Diabetes Care




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About the Artist: Rohan Arora

doi : 10.2337/dci23-0024

Volume 46, Issue 5

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In This Issue of Diabetes Care

Max Bingham, PhD

doi : 10.2337/dc23-ti05

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Metformin and Cancer: Solutions to a Real-World Evidence Failure

Oriana Hoi Yun Yu; Samy Suissa

doi : 10.2337/dci22-0047

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COVID-19 and Rising Incidence of Diabetes: Despite Evolving Data, an Enigma Still to Be Solved

William T. Cefalu

doi : 10.2337/dci22-0067

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Socioeconomic Disparities Across the Spectrum of Genetic Burden in Type 2 Diabetes and Obesity Risk

Paul W. Franks

doi : 10.2337/dci22-0066

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Delivering on the Promise of Technology to Augment Behavioral Interventions in Type 2 Diabetes

Anna R. Kahkoska; Angelica Cristello Sarteau; Matthew J. Crowley

doi : 10.2337/dci23-0009

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Relation of Incident Type 1 Diabetes to Recent COVID-19 Infection: Cohort Study Using e-Health Record Linkage in Scotland

Paul M. McKeigue; Stuart McGurnaghan; Luke Blackbourn; Louise E. Bath; David A. McAllister; Thomas M. Caparrotta; Sarah H. Wild; Simon N. Wood; Diane Stockton; Helen M. Colhoun

doi : 10.2337/dc22-0385

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Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort

Farida S. Akhtari; Dillon Lloyd; Adam Burkholder; Xiaoran Tong; John S. House; Eunice Y. Lee; John Buse; Shepherd H. Schurman; David C. Fargo; Charles P. Schmitt; Janet Hall; Alison A. Motsinger-Reif

doi : 10.2337/dc22-0295

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Comparative Incidence of Diabetes Following Hospital Admission for COVID-19 and Pneumonia: A Cohort Study

Naomi Holman; Emma Barron; Bob Young; Edward W. Gregg; Kamlesh Khunti; Jonathan Valabhji; Naveed Sattar

doi : 10.2337/dc22-0670

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Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity

Sara J. Cromer; Chirag M. Lakhani; Josep M. Mercader; Timothy D. Majarian; Philip Schroeder; Joanne B. Cole; Jose C. Florez; Chirag J. Patel; Alisa K. Manning; Sherri-Ann M. Burnett-Bowie; Jordi Merino; Miriam S. Udler

doi : 10.2337/dc22-1954

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Incidence, Severity, and Presentation of Type 2 Diabetes in Youth During the First and Second Year of the COVID-19 Pandemic

Sabitha Sasidharan Pillai; Phinnara Has; Jose Bernardo Quintos; Monica Serrano Gonzalez; Vania L. Kasper; Lisa Swartz Topor; Meghan E. Fredette

doi : 10.2337/dc22-1702

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An Integrated Digital Health Care Platform for Diabetes Management With AI-Based Dietary Management: 48-Week Results From a Randomized Controlled Trial

You-Bin Lee; Gyuri Kim; Ji Eun Jun; Hyunjin Park; Woo Je Lee; You-Cheol Hwang; Jae Hyeon Kim

doi : 10.2337/dc22-1929

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Cardiovascular Safety in Type 2 Diabetes With Sulfonylureas as Second-line Drugs: A Nationwide Population-Based Comparative Safety Study

Huan Wang; Ruth L.M. Cordiner; Yu Huang; Louise Donnelly; Simona Hapca; Andrew Collier; John McKnight; Brian Kennon; Fraser Gibb; Paul McKeigue; Sarah H. Wild; Helen Colhoun; John Chalmers; John Petrie; Naveed Sattar; Thomas MacDonald; Rory J. McCrimmon; Daniel R. Morales; Ewan R. Pearson; Scottish Diabetes Research Network Epidemiology Group

doi : 10.2337/dc22-1238

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Distinct Mechanisms Responsible for the Increase in Glucose Production and Ketone Formation Caused by Empagliflozin in T2DM Patients

Siham Abdelgani; Ahmed Khattab; John Adams; Mohamed Abu-Farha; Guisepe Daniele; Fahd Al-Mulla; Stefano Del Prato; Ralph A. DeFronzo; Muhammad Abdul-Ghani

doi : 10.2337/dc22-0885

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Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity

Mette K. Andersen; Lars Ängquist; Jette Bork-Jensen; Anna E. Jonsson; Sara E. Stinson; Camilla H. Sandholt; Malte Thodberg; Laura Maarit Pikkupeura; Emily L. Ongstad; Niels Grarup; Arne Astrup; Oluf Pedersen; Kristine Williams; Romain Barrès; Thorkild I.A. Sørensen; Allan Linneberg; Joseph Grimsby; Christopher J. Rhodes; Torben Hansen

doi : 10.2337/dc22-2078

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Noninvasive Hypoglycemia Detection in People With Diabetes Using Smartwatch Data

Vera Lehmann; Simon Föll; Martin Maritsch; Eva van Weenen; Mathias Kraus; Sophie Lagger; Katja Odermatt; Caroline Albrecht; Elgar Fleisch; Thomas Zueger; Felix Wortmann; Christoph Stettler

doi : 10.2337/dc22-2290

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Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes

Tim Heise; J. Hans DeVries; Shweta Urva; Jing Li; Edward J. Pratt; Melissa K. Thomas; Kieren J. Mather; Chrisanthi A. Karanikas; Julia Dunn; Axel Haupt; Zvonko Milicevic; Tamer Coskun

doi : 10.2337/dc22-1710

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Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial

William E. Russell; Brian N. Bundy; Mark S. Anderson; Laura A. Cooney; Stephen E. Gitelman; Robin S. Goland; Peter A. Gottlieb; Carla J. Greenbaum; Michael J. Haller; Jeffrey P. Krischer; Ingrid M. Libman; Peter S. Linsley; S. Alice Long; Sandra M. Lord; Daniel J. Moore; Wayne V. Moore; Antoinette M. Moran; Andrew B. Muir; Philip Raskin; Jay S. Skyler; John M. Wentworth; Diane K. Wherrett; Darrell M. Wilson; Anette-Gabriele Ziegler; Kevan C. Herold; Type 1 Diabetes TrialNet Study Group

doi : 10.2337/dc22-2200

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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

Steffen U. Thorsen; Xiang Liu; Yachana Kataria; Thomas Mandrup-Poulsen; Simranjeet Kaur; Ulla Uusitalo; Suvi M. Virtanen; Jill M. Norris; Marian Rewers; William Hagopian; Jimin Yang; Jin-Xiong She; Beena Akolkar; Stephen Rich; Carin Andrén Aronsson; Åke Lernmark; Anette-Gabriele Ziegler; Jorma Toppari; Jeffrey Krischer; Hemang M. Parikh; Christina Ellervik; Jannet Svensson; TEDDY Study Group

doi : 10.2337/dc22-1359

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Impact of Early Life Factors on Metabolic Phenotypes of Obesity in Preschool Children

Zijun Liao; Xianghui Xie; Jing Wang; Yiren Chen; Ting Zhang; Gongshu Liu; Fangfang Chen

doi : 10.2337/dc22-1851

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Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study

Jessica Edstorp; Emma Ahlqvist; Lars Alfredsson; Dina Mansour Aly; Valdemar Grill; Bahareh Rasouli; Elin P. Sørgjerd; Tiinamaija Tuomi; Bjørn O. Åsvold; Sofia Carlsson

doi : 10.2337/dc22-2284

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CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes: A Danish Cohort Study

Anne Gedebjerg; Mette Bjerre; Alisa Devedzic Kjaergaard; Jens Steen Nielsen; Jørgen Rungby; Ivan Brandslund; Michael Maeng; Henning Beck-Nielsen; Allan Vaag; Henrik Toft Sørensen; Troels Krarup Hansen; Reimar Wernich Thomsen

doi : 10.2337/dc22-1353

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Biomarker Changes Associated With Both Dulaglutide and Cardiovascular Events in the REWIND Randomized Controlled Trial: A Nested Case-Control Post Hoc Analysis

Hertzel C. Gerstein; Shun-Fu Lee; Guillaume Paré; M. Angelyn Bethel; Helen M. Colhoun; Anastasia Hoover; Mark Lakshmanan; Yanzhu Lin; Valentino Pirro; Hui-Rong Qian; Giacomo Ruotolo; Lars Ryden; Jonathan M. Wilson; Kevin L. Duffin

doi : 10.2337/dc22-2397

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Novel Once-Weekly Basal Insulin Fc Achieved Similar Glycemic Control With a Safety Profile Comparable to Insulin Degludec in Patients With Type 1 Diabetes

Christof M. Kazda; Juliana M. Bue-Valleskey; Jenny Chien; Qianyi Zhang; Emmanuel Chigutsa; William Landschulz; Paula Wullenweber; Axel Haupt; Dominik Dahl

doi : 10.2337/dc22-2395

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Once-Weekly Basal Insulin Fc Demonstrated Similar Glycemic Control to Once-Daily Insulin Degludec in Insulin-Naive Patients With Type 2 Diabetes: A Phase 2 Randomized Control Trial

Juliana M. Bue-Valleskey; Christof M. Kazda; Chenchen Ma; Jenny Chien; Qianyi Zhang; Emmanuel Chigutsa; William Landschulz; Axel Haupt; Juan P. Frias

doi : 10.2337/dc22-2396

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Development and Validation of a Diabetic Retinopathy Risk Stratification Algorithm

Dariusz Tarasewicz; Andrew J. Karter; Noel Pimentel; Howard H. Moffet; Khanh K. Thai; David Schlessinger; Oleg Sofrygin; Ronald B. Melles

doi : 10.2337/dc22-1168

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Psychiatric Morbidity in Women With Previous Gestational Diabetes Mellitus: A Nationwide Register-Based Cohort Study

Maria Hornstrup Christensen; Marianne Skovsager Andersen; Katrine Hass Rubin; Ellen Aagaard Nohr; Jori Aalders; Christina Anne Vinter; Dorte Moeller Jensen

doi : 10.2337/dc22-1961

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Earlier Age at Type 2 Diabetes Diagnosis Is Associated With Increased Genetic Risk of Cardiovascular Disease

Hyunsuk Lee; Jaewon Choi; Na Yeon Kim; Jong-Il Kim; Min Kyong Moon; Seunggeun Lee; Kyong Soo Park; Soo Heon Kwak

doi : 10.2337/dc22-2144

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People With Type 1 Diabetes of African Caribbean Ethnicity Are at Increased Risk of Developing Sight-Threatening Diabetic Retinopathy

Anastasios Mangelis; Piyumi Wijewickrama; Abbeyramei Nirmalakumaran; Nikolaos Fountoulakis; Prashanth Vas; Laura Webster; Samantha Mann; Julian Collins; David Hopkins; Stephen Thomas; Salma Ayis; Janaka Karalliedde

doi : 10.2337/dc22-2118

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Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies

Jay M. Sosenko; David Cuthbertson; Emily K. Sims; Heba M. Ismail; Brandon M. Nathan; Laura M. Jacobsen; Mark A. Atkinson; Carmella Evans-Molina; Kevan C. Herold; Jay S. Skyler; Maria J. Redondo; TrialNet Study Group

doi : 10.2337/dc22-2236

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Evaluation of the Clinical Impact of Dapagliflozin Discontinuation as Adjunctive Therapy for Patients With Type 1 Diabetes After Indication Withdrawal: A Two-Center Retrospective Study

José Ignacio Martínez-Montoro; María José Picón-César; Víctor José Simón-Frapolli; José Luis Pinzón-Martín; Jorge García-Alemán; María Durán-Martínez; Francisco J. Tinahones

doi : 10.2337/dc23-0083

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Potential and Pitfalls of ChatGPT and Natural-Language Artificial Intelligence Models for Diabetes Education

Gerald Gui Ren Sng; Joshua Yi Min Tung; Daniel Yan Zheng Lim; Yong Mong Bee

doi : 10.2337/dc23-0197

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Comment on Celis-Morales et al. Type 2 Diabetes, Glycemic Control, and Their Association With Dementia and Its Major Subtypes: Findings From the Swedish National Diabetes Register. Diabetes Care 2022;45:634–641

Xiaoni Meng; Youxin Wang

doi : 10.2337/dc22-0774

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Response to Comment on Celis-Morales et al. Type 2 Diabetes, Glycemic Control, and Their Association With Dementia and Its Major Subtypes: Findings From the Swedish National Diabetes Register. Diabetes Care 2022;45:634–641

Carlos A. Celis-Morales; Bjorn Eliasson; Naveed Sattar

doi : 10.2337/dci22-0026

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Comment on Galvez-Fernandez et al. Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study. Diabetes Care 2022;45:2561–2569

Jingli Yang; Juwel Rana; Aimin Yang

doi : 10.2337/dc22-2140

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Response to Comment on Galvez-Fernandez et al. Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study. Diabetes Care 2022;45:2561–2569

Marta Galvez-Fernandez; Ana Navas-Acien

doi : 10.2337/dci22-0060

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Comment on Duarte et al. Systematic Review and Network Meta-analysis of Neurostimulation for Painful Diabetic Neuropathy. Diabetes Care 2022;45:2466–2475

Ashwini D. Sharan; John A. Hatheway; Melissa Murphy; Tammy Dann; Michael A. Fishman; Xander Zuidema; Jan H.M. van Zundert; Maddie LaRue; Rachel Slangen

doi : 10.2337/dc22-2491

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Comment on Duarte et al. Systematic Review and Network Meta-analysis of Neurostimulation for Painful Diabetic Neuropathy. Diabetes Care 2022;45:2466–2475

Behnam Sadeghirad; Xiaoqin Wang; Jason W. Busse

doi : 10.2337/dc22-2449

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Response to Comment on Duarte et al. Systematic Review and Network Meta-analysis of Neurostimulation for Painful Diabetic Neuropathy. Diabetes Care 2022;45:2466–2475

Rui V. Duarte; Sarah Nevitt; Sue Copley; Michelle Maden; Cecile C. de Vos; Rod S. Taylor; Sam Eldabe

doi : 10.2337/dci23-0008

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Comment on Tang et al. The Impact of Carbamylation and Anemia on HbA1c’s Association With Renal Outcomes in Patients With Diabetes and Chronic Kidney Disease. Diabetes Care 2023;46:130–137

Ninon Foussard; Alice Larroumet; Amandine Ferrière; Laurence Blanco; Kamel Mohammedi; Vincent Rigalleau

doi : 10.2337/dc23-0070

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Response to Comment on Tang et al. The Impact of Carbamylation and Anemia on HbA1c’s Association With Renal Outcomes in Patients With Diabetes and Chronic Kidney Disease. Diabetes Care 2023;46:130–137

Mengyao Tang; Sahir Kalim

doi : 10.2337/dci23-0011

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Comment on Bezin et al. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care 2023;46:384–390

Ronald M. Goldenberg; Akshay B. Jain

doi : 10.2337/dc22-2300

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Comment on Bezin et al. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care 2023;46:384–390

Mayumi Endo; Mara Y. Roth; Tracy S. Tylee; Anthony DeSantis; Irl B. Hirsch

doi : 10.2337/dc22-2454

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Comment on Bezin et al. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care 2023;46:384–390

Ana B. Mañas-Martinez; Jose A. Gimeno-Orna

doi : 10.2337/dc23-0076

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Comment on Bezin et al. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care 2023;46:384–390

Mark M. Smits; Daniël H. van Raalte

doi : 10.2337/dc23-0134

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Response to Comment on Bezin et al. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care 2023;46:384–390

Julien Bezin; Clément Mathieu; Jean-Luc Faillie; Antoine Pariente

doi : 10.2337/dci23-0016

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Erratum. 2. Classification and diagnosis of diabetes: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S19–S40

Nuha A. ElSayed; Grazia Aleppo; Vanita R. Aroda; Raveendhara R. Bannuru; Florence M. Brown; Dennis Bruemmer; Billy S. Collins; Marisa E. Hilliard; Diana Isaacs; Eric L. Johnson; Scott Kahan; Kamlesh Khunti; Jose Leon; Sarah K. Lyons; Mary Lou Perry; Priya Prahalad; Richard E. Pratley; Jane Jeffrie Seley; Robert C. Stanton; Robert A. Gabbay; on behalf of the American Diabetes Association

doi : 10.2337/dc23-er05

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