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Meta-Analysis of Reversal Agents for Severe Bleeding Associated With Direct Oral Anticoagulants
Antonio G?mez-Outes, Pau Alcubilla, Gonzalo Calvo-Rojas, Ana Isabel Terleira-Fern?ndez, Emilio Vargas-Castrill?n
doi : 10.1016/j.jacc.2021.04.061
Volume 77, Issue 24, 22 June 2021, Pages 2987-3001
Direct oral anticoagulants (DOACs) have shown a positive benefit-risk balance in both clinical trials and real-world data, but approximately 2% to 3.5% of patients experience major bleeding annually. Many of these patients require hospitalization, and the administration of reversal agents may be required to control bleeding.
Preventing and Managing Bleeding With Anticoagulation for Atrial Fibrillation?
Christopher B. Granger, Sean D. Pokorney
doi : 10.1016/j.jacc.2021.04.053
Volume 77, Issue 24, 22 June 2021, Pages 3002-3004
Aortic Branch Aneurysms and Vascular Risk in Patients With Marfan Syndrome
Angela Lopez-Sainz, Laia Mila, Jose Rodriguez-Palomares, Javier Limeres, Gisela Teixido-Tura
doi : 10.1016/j.jacc.2021.04.054
Volume 77, Issue 24, 22 June 2021, Pages 3005-3012
Aortic branch aneurysms are not included in the diagnostic criteria for Marfan syndrome (MFS); however, their prevalence and eventual prognostic significance are unknown.
Marfan Syndrome: Expanding the Cardiovascular Phenotype??
Reed E. Pyeritz
doi : 10.1016/j.jacc.2021.04.073
Volume 77, Issue 24, 22 June 2021, Pages 3013-3015
Effectiveness of Blood Lipid Management in Patients With Peripheral Artery Disease
Connie N. Hess, Christopher P. Cannon, Joshua A. Beckman, Philip P. Goodney, Marc P. Bonaca
doi : 10.1016/j.jacc.2021.04.060
Volume 77, Issue 24, 22 June 2021, Pages 3016-3027
Low-density lipoprotein cholesterol (LDL-C) is associated with heightened risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in peripheral artery disease (PAD). Lipid-lowering therapies (LLT) that reduce LDL-C decrease this risk.
The Ongoing Struggle to Optimize Lipid-Lowering Therapy in Patients With PAD: PADdling in Circles?
Eric A. Secemsky, Brett J. Carroll, Anna K. Krawisz
doi : 10.1016/j.jacc.2021.04.057
Volume 77, Issue 24, 22 June 2021, Pages 3028-3030
Triglycerides and Residual Atherosclerotic Risk
Sergio Raposeiras-Roubin, Xavier Rossell?, Belén Oliva, Leticia Fern?ndez-Friera, Valentin Fuster
doi : 10.1016/j.jacc.2021.04.059
Volume 77, Issue 24, 22 June 2021, Pages 3031-3041
Even when low-density lipoprotein-cholesterol (LDL-C) levels are lower than guideline thresholds, a residual risk of atherosclerosis remains. It is unknown whether triglyceride (TG) levels are associated with subclinical atherosclerosis and vascular inflammation regardless of LDL-C.
Triglycerides and Atherosclerosis: Bringing the Association Into Sharper Focus?
Peter P. Toth
doi : 10.1016/j.jacc.2021.04.058
Volume 77, Issue 24, 22 June 2021, Pages 3042-3045
Systematic Coronary Risk Evaluation (SCORE): JACC Focus Seminar 4/8
Ian M. Graham, Emanuele Di Angelantonio, Frank Visseren, Dirk De Bacquer,Marie-Therese Cooney
doi : 10.1016/j.jacc.2021.04.052
Volume 77, Issue 24, 22 June 2021, Pages 3046-3057
Clinical estimation of the combined effect of several risk factors is unreliable and this resulted in the development of a number of risk estimation systems to guide clinical practice.
Current Status and Future Prospects of Transcatheter Mitral Valve Replacement: JACC State-of-the-Art Review
Alberto Alperi, Juan F. Granada, Mathieu Bernier, François Dagenais, Josep Rodés-Cabau
doi : 10.1016/j.jacc.2021.04.051
Volume 77, Issue 24, 22 June 2021, Pages 3058-3078
Mitral regurgitation (MR) is the most prevalent valvular heart disease and, when left untreated, it confers a poorer prognosis. Catheter-based repair therapies face some limitations like their applicability on challenging anatomies and the potential recurrence of significant MR over time.
2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report
Executive Committee, Ivor J. Benjamin, C. Michael Valentine, William J. Oetgen,Richard E. Anderson
doi : 10.1016/j.jacc.2021.04.004
Volume 77, Issue 24, 22 June 2021, Pages 3079-3133
Human Connectedness: Coffee, Conversation, and Inspiration
Dipti Itchhaporia
doi : 10.1016/j.jacc.2021.05.007
Volume 77, Issue 24, 22 June 2021, Pages 3134-3135
Harvesting Endothelial Cells During Routine Invasive Coronary Procedures
Peter D. Zalewski, Zinaida Tvorogova, Adrian Abdo, Anna A. Wawer,John F. Beltrame
doi : 10.1016/j.jacc.2021.04.056
Volume 77, Issue 24, 22 June 2021, Pages 3136-3138
Natriuretic Peptide Deficiency in Obese Individuals: Mechanistic Insights From Healthy Organ Donor Cohort
Vibhu Parcha, Nirav Patel, Kiran Musunuru, Kenneth B. Margulies, Pankaj Arora
doi : 10.1016/j.jacc.2021.04.055
Volume 77, Issue 24, 22 June 2021, Pages 3138-3140
Imaging of Vulnerable Intracranial Atherosclerotic Plaque for Embolic Stroke of Undetermined Source
Chengcheng Zhu, Ajay Malhotra, Mahmud Mossa-Basha
doi : 10.1016/j.jacc.2021.03.339
Volume 77, Issue 24, 22 June 2021, Page 3140
Reply: Imaging of Vulnerable Intracranial Atherosclerotic Plaque for Embolic Stroke of Undetermined Source
Lin Tao, Hui-Sheng Chen
doi : 10.1016/j.jacc.2021.04.045
Volume 77, Issue 24, 22 June 2021, Pages 3140-3141
Ivabradine in POTS: Increase in Central Pressure Rather Than Down-Regulation of Sympathetic Nervous System
Franz H. Messerli, Christian Seiler, Stefano F.E. Rimoldi
doi : 10.1016/j.jacc.2021.03.338
Volume 77, Issue 24, 22 June 2021, Pages 3141-3142
Reply: Ivabradine in POTS: Increase in Central Pressure Rather Than Down-Regulation of Sympathetic Nervous System
Pam R. Taub, Adena Zadourian, Jonathan C. Hsu
doi : 10.1016/j.jacc.2021.04.046
Volume 77, Issue 24, 22 June 2021, Pages 3142-3143
