دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
CRS Local chapters special issue 2023
Yu-Kyoung Oh, Avi Schroeder & Bruno Sarmento
doi : 10.1007/s13346-023-01324-9
Volume 13, issue 5, May 2023
Newly synthesized methionine aminopeptidase 2 inhibitor hinders tumor growth
Rawnaq Esa, Eliana Steinberg, Arie Dagan, Zhanna Yekhtin, Katerina Tischenko & Ofra Benny
doi : 10.1007/s13346-022-01187-6
Methionine aminopeptidase 2 (MetAp2) inhibition has been recognized as a promising approach for suppressing angiogenesis and cancer progression. Small molecule fumagillol derivatives with adamantane side groups were synthesized and evaluated for MetAp2 inhibition activity, and a lead molecule with superior abilities to inhibit the enzymatic activity of MetAp2 was identified.
Customized 3D-printed hollow capsular device filled with norfloxacin-loaded micropellets for controlled-release delivery
Purushottam Suryavanshi, Vishal Sharad Chaudhari & Subham Banerjee
doi : 10.1007/s13346-022-01198-3
Pharmacotherapy has become more focused on the personalized treatment of patients with various diseases. This field of pharmacology and pharmacogenomics focuses on developing drug delivery systems designed to address the unique characteristics of individual patients.
Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles
Federica De Lorenzi, Larissa Yokota Rizzo, Rasika Daware, Alessandro Motta, Maike Baues, Matthias Bartneck, Michael Vogt, Marc van Zandvoort, Leonard Kaps, Qizhi Hu, Marielle Thewissen, Luca Casettari, Cristianne J. F. Rijcken, Fabian Kiessling, Alexandros Marios Sofias & Twan Lammers
doi : 10.1007/s13346-022-01204-8
Polymeric micelles are increasingly explored for tumor-targeted drug delivery. CriPec® technology enables the generation of core�crosslinked polymeric micelles (CCPMs) based on thermosensitive (mPEG-b-pHPMAmLacn) block copolymers, with high drug loading capacity, tailorable size, and controlled drug release kinetics.
Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Minwoo Jung, Minki Jin, Woo-Jin Jeon, HaeSoo Lee, Haeun Kim, Jong-Hee Won, Hyelim Yoo, Hyoung-Woo Bai, Su-Cheol Han, Hearan Suh, Kyoung Un Kang, Hong-Ki Lee & Cheong-Weon Cho
doi : 10.1007/s13346-022-01205-7
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for the enhancement of TCG solubility and permeability.
A mucoadhesive patch loaded with freeze-dried liposomes for the local treatment of oral tumors
Layan Habib, Mohammed Alyan, Yasmine Ghantous, Jeny Shklover, Janna Shainsky, Imad Abu El-Naaj, Havazelet Bianco-Peled & Avi Schroeder
doi : 10.1007/s13346-022-01224-4
Oral cancers affect millions of people globally, with increasing incidences among adults aged 35 and above. Poor drug uptake by lesions in the oral cavity following systemic administration, as well as limited localized treatment modalities for oral tumors, result in poor patient quality of life and high mortality.
A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation
Prakash Khadka, Jack Dummer, Philip C. Hill, Rajesh Katare & Shyamal C. Das
doi : 10.1007/s13346-022-01238-y
Inhaled drug delivery is a promising approach to achieving high lung drug concentrations to facilitate efficient treatment of tuberculosis (TB) and to reduce the overall duration of treatment. Rifampicin is a good candidate for delivery via the pulmonary route.
Iontophoresis application for drug delivery in high resistivity membranes: nails and teeth
Jayanaraian F. Martins Andrade, Thamires da Cunha Miranda, MarcÃlio Cunha-Filho, Stephânia Fleury Taveira, Guilherme M. Gelfuso & TaÃs Gratieri
doi : 10.1007/s13346-022-01244-0
Iontophoresis has been vastly explored to improve drug permeation, mainly for transdermal delivery. Despite the skin’s electrical resistance and barrier properties, it has a relatively high aqueous content and is permeable to many drugs.
Intrinsic lipolysis rate for systematic design of lipid-based formulations
Ann-Christin Jacobsen, Aleksei Kabedev, Patrick D. Sinko, Johan E. Palm, Christel A. S. Bergström & Alexandra Teleki
doi : 10.1007/s13346-022-01246-y
Lipid-based formulations (LBFs) are used by the pharmaceutical industry in oral delivery systems for both poorly water-soluble drugs and biologics. Digestibility is key for the performance of LBFs and in vitro lipolysis is commonly used to compare the digestibility of LBFs.
Boronates as hydrogen peroxide–reactive warheads in the design of detection probes, prodrugs, and nanomedicines used in tumors and other diseases
Jyun�Wei Chen, Tzu�Chien Wu, Wun Liang, Jyun-Jia Ciou & Chian-Hui Lai
doi : 10.1007/s13346-022-01248-w
Hydrogen peroxide (H2O2) has always been a topic of great interests attributed to its vital role in biological process. H2O2 is known as a major reactive oxygen species (ROS) which is involve in numerous physiological processes such as cell proliferation, signal transduction, differentiation, and even pathogenesis.
Multifunctional nanomedicine strategies to manage brain diseases
Paulo Faria, Catarina Pacheco, Rui Pedro Moura, Bruno Sarmento & Cláudia Martins
doi : 10.1007/s13346-022-01256-w
Brain diseases represent a substantial social and economic burden, currently affecting one in six individuals worldwide. Brain research has been focus of great attention in order to unravel the pathogenesis and complexity of brain diseases at the cellular, molecular, and microenvironmental levels.
Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing
Chiara Amante, Valentina Andretto, Annalisa Rosso, Geraldine Augusti, Stefania Marzocco, Giovanna Lollo & Pasquale Del Gaudio
doi : 10.1007/s13346-022-01257-9
This work combines natural polymers with nanoemulsions (NEs) to formulate nanocomposites as an innovative wound dressing. Spray-drying has been used to produce alginate-pectin in situ gelling powders as carriers for NEs loaded with curcumin (CCM), a model antimicrobial drug.
Formulation and characterization of liposomes containing drug absorption enhancers for optimized anti-HIV and antimalarial drug delivery
Poloko Stephen Kheoane, Gillian Mary-Anne Enslin & Clemence Tarirai
doi : 10.1007/s13346-022-01264-w
Most of the current clinically used anti-HIV and antimalarial drugs have low bioavailability, either due to poor solubility and permeability, rapid clearance from anatomical reservoirs and poor retention at their site of action (e.g. due to the p-glycoprotein efflux system), and extreme first-pass metabolism (e.g. by the cytochrome P450 enzymes).
Comparative study on the topical and transdermal delivery of diclofenac incorporated in nano-emulsions, nano-emulgels, and a colloidal suspension
Estelle-Vionè Louw, Wilna Liebenberg, Clarissa Willers, Admire Dube, Marique E. Aucamp & Minja Gerber
doi : 10.1007/s13346-022-01267-7
Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The lack thereof would require that APIs be included in drug delivery vehicles to enhance skin permeation.
Investigating the influence of ultrasound parameters on ibuprofen drug release from hydrogels
Svenja Meissner, Jhansi H. Akepogu, Samantha M. Arnet, Mohammed Z. Dean, Jessie Ji, Grace Wright, Bruce Harland, Brad Raos, Darren Svirskis & Sachin S. Thakur
doi : 10.1007/s13346-022-01277-5
Hydrogels are promising ultrasound-responsive drug delivery systems. In this study, we investigated how different ultrasound parameters affected drug release and structural integrity of self-healing hydrogels composed of alginate or poloxamers.
The development of a 3D-printed in vitro integrated oro-pharyngeal air–liquid interface cellular throat model for drug transport
Zara Sheikh, Antonella Granata, Ye Zhang, Hanieh Mohammad Gholizadeh Mahvizani, Dina Silva, Paul M. Young, Luca Casettari, Hui Xin Ong & Daniela Traini
doi : 10.1007/s13346-023-01302-1
To simulate the deposition of drugs in the oro-pharynx region, several in vitro models are available such as the United States Pharmacopeia-Induction Port (USP-IP) throat and the Virginia Commonwealth University (VCU) models.
Oral formulation of Wnt inhibitor complex reduces inflammation and fibrosis in intraperitoneal implants in vivo
Ana LuÃza de Castro Santos, Natália Jordana Alves da Silva, Celso Tarso Rodrigues Viana, LetÃcia Cristine Cardoso dos Santos, Gabriel Henrique Costa da Silva, Sérgio Ricardo Aluotto Scalzo Júnior, Pedro Augusto Carvalho Costa, Walison Nunes da Silva, Itamar Couto Guedes de Jesus, Alexander Birbrair, Mariana T. Q. de Magalhães, Frédéric Frézard, Silvia Guatimosim, Rebecca M. Haley, Michael J. Mitchell, Silvia Passos Andrade, Paula Peixoto Campos & Pedro Pires Goulart Guimaraes
doi : 10.1007/s13346-023-01303-0
The use of implantable biomaterials to replace physiological and anatomical functions has been widely investigated in the clinic.
Chitosan-based drug delivery systems for skin atopic dermatitis: recent advancements and patent trends
Lay-Hong Chuah, Hooi-Leong Loo, Choon Fu Goh, Ju-Yen Fu & Shiow-Fern Ng
doi : 10.1007/s13346-023-01307-w
Atopic dermatitis (AD) is a complex, relapsing inflammatory skin disease with a considerable social and economic burden globally. AD is primarily characterized by its chronic pattern and it can have important modifications in the quality of life of the patients and caretakers.
Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets
Janni Støvring Mortensen, Duc Ninh Nguyen, Hanne Mørck Nielsen & Stine Rønholt
doi : 10.1007/s13346-023-01309-8
Early intervention and short-duration treatments with antibiotics in premature infants are reported to reduce the incidence of necrotizing enterocolitis (NEC), a terrible disease with severe inflammation and impaired intestinal barrier properties.
Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy
Dwi L. Priwitaningrum, Kunal Pednekar, Alexandros V. Gabriël, Aida A. Varela-Moreira, Severine Le Gac, Ivo Vellekoop, Gert Storm, Wim E. Hennink & Jai Prakash
doi : 10.1007/s13346-023-01310-1
Since tumor stroma poses as a barrier to achieve efficacy of nanomedicines, it is essential to evaluate nano-chemotherapeutics in stroma-mimicking 3D models that reliably predict their behavior regarding these hurdles limiting efficacy.
Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids
Mette Klitgaard, Maja Nørgaard Kristensen, Ramakrishnan Venkatasubramanian, Priscila Guerra, Jette Jacobsen, Ragna Berthelsen, Thomas Rades & Anette Müllertz
doi : 10.1007/s13346-023-01313-y
Dextran sulfate sodium (DSS) is commonly used to induce colitis in rats. While the DSS-induced colitis rat model can be used to test new oral drug formulations for the treatment of inflammatory bowel disease, the effect of the DSS treatment on the gastrointestinal tract has not been thoroughly characterized.
Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
Frazer Sinclair, Anjuman A. Begum, Charles C. Dai, Istvan Toth & Peter M. Moyle
doi : 10.1007/s13346-023-01320-z
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing system has been a major technological breakthrough that has brought revolutionary changes to genome editing for therapeutic and diagnostic purposes and precision medicine.
Tumour-derived extracellular vesicle based vaccines for melanoma treatment
Lorena Gonzalez-Melero, Rosa Maria Hernandez, Edorta Santos-Vizcaino & Manoli Igartua
doi : 10.1007/s13346-023-01328-5
The interest of extracellular vesicles (EVs) in cancer immunotherapy is increasing every day. EVs are lipid bilayer vesicles released by most cells, which contain the molecular signature of their parent cell.
