Brain

Modulation of cognitive functions supporting human declarative memory is one of the grand challenges of neuroscience, and of vast importance for a variety of neuropsychiatric, neurodegenerative and neurodevelopmental diseases.

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Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases

Miriam Mistretta, Andrea Farini, Yvan Torrente, Chiara Villa

doi : 10.1093/brain/awad014

Brain, Volume 146, Issue 6, June 2023, Pages 2227â€“2240

Neurodegenerative diseases are a major global health burden particularly with the increasing ageing population. Hereditary predisposition and environmental risk factors contribute to the heterogeneity of existing pathological phenotypes.

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Neuropsychiatric disorders following SARS-CoV-2 infection

Paul J Harrison, Maxime Taquet

doi : 10.1093/brain/awad008

Brain, Volume 146, Issue 6, June 2023, Pages 2241â€“2247

Several large-scale electronic health records studies have reported increased diagnostic rates for neuropsychiatric disorders following Coronavirus disease 2019 [COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection)], but many questions remain.

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Quantitative approaches to guide epilepsy surgery from intracranial EEG

John M Bernabei, Adam Li, Andrew Y Revell, Rachel J Smith, Kristin M Gunnarsdottir, Ian Z Ong, Kathryn A Davis, Nishant Sinha, Sridevi Sarma, Brian Litt

doi : 10.1093/brain/awad007

Brain, Volume 146, Issue 6, June 2023, Pages 2248â€“2258

Over the past 10 years, the drive to improve outcomes from epilepsy surgery has stimulated widespread interest in methods to quantitatively guide epilepsy surgery from intracranial EEG (iEEG).

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A critical brainstem relay for mediation of diffuse noxious inhibitory controls

Mateusz W Kucharczyk, Francesca Di Domenico, Kirsty Bannister

doi : 10.1093/brain/awad002

Brain, Volume 146, Issue 6, June 2023, Pages 2259â€“2267

The CNS houses naturally occurring pathways that project from the brain to modulate spinal neuronal activity.

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Sex-dependent effects of acute stress on amyloid-Î² in male and female mice

Hannah M Edwards, Clare E Wallace, Woodrow D Gardiner, Brookelyn M Doherty, Ryan T Harrigan, Kayla M Yuede, Carla M Yuede, John R Cirrito

doi : 10.1093/brain/awad052

Brain, Volume 146, Issue 6, June 2023, Pages 2268â€“2274

The risk of developing Alzheimerâ€™s disease is mediated by a combination of genetics and environmental factors, such as stress, sleep abnormalities and traumatic brain injury.

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Tilavonemab in early Alzheimerâ€™s disease: results from a phase 2, randomized, double-blind study

Hana Florian, Deli Wang, Steven E Arnold, MercÃ¨ Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold on behalf of the Aware Investigators

doi : 10.1093/brain/awad024

Brain, Volume 146, Issue 6, June 2023, Pages 2275â€“2284

Tau accumulation in patients with Alzheimerâ€™s disease tracks closely with cognitive decline and plays a role in the later stages of disease progression. This phase 2 study evaluated the safety and efficacy of tilavonemab, an anti-tau monoclonal antibody, in patients with early Alzheimerâ€™s disease.

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Variants in CLDN5 cause a syndrome characterized by seizures, microcephaly and brain calcifications

Ashish R Deshwar, Cheryl Cytrynbaum, Harsha Murthy, Jessica Zon, David Chitayat, Jonathan Volpatti, Ruth Newbury-Ecob, Sian Ellard, Hana Lango Allen, Emily P Yu, Ramil Noche, Suzi Walker, Stephen W Scherer, Sonal Mahida, Christopher M Elitt, GaÃ«l Nicolas, Alice Goldenberg, Pascale Saugier-Veber, Francois Lecoquierre, Ivana Dabaj, Hannah Meddaugh, Michael Marble, Kim M Keppler-Noreuil, Lucy Drayson, Kristin W BaraÃ±ano, Anna Chassevent, Katie Agre, Pascaline LÃ©tard, Frederic Bilan, GwenaÃ«l Le Guyader, Annie LaquerriÃ¨re, Keri Ramsey, Lindsay Henderson, Lauren Brady, Mark Tarnopolsky, Matthew Bainbridge, Jennifer Friedman, Yline Capri, Larissa Athayde, Fernando Kok, Juliana Gurgel-Giannetti, Luiza L P Ramos, Susan Blaser, James J Dowling, Rosanna Weksberg

doi : 10.1093/brain/awac461

Brain, Volume 146, Issue 6, June 2023, Pages 2285â€“2297

The bloodâ€“brain barrier ensures CNS homeostasis and protection from injury. Claudin-5 (CLDN5), an important component of tight junctions, is critical for the integrity of the bloodâ€“brain barrier.

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AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntingtonâ€™s disease mouse model

Sarah B Thomson, Anouk Stam, Cynthia Brouwers, Valentina Fodale, Alberto Bresciani, Michael Vermeulen, Sara Mostafavi, Terri L Petkau, Austin Hill, Andrew Yung, Bretta Russell-Schulz, Piotr Kozlowski, Alex MacKay, Da Ma, Mirza Faisal Beg, Melvin M Evers, Astrid VallÃ¨s, Blair R Leavitt

doi : 10.1093/brain/awac458

Brain, Volume 146, Issue 6, June 2023, Pages 2298â€“2315

Huntingtin (HTT)-lowering therapies show great promise in treating Huntingtonâ€™s disease. We have developed a microRNA targeting human HTT that is delivered in an adeno-associated serotype 5 viral vector (AAV5-miHTT), and here use animal behaviour, MRI, non-invasive proton magnetic resonance spectroscopy and striatal RNA sequencing as outcome measures in preclinical mouse studies of AAV5-miHTT.

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Not all roads lead to the immune system: the genetic basis of multiple sclerosis severity

Vilija G Jokubaitis, Maria Pia Campagna, Omar Ibrahim, Jim Stankovich, Pavlina Kleinova, Fuencisla Matesanz, Daniel Hui, Sara Eichau, Mark Slee, Jeannette Lechner-Scott, Rodney Lea, Trevor J Kilpatrick, Tomas Kalincik, Philip L De Jager, Ashley Beecham, Jacob L McCauley, Bruce V Taylor, Steve Vucic, Louise Laverick, Karolina Vodehnalova, Maria-Isabel GarcÃa-SanchÃ©z, Antonio Alcina, Anneke van der Walt, Eva Kubala Havrdova, Guillermo Izquierdo, Nikolaos Patsopoulos, Dana Horakova, Helmut Butzkueven

doi : 10.1093/brain/awac449

Brain, Volume 146, Issue 6, June 2023, Pages 2316â€“2331

Multiple sclerosis is a leading cause of neurological disability in adults. Heterogeneity in multiple sclerosis clinical presentation has posed a major challenge for identifying genetic variants associated with disease outcomes.

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Pre-ataxic loss of intrinsic plasticity and motor learning in a mouse model of SCA1

Catarina OsÃ³rio, Joshua J White, Heiling Lu, Gerrit C Beekhof, Francesca Romana Fiocchi, Charlotte A Andriessen, Stephanie Dijkhuizen, Laura Post, Martijn Schonewille

doi : 10.1093/brain/awac422

Brain, Volume 146, Issue 6, June 2023, Pages 2332â€“2345

Spinocerebellar ataxias are neurodegenerative diseases, the hallmark symptom of which is the development of ataxia due to cerebellar dysfunction. Purkinje cells, the principal neurons of the cerebellar cortex, are the main cells affected in these disorders, but the sequence of pathological events leading to their dysfunction is poorly understood.

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The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits

Rebekah Koppenol, AndrÃ© ConceiÃ§Ã£o, InÃªs T Afonso, Ricardo Afonso-Reis, Rafael G Costa, Sandra TomÃ©, Diogo Teixeira, Joana Pinto da Silva, JosÃ© Miguel CÃ´desso, David V C Brito, Liliana MendonÃ§a, Adriana Marcelo, LuÃs Pereira de Almeida, Carlos A Matos, ClÃ©vio NÃ³brega

doi : 10.1093/brain/awac473

Brain, Volume 146, Issue 6, June 2023, Pages 2346â€“2363

Polyglutamine diseases are a group of neurodegenerative disorders caused by an abnormal expansion of CAG repeat tracts in the codifying regions of nine, otherwise unrelated, genes.

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The genetic and phenotypic spectra of adult genetic leukoencephalopathies in a cohort of 309 patients

Chujun Wu, Mengwen Wang, Xingao Wang, Wei Li, Shaowu Li, Bin Chen, Songtao Niu, Hongfei Tai, Hua Pan, Zaiqiang Zhang

doi : 10.1093/brain/awac426

Brain, Volume 146, Issue 6, June 2023, Pages 2364â€“2376

Genetic leukoencephalopathies (gLEs) are a highly heterogeneous group of rare genetic disorders.

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Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery

Davide Giampiccolo, Lawrence P Binding, Lorenzo Caciagli, Roman Rodionov, Chris Foulon, Jane de Tisi, Alejandro Granados, Roisin Finn, Debayan Dasgupta, Fenglai Xiao, Beate Diehl, Emma Torzillo, Jan Van Dijk, Peter N Taylor, Matthias Koepp, Andrew W McEvoy, Sallie Baxendale, Fahmida Chowdhury, John S Duncan, Anna Miserocchi

doi : 10.1093/brain/awad085

Brain, Volume 146, Issue 6, June 2023, Pages 2377â€“2388

Around 50% of patients undergoing frontal lobe surgery for focal drug-resistant epilepsy become seizure free post-operatively; however, only about 30% of patients remain seizure free in the long-term. Early seizure recurrence is likely to be caused by partial resection of the epileptogenic lesion, whilst delayed seizure recurrence can occur even if the epileptogenic lesion has been completely excised.

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Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults

Carolina Ferreira-Atuesta, Jane de Tisi, Andrew W McEvoy, Anna Miserocchi, Jean Khoury, Ruta Yardi, Deborah T Vegh, James Butler, Hamin J Lee, Victoria Deli-Peri, Yi Yao, Feng-Peng Wang, Xiao-Bin Zhang, Lubna Shakhatreh, Pakeeran Siriratnam, Andrew Neal, Arjune Sen, Maggie Tristram, Elizabeth Varghese, Wendy Biney, William P Gray, Ana Rita Peralta, Alexandre Rainha-Campos, AntÃ³nio J C GonÃ§alves-Ferreira, JosÃ© Pimentel, Juan Fernando Arias, Samuel Terman, Robert Terziev, Herm J Lamberink, Kees P J Braun, Willem M Otte, Fergus J Rugg-Gunn, Walter Gonzalez, Carla Bentes, Khalid Hamandi, Terence J Oâ€™Brien, Piero Perucca, Chen Yao, Richard J Burman, Lara Jehi, John S Duncan, Josemir W Sander, Matthias Koepp, Marian Galovic

doi : 10.1093/brain/awac437

Brain, Volume 146, Issue 6, June 2023, Pages 2389â€“2398

More than half of adults with epilepsy undergoing resective epilepsy surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications. We aimed to identify predictors of seizure recurrence after starting postoperative antiseizure medication withdrawal and develop and validate predictive models.

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Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy

Nicola Masala, Martin Pofahl, AndrÃ© N Haubrich, Khondker Ushna Sameen Islam, Negar Nikbakht, Maryam Pasdarnavab, Kirsten Bohmbach, Kunihiko Araki, Fateme Kamali, Christian Henneberger, Kurtulus Golcuk, Laura A Ewell, Sandra Blaess, Tony Kelly, Heinz Beck

doi : 10.1093/brain/awac455

Brain, Volume 146, Issue 6, June 2023, Pages 2399â€“2417

Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding and deficits in spatial memory.

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Case-control study developing Scottish Epilepsy Deaths Study Score to predict epilepsy-related death

Gashirai K Mbizvo, Christian Schnier, Colin R Simpson, Susan E Duncan, Richard F M Chin

doi : 10.1093/brain/awac463

Brain, Volume 146, Issue 6, June 2023, Pages 2418â€“2430

This study aimed to develop a risk prediction model for epilepsy-related death in adults.

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Properties of REM sleep alterations with epilepsy

Yoko Ikoma, Yusuke Takahashi, Daichi Sasaki, Ko Matsui

doi : 10.1093/brain/awac499

Brain, Volume 146, Issue 6, June 2023, Pages 2431â€“2442

It is usually assumed that individuals rest during sleep. However, coordinated neural activity that presumably requires high energy consumption is increased during REM sleep.

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The low dimensionality of post-stroke cognitive deficits: itâ€™s the lesion anatomy!

Christoph Sperber, Laura Gallucci, Roza Umarova

doi : 10.1093/brain/awac443

Brain, Volume 146, Issue 6, June 2023, Pages 2443â€“2452

For years, dissociation studies on neurological single-case patients with brain lesions were the dominant method to infer fundamental cognitive functions in neuropsychology. In contrast, the association between deficits was considered to be of less epistemological value.

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Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies

Esther Henriet, Elodie M Martin, Pauline Jubin, Dominique Langui, Abdelkrim Mannioui, Bruno Stankoff, Catherine Lubetzki, Arseny Khakhalin, Bernard Zalc

doi : 10.1093/brain/awad051

Brain, Volume 146, Issue 6, June 2023, Pages 2453â€“2463

In multiple sclerosis, while remarkable progress has been accomplished to control the inflammatory component of the disease, repair of demyelinated lesions is still an unmet need. Despite encouraging results generated in experimental models, several candidates favouring or promoting remyelination have not reached the expected outcomes in clinical trials.

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Novel plasma and brain proteins that are implicated in multiple sclerosis

Xin Lin, Yuanhao Yang, Melissa Gresle, Gabriel Cuellar-Partida, Xikun Han, Jim Stankovich, AusLong/Ausimmune Investigators Group , Steve Simpson-Yap, Valery Fuh-Ngwa, Jac Charlesworth, Kathryn P Burdon, Helmut Butzkueven, Bruce V Taylor, Yuan Zhou

doi : 10.1093/brain/awac420

Brain, Volume 146, Issue 6, June 2023, Pages 2464â€“2475

Understanding how variations in the plasma and brain proteome contribute to multiple sclerosis susceptibility can provide important insights to guide drug repurposing and therapeutic development for the disease. However, the role of genetically predicted protein abundance in multiple sclerosis remains largely unknown.

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A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage

Jenny A Nij Bijvank, Sam N Hof, Stefanos E Prouskas, Menno M Schoonheim, Bernard M J Uitdehaag, Laurentius J van Rijn, Axel Petzold

doi : 10.1093/brain/awac474

Brain, Volume 146, Issue 6, June 2023, Pages 2476â€“2488

In multiple sclerosis, remyelination trials have yet to deliver success like that achieved for relapse rates with disease course modifying treatment trials. The challenge is to have a clinical, functional outcome measure. Currently, there are none that have been validated, other than visual evoked potentials in optic neuritis.

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Clinical and MRI measures to identify non-acute MOG-antibody disease in adults

Rosa Cortese, Marco Battaglini, Ferran Prados, Alessia Bianchi, Lukas Haider, Anu Jacob, Jacqueline Palace, Silvia Messina, Friedemann Paul, Jens Wuerfel, Romain Marignier, FranÃ§oise Durand-Dubief, Carolina de Medeiros Rimkus, Dagoberto Callegaro, Douglas Kazutoshi Sato, Massimo Filippi, Maria Assunta Rocca, Laura Cacciaguerra, Alex Rovira, Jaume Sastre-Garriga, Georgina Arrambide, Yaou Liu, Yunyun Duan, Claudio Gasperini, Carla Tortorella, Serena Ruggieri, Maria Pia Amato, Monica Ulivelli, Sergiu Groppa, Matthias Grothe, Sara Llufriu, Maria Sepulveda, Carsten Lukas, Barbara Bellenberg, Ruth Schneider, Piotr Sowa, Elisabeth G Celius, Anne-Katrin Proebstel, Ã–zgÃ¼r Yaldizli, Jannis MÃ¼ller, Bruno Stankoff, Benedetta Bodini, Luca Carmisciano, Maria Pia Sormani, Frederik Barkhof, Nicola De Stefano, Olga Ciccarelli, for the MAGNIMS Study Group

doi : 10.1093/brain/awac480

Brain, Volume 146, Issue 6, June 2023, Pages 2489â€“2501

MRI and clinical features of myelin oligodendrocyte glycoprotein (MOG)-antibody disease may overlap with those of other inflammatory demyelinating conditions posing diagnostic challenges, especially in non-acute phases and when serologic testing for MOG antibodies is unavailable or shows uncertain results.

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Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder

Thomas R Barber, Kinan Muhammed, Daniel Drew, Kevin M Bradley, Daniel R McGowan, Johannes C Klein, Sanjay G Manohar, Michele T M Hu, Masud Husain

doi : 10.1093/brain/awac430

Brain, Volume 146, Issue 6, June 2023, Pages 2502â€“2511

Idiopathic rapid eye movement sleep behaviour disorder (iRBD) has now been established as an important marker of the prodromal stage of Parkinsonâ€™s disease and related synucleinopathies.

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Metabolic patterns in brain 18F-fluorodeoxyglucose PET relate to aetiology in paediatric dystonia

Stavros Tsagkaris, Eric K C Yau, Verity McClelland, Apostolos Papandreou, Ata Siddiqui, Daniel E Lumsden, Margaret Kaminska, Eric Guedj, Alexander Hammers, Jean-Pierre Lin

doi : 10.1093/brain/awac439

Brain, Volume 146, Issue 6, June 2023, Pages 2512â€“2523

There is a lack of imaging markers revealing the functional characteristics of different brain regions in paediatric dystonia. In this observational study, we assessed the utility of [18F]2-fluoro-2-deoxy-D-glucose (FDG)-PET in understanding dystonia pathophysiology by revealing specific resting awake brain glucose metabolism patterns in different childhood dystonia subgroups.

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Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates

Morgane Darricau, Taxiarchis Katsinelos, Flavio Raschella, Tomislav Milekovic, Louis Crochemore, Qin Li, GrÃ©goire Courtine, William A McEwan, Benjamin Dehay, Erwan Bezard, Vincent Planche

doi : 10.1093/brain/awac428

Brain, Volume 146, Issue 6, June 2023, Pages 2524â€“2534

Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell to cell in a â€˜prion-likeâ€™ manner. However, direct experimental evidence of this phenomenon, and its consequences on brain functions, is still lacking in primates.

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Reproductive characteristics, use of exogenous hormones and Parkinson disease in women from the E3N study

Giancarlo Pesce, Fanny Artaud, Emmanuel Roze, Isabelle Degaey, Berta Portugal, Thi Thu Ha Nguyen, AgnÃ¨s Fournier, Marie-Christine Boutron-Ruault, Gianluca Severi, Alexis Elbaz, Marianne Canonico

doi : 10.1093/brain/awac440

Brain, Volume 146, Issue 6, June 2023, Pages 2535â€“2546

Despite experimental studies suggesting a disease-modifying role of oestrogens, results from epidemiological studies on the relation of reproductive characteristics and hormonal exposures with Parkinson disease in women are conflicting.

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RNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis

Mahmoud-Reza Rafiee, Sara Rohban, Karen Davey, Jernej Ule, Nicholas M Luscombe

doi : 10.1093/brain/awad046

Brain, Volume 146, Issue 6, June 2023, Pages 2547â€“2556

Valosin-containing protein (VCP) is a hexameric ATPase associated with diverse cellular activities. Genetic mutations in VCP are associated with several forms of muscular and neuronal degeneration, including amyotrophic lateral sclerosis (ALS).

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Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated

John L Robinson, Sharon X Xie, Daniel R Baer, EunRan Suh, Vivianna M Van Deerlin, Nicholas J Loh, David J Irwin, Corey T McMillan, David A Wolk, Alice Chen-Plotkin, Daniel Weintraub, Theresa Schuck, Virginia M Y Lee, John Q Trojanowski, Edward B Lee

doi : 10.1093/brain/awad059

Brain, Volume 146, Issue 6, June 2023, Pages 2557â€“2569

Pathologies that are causative for neurodegenerative disease (ND) are also frequently present in unimpaired, older individuals.

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Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease

Tze How Mok, Akin Nihat, Nour Majbour, Danielle Sequeira, Leah Holm-Mercer, Thomas Coysh, Lee Darwent, Mark Batchelor, Bradley R Groveman, Christina D Orr, Andrew G Hughson, Amanda Heslegrave, Rhiannon Laban, Elena Veleva, Ross W Paterson, Ashvini Keshavan, Jonathan M Schott, Imogen J Swift, Carolin Heller, Jonathan D Rohrer, Alexander Gerhard, Christopher Butler, James B Rowe, Mario Masellis, Miles Chapman, Michael P Lunn, Jan Bieschke, Graham S Jackson, Henrik Zetterberg, Byron Caughey, Peter Rudge, John Collinge, Simon Mead

doi : 10.1093/brain/awad101

Brain, Volume 146, Issue 6, June 2023, Pages 2570â€“2583

Human prion diseases are remarkable for long incubation times followed typically by rapid clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are remarkably useful in the clinical phase, but their potential to predict clinical onset in healthy people remains unclear.

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Neurophysiological consequences of synapse loss in progressive supranuclear palsy

Natalie E Adams, Amirhossein Jafarian, Alistair Perry, Matthew A Rouse, Alexander D Shaw, Alexander G Murley, Thomas E Cope, W Richard Bevan-Jones, Luca Passamonti, Duncan Street, Negin Holland, David Nesbitt, Laura E Hughes, Karl J Friston, James B Rowe

doi : 10.1093/brain/awac471

Brain, Volume 146, Issue 6, June 2023, Pages 2584â€“2594

Synaptic loss occurs early in many neurodegenerative diseases and contributes to cognitive impairment even in the absence of gross atrophy. Currently, for human disease there are few formal models to explain how cortical networks underlying cognition are affected by synaptic loss.

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IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels

Shakil Khan, Pabitra Hriday Patra, Hannah Somerfield, Hattaya Benya-Aphikul, Manoj Upadhya, Xuming Zhang

doi : 10.1093/brain/awac462

Brain, Volume 146, Issue 6, June 2023, Pages 2595â€“2611

TRPA1 channels have been implicated in mechanical and cold hypersensitivity in chronic pain. But how TRPA1 mediates this process is unclear. Here we show that IQ motif containing GTPase activating protein 1 is responsible using a combination of biochemical, molecular, Ca2+ imaging and behavioural approaches

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Sex bias in social deficits, neural circuits and nutrient demand in Cttnbp2 autism models

Tzu-Li Yen, Tzyy-Nan Huang, Ming-Hui Lin, Tsan-Ting Hsu, Ming-Hsuan Lu, Pu-Yun Shih, Jacob Ellegood, Jason Lerch, Yi-Ping Hsueh

doi : 10.1093/brain/awac429

Brain, Volume 146, Issue 6, June 2023, Pages 2612â€“2626

Autism spectrum disorders caused by both genetic and environmental factors are strongly male-biased neuropsychiatric conditions. However, the mechanism underlying the sex bias of autism spectrum disorders remains elusive. Here, we use a mouse model in which the autism-linked gene Cttnbp2 is mutated to explore the potential mechanism underlying the autism sex bias.

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Identification of biopsychological trait markers in functional neurological disorders

Brain, Volume 146, Issue 6, June 2023, Pages 2627â€“2641

doi : 10.1093/brain/awac442

Brain, Volume 146, Issue 6, June 2023, Pages 2627â€“2641

Stress is a well-known risk factor to develop a functional neurological disorder, a frequent neuropsychiatric medical condition in which patients experience a variety of disabling neurological symptoms.

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Risk and aversion coding in human habenula high gamma activity

Luis Manssuer, Qiong Ding, Yingying Zhang, Hengfeng Gong, Wei Liu, Ruoqi Yang, Chencheng Zhang, Yijie Zhao, Yixin Pan, Shikun Zhan, Dianyou Li, Bomin Sun, Valerie Voon

doi : 10.1093/brain/awac456

Brain, Volume 146, Issue 6, June 2023, Pages 2642â€“2653

Neurons in the primate lateral habenula fire in response to punishments and are inhibited by rewards. Through its modulation of midbrain monoaminergic activity, the habenula is believed to play an important role in adaptive behavioural responses to punishment and underlie depressive symptoms and their alleviation with ketamine.

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