Acta Paediatrica, International Journal of Paediatrics




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Issue highlights

Anna Käll, Hugo Lagercrantz

doi : 10.1111/apa.16793

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Young Investigator Award 2022

Hugo Lagercrantz

doi : 10.1111/apa.16739

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Unique Swedish data on young children's growth help to fill the gap identified by the World Health Organization

Annika Janson

doi : 10.1111/apa.16771

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Automated oxygen control for routine use in the NICU�Are we there?

Ola Didrik Saugstad

doi : 10.1111/apa.16751

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Emerging, re-emerging and/or atypically behaving infectious diseases

Claudia Mandato, Angelo Colucci, Pietro Vajro

doi : 10.1111/apa.16744

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Multi-country outbreak of severe acute hepatitis of unknown origin in children, 2022

Irena Ilic, Milena Ilic

doi : 10.1111/apa.16685

To describe epidemiological characteristics of multi-country outbreak of severe acute hepatitis of unknown origin in children in 2022.

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Outcomes of very preterm infants with hyperglycaemia treated with insulin: A systematic review and meta-analysis

Nital Patidar, Chandra Prakash Rath, Shripada Rao, Sanjay Patole

doi : 10.1111/apa.16748

To study the outcomes of very preterm infants with hyperglycaemia treated with Insulin.

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Challenges and unique considerations of adolescents with chronic kidney disease

Nikhil Nair, Saurav Prashant Kadatane, Rita Marie Yaacoub, Jazlyn M. Sandhu, Shreeyans Bhavaraju, Rupesh Raina

doi : 10.1111/apa.16752

Chronic kidney disease (CKD) is an increasingly prevalent disease that burdens patients of all ages significantly. While much data have been gathered on adult and paediatric populations, there is a lack of data on the effects of CKD on young adults and adolescents.

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Breastfeeding provides a protective hug and the benefits have outweighed the risks during the COVID-19 pandemic

Despina D. Briana, Ariadne Malamitsi-Puchner

doi : 10.1111/apa.16769

Mothers have been very hesitant about breastfeeding when they have COVID-19 infection or vaccinations. Maternal milk protects neonates through its high biological value, immune factors and anti-infectious molecules and this review shows that the virus that causes COVID-19 is not transmitted through breast milk.

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Sir George Frederic Still (1868–1941) and his service to paediatrics and society

Stefan Kutzsche

doi : 10.1111/apa.16713

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Closed-loop oxygen system in late preterm/term, ventilated infants with different severities of respiratory disease

Ourania Kaltsogianni, Theodore Dassios, Christopher Harris, Allan Jenkinson, Rebecca Ann Lee, Masashiro Sugino, Anne Greenough

doi : 10.1111/apa.16678

To evaluate closed-loop automated oxygen control (CLAC) in ventilated infants >33 weeks of gestation with different respiratory disease severities.

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Vaccination timeliness of preterm infants hospitalised in a neonatal intensive care unit in Denmark

Christine Manich Bech Baggesgaard, Anja Poulsen, Kia Hee Schultz Dungu, Lotte Jensen, Hanna Rahimi, Lise Aunsholt, Stine Lund

doi : 10.1111/apa.16724

In Denmark, preterm infants are recommended to receive childhood vaccinations without correction for gestational age. This study aimed to describe the timeliness of the Danish Childhood Vaccination Program in preterm infants during the first 13 months of life and to evaluate possible determinants of delay.

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Dutch professionals' discussion preferences with the parents of extremely premature infants varied, but the trend was towards shared decision-making

R. Geurtzen, L. De Proost, A. A. E. Verhagen, I. K. M. Reiss, M. Hogeveen, E. J. T. Verweij

doi : 10.1111/apa.16721

We explored professionals' views on sharing decision-making with parents before and after an extremely preterm birth and what healthcare professionals considered severe outcomes.

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Bronchopulmonary dysplasia and carbon dioxide retention

Kristin O'Connor, Mark William Davies

doi : 10.1111/apa.16773

The aim of this study was to determine the pre-discharge carbon dioxide (CO2) levels of preterm neonates with bronchopulmonary dysplasia (BPD) requiring ongoing nasal cannulae oxygen therapy and who were ready for discharge home.

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Trends in cyclicity and amplitudes on amplitude-integrated electroencephalography during transition in extremely low gestational age infants

Poorva Deshpande, Julia Dirks, Amish Jain, Patrick J. McNamara, Cecil Hahn, Prakesh S. Shah, Anne-Marie Guerguerian

doi : 10.1111/apa.16761

The aim of the study was to describe amplitude integrated electroencephalography (aEEG) cyclicity, background pattern, voltage margins and maturation scores in extremely low gestational age neonates (ELGANs) in the first 72 h.

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ALPS-Neo pain and stress assessment scale for neonates—A measure for procedural pain

Bente Johanne Vederhus, Merete Susan Olsen, Geir Egil Eide, Hanne Storm, Hans Jørgen Guthe

doi : 10.1111/apa.16759

The aim of this study was to investigate psychometric properties, reliability and validity, of Astrid Lindgren and Lund Children's Hospitals Pain and Stress Assessment Scale for Preterm and Sick Newborn Infants (ALPS-Neo), as a measure for procedural pain.

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Postnatal corticosteroids and developmental outcomes in extremely preterm or extremely low birth weight infants: The Victorian Infant Collaborative Study 2016–17 cohort

Ellen Douglas, Kate A. Hodgson, Joy E. Olsen, Brett J. Manley, Calum T. Roberts, Elisha Josev, Peter J. Anderson, Lex W. Doyle, Peter G. Davis, Jeanie L. Y. Cheong, the Victorian Infant Collaborative Study Group

doi : 10.1111/apa.16696

Systemic postnatal corticosteroids are used to treat or prevent bronchopulmonary dysplasia (BPD) in extremely preterm (EP) or extremely low birth weight (ELBW) infants but are associated with long-term harm.

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Delivering high birth weight babies by emergency caesarean section may increase the risk of attention-deficit/hyperactivity disorder

Yi-Lung Chen, Ray C. Hsiao, Wen-Jiun Chou, Cheng-Fang Yen

doi : 10.1111/apa.16711

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Changing diagnostic patterns in cases of sudden and unexpected natural death in infants and young children: 1994–2018

Roger W. Byard, Luzern Tan

doi : 10.1111/apa.16669

To determine whether there has been a change in the incidence and type of conditions causing sudden and unexpected natural death in infants and young children in recent years.

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Growth hormone treatment and the risk of adolescent scoliosis: A large matched cohort study

Tomer Ziv-Baran, Dalit Modan-Moses, Galia Zacay, Nissim Ackshota, Yael Levy-Shraga

doi : 10.1111/apa.16749

We aimed to evaluate the risk of developing adolescent scoliosis among recipients of recombinant human growth hormone (rhGH).

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The 2022 Pakistani references from birth to 60 months for length/height, weight and body mass index

Natasha Akbar, Muhammad Aslam, Jørge Holm Petersen, Ghulam Mustafa

doi : 10.1111/apa.16770

The present study aimed to develop age- and sex-specific anthropometric reference growth curves for the Pakistani children, aged 1–60 months.

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Reliability of the Motor Optimality Score-Revised: A study of infants at elevated likelihood for adverse neurological outcomes

Maria Örtqvist, Peter B. Marschik, Moreno Toldo, Dajie Zhang, Viviana Fajardo-Martinez, Karin Nielsen-Saines, Ulrika Ã…dén, Christa Einspieler

doi : 10.1111/apa.16747

To assess the inter-assessor reliability of the Motor Optimality Score-Revised (MOS-R) when used in infants at elevated likelihood for adverse neurological outcome.

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Face-to-face classroom learning produced greater brain synchronisation in children than a zoom-based online session

Tzipi Horowitz-Kraus, Einat Heyd-Metzuyanim, Michal Zivan

doi : 10.1111/apa.16728

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National data showed an increased prevalence of overweight and obesity among four-year-old Swedish children during the first year of COVID-19

Jessica MiregÃ¥rd, Paulina Nowicka, Charlotte Nylander

doi : 10.1111/apa.16707

This paper summarised national data on the prevalence of overweight and obesity among 4-year-old children in Sweden in 2020, the first year of the COVID-19 pandemic. It compares this with data from 2018. Differences between regions and sex were identified.

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Perceptions of the COVID-19 pandemic as demonstrated in drawings of Swedish children aged 4–6 years

Anna Sarkadi, Maria Thell, Klara Jirblom

doi : 10.1111/apa.16706

To explore the perceptions of the COVID-19 pandemic, as expressed in the drawings of Swedish children aged 4–6 years.

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Risk of long Covid in children infected with Omicron or pre-Omicron SARS-CoV-2 variants

Danilo Buonsenso, Rosa Morello, Francesco Mariani, Cristina De Rose, Luca Mastrantoni, Giuseppe Zampino, Piero Valentini

doi : 10.1111/apa.16764

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Acute Epstein–Barr virus infection: Diagnostic challenge in young children, risk factors for hospitalisation and cytomegalovirus co-detection

Ana Gutiérrez-Vélez, Cristina Castro-Rodríguez, Ana Jové-Blanco, David Aguilera-Alonso, Elena María Rincón-López, Alicia Hernanz-Lobo, Marisa Navarro Gómez, Teresa Hernández-Sampelayo, Roberto Alonso-Fernández, Jesús Saavedra-Lozano

doi : 10.1111/apa.16760

Acute Epstein–Barr virus (aEBV) and cytomegalovirus (CMV) infections frequently have similar manifestations. We aim to evaluate the characteristics of aEBV infection, risk factors for hospitalisation and differences according to CMV IgM detection (EBV-CMV co-detection) in children.

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Adherence to blood culture extraction guidelines and contamination risk in paediatric patients

Asunción Pérez-Madrigal, Laura Gutierrez-Chicote, Elena Granda, Roberto Velasco

doi : 10.1111/apa.16714

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Long-term milrinone therapy in children with dilated cardiomyopathy

Samuel Brown, Oscar Nolan, Esther Poole, Justine Kidd, Jane Cassidy, Phil Botha, Milind Chaudhari

doi : 10.1111/apa.16738

The aim of this study was to assess the safety and efficacy of long-term milrinone therapy in children with acute decompensated heart failure due to dilated cardiomyopathy (DCM).

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European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe

Ester Garne, Maria Loane, Joachim Tan, Elisa Ballardini, Joanna Brigden, Clara Cavero-Carbonell, Alessio Coi, Mads Damkjær, Laura Garcia-Villodre, Mika Gissler, Joanne Given, Anna Heino, Sue Jordan, Elizabeth Limb, Amanda Neville, Anke Rissmann, Michele Santoro, Ieuan Scanlon, Stine Kjaer Urhoj, Diana Wellesley, Joan Morris

doi : 10.1111/apa.16726

Children with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.

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Childhood manifestations of 22q11.2 deletion syndrome: A Finnish nationwide register-based cohort study

Sakari Wahrmann, Leena Kainulainen, Ville Kytö, Johanna Lempainen

doi : 10.1111/apa.16737

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Medical clowns versus sedation for paediatric urinary catheter insertion�A randomised pilot study

Galiya Raisin, Rachel Cohen, Orit Galant, Miriam Vaisfish, Sol Jaworowski, Jawdat Jaber, Stanislav Kocherov, Boris Chertin

doi : 10.1111/apa.16733

To investigate the potential benefits of medical clowns (MCs) in reducing anxiety and pain during paediatric urinary catheter insertion.

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Genetic stratification reveals COL4A variants and spontaneous remission in Egyptian children with proteinuria in the first 2 years of life

Samar Atef Elshafey, Mohamed Alaa Eldin Hassan Thabet, Reham Abdel Haleem Abo Elwafa, Ronen Schneider, Shirlee Shril, Florian Buerger, Friedhelm Hildebrandt, Hanan M Fathy

doi : 10.1111/apa.16732

The earlier the onset of proteinuria, the higher the incidence of genetic forms. Therefore, we aimed to analyse the spectrum of monogenic proteinuria in Egyptian children presenting at age <2 years.

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Generation and application of a convolutional neural networks algorithm in evaluating stool consistency in diapers

Fangfei Xiao, Yizhong Wang, Thomas Ludwig, Xiaolu Li, Sijia Chen, Nan Sun, Yixiao Zheng, Koen Huysentruyt, Yvan Vandenplas, Ting Zhang

doi : 10.1111/apa.16731

The aim of the study was to develop a deep convolutional neural networks (CNNs) algorithm for automated assessment of stool consistency from diaper photographs and test its performance under real-world conditions.

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Bowel habits in healthy infants and the prevalence of functional constipation, infant colic and infant dyschezia

Cathrine Gatzinsky, Ulla Sillén, Sarah Thornberg, Sofia Sjöström

doi : 10.1111/apa.16736

During infancy bowel habits change. Most infants with gastrointestinal problems have a functional gastrointestinal disorder (FGID), a major reason for visiting paediatricians. This study aims to provide data on stool frequency and consistency during the first year, prevalence rates for functional constipation (FC) and to establish associations with relevant demographic data. The occurrence of infant colic (IC) and infant dyschezia (ID) was also reported.

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Cerebral palsy and postnatal steroids

Shabih Manzar

doi : 10.1111/apa.16742

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Cerebral palsy and postnatal steroids�Reply

K. A. Hodgson, B. J. Manley, J. L. Y. Cheong

doi : 10.1111/apa.16743

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EBNEO commentary: Fluid balance as a critical factor in neonatal outcomes

Brianna M. Liberio, Rebecca S. Rose

doi : 10.1111/apa.16754

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EBNEO commentary: Long-term outcome of necrotizing enterocolitis and spontaneous intestinal perforation

Jessica Jakubowicz

doi : 10.1111/apa.16762

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