ZhenZhouPhDaJoanneRyanPhDbMichael E.ErnstPharmDcdSophiaZoungasMBBS, PhDbAndrew M.TonkinPhDbRobyn L.WoodsPhDbJohn J.McNeilMBBS, PhDbChristopher M.ReidPhDeAndrea J.CurtisPhDbRoryWolfePhDbJoWrigglesworthBSc(Hons)bRaj C.ShahMDfElsdonStoreyMBBS, DPhilbAnneMurrayMD, MScghSuzanne G.OrchardPhDbMark R.NelsonMBBS, PhDaASPREE Investigator Group
doi : 10.1016/j.jacc.2021.04.075
Volume 77, Issue 25, 29 June 2021, Pages 3145-3156
The neurocognitive effect of statins in older adults remain uncertain.
Christie M.BallantyneMDaVijayNambiMD, PhDab
doi : 10.1016/j.jacc.2021.04.076
Volume 77, Issue 25, 29 June 2021, Pages 3157-3159
OlatundeOlaMD, MPHabAshokAkulaMDabLauraDe MichieliMDcdMarshallDworakBSeErikaCrockfordDOfRonstanLoboMB, BCh, BAOcNicholasRastasBSeJonathan D.KnottMDgRamila A.MehtaMShDavid O.HodgeMSiEricGrubeDOjSwethaKarturiMDaScottWohlrabMBAkTahirTakMDeCharlesCaginDOeRajivGulatiMD, PhDcAllan S.JaffeMDclYaderSandovalMDc
doi : 10.1016/j.jacc.2021.04.050
Volume 77, Issue 25, 29 June 2021, Pages 3160-3170
Limited U.S. data exist regarding high-sensitivity cardiac troponin (cTn) implementation.
IshaniGanguliMD, MPHabJinghanCuiMScNityaThakoreBAbE. JohnOravPhDbdJames L.JanuzziMDacChristopher W.BaughMD, MBAaeThomas D.SequistMD, MPHabfJason H.WasfyMD, Mphilac
doi : 10.1016/j.jacc.2021.04.049
Volume 77, Issue 25, 29 June 2021, Pages 3171-3179
Patients with chest pain are often evaluated for acute myocardial infarction through troponin testing, which may prompt downstream services (cascades) of uncertain value.
ChristianMuellerMDaJasperBoeddinghausMDaThomasNestelbergerMDab
doi : 10.1016/j.jacc.2021.04.063
Volume 77, Issue 25, 29 June 2021, Pages 3180-3183
Craig G.RusinPhDaSebastian I.AcostaPhDaEric L.VuMDbMubbasheerAhmedMDcKennith M.BradyMDbDaniel J.PennyMD, PhD, MHAa
doi : 10.1016/j.jacc.2021.04.072
Volume 77, Issue 25, 29 June 2021, Pages 3184-3192
Patients with single-ventricle physiology have a significant risk of cardiorespiratory deterioration between their first and second stage palliation surgeries.
ChitraRavishankarMBBSaMaryam Y.NaimMD, MSCEb
doi : 10.1016/j.jacc.2021.04.074
Volume 77, Issue 25, 29 June 2021, Pages 3193-3194
Michael J.BlahaMD, MPHaAndrew P.DeFilippisMD Mscab
doi : 10.1016/j.jacc.2021.05.006
Volume 77, Issue 25, 29 June 2021, Pages 3195-3216
The MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute–sponsored prospective study aimed at studying the prevalence, progression, determinants, and prognostic significance of subclinical cardiovascular disease in a sex-balanced, multiethnic, community-dwelling U.S. cohort. MESA helped usher in an era of noninvasive evaluation of subclinical atherosclerosis presence, burden, and progression for the evaluation of atherosclerotic cardiovascular disease risk, beyond what could be predicted by traditional risk factors alone.
Carolyn S.P.LamPhD, MBBSabScott D.SolomonMDc
doi : 10.1016/j.jacc.2021.04.070
Volume 77, Issue 25, 29 June 2021, Pages 3217-3225
The recent U.S. Food and Drug Administration expanded indication for sacubitril/valsartan introduces a new potential taxonomy for heart failure, with no reference to “preserved” ejection fraction but referring to “below normal” ejection fraction as those most likely to benefit. This review summarizes the evolution of nomenclature in heart failure and examines evidence showing that patients with ejection fraction in the “mid range” may benefit from neurohormonal blockade similar to those with more severely reduced (<40%) ejection fraction. Furthermore, prominent sex differences have been observed wherein the benefit of neurohormonal blockade appears to extend to a higher ejection fraction range in women compared to men. Based on emerging evidence, revised nomenclature is proposed defining heart failure with “reduced” (<40%), “mildly reduced,” and “normal” (?55% in men, ?60% in women) ejection fraction.
JuliaGrapsaMD, PhD(Editor-in-Chief, JACC: Case Reports)ValentinFusterMD, PhD(Editor-in-Chief, JACC)
doi : 10.1016/j.jacc.2021.05.029
Volume 77, Issue 25, 29 June 2021, Pages 3226-3227
Nasia A.SheikhBScShaunRanadaBScKarolinaKogutBScKate M.BourneBScLucy Y.LeiBHScRobert S.SheldonMD, PhDDerek V.ExnerMDAaron A.PhillipsPhDMaryRuntePhDSatish R.RajMD, MSCI
doi : 10.1016/j.jacc.2021.04.068
Volume 77, Issue 25, 29 June 2021, Pages 3228-3229
Jason M.NagataMD, MScKyle T.GansonPhD, MSWJingyiLiuMDHolly C.GoodingMD, MSAndrea K.GarberPhD, RDKirstenBibbins-DomingoPhD, MD, MAS
doi : 10.1016/j.jacc.2021.04.071
Volume 77, Issue 25, 29 June 2021, Pages 3229-3231
LuigiCappannoliMDMattiaGalliMDRaimondoDe CristofaroMDFilippoCreaMDDomenicoD'AmarioMD, PhD
doi : 10.1016/j.jacc.2021.03.340
Volume 77, Issue 25, 29 June 2021, Pages 3231-3232
JanSteffelMDChristian T.RuffMD, MPHElliott M.AntmanMDEugeneBraunwaldMDRobert P.GiuglianoMD, SM
doi : 10.1016/j.jacc.2021.04.066
Volume 77, Issue 25, 29 June 2021, Pages 3232-3233
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