دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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ChatGPT, et al…Artificial Intelligence, Authorship, and Medical Publishing
Daniel H. Solomon, Kelli D. Allen, Patricia Katz, Amr H. Sawalha, Ed Yelin
doi : 10.1002/art.42497
Gene–Diet Interactions: Beyond Duelling Views of Gout Pathogenesis
Nicola Dalbeth
doi : 10.1002/art.42473
Disease Activity and Health-Related Quality of Life Among Patients With Rheumatoid Arthritis With Different Alcohol Consumption Habits
Lars Alfredsson, Lars Klareskog, Anna Karin Hedström
doi : 10.1002/art.42442
Multiple studies have found a relationship between alcohol consumption and disease activity in rheumatoid arthritis (RA), although reverse causation has been suggested to explain the association. We aimed to study the relationship between alcohol consumption and disease activity, disease progression, and health-related quality of life in patients with RA.
Efficacy and Safety of ABBV-3373, a Novel Anti–Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody–Drug Conjugate, in Adults with Moderate-to-Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double-Blind, Active-Controlled Proof-of-Concept Phase IIa Trial
Frank Buttgereit, Jacob Aelion, Bernadette Rojkovich, Anna Zubrzycka-Sienkiewicz, Su Chen, Yang Yang, Dilek Arikan, Ronilda D'Cunha, Yinuo Pang, Hartmut Kupper, Timothy Radstake, Howard Amital
doi : 10.1002/art.42415
To assess the efficacy and safety of ABBV-3373, a novel antibody–drug conjugate (ADC) composed of the anti–tumor necrosis factor (anti-TNF) monoclonal antibody adalimumab linked to a glucocorticoid receptor modulator (GRM), compared to adalimumab, in patients with rheumatoid arthritis (RA).
Prediction of Erosive Disease Development by Antimitochondrial Antibodies in Rheumatoid Arthritis
Richard E. Moore, Ting Wang, Bhargavi Duvvuri, Marie L. Feser, Kevin D. Deane, Joshua J. Solomon, J. Lee Nelson, M. Kristen Demoruelle, Christian Lood
doi : 10.1002/art.42428
Mitochondria are found in the extracellular space in rheumatoid arthritis (RA). However, whether mitochondria are a source of autoantigens in RA has not been carefully addressed. Thus, we undertook this study to investigate the presence and significance of antimitochondrial antibodies (AMAs) in patients with RA.
A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults
Benjamin G. Faber, Monika Frysz, April E. Hartley, Raja Ebsim, Cindy G. Boer, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Lorraine Southam, William Giles, Christine L. Le Maitre, J. Mark Wilkinson, Joyce B. J. van Meurs, Eleftheria Zeggini, Timothy Cootes, Claudia Lindner, John P. Kemp, George Davey Smith, Jonathan H. Tobias
doi : 10.1002/art.42451
To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR) to evaluate its causal relationship with hip osteoarthritis (OA).
Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk–Conferring Alleles on a Shared Target Gene, COLGALT2
Yulia S. Kehayova, J. Mark Wilkinson, Sarah J. Rice, John Loughlin
doi : 10.1002/art.42427
Over 100 DNA variants have been associated with osteoarthritis (OA), including rs1046934, located within a linkage disequilibrium block encompassing part of COLGALT2 and TSEN15. The present study was undertaken to determine the target gene(s) and the mechanism of action of the OA locus using human fetal cartilage, cartilage from OA and femoral neck fracture arthroplasty patients, and a chondrocyte cell model.
Targeting Synovial Lymphatic Function as a Novel Therapeutic Intervention for Age-Related Osteoarthritis in Mice
Xi Lin, Richard D. Bell, Sarah E. Catheline, Takahiro Takano, Andrew McDavid, Jennifer H. Jonason, Edward M. Schwarz, Lianping Xing
doi : 10.1002/art.42441
The synovial lymphatic system (SLS) removes catabolic factors from the joint. Vascular endothelial growth factor C (VEGF-C) and its receptor, VEGFR-3, are crucial for lymphangiogenesis. However, their involvement in age-related osteoarthritis (OA) is unknown.
Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models
Taisuke Uchida, Yukio Akasaki, Takuya Sueishi, Ichiro Kurakazu, Masakazu Toya, Masanari Kuwahara, Ryota Hirose, Yuki Hyodo, Hidetoshi Tsushima, Martin K. Lotz, Yasuharu Nakashima
doi : 10.1002/art.42421
NF-κB signaling is an important modulator in osteoarthritis (OA), and IκB kinase ε (IKKε) regulates the NF-κB pathway. This study was undertaken to identify the functional involvement of IKKε in the pathogenesis of OA and the effectiveness of IKKε inhibition as a modulatory treatment.
Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2
Shigeo Yoshida, Kohei Nishitani, Hiroyuki Yoshitomi, Shinichi Kuriyama, Shinichiro Nakamura, Takayuki Fujii, Motoo Saito, Yu Kobori, Akinori Murakami, Koichi Murata, Hiromu Ito, Hideki Ueno, Shuichi Matsuda
doi : 10.1002/art.42424
This study aimed to determine whether alignment correction by high tibial osteotomy (HTO) can change the biologic intraarticular microenvironment of osteoarthritic (OA) knees.
Down-Regulation–Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production
Iris K. Madera-Salcedo, Ada L. RamÃÂrez-Sánchez, Noé RodrÃÂguez-RodrÃÂguez, Roberto GarcÃÂa-Quintero, Rosa M. Rubio, Gabriela Morales-Montes de Oca, Emmanuel Dávalos, Rogelio Cuervo, Janette Furuzawa-Carballeda, Jorge Alcocer-Varela, Diana Gómez-MartÃÂn, Marysol González-Yáñez, Abigail de la Cruz, Adrián Albarrán-GodÃÂnez, Gerardo Suárez-Rojas, Juanita Romero-DÃÂaz, Norma O. Uribe-Uribe, Marta Alarcón-Riquelme, Mayra Furlan-Magaril, Juan Manuel MejÃÂa-Vilet, José C. CrispÃÂn, Florencia Rosetti
doi : 10.1002/art.42435
Variants in STAT4 are associated with systemic lupus erythematosus (SLE) and other autoimmune diseases. We undertook this study to investigate how disease-associated variants affect STAT4 expression, in particular in CD4+ T cells where STAT4 plays an essential role.
Association of Circulating Antibody-Secreting Cell Maturity With Disease Features in Primary Sjögren's Syndrome
Tobit D. Steinmetz, Gwenny M. Verstappen, Sebastian R. Schulz, Liseth de Wolff, Rick Wilbrink, Annie Visser, Janneke Terpstra, Hendrika Bootsma, Frans G. M. Kroese
doi : 10.1002/art.42422
B cell hyperactivity plays an important role in primary Sjögren's syndrome (SS). We undertook this study to better understand the B cell effector branch, namely antibody-secreting cells (ASCs) in primary SS, and to examine the quantity, maturity, and inflammatory properties of ASCs in primary SS patients.
Fluctuation of Anti–Domain 1 and Anti–β2-Glycoprotein I Antibody Titers Over Time in Patients With Persistently Positive Antiphospholipid Antibodies
Cecilia B. Chighizola, Francesca Pregnolato, Danieli Andrade, Maria Tektonidou, Vittorio Pengo, Guillermo Ruiz-Irastorza, H. Michael Belmont, Maria Gerosa, Paul Fortin, D. Ware Branch, Laura Andreoli, Michelle A. Petri, Ricard Cervera, Jason S. Knight, Rohan Willis, Maria Efthymiou, Hannah Cohen, Doruk Erkan, Maria Laura Bertolaccini,Â
doi : 10.1002/art.42459
The present study was undertaken to longitudinally evaluate titers of antibodies against β2-glycoprotein I (anti-β2GPI) and domain 1 (anti-D1), to identify predictors of variations in anti-β2GPI and anti-D1 titers, and to clarify whether antibody titer fluctuations predict thrombosis in a large international cohort of patients who were persistently positive for antiphospholipid antibodies (aPL) in the APS ACTION Registry.
Protein Profiling in Presymptomatic Individuals Separates Myeloperoxidase–Antineutrophil Cytoplasmic Antibody and Proteinase 3–Antineutrophil Cytoplasmic Antibody Vasculitides
Mikael Brink, Ewa Berglin, Aladdin J. Mohammad, Anders Lundquist, Inger Gjertsson, Andrey Alexeyenko, Kristina Lejon, Solbritt Rantapää-Dahlqvist
doi : 10.1002/art.42425
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is a chronic relapsing condition with unknown etiology. To gain insight into the molecular processes underlying the disease, we examined biomarkers in blood samples collected prior to symptom onset.
Identification of Mechanisms by Which Genetic Susceptibility Loci Influence Systemic Sclerosis Risk Using Functional Genomics in Primary T Cells and Monocytes
David González-Serna, Chenfu Shi, Martin Kerick, Jenny Hankinson, James Ding, Amanda McGovern, Mauro Tutino, Gonzalo Villanueva-Martin, Norberto Ortego-Centeno, José Luis Callejas, Javier Martin, Gisela Orozco
doi : 10.1002/art.42396
Systemic sclerosis (SSc) is a complex autoimmune disease with a strong genetic component. However, most of the genes associated with the disease are still unknown because associated variants affect mostly noncoding intergenic elements of the genome. We used functional genomics to translate the genetic findings into a better understanding of the disease.
Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation
Simon Rothwell, Christopher I. Amos, Frederick W. Miller, Lisa G. Rider, Ingrid E. Lundberg, Peter K. Gregersen, Jiri Vencovsky, Neil McHugh, Vidya Limaye, Albert Selva-O'Callaghan, Michael G. Hanna, Pedro M. Machado, Lauren M. Pachman, Ann M. Reed, Ã˜yvind Molberg, Olivier Benveniste, Pernille Mathiesen, Timothy Radstake, Andrea Doria, Jan L. De Bleecker, Boel De Paepe, Britta Maurer, William E. Ollier, Leonid Padyukov, Terrance P. O'Hanlon, Annette Lee, Lucy R. Wedderburn, Hector Chinoy, Janine A. Lamb, the Myositis Genetics Consortium
doi : 10.1002/art.42434
The idiopathic inflammatory myopathies (IIMs) are heterogeneous diseases thought to be initiated by immune activation in genetically predisposed individuals. We imputed variants from the ImmunoChip array using a large reference panel to fine-map associations and identify novel associations in IIM.
Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts
Kehuan Lin, Natalie McCormick, Chio Yokose, Amit D. Joshi, Na Lu, Gary C. Curhan, Tony R. Merriman, Kenneth G. Saag, Paul M. Ridker, Julie E. Buring, Daniel I. Chasman, Frank B. Hu, Hyon K. Choi
doi : 10.1002/art.42419
To examine whether the cross-sectional gene–diet interaction for prevalent hyperuricemia among women translates prospectively to risk of incident female gout.
Neutrophil Extracellular Trap–Borne Elastase Prevents Inflammatory Relapse in Intercritical Gout
Lei Liu, Lizhen Shan, Han Wang, Christine Schauer, Janina Schoen, Lingjiang Zhu, Ci Lu, Zitao Wang, Yu Xue, Huaxiang Wu, Martin Herrmann
doi : 10.1002/art.42431
Gout flares that occur during urate-lowering therapy (ULT) are typically related to the shrinkage of tophi due to aggregated neutrophil extracellular traps (NETs) that have captured monosodium urate crystals in the tissues. The present study was undertaken to analyze the blocking effect of α1-antitrypsin on neutrophil elastase, and it was found that α1-antitrypsin induced rapid inflammation in the presence of unstable tophi.
Association Between HLA–DPB1 and Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Children
Kristen M. Gibson, Britt I. Drögemöller, Dirk Foell, Susanne M. Benseler, Jinko Graham, Robert E. W. Hancock, Raashid A. Luqmani, David A. Cabral, Kelly L. Brown, Colin J. Ross, on behalf of the PedVas Investigator's Network
doi : 10.1002/art.42423
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is a rare, life-threatening inflammation of blood vessels that can affect both adults and children. Compared to adult-onset disease, AAV is especially rare in children, with an annual prevalence of 0.5–6.4 cases per million children.
De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation
Chengmei Xie, Haibo Zhou, Vicki Athanasopoulos, Qian Shen, Yaoyuan Zhang, Xiangpeng Meng, Gaetan Burgio, Todor Arsov, Adrian C. Lungu, Pingjing Zhang, Yuting Qin, Jiangyang Ma, Xiaoqian Wu, Xiaoyue Jiang, Huihua Ding, Yao Meng, Nan Shen, Yuke He, Carola G. Vinuesa
doi : 10.1002/art.42416
Increased Toll-like receptor 7 (TLR-7) signaling leading to the production of type I interferon (IFN) is an important contributor to human systemic lupus erythematosus (SLE). Protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), a molecule that regulates synaptic vesicle recycling, has been linked to TLR-7/TLR-9–mediated type I IFN production in humans and mice, but the underlying mechanism is unknown.
Clinical Images: Increased bone metabolism in secondary hyperparathyroidism
Larissa Valor-Méndez, Armin Atzinger, Petra Reis, Bernhard Manger, Georg Schett
doi : 10.1002/art.42458
Clinical Images: Optic perineuritis in relapsing granulomatosis with polyangiitis
Ole Hudowenz, Peter Lamprecht
doi : 10.1002/art.42426
The 2022 American College of Rheumatology/EULAR classification criteria for giant cell arteritis and Takayasu arteritis: comment on the articles by Ponte et al and Grayson et al
Albrecht Betrains, Lien Moreel, Daniel Blockmans
doi : 10.1002/art.42444
Classifying extracranial large-vessel giant cell arteritis using the new 2022 American College of Rheumatology/EULAR classification criteria: comment on the article by Ponte et al
Santos Castañeda, Esther F. Vicente-Rabaneda, Miguel A. González-Gay
doi : 10.1002/art.42439
A diagnostic performance study of the 2022 American College of Rheumatology/EULAR classification criteria for giant cell arteritis in a cohort of patients presenting with suspected giant cell arteritis
Andrea K. Hemmig, Markus Aschwanden, Stephan Imfeld, Christoph T. Berger, Thomas Daikeler
doi : 10.1002/art.42440
Reply
Cristina Ponte, Peter C. Grayson, Katherine Bates Gribbons, Joanna C. Robson, Ravi Suppiah, Andrew Judge, Richard A. Watts, Raashid A. Luqmani, Peter A. Merkel, for the DCVAS Study Group
doi : 10.1002/art.42448
Association of change in metabolic syndrome status with altered risk of incident gout: comment on the article by Eun et al
Gang Wang, Ning Zhuo, Mei Tang, Leixi Xue, Zhichun Liu
doi : 10.1002/art.42436
