Journal of the American College of Cardiology




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doi : 10.1016/S0735-1097(21)05141-X

Volume 77, Issue 25, 29 June 2021, Page e323

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Contents

doi : 10.1016/S0735-1097(21)05238-4

Volume 77, Issue 25, 29 June 2021, Pages e325-e328

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Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults

ZhenZhouPhDaJoanneRyanPhDbMichael E.ErnstPharmDcdSophiaZoungasMBBS, PhDbAndrew M.TonkinPhDbRobyn L.WoodsPhDbJohn J.McNeilMBBS, PhDbChristopher M.ReidPhDeAndrea J.CurtisPhDbRoryWolfePhDbJoWrigglesworthBSc(Hons)bRaj C.ShahMDfElsdonStoreyMBBS, DPhilbAnneMurrayMD, MScghSuzanne G.OrchardPhDbMark R.NelsonMBBS, PhDaASPREE Investigator Group

doi : 10.1016/j.jacc.2021.04.075

Volume 77, Issue 25, 29 June 2021, Pages 3145-3156

The neurocognitive effect of statins in older adults remain uncertain.

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Statins and Your Memory: “Forget” About It??

Christie M.BallantyneMDaVijayNambiMD, PhDab

doi : 10.1016/j.jacc.2021.04.076

Volume 77, Issue 25, 29 June 2021, Pages 3157-3159

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Clinical Impact of High-Sensitivity Cardiac Troponin T Implementation in the Community

OlatundeOlaMD, MPHabAshokAkulaMDabLauraDe MichieliMDcdMarshallDworakBSeErikaCrockfordDOfRonstanLoboMB, BCh, BAOcNicholasRastasBSeJonathan D.KnottMDgRamila A.MehtaMShDavid O.HodgeMSiEricGrubeDOjSwethaKarturiMDaScottWohlrabMBAkTahirTakMDeCharlesCaginDOeRajivGulatiMD, PhDcAllan S.JaffeMDclYaderSandovalMDc

doi : 10.1016/j.jacc.2021.04.050

Volume 77, Issue 25, 29 June 2021, Pages 3160-3170

Limited U.S. data exist regarding high-sensitivity cardiac troponin (cTn) implementation.

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Downstream Cascades of Care Following High-Sensitivity Troponin Test Implementation

IshaniGanguliMD, MPHabJinghanCuiMScNityaThakoreBAbE. JohnOravPhDbdJames L.JanuzziMDacChristopher W.BaughMD, MBAaeThomas D.SequistMD, MPHabfJason H.WasfyMD, Mphilac

doi : 10.1016/j.jacc.2021.04.049

Volume 77, Issue 25, 29 June 2021, Pages 3171-3179

Patients with chest pain are often evaluated for acute myocardial infarction through troponin testing, which may prompt downstream services (cascades) of uncertain value.

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Downstream Consequences of Implementing High-Sensitivity Cardiac Troponin: Why Indication and Education Matter?

ChristianMuellerMDaJasperBoeddinghausMDaThomasNestelbergerMDab

doi : 10.1016/j.jacc.2021.04.063

Volume 77, Issue 25, 29 June 2021, Pages 3180-3183

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Automated Prediction of Cardiorespiratory Deterioration in Patients With Single Ventricle

Craig G.RusinPhDaSebastian I.AcostaPhDaEric L.VuMDbMubbasheerAhmedMDcKennith M.BradyMDbDaniel J.PennyMD, PhD, MHAa

doi : 10.1016/j.jacc.2021.04.072

Volume 77, Issue 25, 29 June 2021, Pages 3184-3192

Patients with single-ventricle physiology have a significant risk of cardiorespiratory deterioration between their first and second stage palliation surgeries.

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Prediction of Cardiac Arrest: A Dream or Reality??

ChitraRavishankarMBBSaMaryam Y.NaimMD, MSCEb

doi : 10.1016/j.jacc.2021.04.074

Volume 77, Issue 25, 29 June 2021, Pages 3193-3194

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Multi-Ethnic Study of Atherosclerosis (MESA): JACC Focus Seminar 5/8

Michael J.BlahaMD, MPHaAndrew P.DeFilippisMD Mscab

doi : 10.1016/j.jacc.2021.05.006

Volume 77, Issue 25, 29 June 2021, Pages 3195-3216

The MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute–sponsored prospective study aimed at studying the prevalence, progression, determinants, and prognostic significance of subclinical cardiovascular disease in a sex-balanced, multiethnic, community-dwelling U.S. cohort. MESA helped usher in an era of noninvasive evaluation of subclinical atherosclerosis presence, burden, and progression for the evaluation of atherosclerotic cardiovascular disease risk, beyond what could be predicted by traditional risk factors alone.

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Classification of Heart Failure According to Ejection Fraction: JACC Review Topic of the Week

Carolyn S.P.LamPhD, MBBSabScott D.SolomonMDc

doi : 10.1016/j.jacc.2021.04.070

Volume 77, Issue 25, 29 June 2021, Pages 3217-3225

The recent U.S. Food and Drug Administration expanded indication for sacubitril/valsartan introduces a new potential taxonomy for heart failure, with no reference to “preserved” ejection fraction but referring to “below normal” ejection fraction as those most likely to benefit. This review summarizes the evolution of nomenclature in heart failure and examines evidence showing that patients with ejection fraction in the “mid range” may benefit from neurohormonal blockade similar to those with more severely reduced (<40%) ejection fraction. Furthermore, prominent sex differences have been observed wherein the benefit of neurohormonal blockade appears to extend to a higher ejection fraction range in women compared to men. Based on emerging evidence, revised nomenclature is proposed defining heart failure with “reduced” (<40%), “mildly reduced,” and “normal” (?55% in men, ?60% in women) ejection fraction.

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JACC: Case Reports: A Year of Transformation

JuliaGrapsaMD, PhD(Editor-in-Chief, JACC: Case Reports)ValentinFusterMD, PhD(Editor-in-Chief, JACC)

doi : 10.1016/j.jacc.2021.05.029

Volume 77, Issue 25, 29 June 2021, Pages 3226-3227

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Exploring the Refractory Period of an Active Stand in Females With Initial Orthostatic Hypotension

Nasia A.SheikhBScShaunRanadaBScKarolinaKogutBScKate M.BourneBScLucy Y.LeiBHScRobert S.SheldonMD, PhDDerek V.ExnerMDAaron A.PhillipsPhDMaryRuntePhDSatish R.RajMD, MSCI

doi : 10.1016/j.jacc.2021.04.068

Volume 77, Issue 25, 29 June 2021, Pages 3228-3229

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Adolescent Body Mass Index and Health Outcomes at 24-Year Follow-Up: A Prospective Cohort Study

Jason M.NagataMD, MScKyle T.GansonPhD, MSWJingyiLiuMDHolly C.GoodingMD, MSAndrea K.GarberPhD, RDKirstenBibbins-DomingoPhD, MD, MAS

doi : 10.1016/j.jacc.2021.04.071

Volume 77, Issue 25, 29 June 2021, Pages 3229-3231

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Do We Need to Define Therapeutic Ranges for Edoxaban Plasma Concentration?

LuigiCappannoliMDMattiaGalliMDRaimondoDe CristofaroMDFilippoCreaMDDomenicoD'AmarioMD, PhD

doi : 10.1016/j.jacc.2021.03.340

Volume 77, Issue 25, 29 June 2021, Pages 3231-3232

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Reply: Do We Need to Define Therapeutic Ranges for Edoxaban Plasma Concentration?

JanSteffelMDChristian T.RuffMD, MPHElliott M.AntmanMDEugeneBraunwaldMDRobert P.GiuglianoMD, SM

doi : 10.1016/j.jacc.2021.04.066

Volume 77, Issue 25, 29 June 2021, Pages 3232-3233

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