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Effects of Diet and Sodium Reduction on Cardiac Injury, Strain, and Inflammation: The DASH-Sodium Trial
Stephen P. Juraschek, Lara C. Kovell, Lawrence J. Appel, Edgar R. Miller, ... Kenneth J. Mukamal
doi : 10.1016/j.jacc.2021.03.320
Volume 77, Issue 21, 1 June 2021, Pages 2625-2634
The DASH (Dietary Approaches to Stop Hypertension) diet has been determined to have beneficial effects on cardiac biomarkers. The effects of sodium reduction on cardiac biomarkers, alone or combined with the DASH diet, are unknown.
Time for a Renewed Focus on the DASH-Low Sodium Diet?
Neha J. Pagidipati, Laura P. Svetkey
doi : 10.1016/j.jacc.2021.03.323
Volume 77, Issue 21, 1 June 2021, Pages 2635-2637
Pericardial Fat and the Risk of Heart Failure
Satish Kenchaiah, Jingzhong Ding, J. Jeffrey Carr, Matthew A. Allison, ... David A. Bluemke
doi : 10.1016/j.jacc.2021.04.003
Volume 77, Issue 21, 1 June 2021, Pages 2638-2652
Obesity is a well-established risk factor for heart failure (HF). However, implications of pericardial fat on incident HF is unclear.
Insights From MESA (Multi-Ethnic Study of Atherosclerosis): Into the Crypts of Fat?
Andreas P. Kalogeropoulos, Michael E. Hall
doi : 10.1016/j.jacc.2021.04.007
Volume 77, Issue 21, 1 June 2021, Pages 2653-2655
Risk Associated With Valvular Regurgitation During Pregnancy
Birgit Pfaller, Angelo Dave Javier, Jasmine Grewal, Nadia Gabarin, Candice K. Silversides
doi : 10.1016/j.jacc.2021.03.327
Volume 77, Issue 21, 1 June 2021, Pages 2656-2664
Pregnancies in women with regurgitant valve lesions are generally considered low risk, but this has not been well studied.
Heart Valve Regurgitation in Pregnancy: Risks Related to the Company It Keeps?
John McAnulty
doi : 10.1016/j.jacc.2021.04.015
Volume 77, Issue 21, 1 June 2021, Pages 2665-2666
Urinary Dickkopf-3 and Contrast-Associated Kidney Damage
Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Carlo Briguori
doi : 10.1016/j.jacc.2021.03.330
Volume 77, Issue 21, 1 June 2021, Pages 2667-2676
Administration of iodinated contrast medium (CM) during invasive cardiovascular procedures may be associated with impairment of kidney function.
Will Urinary Dickkopf-3 Disrupt the Field of Contrast-Induced Acute Kidney Injury??
Hitinder S. Gurm
doi : 10.1016/j.jacc.2021.04.022
Volume 77, Issue 21, 1 June 2021, Pages 2677-2679
Framingham Heart Study: JACC Focus Seminar, 1/8
Charlotte Andersson, Matthew Nayor, Connie W. Tsao, Daniel Levy, Ramachandran S. Vasan
doi : 10.1016/j.jacc.2021.01.059
Volume 77, Issue 21, 1 June 2021, Pages 2680-2692
The Framingham Heart Study is the longest-running cardiovascular epidemiological study, starting in 1948. This paper gives an overview of the various cohorts, collected data, and most important research findings to date. In brief, the Framingham Heart Study, funded by the National Institutes of Health and managed by Boston University, spans 3 generations of well phenotyped White persons and 2 cohorts comprised of racial and ethnic minority groups.
Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review
Vijay U. Rao, David J. Reeves, Atul R. Chugh, Rupal O’Quinn, Daniel Lenihan
doi : 10.1016/j.jacc.2021.04.009
Volume 77, Issue 21, 1 June 2021, Pages 2693-2716
Precision medicine has ushered in a new era of targeted treatments for numerous malignancies, leading to improvements in overall survival. Unlike traditional chemotherapy, many molecular targeted antineoplastic agents are available in oral formulation, leading to enhanced patient convenience and a perception of reduced risk of adverse effects. Although oral antineoplastic agents are generally well-tolerated, cardiovascular toxicities are being reported with increasing frequency in part due to U.S. Food and Drug Administration and manufacturer recommended cardiac monitoring. Monitoring strategies have focused on left ventricular dysfunction, hypertension, and QT prolongation/arrhythmias. Given the rapid pace of development and availability of new oral antineoplastic agents, the purpose of this review is to provide clinicians with an up-to-date practical approach to monitoring and management of cardiovascular toxicities with the aim of improving overall outcomes for patients with cancer.
Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research
VARC-3 WRITING COMMITTEE:, Philippe Généreux, Nicolo Piazza, Maria C. Alu, Martin B. Leon
doi : 10.1016/j.jacc.2021.02.038
Volume 77, Issue 21, 1 June 2021, Pages 2717-2746
The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trials. Rapid evolution of the field, including the emergence of new complications, expanding clinical indications, and novel therapy strategies have mandated further refinement and expansion of these definitions to ensure clinical relevance. This document provides an update of the most appropriate clinical endpoint definitions to be used in the conduct of transcatheter and surgical aortic valve clinical research.
JACC Pivots to History to Inspire Creativity
Justine Varieur Turco, Bryony M. Mearns, Valentin Fuster
doi : 10.1016/j.jacc.2021.04.041
Volume 77, Issue 21, 1 June 2021, Pages 2747-2748
Global Health Imperative to Prioritizing Cardiovascular Education
Norrisa Haynes, Veauthyelau Saint-Joy, JaBaris Swain
doi : 10.1016/j.jacc.2021.03.326
Volume 77, Issue 21, 1 June 2021, Pages 2749-2753
RESPONSE: Multilateral Cardiovascular Education and Training in Haiti
Mark D. Huffman, Gene F. Kwan
doi : 10.1016/j.jacc.2021.03.331
Volume 77, Issue 21, 1 June 2021, Pages 2752-2753
Effectiveness of Cardiac Telerehabilitation With Relapse Prevention: SmartCare-CAD Randomized Controlled Trial
Rutger W.M. Brouwers, Jos J. Kraal, Marta Regis, Ruud F. Spee, Hareld M.C. Kemps
doi : 10.1016/j.jacc.2021.03.328
Volume 77, Issue 21, 1 June 2021, Pages 2754-2756
All Fat Is Not Created Equal: The Problem of Defining Obesity in the Elderly
Bartosz Hudzik, Barbara Zubelewicz-Szkodzi?ska
doi : 10.1016/j.jacc.2021.02.067
Volume 77, Issue 21, 1 June 2021, Page 2756
Reply: All Fat Is Not Created Equal: The Problem of Defining Obesity in the Elderly
Tomasz J. Guzik, John W. Eikelboom
doi : 10.1016/j.jacc.2021.03.324
Volume 77, Issue 21, 1 June 2021, Page 2757
Protocolized Diuretic Approach Using the Natriuretic Equation: Careful Patient Selection Is Needed
Kevin Bryan Lo, Francisco Aguilar, Janani Rangaswami
doi : 10.1016/j.jacc.2021.02.066
Volume 77, Issue 21, 1 June 2021, Pages 2757-2758
Reply: Protocolized Diuretic Approach Using the Natriuretic Equation: Careful Patient Selection Is Needed
Veena S. Rao, Juan B. Ivey-Miranda, Zachary L. Cox, Jeffrey M. Testani
doi : 10.1016/j.jacc.2021.03.322
Volume 77, Issue 21, 1 June 2021, Pages 2758-2759
