhD; Tsujikawa, Akitaka MD, PhD

doi : 10.1097/IAE.0000000000003026

Retina: June 2021 - Volume 41 - Issue 6 - p 1219-1226

To examine angiographic risk factors for the recurrence of macular edema associated with branch retinal vein occlusion.

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GAP IN CAPILLARY PERFUSION AND BURDEN OF TREATMENT IN BRANCH RETINAL VEIN OCCLUSION

Bae, Kunho MD*; Bang, Seul-Ki MD†; Kang, Se Woong PhD‡; Kim, Eung Suk PhD†; Yu, Seung-Young PhD†

doi : 10.1097/IAE.0000000000003006

Retina: June 2021 - Volume 41 - Issue 6 - p 1227-1235

To evaluate correlations between the burden of antivascular endothelial growth factor treatment and microperfusion status in superficial capillary plexus and deep capillary plexus (SCP and DCP) using wide-field optical coherence tomography angiography.

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LONGITUDINAL CHANGES IN QUANTITATIVE AUTOFLUORESCENCE DURING PROGRESSION FROM INTERMEDIATE TO LATE AGE-RELATED MACULAR DEGENERATION

Reiter, Gregor S. MD*,†; Hacker, Valentin MD†; Told, Reinhard MD, PhD†; Schranz, Markus MD†; Krotka, Pavla BSc‡; Schlanitz, Ferdinand G. MD, PhD†; Sacu, Stefan MD†; Pollreisz, Andreas MD†; Schmidt-Erfurth, Ursula MD*,†

doi : 10.1097/IAE.0000000000002995

Retina: June 2021 - Volume 41 - Issue 6 - p 1236-1241

To prospectively investigate the development of quantitative autofluorescence (qAF) during progression from intermediate to late age-related macular degeneration (AMD).

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CLINICAL OUTCOMES AND TREATMENT COURSE OF EYES WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION FOLLOWING THE DEVELOPMENT OF ENDOPHTHALMITIS

Koulisis, Nicole MD*,†; Moysidis, Stavros N. MD*,‡; Govindaraju, Viren K. MD*; Dersch, Anne Merrylees MD*; Capone, Antonio Jr MD*; Covert, Douglas J. MD, MPH*; Dadgostar, Hajir MD, PhD‡; Dass, A. Bawa MD*; Drenser, Kimberly A. MD, PhD*; Engstrom, Robert E. Jr MD‡; Faia, Lisa J. MD*; Garretson, Bruce R. MD*; Guerami, Amir H. MD‡; Hanscom, Thomas A. MD‡; Mahmoud, Tamer H. MD, PhD*; Margherio, Alan R. MD*; Oh, Kean T. MD*; Randhawa, Sandeep MD*; Raphaelian, Paul V. MD*; Rhoades, William R. MD*; Ruby, Alan J. MD*; Sanfilippo, Christian J. MD‡; Sneed, Scott R. MD*; Trese, Michael T. MD*; Wolfe, Jeremy D. MD, MS*; Williams, George A. MD*; Yedavally, Sunita DO*; Hassan, Tarek S. MD*

doi : 10.1097/IAE.0000000000002998

Retina: June 2021 - Volume 41 - Issue 6 - p 1242-1250

To evaluate the clinical course of patients with neovascular age-related macular degeneration (nAMD) after developing endophthalmitis during their treatment with intravitreal injections.

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LONG-TERM CHANGES IN CHOROIDAL THICKNESS IN EYES WITH TYPE 3 MACULAR NEOVASCULARIZATION

Kim, Jae Hui MD; Kim, Jong Woo MD; Kim, Chul Gu MD; Lee, Dong Won MD

doi : 10.1097/IAE.0000000000003010

Retina: June 2021 - Volume 41 - Issue 6 - p 1251-1258

To evaluate the long-term changes in subfoveal choroidal thickness (SCT) in eyes with Type 3 macular neovascularization that underwent anti–vascular endothelial growth factor therapy.

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SUSPENDED SCATTERING PARTICLES IN MOTION MAY INFLUENCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VESSEL DENSITY METRICS IN EYES WITH DIABETIC MACULAR EDEMA

Maltsev, Dmitrii S. MD, PhD*; Kulikov, Alexei N. MD, DSc*; Kazak, Alina A. MD*; Freund, K. Bailey MD†,‡,§

doi : 10.1097/IAE.0000000000003016

Retina: June 2021 - Volume 41 - Issue 6 - p 1259-1264

To study the effect of the suspended scattering particles in motion (SSPiM) on optical coherence tomography angiography (OCTA) vessel density metrics in eyes with diabetic macular edema (DME).

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NOVEL THREE TYPES OF NEOVASCULARIZATION ELSEWHERE DETERMINE THE DIFFERENTIAL CLINICAL FEATURES OF PROLIFERATIVE DIABETIC RETINOPATHY

Pan, Jiandong MD*; Chen, Feng MD, PhD*; Chen, Ding MD*; Yang, Xiaoling MD*; Wang, Jie MD†; Chen, Zuzheng MD‡; He, Xiaojie MD*; Zhou, Tingye MD*; Zheng, Jingwei MD*; Chen, Hao MD, PhD*

doi : 10.1097/IAE.0000000000003005

Retina: June 2021 - Volume 41 - Issue 6 - p 1265-1274

To explore the pathological features and clinical significance of three types of neovascularization elsewhere (NVE) in proliferative diabetic retinopathy.

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SYSTEMIC FACTORS AND EARLY TREATMENT RESPONSE TO INTRAVITREAL INJECTION FOR DIABETIC MACULAR EDEMA

Hwang, Hyeseong MD*; Lee, Hwanho MD*; Kim, Jin Young MD†; Lee, Suhwan MD‡; Seo, Eoi Jong MD, PhD*; Chae, Ju Byung MD, PhD*; Kim, Dong Yoon MD, PhD*

doi : 10.1097/IAE.0000000000003012

Retina: June 2021 - Volume 41 - Issue 6 - p 1275-1282

To investigate the effect of systemic factors on early treatment response to intravitreal bevacizumab injection (IVBI) and intravitreal dexamethasone implant (IVDI) in patients with diabetic macular edema (DME).

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CHANGES IN SUBFOVEAL CHOROIDAL THICKNESS AFTER INTRAVITREAL DEXAMETHASONE IMPLANT THERAPY FOR DIABETIC MACULAR EDEMA

Moon, Ka Young MD; Choi, Shin Young MD; Song, Ji Hun MD, PhD

doi : 10.1097/IAE.0000000000003029

Retina: June 2021 - Volume 41 - Issue 6 - p 1283-1292

To investigate changes in subfoveal choroidal thickness (SFCT) and their relationship with best-corrected visual acuity and optical coherence tomography parameters after intravitreal dexamethasone implant injection for diabetic macular edema.

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FOLLOW-UP ADHERENCE IN PATIENTS WITH NONPROLIFERATIVE DIABETIC RETINOPATHY PRESENTING TO AN OPHTHALMIC EMERGENCY DEPARTMENT

Watane, Arjun BS; Kalavar, Meghana MHS; Vanner, Elizabeth A. PhD; Cavuoto, Kara MD; Sridhar, Jayanth MD

doi : 10.1097/IAE.0000000000003037

Retina: June 2021 - Volume 41 - Issue 6 - p 1293-1301

To determine the rate of follow-up after emergent encounters for nonproliferative diabetic retinopathy and to identify patient or visit characteristics associated with follow-up adherence.

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THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY

?abuz, Grzegorz PhD*; Rayamajhi, Asu MSc*; Khoramnia, Ramin MD, PhD*; Palczewska, Gra?yna PhD†,‡; Palczewski, Krzysztof PhD†,‡; Holschbach, Andreas MD, PhD§; Auffarth, Gerd U. MD, PhD*

doi : 10.1097/IAE.0000000000003032

Retina: June 2021 - Volume 41 - Issue 6 - p 1302-1308

Human photoreceptors are sensitive to infrared light (IR). This sensitivity can be used as a novel indicator of retinal function. Diabetic retinopathy patients were assessed using in vivo two-photon excitation and compared their scotopic IR threshold with that of healthy patients.

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REPLACEMENT OF LIDOCAINE GEL WITH TOPICAL PROPARACAINE ANESTHESIA FOR ROUTINE INTRAVITREAL INJECTIONS

Alex, Varsha MD; Singh, Sumit R. MD; Motevasseli, Tahmineh MD; Cavicchini, Melina MD; Jhingan, Mahima MD; Bartsch, Dirk-Uwe PhD; Cheng, Lingyun MD; Freeman, William R. MD

doi : 10.1097/IAE.0000000000003013

Retina: June 2021 - Volume 41 - Issue 6 - p 1309-1313

Lidocaine gel was suggested to be highly effective in providing anesthesia for intravitreal injections but adverse effects include a possibility of making sterilization of the conjunctiva difficult. Hence, we wished to determine the effect of using 0.5% proparacaine drops alone over the use of 3.5% lidocaine hydrochloride gel anesthesia during office-based intravitreal injections.

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INTERMEDIATE AND DEEP CAPILLARY PLEXUSES IN MACHINE LEARNING SEGMENTATION OF HIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY IMAGING

Spaide, Richard F. MD*; Caujolle, Sophie PhD†; Otto, Tilman PhD†

doi : 10.1097/IAE.0000000000003097

Retina: June 2021 - Volume 41 - Issue 6 - p 1314-1317

To describe imaging produced by machine learning-based segmentation of high-resolution optical coherence tomography imaging of the intermediate capillary plexus and deep capillary plexus, layers of vessels not imaged well by dye-based angiography.

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ANALYSIS OF FLUID VOLUME AND ITS IMPACT ON VISUAL ACUITY IN THE FLUID STUDY AS QUANTIFIED WITH DEEP LEARNING

Reiter, Gregor S. MD*; Grechenig, Christoph MD*; Vogl, Wolf-Dieter PhD*; Guymer, Robyn H. PhD†; Arnold, Jennifer J. MBBS‡; Bogunovic, Hrvoje PhD*; Schmidt-Erfurth, Ursula MD*

doi : 10.1097/IAE.0000000000003023

Retina: June 2021 - Volume 41 - Issue 6 - p 1318-1328

To investigate quantitative differences in fluid volumes between subretinal fluid (SRF)–tolerant and SRF-intolerant treat-and-extend regimens for neovascular age-related macular degeneration and analyze the association with best-corrected visual acuity.

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CHARACTERIZING THE NATURAL HISTORY OF FOVEAL-SPARING ATROPHIC LATE-ONSET RETINAL DEGENERATION

Borooah, Shyamanga FRCOphth, PhD*,†; Papastavrou, Vasileios T. MD‡; Lando, Leonardo MD§,¶; Moghimi, Sasan MD§; Lin, Tiezhu MD*; Dans, Kunny MD*; Motevasseli, Tahmineh MD*; Cameron, James R. FRCOphth, PhD†; Freeman, William R. MD*; Dhillon, Baljean FRCOphth†; Browning, Andrew C. PhD‡

doi : 10.1097/IAE.0000000000003017

Retina: June 2021 - Volume 41 - Issue 6 - p 1329-1337

To identify quantifiable markers of disease progression in patients with foveal-sparing atrophic late-onset retinal degeneration using fundus autofluorescence and spectral-domain optical coherence tomography imaging.

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UTILITY OF ORAL FLUORESCEIN ANGIOGRAPHY WITH ULTRA-WIDEFIELD IMAGING SYSTEM FOR EVALUATION OF VARIOUS RETINAL DISORDERS

Yamao, Sayaka MD, PhD*; Tsujioka, Taishi MD†; Takada, Ryota CO*; Matsumoto, Fumiko CO*; Kusaka, Shunji MD, PhD*

doi : 10.1097/IAE.0000000000003011

Retina: June 2021 - Volume 41 - Issue 6 - p 1338-1345

To evaluate the utility of oral fluorescein angiography with ultra-widefield imaging system (oral UWF-FA) predominantly in children.

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ISOLATED MACULOPATHY AND MODERATE ROD–CONE DYSTROPHY REPRESENT THE MILDER END OF THE RDH12-RELATED RETINAL DYSTROPHY SPECTRUM

De Zaeytijd, Julie MD*; Van Cauwenbergh, Caroline PhD*,†,‡; De Bruyne, Marieke MSc‡,§; Van Heetvelde, Mattias PhD‡,§; De Baere, Elfride MD, PhD‡,§; Coppieters, Frauke PhD‡,§; Leroy, Bart P. MD, PhD*,†,‡,¶,**

doi : 10.1097/IAE.0000000000003028

Retina: June 2021 - Volume 41 - Issue 6 - p 1346-1355

To describe an isolated maculopathy and an intermediate rod–cone dystrophy phenotype as the milder end of the RDH12-related retinal dystrophy spectrum.

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Diagnostic and Therapeutic Challenges

Binkley, Elaine M. Drs.; Biscotti, Charles V.; Singh, Annapurna; Sears, Jonathan; Singh, Arun D.; Narala, Ramsudha; Mruthyunjaya, Prithvi

doi : 10.1097/IAE.0000000000002767

Retina: June 2021 - Volume 41 - Issue 6 - p 1356-1359

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Visual Impairment in Retinitis Pigmentosa: Erratum

doi : 10.1097/IAE.0000000000003174

Retina: June 2021 - Volume 41 - Issue 6 - p e46

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