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Evaluating pain behaviours: Widely used mechanical and thermal methods in rodents
Akshat D. Modi a,b,*, Anavi Parekh c, Yajan N. Pancholi
doi : 10.1016/j.bbr.2023.114417
Volume 446, 28 May 2023, 114417
Globally, over 300 million surgical procedures are performed annually, with pain being one of the most common post-operative side effects. During the onset of injury, acute pain plays a protective role in alerting the individual to remove noxious stimuli, while long-lasting chronic pain without any physiological reason is detrimental to the recovery process.
The effect of intraperitoneal and intra-RMTg infusions of CTAP on rats’ social interaction
Xuhong Li a,b,1, Jing Wu a,c, Xinwang Li a,*,2, Jianjun Zhang
doi : 10.1016/j.bbr.2023.114333
Volume 446, 28 May 2023, 114333
Social interaction is necessary for the development of individuals and society. Social interaction behaviors are rewarding. Similar to exogenous opioids, social interaction behaviors are able to induce rewarding effects that are regulated by the endogenous opioid system as well.
Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes
Lihao Chen , Feng Lv , Su Min *,1, You Yang , Di Liu
doi : 10.1016/j.bbr.2023.114350
Volume 446, 28 May 2023, 114350
Electroconvulsive shock (ECT) is the most effective treatment for depression but can impair learning and memory. ECT is increasingly being shown to activate astrocytes and induce neuroinflammation, resulting in cognitive decline.
The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice
Wei Shen 1, Yanlin Tao 1, Fang Zheng , Houyuan Zhou , Hui Wu , Hailian Shi , Fei Huang *, Xiaojun Wu
doi : 10.1016/j.bbr.2023.114399
Volume 446, 28 May 2023, 114399
Depression is associated with intestinal dysbiosis. Venlafaxine is a commonly used antidepressant in clinical practice as a serotonin and noradrenaline reuptake inhibitor. However, its effects on gut bacteria in depression remain unclear.
Empathic concern induction modulates behavioral ratings and neural responses to harm-related moral judgment: An event-related potentials study
Yunyun Huang a,*, Ping Hu b, Huan Deng
doi : 10.1016/j.bbr.2023.114397
Volume 446, 28 May 2023, 114397
Although empathic concern is critical in harm-related moral judgment, the temporal dynamics underlying the impact of empathic concern on moral judgment remain unclear. This study used event-related potentials (ERPs) to investigate how empathic concern induction shaped the way individuals perceive harmful/helpful behaviors.
Pausing and reorienting behaviors enhance the performance of a spatial working memory task
Allison E. George a,1, John J. Stout a, Amy L. Griffin
doi : 10.1016/j.bbr.2023.114410
Volume 446, 28 May 2023, 114410
During spatial working memory tasks, animals need to retain information about a previous trial in order to successfully select their next trajectory.
Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia
Anika Sood 1, Valencia Fernandes 2, Kumari Preeti 3, Dharmendra Kumar Khatri *,4, Shashi Bala Singh
doi : 10.1016/j.bbr.2023.114415
Volume 446, 28 May 2023, 114415
Sphingosine-1-phosphate (S1P) is emerging as a crucial sphingolipid modulating neuroinflammation and cognition. S1P levels in the brain have been found to be decreased in cognitive impairment. S1P lyase (S1PL) is the key enzyme in metabolizing S1P and has been implicated in neuroinflammation.
Kratom (M. speciosa) exposure during adolescence caused long-lasting cognitive behavioural deficits associated with perturbated brain metabolism pathways in adult rats
Farah Wahida Suhaimi a,*, Aiman Nadhirah Zul Aznal a, Nurul Aqmar Mohamad Nor Hazalin b, Lay Kek Teh b, Zurina Hassan a, Mohd Zaki Salleh
doi : 10.1016/j.bbr.2023.114411
Volume 446, 28 May 2023, 114411
Kratom (M. speciosa Korth) is an herbal plant native to Southeast Asia. The leaves have been widely used to alleviate pain and opioid withdrawal symptoms. However, the increasing trend of recreational use of kratom among youth is concerning because substance abuse may render the adolescent brain more susceptible to neuropathological processes, causing dramatic consequences that persist into adulthood.
Mechanisms underlying performance in a cued go/no-go Pavlovian-to-instrumental transfer paradigm
Poppy Watson a,*, Justin Mahlberg
doi : 10.1016/j.bbr.2023.114413
Volume 446, 28 May 2023, 114413
Environmental cues that remind us of rewarding outcomes (drugs, food) play a significant role in addiction relapse.
Repeated neonatal isoflurane exposure facilitated stress-related fear extinction impairment in male mice and was associated with ΔFosB accumulation in the basolateral amygdala and the hippocampal dentate gyrus
JiaLing Zhong a,b, ChunLing Li a,b, LuoFang Peng a,c,*, Yundan Pan a,b, Yong Yang a,b, QuLian Guo a,b, Tao Zhong
doi : 10.1016/j.bbr.2023.114416
Volume 446, 28 May 2023, 114416
Volatile anesthetics elicit neurodevelopmental toxicity in rodents and primates and lead to more exaggerated anxiety-like behavior in response to future stress. Anxiety and fear are closely correlated and maladaptive fear-associated learning is regarded as the core mechanism underlying anxiety-related disorders.
The impact of social defeat on basomedial amygdala neuronal activity in adult male rats
Alexandra C. Ritger a,c, Courtney P. Stickling c, Nicole C. Ferrara b,c,*
doi : 10.1016/j.bbr.2023.114418
Volume 446, 28 May 2023, 114418
Social stressors negatively impact social function, and this is mediated by the amygdala across species. Social defeat stress is an ethologically relevant social stressor in adult male rats that increases social avoidance, anhedonia, and anxiety-like behaviors.
Persistent peripheral inflammation and pain induces immediate early gene activation in supraspinal nuclei in rats
Julio C Ì�esar Morales-Medina a,*,1,2, Mario Alberto Bautista-Carro a,b,1, Gilberto Serrano-Bello a, Patricia S Ì�anchez-Teoyotl a,b, Ana Gloria V Ì�asquez-RamÃrez a,c, Tommaso Iannitti
doi : 10.1016/j.bbr.2023.114395
Volume 446, 28 May 2023, 114395
Pain is a public health concern worldwide and can present simultaneously with anxiety and depression. c-Fos is a marker used to identify activated cells in response to various stimuli. Specifically, it can be used as a brain marker of pain.
Retraction notice to "BNDF heterozygosity is associated with memory deficits and alterations in cortical and hippocampal EEG power", [Behav. Brain Res., 332, 2017: 154−163]
Phillip A. Geist a, Brooke N. Dulka b, Abigail Barnes a,b, Michael Totty a, Subimal Datta
doi : 10.1016/j.bbr.2023.114400
Volume 446, 28 May 2023, 114400
