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Issues With the Design of Randomized Trials of Temporary Mechanical Circulatory Support for Cardiogenic Shock.
Dalzell, Jonathan R. MBChB, MD
doi : 10.1161/CIRCULATIONAHA.122.063616
Volume 147(20) pgs. 1489-1563,e718-e718 May 16, 2023
Self-Management Support Using Advertising Principles for Older Adults With Low Income at High Cardiovascular Risk: A Randomized Controlled Trial.
Campbell, David J.T. MD, PhD; Tonelli, Marcello MD, SM; Hemmelgarn, Brenda R. MD, PhD; Faris, Peter PhD; Zhang, Jianguo MSc; Au, Flora MSc; Tsuyuki, Ross T. BSc(Pharm), PharmD, MSc; Mitchell, Chad MSc; Pannu, Raj PhD; Campbell, Tavis PhD; Ivers, Noah MD, PhD; Fletcher, Jane MSc; Exner, Derek V. MD, MPH; Manns, Braden J. MD, MSc; for the Interdisciplinary Chronic Disease Collaboration
doi : 10.1161/CIRCULATIONAHA.123.064189
Self-management education and support (SMES) interventions have modest effects on intermediate outcomes for those at risk of cardiovascular disease, but few studies have measured or demonstrated an effect on clinical end points.
Eliminating Medication Copayments for Low-Income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial.
Campbell, David J.T. MD, PhD; Mitchell, Chad MSc; Hemmelgarn, Brenda R. MD, PhD; Tonelli, Marcello MD, SM; Faris, Peter PhD; Zhang, Jianguo MSc; Tsuyuki, Ross T. BSc(Pharm), PharmD; Fletcher, Jane MSc; Au, Flora MSc; Klarenbach, Scott MD, MSc; Exner, Derek V. MD, MPH; Manns, Braden J. MD, MSc; for the Interdisciplinary Chronic Disease Collaboration
doi : 10.1161/CIRCULATIONAHA.123.064188
One in eight people with heart disease has poor medication adherence that, in part, is related to copayment costs. This study tested whether eliminating copayments for high-value medications among low-income older adults at high cardiovascular risk would improve clinical outcomes.
Raising the Bar for Implementation Science.
Vigen, Rebecca MD, MPA, MSCS; Das, Sandeep R. MD, MPH, MBA
Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.
Gollmann-Tepekoylu, Can MD, PhD ,*; Graber, Michael MD, PhD ,*; Hirsch, Jakob MD; Mair, Sophia MSc; Naschberger, Andreas PhD; Polzl, Leo MD; Nagele, Felix MD; Kirchmair, Elke; Degenhart, Gerald MSc; Demetz, Egon PhD; Hilbe, Richard MSc; Chen, Hao-Yu PhD; Engert, James C. PhD; Bohm, Anna MD; Franz, Nadja MD; Lobenwein, Daniela MD, PhD; Lener, Daniela MSc; Fuchs, Christiane PhD; Weihs, Anna PhD; Tochterle, Sonja MSc; Vogel, Georg F. MD, PhD; Schweiger, Victor MD; Eder, Jonas; Pietschmann, Peter MD; Seifert, Markus; Kronenberg, Florian MD; Coassin, Stefan PhD; Blumer, Michael PhD; Hackl, Hubert PhD; Meyer, Dirk PhD; Feuchtner, Gudrun MD; Kirchmair, Rudolf MD; Troppmair, Jakob PhD; Krane, Markus MD; Weiss, Gunther MD; Tsimikas, Sotirios MD; Thanassoulis, George MD; Grimm, Michael MD; Rupp, Bernhard PhD; Huber, Lukas A. MD; Zhang, Shen-Ying MD, PhD; Casanova, Jean-Laurent MD, PhD; Tancevski, Ivan MD; Holfeld, Johannes MD
doi : 10.1161/CIRCULATIONAHA.122.063481
Calcific aortic valve disease (CAVD) is characterized by a phenotypic switch of valvular interstitial cells to bone-forming cells. Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors at the interface between innate immunity and tissue repair. Type I interferons (IFNs) are not only crucial for an adequate antiviral response but also implicated in bone formation.
Sarcopenia and Cardiovascular Diseases.
Damluji, Abdulla A. MD, PhD ,,*; Alfaraidhy, Maha MBBS ,*; AlHajri, Noora MD, MPH; Rohant, Namit N. MD; Kumar, Manish MD; Al Malouf, Christina MD; Bahrainy, Samira MD; Ji Kwak, Min MD, DrPH; Batchelor, Wayne B. MD, MHS; Forman, Daniel E. MD; Rich, Michael W. MD; Kirkpatrick, James MD; Krishnaswami, Ashok MD, MAS; Alexander, Karen P. MD; Gerstenblith, Gary MD; Cawthon, Peggy PhD; deFilippi, Christopher R. MD; Goyal, Parag MD, MSc
doi : 10.1161/CIRCULATIONAHA.123.064071
AB Sarcopenia is the loss of muscle strength, mass, and function, which is often exacerbated by chronic comorbidities including cardiovascular diseases, chronic kidney disease, and cancer.
"One Brave Idea" Project Yields New Disease Pathways and Tools to Speed Up Heart Research.
Kuehn, Bridget M.
Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease.
Zhang, Yiyi PhD; Dron, Jacqueline S. PhD; Bellows, Brandon K. PharmD, MS; Khera, Amit V. MD, MSc; Liu, Junxiu PhD; Balte, Pallavi P. PhD; Oelsner, Elizabeth C. MD; Amr, Sami Samir PhD; Lebo, Matthew S. PhD; Nagy, Anna MS; Peloso, Gina M. PhD; Natarajan, Pradeep MD, MMSc; Rotter, Jerome I. MD; Willer, Cristen PhD; Boerwinkle, Eric PhD; Ballantyne, Christie M. MD; Lutsey, Pamela L. PhD; Fornage, Myriam PhD; Lloyd-Jones, Donald M. MD, ScM; Hou, Lifang MD, PhD; Psaty, Bruce M. MD, PhD; Bis, Joshua C. PhD; Floyd, James S. MD, MS; Vasan, Ramachandran S. MD; Heard-Costa, Nancy L. PhD, MPH; Carson, April P. PhD; Hall, Michael E. MD, MS; Rich, Stephen S. PhD; Guo, Xiuqing PhD; Kazi, Dhruv S. MD, MSc; de Ferranti, Sarah D. MD, MPH ,,*; Moran, Andrew E. MD, MPH ,*
Letter by Yang et al Regarding Article, "Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2".
Yang, Yuxue MD ,,*; Wang, Daxin MD ,*; Fan, Min MD
Response by Sun et al to Letter Regarding Article, "Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2".
Sun, Ling-Yue MD, PhD ,*; Lyu, Yu-Yan MD, PhD ,*; Pu, Jun MD, PhD
Correction to: Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension.
