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Exposure to anandamide on young rats causes deficits in learning, temporal perception and induces changes in NMDA receptor expression
C Ì�esar Hern Ì�andez-Guerrero a, Ver Ì�onica GarcÃa-Salcedo b,d, Mario Buenrostro-Jauregui b, Hugo Sanchez-Castillo c, Ulises Aguilera-Reyes d, Noemi MartÃnez-Castro a, Oscar Galicia- Castillo
doi : 10.1016/j.bbr.2023.114377
Volume 445, 8 May 2023, 114377
Human use of marijuana at an early age has been reported to lead to cognitive impairment. However, researchers have not yet clearly determined whether this impairment is due to marijuana-induced alterations in the developing nervous system and whether this deficit persists into adulthood after marijuana use has ceased.
Is approaching sedentary behaviour or physical activity a reward? An EEG study
Yu-Bu Wang , Xiao-Tong Sun , Zhi-Xiong Mao
doi : 10.1016/j.bbr.2023.114364
Volume 445, 8 May 2023, 114364
To understand why individuals (do not) exercise, our study examined differences in approach and avoidance tendencies towards physical activity and sedentary behaviours among runners and non-runners, especially at the neural level.
Association of circulatory Klotho levels and its expression with miRNA- 339 in patients with schizophrenia
Amandeep Birdi a, PVSN Kiran Kumar a, Naresh Nebhinani b, Tanu Gupta b, Sojit Tomo a, Purvi Purohit a, Mithu Banerjee a, Prasenjit Mitra a,c, Praveen Sharma a, Dharmveer Yadav
doi : 10.1016/j.bbr.2023.114359
Volume 445, 8 May 2023, 114359
Schizophrenia is one of the major neuropsychiatric disorders affecting 1% of the population worldwide. Neuroinflammation, neurodevelopment, and oxidative stress are some of the crucial factors that can contribute to the pathogenesis of Schizophrenia.
Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice
Peiyan Jiang a,b,1, Lianyu Zhou b,c,1, Zhulin Du d, Linyang Zhao b, Yexi Tang c, Xinghang Fei b,c, Lian Wang b, Dabing Li f, Song Li c,e, Hui Yang c,e,*, Xiaotang Fan b,**, Huiling Liao
doi : 10.1016/j.bbr.2023.114384
Volume 445, 8 May 2023, 114384
Autism spectrum disorder (ASD) is a complicated, heterogeneous disorder characterized by social interaction deficits and repetitive stereotypical behaviors. Neuroinflammation and synaptic protein dysregulation have been implicated in ASD pathogenesis.
Changes in emotion-related EEG components and brain lateralization response to negative emotions in adolescents with nonsuicidal self-injury: An ERP study
Lin Zhao a, Dongdong Zhou b, Lingli Ma a, Jinhui Hu b, Ran Chen b, Xiaoqing He b, Xinyu Peng a, Zhenghao Jiang b, Liuyi Ran b, Jiaojiao Xiang a, Qi Zeng b, Yi Zhou a, Linxi Dai a, Qi Zhang a, Su Hong a, Wo Wang b, Li Kuang
doi : 10.1016/j.bbr.2023.114324
Volume 445, 8 May 2023, 114324
Nonsuicidal self-injury (NSSI) is a serious risk behavior in adolescents and is a high risk factor for suicide, while negative emotions can lead to increased NSSI behaviors.
Involvement of canonical Wnt/β-catenin signaling in the extinction of auditory fear conditioning in male mice
Ning Xu a, Lian Geng b, Xianxia Yan c, Aijun Niu a, Hui Yu b,*, Bo Su
doi : 10.1016/j.bbr.2023.114378
Volume 445, 8 May 2023, 114378
The Wnt signaling pathway plays a critical role in activity-dependent plasticity processes such as long-term potentiation, learning and memory. However, the role of the Wnt signaling pathway in adult extinction is still not well understood.
Diet, sex, and genetic predisposition to obesity and type 2 diabetes modulate motor and anxiety-related behaviors in mice, and alter cerebellar gene expression
Lawrence Grover , Kristiana Sklioutovskaya-Lopez , Jacaline K. Parkman 1, Katherine Wang , Emily Hendricks , Jessica Adams-Duffield , Jung Han Kim
doi : 10.1016/j.bbr.2023.114376
Volume 445, 8 May 2023, 114376
Obesity and type 2 diabetes (T2D) are serious health problems linked to neurobehavioral alterations. We compared motor function, anxiety-related behavior, and cerebellar gene expression in TALLYHO/Jng (TH), a polygenic model prone to insulin resistance, obesity, and T2D, and normal C57BL/6Â J (B6) mice.
The role of primary motor cortex in manual inhibition of return: A transcranial magnetic stimulation study
Judith Bek a,*, Merryn D. Constable a,b,1, Matthew Hilchey b,2, Timothy N. Welsh
doi : 10.1016/j.bbr.2023.114380
Volume 445, 8 May 2023, 114380
Inhibition of return (IOR) is a behavioural phenomenon characterised by longer response times (RTs) to stimuli presented at previously cued versus uncued locations. The neural mechanisms underlying IOR effects are not fully understood
The contribution of the supplementary motor area to explicit and implicit timing: A high-definition transcranial Random Noise Stimulation (HD-tRNS) study
M. Capizzi a,b,*,1, A. Visalli c,1, M. Wiener d, G. Mioni
doi : 10.1016/j.bbr.2023.114383
Volume 445, 8 May 2023, 114383
It is becoming increasingly accepted that timing tasks, and underlying temporal processes, can be partitioned on the basis of whether they require an explicit or implicit temporal judgement. Most neuroimaging studies of timing associated explicit timing tasks with activation of the supplementary motor area (SMA).
Assessment of brain imaging and cognitive function in a modified rhesus monkey model of depression
Guopeng Chen a,1, Simeng Ma a,1, Qian Gong a,1, Xinhui Xie a, Peng Wu b, Wenbi Guo c, Lijun Kang a, Meng Li d, Honghan Zhang a, Enqi Zhou a, Yuhui Zhang a, Jingtong Rong a, Hao Duan a, Liuyin Jin a, Shuxian Xu a, Nan Zhang a, Siqi Sun a, Ruiling Li a, Lihua Yao a, Dan Xiang a, Lihong Bu d,*, Zhongchun Liu
doi : 10.1016/j.bbr.2023.114382
Volume 445, 8 May 2023, 114382
Depression incurs a huge personal and societal burden, impairing cognitive and social functioning and affecting millions of people worldwide. A better understanding of the biological basis of depression could facilitate the development of new and improved therapies.
Effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens
Lisha Deng a,b, Zheng Chu c, Peng Liu d, Baijia Li a, Gang Lei b, Shaofu Li b, Yongkang Ma b, Yonghui Dang
doi : 10.1016/j.bbr.2023.114385
Volume 445, 8 May 2023, 114385
Morphine remains the standard analgesic for severe pain. However, the clinical use of morphine is limited by the innate tendency of opiates to become addictive. Brain-derived neurotrophic factor (BDNF) is a growth factor that is protective against many mental disorders.
GLP-1 agonist Liraglutide prevents MK‑801–induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice
Meltem Donmez Kutlu *,1, Seda Kose 2, Kubra Akillioglu
doi : 10.1016/j.bbr.2023.114386
Volume 445, 8 May 2023, 114386
Glucagon-like peptide 1 (GLP-1) agonists are among the agents that can be used to treat type 2 diabetes mellitus, and they have also been reported to have neuroprotective effects.
Resistance exercise was safe for the pregnancy and offspring’s development and partially protected rats against early life stress-induced effects
Adriana Souza dos Santos a,b, Ethiane Segabinazi a,b, Wellington de Almeida a,b, Aline Martins Faustino b, Loise Peres Bronauth b, Tiago Marcon dos Santos c, Fernanda Silva Ferreira c, Angela T.S. Wyse c, Simone Marcuzzo a,b, Lenir Orlandi Pereira
doi : 10.1016/j.bbr.2023.114362
Volume 445, 8 May 2023, 114362
Promising evidence points to gestational physical exercise as the key to preventing various disorders that affect the offspring neurodevelopment, but there are no studies showing the impact of resistance exercise on offspring health.
A maternal high-fat diet during pregnancy and lactation disrupts short-term memory functions via altered hippocampal glutamatergic signaling in female rat offspring
Irena Smaga *, Kinga Gawli �nska , Dawid Gawli �nski , Paulina Sur �owka , Małgorzata Filip
doi : 10.1016/j.bbr.2023.114396
Volume 445, 8 May 2023, 114396
A maternal high-fat diet (HFD) provokes changes in the offspring's brain's structure, function, and development. These changes may cause neuropsychiatric disorders in the early life of offspring the basis of which may be memory impairment.
Serotonin in synucleinopathies
Ohnmar Hsam , Zacharias Kohl
doi : 10.1016/j.bbr.2023.114367
Volume 445, 8 May 2023, 114367
Dysfunction of the serotonergic system represents an important feature in synucleinopathies like Parkinson disease (PD), dementia with Lewy bodies (DLB) and Multiple system atrophy (MSA).
