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Augmented Transdermal Delivery of Curcumin for the Effective Management of Plaque Psoriasis – Design, Formulation, Characterisation, and In Vivo Studies
Bhumika Kumar & Pravat Kumar Sahoo
doi : 10.1208/s12249-023-02595-8
Volume 24, issue 5, June 2023
Psoriasis is a recurrent, life-threatening anti-inflammatory condition that affects nearly 1–3% of the global population. It is an autoimmune illness distinguished by hyperplasia of skin cells or fast skin cell development, resulting in abnormally irritating scales and skin patches.
Strategizing Spray Drying Process Optimization for the Manufacture of Redispersible Indomethacin Nanoparticles Using Quality-by-Design Principles
Vishal Rathod, Bhavin Gajera, Anusha Pinninti, Irfan A. Mohammed & Rutesh H. Dave
doi : 10.1208/s12249-023-02589-6
The present study adopted a Quality by Design (QbD) approach to spray dry indomethacin nanosuspension (IMC-NS) consisting of HPC-SL, poloxamer 407, and lactose monohydrate.
Development of Child-Friendly Lisdexamfetamine Chewable Tablets Using Ion Exchange Resin as a Taste-Masking Carrier Based on the Concept of Quality by Design (QbD)
Chunmei Zhu, Jinmin Chen, Limin Shi, Qing Liu, Chunfeng Liu, Fuli Zhang & Haoxiang Wu
doi : 10.1208/s12249-023-02592-x
Taste masking is critical to improving the compliance of pediatric oral dosage forms. However, it is challenging for extremely bitter lisdexamfetamine dimesylate (LDX) with a long half-life and given in large dose.
Formulation of Resveratrol-Loaded Polycaprolactone Inhalable Microspheres Using Tween 80 as an Emulsifier: Factorial Design and Optimization
Riya Mahar, Arpita Chakraborty & Nidhi Nainwal
doi : 10.1208/s12249-023-02587-8
Resveratrol (RSV) is a bioactive phytoconstituent that has potential applications in respiratory diseases. However, poor oral bioavailability is the major hurdle to its clinical use. In the present work, resveratrol-loaded polycaprolactone (PCL) inhalable microspheres (MSs) were formulated to improve their therapeutic potential.
Inhaled Adjunct Therapy with Second-Line Drug Candidates for Dose Reduction in Chemotherapeutic Regimens for Multi-drug-Resistant Tuberculosis
Sonia Verma, Nils-Jorgen K. Dal, Ashish Srivastava, Reena Bharti, D. V. Siva Reddy, Hasham Shafi Sofi, Trisha Roy, Khushboo Verma, Sunil K. Raman, Lubna Azmi, Lipika Ray, Madhav N. Mugale, Amit K. Singh, Jyotsna Singh, Gareth Griffiths & Amit Misra
doi : 10.1208/s12249-023-02585-w
Chemotherapy of multi-drug-resistant tuberculosis (TB) requires prolonged administration of multiple drugs. We investigated whether pulmonary delivery of minute doses of drugs, along with reduced oral doses of the same agents, would affect preclinical efficacy.
Retraction Note: Optimization of Thymoquinone-Loaded Coconut Oil Nanostructured Lipid Carriers for the Management of Ethanol-Induced Ulcer
Usama A. Fahmy, Ahmed L. Alaofi, Zuhier A. Awan, Hani M. Alqarni & Nabil A. Alhakamy
Retraction Note: Fluvastatin-Loaded Emulsomes Exhibit Improved Cytotoxic and Apoptosis in Prostate Cancer Cells
Nabil A. Alhakamy, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Anas Alfarsi, Thikryat Neamatallah, Solomon Z. Okbazghi, Usama A. Fahmy, Osama A. A. Ahmad, Basma G. Eid, Wael Ali Mahdi, Adel F. Alghaith, Sultan Alshehri & Shadab Md
An Intragastric Delivery Device Employing FDM Technology: 3D-Printed Tablet Containing Green Developed Mosapride-Saccharin Co-crystals
Omnya Mahmoud Amin, Hesham Nassereldin EL Qady & Marwa Adel Abd El-Fattah
doi : 10.1208/s12249-023-02578-9
Mosapride citrate (MC) is a poorly soluble short half-life drug with more pronounced absorption in the stomach. The present study aimed to incorporate MC co-crystals with enhanced solubility into 3D-printed floating tablets.
Naringenin-Capped Silver Nanoparticles Amalgamated Gel for the Treatment of Cutaneous Candidiasis
Chantibabu Katta, Arbaz Sujat Shaikh, Nagesh Bhale, Vaskuri G. S. Sainaga Jyothi, Venkata Rao Kaki, Amol G. Dikundwar, Pankaj Kumar Singh, Renu Shukla, Krishnaveni Mishra & Jitender Madan
doi : 10.1208/s12249-023-02581-0
The current research was aimed to synthesize a phytomolecule, naringenin (NRG)-mediated silver nanoparticles (NRG-SNPs) to study their antifungal potential against Candida albicans (C. albicans) and Candida glabrata (C. glabrata).
Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers
Kyung Hwa Chang, Bong Joo Park & Ki Chang Nam
doi : 10.1208/s12249-023-02579-8
Recently, many preclinical and clinical studies have been conducted on the delivery of therapeutic antibodies to the lungs using nebulizers, but standard treatment guidelines have not yet been established.
Highlights on Cell-Penetrating Peptides and Polymer-Lipid Hybrid Nanoparticle: Overview and Therapeutic Applications for Targeted Anticancer Therapy
Pragathi Devanand Bangera, Divya Dhatri Kara, Katikala Tanvi, Vamshi Krishna Tippavajhala & Mahalaxmi Rathnanand
doi : 10.1208/s12249-023-02576-x
Polymer-lipid hybrid nanoparticles (PLHNs) have been widely used as a vehicle for carrying anticancer owing to its unique framework of polymer and lipid combining and giving the maximum advantages over the lipid and polymer nanoparticle drug delivery system.
In Vitro Prototyping of a Nano-Organogel for Thermo-Sonic Intra-Cervical Delivery of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles for Cervical Cancer
Samson A. Adeyemi, Zardad Az-Zamakhshariy & Yahya E. Choonara
doi : 10.1208/s12249-023-02583-y
Solid lipid nanoparticles (SLNs) are used extensively to achieve site-specific drug delivery with improved bioavailability and reduced toxicity. This work focused on a new approach to provide site-specific stimuli-responsive delivery of SLNs loaded within thermo-sonic nano-organogel (TNO) variants to deliver the model chemotherapeutic agent 5-FU in treating cervical cancer.
Preliminary Study on the Development of Caffeine Oral Solid Form 3D Printed by Semi-Solid Extrusion for Application in Neonates
Agnès Roche, Noelia M. Sanchez-Ballester, Adrien Aubert, Jean-Christophe Rossi, Sylvie Begu & Ian Soulairol
doi : 10.1208/s12249-023-02582-z
Apnea of prematurity can be treated with a body-weight-adjusted dosage of caffeine. Semi-solid extrusion (SSE) 3D printing represents an interesting approach to finely tailor personalized doses of active ingredients.
A Combined In-Vitro and GastroPlus® Modeling to Study the Effect of Intestinal Precipitation on Cinnarizine Plasma Profile in a Fasted State
Siddharth S. Kesharwani & Fady Ibrahim
doi : 10.1208/s12249-023-02577-w
Poorly water-soluble weak base molecules such as cinnarizine often exhibit pH-dependent solubility within the gastrointestinal tract. This means that their solubility can be influenced by the pH of the surrounding environment, and this can affect their oral absorption.
Darifenacin Self-assembled Liquid Crystal Cubic Nanoparticles: a Sustained Release Approach for an Overnight Control of Overactive Bladder
Michael M. Farag, Wessam El-Sebaie, Emad B. Basalious & Omaima N. El-Gazayerly
doi : 10.1208/s12249-023-02575-y
The current study is regarding the development and characterization of Darifenacin-loaded self-assembled liquid crystal cubic nanoparticles (LCCN). An anhydrous approach was used for the preparation of these cubic nanoparticles using a hydrotropic agent (propylene glycol), with minimal energy input.
Non-systemic Approaches for Ductal Carcinoma In Situ: Exploring the Potential of Ultra-flexible Combisomes as a Novel Drug Delivery Strategy—a Review
Cynthia Lizzie Lobo, Amitha Shetty, Manohar M, Akhilesh Dubey & Sally A. El-Zahaby
doi : 10.1208/s12249-023-02574-z
Ductal carcinoma in situ (DCIS) is currently treated through breast-conserving surgery (lumpectomy), radiation therapy, breast-removing surgery (mastectomy), and hormone therapy to prevent further progression into invasive breast cancer and recurrence.
Liposomal Nanodrug Based on Norcantharidin Derivative for Increased in Vivo Activity
Hailong Kuang, Peipei Wang, Yuhang Wang, Jinbo Li, Jiang Yu, Lirui Jia, Shuo Li, Yan Ma, Hongzhuo Liu, Zhonggui He & Yongjun Wang
doi : 10.1208/s12249-023-02572-1
To address the limitations of norcantharidin (NCTD) in clinical applications, including restricted tumor accumulation and intense irritation, we have developed a new derivative of NCTD with (S)-1-benzyl-3-pyrrolidinol, which can be actively loaded into liposomes to achieve drug encapsulation and sustained release properties by using pH gradient loading technique.
Drug-Excipient Compatibility Study Through a Novel Vial-in-Vial Experimental Setup: A Benchmark Study
Sonali Jain & Ravi P. Shah
doi : 10.1208/s12249-023-02573-0
Drug-excipient compatibility study (DECS) is one of the critical steps during pre-formulation studies to select the appropriate excipient to obtain a stable formulation/dosage form. As such, there is no recommended guideline for DECS.
A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets
AbdAlmonem Doolaanea, NurFaezah Latif, Shubham Singh, Mohit Kumar, Mohamad Faizal Safa’at, Mulham Alfatama, Raihana Edros & Amit Bhatia
doi : 10.1208/s12249-023-02570-3
Three-dimensional (3D) printing technology has presently been explored widely in the field of pharmaceutical research to produce various conventional as well as novel dosage forms such as tablets, capsules, oral films, pellets, subcutaneous implants, scaffolds, and vaginal rings.
Enhancement of Valsartan Oral Bioavailability by Preparing a Microwave-Irradiated Inclusion Complex with Sulfobutyl Ether β-Cyclodextrin Using a Central Composite Face Design for Optimising Process Parameters
Venkata Ramana Maddula & Rama Sekhara Reddy Dachuru
doi : 10.1208/s12249-023-02571-2
The purpose of the study is to investigate the influence of sulfobutyl ether β-cyclodextrin (SBE7-β-CD) on the bioavailability of valsartan. Phase solubility investigations showed an AL type curve. The estimated apparent stability constant for valsartan SBE7-β-CD is 427 ± 0.32 M−1.
Preparation of Sustained Release Formulation of Verapamil Hydrochloride Using Ion Exchange Resins
Hussein Allaboun, Khouloud A. Alkhamis & Suhair S. Al-Nimry
doi : 10.1208/s12249-023-02569-w
The purpose of this investigation was to formulate and evaluate the interaction between cation exchange resins and verapamil hydrochloride. The uptake studies were conducted using the rotating bottle apparatus.
Evaluating the Effect of Microcrystalline Cellulose Variations on Tablet Quality of Natural Plant Product Using a Design of Experiment Approach
Haiyue Zhao, Chuting Shi, Zhenda Liu, Lijie Zhao & Lan Shen
doi : 10.1208/s12249-023-02556-1
Microcrystalline cellulose (MCC) of different grades from different manufacturers differ in particulate and powder properties significantly. The choice of MCC is important to the development of a tablet formulation with satisfactory quality.
Achillea wilhelmsii–Incorporated Chitosan@Eudragit Nanoparticles Intended for Enhanced Ulcerative Colitis Treatment
Hassan Maleki, Maryam Doostan, Mohammad Hosein Farzaei, Parisa Seifi, Shahram Miraghaee & Mahtab Doostan
doi : 10.1208/s12249-023-02568-x
Achillea wilhelmsii (A. wilhelmsii) contains several therapeutic phytochemicals, proposing a protective effect on inflammatory responses in autoimmune diseases such as ulcerative colitis (UC). However, its activities against UC encounter multiple obstacles.
Emerging Advances in Nanocarriers Approaches in the Effective Therapy of Pain Related Disorders: Recent Evidence and Futuristic Needs
Nishtha Chaurawal, Mohak Kataria, Muniramiah Vinod Kumar, Narayan Prasad Mishra, Vijay G. Goni & Kaisar Raza
doi : 10.1208/s12249-023-02567-y
Pain disorders are the primary cause of disability nowadays. These disorders, such as rheumatoid arthritis (RA) and osteoarthritis (OA), cause loss of function, joint pain and inflammation and deteriorate the quality of life.
Correction: Biomimetic Antidote Nanoparticles: A Novel Strategy for Chronic Heavy Metal Poisoning
Hao Wang, Qing Yao, Wenquan Zhu, Yang Yang, Chunsheng Gao, Xiaoyang Chu & Cuiyan Han
Dapsone-Loaded Mixed Micellar Gel for Treatment OF Acne Vulgaris
Monica RP Rao, Sushant Deshpande & Padmanabh Deshpande
doi : 10.1208/s12249-023-02564-1
Mixed polymeric micelles are potential nanocarriers for topical drug delivery. Dapsone (DAP) is an antibacterial used as anti-acne agent, but challenged by low water solubility and poor skin permeability.
Topical Nanotherapeutics for Treating MRSA-Associated Skin and Soft Tissue Infection (SSTIs)
Sriravali Karnam, Anil B. Jindal, Charu Agnihotri, Bhim Pratap Singh & Atish T. Paul
doi : 10.1208/s12249-023-02563-2
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) imposes a major challenge for the treatment of infectious diseases with existing antibiotics. MRSA associated with superficial skin and soft tissue infections (SSTIs) is one of them, affecting the skin’s superficial layers, and it includes impetigo, folliculitis, cellulitis, furuncles, abscesses, surgical site infections, etc.
Influence of Poloxamer on the Dissolution and Stability of Hot-Melt Extrusion–Based Amorphous Solid Dispersions Using Design of Experiments
Ashay Shukla, Nagi Reddy Dumpa, Rishi Thakkar, Abhishek Shettar, Eman Ashour, Suresh Bandari & Michael A. Repka
doi : 10.1208/s12249-023-02562-3
The current study aimed to see the effects of poloxamer P407 on the dissolution performance of hydroxypropyl methylcellulose acetate succinate (AquaSolveâ„¢ HPMC-AS HG)-based amorphous solid dispersions (ASD).
Nanostructured Lipid Carrier–Based Gel for Repurposing Simvastatin in Localized Treatment of Breast Cancer: Formulation Design, Development, and In Vitro and In Vivo Characterization
Popat S. Kumbhar, Arehalli S. Manjappa, Rohit R. Shah, Sameer J. Nadaf & John I. Disouza
doi : 10.1208/s12249-023-02565-0
Simvastatin (SMV) is noticed as a repurposed candidate to be effective against breast cancer (BC). However, poor solubility, dose-limiting toxicities, and side effects are critical hurdles in its use against BC. The above drawbacks necessitate the site-specific (localized) delivery of SMV via suitable nanocarriers.
Plaster Gel Loaded with Silver Nanoparticle-Mediated Ganoderma applanatum: from Fabrication to Evaluation
Pattwat Maneewattanapinyo, Chaowalit Monton, Wiwat Pichayakorn, Nattakan Dangmanee, Thaniya Wunnakup & Jirapornchai Suksaeree
doi : 10.1208/s12249-023-02566-z
Traditional Asian remedies have mainly employed the macrofungus Ganoderma applanatum, which belongs to the family Ganodermataceae, as a medicinal mushroom due to its high antibacterial and antioxidant activity.
Comparison of Protein Particle Formation in IgG1 mAbs Formulated with PS20 Vs. PS80 When Subjected to Interfacial Dilatational Stress
Coleman Vaclaw, Kimberly Merritt, Valerie P. Griffin, Neal Whitaker, Madhushree Gokhale, David B. Volkin, Maria O. Ogunyankin & Prajnaparamita Dhar
doi : 10.1208/s12249-023-02561-4
Polysorbates (PS) are nonionic surfactants that are commonly included in protein formulations to mitigate the formation of interfacial stress-induced protein particles and thus increase their long-term storage stability.
Predicting Glass-Forming Ability of Pharmaceutical Compounds by Using Machine Learning Technologies
Junhuang Jiang, Defang Ouyang & Robert O. Williams III
doi : 10.1208/s12249-023-02535-6
Low aqueous solubility is a common and serious challenge for most drug substances not only in development but also in the market, and it may cause low absorption and bioavailability as a result.
