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Circadian Factors in Cluster Headache and Migraine: It's All About the Timing.
Sutherland, Heidi G. PhD; Griffiths, Lyn R. PhD
doi : 10.1212/WNL.0000000000207329
Volume 100(22) pgs. 1035-1075,e2237-e2323 May 30, 2023
The Alzheimer Disconnectome.
Brodtmann, Amy MBBS, PhD; Beversdorf, David Q. MD
To Use Perfusion Imaging or Not in Patient Selection for Late Window Endovascular Thrombectomy?: That Is the Question.
Katsanos, Aristeidis H. MD; Catanese, Luciana MD; Shoamanesh, Ashkan MD
Relationship of Bern Score, Spinal Elastance, and Opening Pressure in Patients With Spontaneous Intracranial Hypotension.
Callen, Andrew L. MD; Pattee, Jack PhD; Thaker, Ashesh A. MD; Timpone, Vincent M. MD; Zander, David A. MD; Turner, Ryan BA; Birlea, Marius MD; Wilhour, Danielle MD; O'Brien, Chantal MD; Evan, Jennifer MD; Grassia, Fabio MD; Carroll, Ian R. MD, MS
doi : 10.1212/WNL.0000000000207267
Existing tools to diagnose spontaneous intracranial hypotension (SIH), namely spinal opening pressure (OP) and brain MRI, have limited sensitivity
Outcomes in Patients With COVID-19 With Acute Encephalopathy and Coma: An International Prospective Study.
Legriel, Stephane MD, PhD; Badenes, Rafael MD, PhD; Engrand, Nicolas MD, MSc; Mendoza-Trujillo, Rocio MD; Soulier, Pauline MD; Benghanem, Sarah MD; Pizzi, Michael DO, PhD; Maciel, Carolina MD, MSCR; Chelly, Jonathan MD; Zuber, Benjamin MD; Labruyere, Marie MD; Plantefeve, Gaetan MD; Jacq, Gwenaelle RN, MSc; Galbois, Arnaud MD, PhD; Launey, Yoann MD, PhD; Argaud, Laurent MD, PhD; Lesieur, Olivier MD, PhD; Ferre, Alexis MD; Paul, Marine MD; Guillon, Antoine MD, PhD; Bailly, Pierre MD; Beuret, Pascal MD; de-Carne, Marie-Charlotte MD; Siami, Shidasp MD, PhD; Benzekri, Dalila MD; Colin, Gwenhael MD; Gaviria, Leidy MD; Aldana, Jose Luis MD; Bruel, Cedric MD; Stoclin, Annabelle MD; Sedillot, Nicholas MD; Geri, Guillaume MD, PhD; Samano, Daniel MD, MPH; Sobczak, Evie MS; Swafford, Emily BS; O'Phelan, Kristine MD; Meffert, Arnaud MD; Holleville, Mathilde MD; Silva, Stein MD, PhD; Alves da Costa, Manoel Jose MD; Mejia, Jorge MD, MSc; Alkhachroum, Ayham MD; for NeuroCovid19; for NeuroCovid19; Bruneel, Fabrice MD; Lopez, Berta Monleon- MD; Monchi, Mehran MD; Cariou, Alain MD, PhD; Cerf, Charles MD; Quenot, Jean-Pierre MD, PhD; Tadie, Jean-Marc MD, PhD; Lher, Erwan MD; Belan, Alix Greder- MD; Muller, Gregoire MD; Baron, Antoine Vieillard- MD, PhD; Mongardon, Nicolas MD, PhD
doi : 10.1212/WNL.0000000000207263
To report the prevalence of acute encephalopathy and outcomes in patients with severe coronavirus disease 2019 (COVID-19) and to identify determinants of 90-day outcomes.
Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology.
Agarwal, Puja PhD; Leurgans, Sue E. PhD; Agrawal, Sonal PhD; Aggarwal, Neelum T. MD; Cherian, Laurel J. MD; James, Bryan D. PhD; Dhana, Klodian MD, PhD; Barnes, Lisa L. PhD; Bennett, David A. MD; Schneider, Julie A. MD
doi : 10.1212/WNL.0000000000207176
Diet may reduce Alzheimer dementia risk and slow cognitive decline, but the understanding of the relevant neuropathologic mechanisms remains limited.
White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease.
Tian, Jianqiao MS; Raghavan, Sheelakumari PhD; Reid, Robert I. PhD; Przybelski, Scott A. BS; Lesnick, Timothy G. MS; Gebre, Robel K. PhD; Graff-Radford, Jonathan MD; Schwarz, Christopher G. PhD; Lowe, Val J. MD; Kantarci, Kejal MD; Knopman, David S. MD; Petersen, Ronald C. MD, PhD; Jack, Clifford R. Jr MD; Vemuri, Prashanthi PhD
doi : 10.1212/WNL.0000000000207250
The dynamics of white matter (WM) changes are understudied in Alzheimer disease (AD). Our goal was to study the association between flortaucipir PET and WM health using neurite orientation dispersion and density imaging (NODDI) and evaluate its association with cognitive performance.
Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals.
Grober, Ellen PhD; Petersen, Kellen K. PhD; Lipton, Richard B. MD; Hassenstab, Jason PhD; Morris, John C. MD; Gordon, Brian A. PhD; Ezzati, Ali MD
doi : 10.1212/WNL.0000000000207276
Increasing evidence indicates that a subset of cognitively normal individuals has subtle cognitive impairment at baseline. We sought to identify them using the Stages of Objective Memory Impairment (SOMI) system
Functional Connectivity From Disease Epicenters in Frontotemporal Dementia.
Agosta, Federica MD, PhD; Spinelli, Edoardo Gioele MD; Basaia, Silvia PhD; Cividini, Camilla MSc; Falbo, Francesco MD; Pavone, Costanza MD; Riva, Nilo MD, PhD; Canu, Elisa PhD; Castelnovo, Veronica MSc; Magnani, Giuseppe MD; Caso, Francesca MD, PhD; Caroppo, Paola MD, PhD; Prioni, Sara MSc; Villa, Cristina PhD; Tremolizzo, Lucio MD; Appollonio, Ildebrando MD; Silani, Vincenzo MD; Josephs, Keith A. MD, MST, MSc; Whitwell, Jennifer PhD; Filippi, Massimo MD
doi : 10.1212/WNL.0000000000207277
MRI connectomics is an ideal tool to test a network-based model of pathologic propagation from a disease epicenter in neurodegenerative disorders.
CT Perfusion vs Noncontrast CT for Late Window Stroke Thrombectomy: A Systematic Review and Meta-analysis.
Kobeissi, Hassan BS *; Ghozy, Sherief MD *; Adusumilli, Gautam MD; Bilgin, Cem MD; Tolba, Hatem MD; Amoukhteh, Melika MD; Kadirvel, Ramanathan PhD; Brinjikji, Waleed MD; Heit, Jeremy J. MD, PhD; Rabinstein, Alejandro A. MD; Kallmes, David F. MD
doi : 10.1212/WNL.0000000000207262
Patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) in the late window (6-24 hours) can be evaluated with CT perfusion (CTP) or with noncontrast CT (NCCT) only.
Association of Circulating Metabolites With Racial Disparities in Hypertension and Stroke in the REGARDS Study.
Kijpaisalratana, Naruchorn MD, PhD; Ament, Zsuzsanna PhD; Patki, Amit MS; Bhave, Varun M. BA; Garcia-Guarniz, Ana-Lucia MD; Judd, Suzanne E. PhD; Cushman, Mary MD, MSc; Long, D. Leann PhD; Irvin, M. Ryan PhD; Kimberly, W. Taylor MD, PhD
doi : 10.1212/WNL.0000000000207264
In the United States, the risk of stroke is greater among Black compared with that among White individuals. However, the reasons for the difference in stroke incidence are not fully elucidated.
Adapting to Evolving Technologies and Treatment Guidelines in a Procedural Trial: A Qualitative Review of the CREST-2 Experience.
Meschia, James F. MD; Lal, Brajesh MD; Roubin, Gary MD; Turan, Tanya N. MD, MSCR; Howard, Virginia J. PhD; Benson, Richard T. MD, PhD; Carman, Kaley PhD; Howard, George DrPH; Brott, Thomas G. MD
doi : 10.1212/WNL.0000000000207075
AB Multiple challenges confront procedural trials, including slow enrollment, lack of equipoise among patients and physicians, and failure to achieve adequate masking.
Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI.
Parasuram, Nethra R. BS; Crawford, Anna L. MS; Mazurek, Mercy H. BS; Chavva, Isha R. BS; Beekman, Rachel MD; Gilmore, Emily J. MD; Petersen, Nils H. MD; Payabvash, Seyedmehdi MD; Sze, Gordon MD, FACR; Eugenio Iglesias, Juan PhD; Omay, Sacit B. MD, FAANS; Matouk, Charles MD; Longbrake, Erin E. MD, PhD; de Havenon, Adam MD; Schiff, Steven J. MD, PhD; Rosen, Matthew S. PhD; Kimberly, W. Taylor MD, PhD; Sheth, Kevin N. MD
doi : 10.1212/WNL.0000000000207074
AB In the 20th century, the advent of neuroimaging dramatically altered the field of neurologic care. However, despite iterative advances since the invention of CT and MRI, little progress has been made to bring MR neuroimaging to the point of care.
Teaching NeuroImage: Primary CNS Vasculitis Mimicking Intracranial Tumor.
Sun, Hanlin MD; Zhang, Shujiang MD; Yu, Tianping MD; Zhou, Dong PhD; Li, Jinmei PhD
Editors' Note: D313Y Variant in Fabry Disease: A Systematic Review and Meta-analysis.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: D313Y Variant in Fabry Disease: A Systematic Review and Meta-analysis.
Lackova, Alexandra; Szilasiova, Jarmila; Vitkova, Marianna; Ostrozovicova, Miriam; Skorvanek, Matej
Incidence of Amyloid-Related Imaging Abnormalities in Patients With Alzheimer Disease Treated With Anti-[beta]-Amyloid Immunotherapy: A Meta-analysis.
Author Response: D313Y Variant in Fabry Disease: A Systematic Review and Meta-analysis.
Palaiodimou, Lina; Stefanou, Maria-Ioanna; Tsivgoulis, Georgios
Circadian Features of Cluster Headache and Migraine: A Systematic Review, Meta-analysis, and Genetic Analysis.
Benkli, Barlas MD; Kim, Sun Young BA; Koike, Nobuya PhD; Han, Chorong PhD; Tran, Celia K. BS; Silva, Emma MLS; Yan, Yuanqing PhD; Yagita, Kazuhiro PhD; Chen, Zheng PhD; Yoo, Seung-Hee PhD *; Burish, Mark J. MD, PhD *
doi : 10.1212/WNL.0000000000207240
Cluster headache and migraine have circadian features at multiple levels (cellular, systems, and behavioral). A thorough understanding of their circadian features informs their pathophysiologies.
How Dietary Habits Can Affect Abnormal Protein Buildup in the Brain.
Yasar, Sevil MD, PhD
