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A Step Forward in the Fight Against Dementia—Are We There Yet?
David A. Wolk, MD1; Gil D. Rabinovici, MD2,3; Bradford C. Dickerson, MD4
doi : 10.1001/jamaneurol.2023.0123
May 2023, Vol 80, No. 5, Pages 428-533
Lecanemab and APOE Genotyping in Clinical Practice—Navigating Uncharted Terrain
Madhav Thambisetty, MD, PhD1; Robert Howard, MRCPsych, MD2
JAMA Neurology—The Year in Review, 2022
S. Andrew Josephson, MD1,2
Transcarotid Artery Revascularization for Stroke Prevention—Multiple Elephants in the Room
Seemant Chaturvedi, MD1
Risk of Stroke, Death, and Myocardial Infarction Following Transcarotid Artery Revascularization vs Carotid Endarterectomy in Patients With Standard Surgical Risk
Patric Liang, MD1; Jack L. Cronenwett, MD2; Eric A. Secemsky, MD3; Jens Eldrup-Jorgensen, MD4; Mahmoud B. Malas, MD, MHS5; Grace J. Wang, MD, MSCE6; Brian W. Nolan, MD7; Vikram S. Kashyap, MD8; Raghu L. Motaganahalli, MD9; Marc L. Schermerhorn, MD1
doi : 10.1001/jamaneurol.2023.0285
Importance Carotid artery stenting has been limited to use in patients with high surgical risk; outcomes in patients with standard surgical risk are not well known.
Association of Dementia Risk With Focal Epilepsy and Modifiable Cardiovascular Risk Factors
Xin You Tai, MD1,2; Emma Torzillo, MD3; Donald M. Lyall, PhD4; Sanjay Manohar, DPhil1,2,5; Masud Husain, DPhil1,2,5; Arjune Sen, DPhil1,2,6
doi : 10.1001/jamaneurol.2023.0339
Importance Epilepsy has been associated with cognitive impairment and potentially dementia in older individuals. However, the extent to which epilepsy may increase dementia risk, how this compares with other neurological conditions, and how modifiable cardiovascular risk factors may affect this risk remain unclear.
Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease
Zekun Zheng, MD1,2; Yanling Lv, MD1,2; Shuang Rong, PhD3; Taoping Sun, PhD4; Liangkai Chen, PhD1,2
doi : 10.1001/jamaneurol.2023.0183
Importance Cross-sectional evidence implicates high prevalent frailty in patients with Parkinson disease (PD), whereas the longitudinal association remains unknown.
Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography
Gillian T. Coughlan, MS, PhD1; Tobey J. Betthauser, PhD2,3; Rory Boyle, PhD1; Rebecca L. Koscik, PhD2,3; Hannah M. Klinger, MS1; Lori B. Chibnik, PhD, MPH1,4; Erin M. Jonaitis, PhD, MS2,3; Wai-Ying Wendy Yau, MD1; Allen Wenzel, BS3; Bradley T. Christian, PhD2; Carey E. Gleason, PhD2; Ursula G. Saelzler, PhD5; Michael J. Properzi, BEng, BCompSci1; Aaron P. Schultz, PhD1,6; Bernard J. Hanseeuw, MD, PhD1,6,7,8,9; JoAnn E. Manson, MD, DrPH, MACP4; Dorene M. Rentz, PsyD1,6; Keith A. Johnson, MD6,8; Reisa Sperling, MD1,6; Sterling C. Johnson, PhD2,3; Rachel F. Buckley, PhD1,6,10
doi : 10.1001/jamaneurol.2023.0455
Importance Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels of tau in cognitively unimpaired postmenopausal females compared with age-matched males, particularly in the setting of high β-amyloid (Aβ). The biological mechanisms associated with higher tau deposition in female individuals remain elusive.
Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke
Russell Chabanne, MD, MSc1; Thomas Geeraerts, MD, PhD2; Marc Begard, MD1; Baptiste Balança, MD, PhD3; Francesca Rapido, MD4; Vincent Degos, MD, PhD5; Benoit Tavernier, MD, PhD6; Serge Molliex, MD, PhD7; Lionel Velly, MD, PhD8; Franck Verdonk, MD, PhD9; Anne-Claire Lukaszewicz, MD, PhD3; Pierre-François Perrigault, MD4; Jean-François Albucher, MD10; Christophe Cognard, MD, PhD11; Adrien Guyot, MD1; Charlotte Fernandez, MD1; Aurélie Masgrau, MSc12; Ricardo Moreno, MD, MSc13; Anna Ferrier, MD14; Samir Jaber, MD, PhD15; Jean-Etienne Bazin, MD, PhD1; Bruno Pereira, PhD12; Emmanuel Futier, MD, PhD1,16; for the ANARLF NetworkAMETIS Study Group
doi : 10.1001/jamaneurol.2023.0413
Importance General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks and benefits of each strategy are unclear.
Comparison of Perinatal Outcomes for Women With and Without Epilepsy
Paolo Pierino Mazzone, MSc1,6,7; Kirsty Mhairi Hogg, MBChB2; Christopher J. Weir, PhD1,3; Jacqueline Stephen, PhD3,4; Sohinee Bhattacharya, PhD5; Richard F. M. Chin, PhD1,2,3,6,7
doi : 10.1001/jamaneurol.2023.0148
Importance Pregnant women who have epilepsy need adequate engagement, information, and pregnancy planning and management to improve pregnancy outcomes.
Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome
Lawren VandeVrede, MD, PhD1; Renaud La Joie, PhD1,2; Elisabeth H. Thijssen, PhD3; Breton M. Asken, PhD4; Stephanie A. Vento, BS1; Torie Tsuei, MSc1; Suzanne L. Baker, PhD2; Yann Cobigo, PhD1; Corrina Fonseca, BS1; Hilary W. Heuer, PhD1; Joel H. Kramer, PhD1; Peter A. Ljubenkov, MD1; Gil D. Rabinovici, MD1,5; Julio C. Rojas, MD, PhD1; Howie J. Rosen, MD1; Adam M. Staffaroni, PhD1; Brad F. Boeve, MD6; Brad C. Dickerson, MD7; Murray Grossman, MD8; Edward D. Huey, MD9,10; David J. Irwin, MD7; Irene Litvan, MD11; Alexander Y. Pantelyat, MD12; Maria Carmela Tartaglia, MD13; Jeffrey L. Dage, PhD14; Adam L. Boxer, MD, PhD1
doi : 10.1001/jamaneurol.2023.0488
Importance Plasma phosphorylated tau217 (p-tau217), a biomarker of Alzheimer disease (AD), is of special interest in corticobasal syndrome (CBS) because autopsy studies have revealed AD is the driving neuropathology in up to 40% of cases.
Association Between Magnitude of Differential Blood Pressure Reduction and Secondary Stroke Prevention
Chia-Yu Hsu, MD1; Jeffrey L. Saver, MD2; Bruce Ovbiagele, MD3; Yi-Ling Wu, DrPH4; Chun-Yu Cheng, MD5; Meng Lee, MD1
doi : 10.1001/jamaneurol.2023.0218
Importance The degree to which more intensive blood pressure reduction is better than less intensive for secondary stroke prevention has not been delineated.
Mitigating the Associations of Kidney Dysfunction With Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau Ratios
Shorena Janelidze, PhD1; Nicolas R. Barthélemy, PhD2,3; Yingxin He, PhD2,3; Randall J. Bateman, MD2,3; Oskar Hansson, MD, PhD1,4
doi : 10.1001/jamaneurol.2023.0199
Importance Chronic kidney disease (CKD) has been associated with increased plasma concentrations of phosphorylated tau (p-tau) 217 and p-tau181, which potentially decreases their usefulness in the diagnostic workup of Alzheimer disease (AD).
Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke With Large Vessel Occlusion
Pierre Seners, MD, PhD1,2,3; Nicole Yuen, MSc1; Michael Mlynash, MD1; Sarah J. Snyder, BS4; Jeremy J. Heit, MD, PhD4; Maarten G. Lansberg, MD, PhD1; Soren Christensen, PhD1; Jean-François Albucher, MD5; Christophe Cognard, MD6; Igor Sibon, MD, PhD7; Michael Obadia, MD2; Julien Savatovsky, MD8; Jean-Claude Baron, MD, ScD3,9; Jean-Marc Olivot, MD, PhD5; Gregory W. Albers, MD1; for the Mismatch Prevalence Investigators
doi : 10.1001/jamaneurol.2023.0265
Importance The benefit of reperfusion therapies for acute ischemic stroke decreases over time. This decreasing benefit is presumably due to the disappearance of salvageable ischemic brain tissue (ie, the penumbra).
Limb to Cranial Overflow Dystonia in a Patient After Stroke
Arka Prava Chakraborty, MBBS, MD (Medicine), DM (Neurology)1; Adreesh Mukherjee, MBBS, MD (Medicine), DM (Neurology)1; Atanu Biswas, MBBS, MD (Medicine), DM (Neurology)1
Multimodal Neuroimaging of Intimal Flap in a Basilar Artery Dissection
Marialuisa Zedde, MD1; Claudio Moratti, MD2; Rosario Pascarella, MD2
Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke With Large Vessel Occlusion
Pierre Seners, MD, PhD1,2,3; Nicole Yuen, MSc1; Michael Mlynash, MD1; Sarah J. Snyder, BS4; Jeremy J. Heit, MD, PhD4; Maarten G. Lansberg, MD, PhD1; Soren Christensen, PhD1; Jean-François Albucher, MD5; Christophe Cognard, MD6; Igor Sibon, MD, PhD7; Michael Obadia, MD2; Julien Savatovsky, MD8; Jean-Claude Baron, MD, ScD3,9; Jean-Marc Olivot, MD, PhD5; Gregory W. Albers, MD1; for the Mismatch Prevalence Investigators
doi : 10.1001/jamaneurol.2023.0265
Importance The benefit of reperfusion therapies for acute ischemic stroke decreases over time. This decreasing benefit is presumably due to the disappearance of salvageable ischemic brain tissue (ie, the penumbra).
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension
Rachel Ryu, PharmD, BCPS1; Jonathan Kuo, MD2
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension—Reply
Corinna Doege, MD1; Mark Luedde, MD2; Karel Kostev3
