دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Evidence-based European recommendations for the dietary management of diabetes
The Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD)
doi : 10.1007/s00125-023-05894-8
Diabetes management relies on effective evidence-based advice that informs and empowers individuals to manage their health. Alongside other cornerstones of diabetes management, dietary advice has the potential to improve glycaemic levels, reduce risk of diabetes complications and improve health-related quality of life.
Sex differences in type 2 diabetes
Alexandra Kautzky-Willer, Michael Leutner & Jürgen Harreiter
doi : 10.1007/s00125-023-05891-x
The prevalence of type 2 diabetes mellitus is increasing in both sexes, but men are usually diagnosed at a younger age and lower body fat mass than women. Worldwide, an estimated 17.7Â million more men than women have diabetes mellitus.
Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders
Jacqueline M. Ratter-Rieck, Michael Roden & Christian Herder
doi : 10.1007/s00125-023-05901-y
Climate change will be a major challenge for the world’s health systems in the coming decades. Elevated temperatures and increasing frequencies of heat waves, wildfires, heavy precipitation and other weather extremes can affect health in many ways, especially if chronic diseases are already present.
The prediabetes conundrum: striking the balance between risk and resources
Martin B. Blond, Kristine Færch, Christian Herder, Dan Ziegler & Coen D. A. Stehouwer
doi : 10.1007/s00125-023-05890-y
The current definition of prediabetes is controversial and subject to continuous debate. Nonetheless, prediabetes is a risk factor for type 2 diabetes, is highly prevalent and is associated with diabetic complications and mortality.
Significant impact of time-of-day variation on metformin pharmacokinetics
Denise Türk, Nina Scherer, Dominik Selzer, Christiane Dings, Nina Hanke, Robert Dallmann, Matthias Schwab, Peter Timmins, Valerie Nock & Thorsten Lehr
doi : 10.1007/s00125-023-05898-4
The objective was to investigate if metformin pharmacokinetics is modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic modelling techniques on a large clinical dataset. This study also aimed to generate and test hypotheses on the underlying mechanisms, including evidence for chronotype-dependent interindividual differences in metformin plasma and efficacy-related tissue concentrations.
No insulin degludec dose adjustment required after aerobic exercise for people with type 1 diabetes: the ADREM study
Linda C. A. Drenthen, Mandala Ajie, Evertine J. Abbink, Laura Rodwell, Dick H. J. Thijssen, Cees J. Tack & Bastiaan E. de Galan
doi : 10.1007/s00125-023-05893-9
It is generally recommended to reduce basal insulin doses after exercise to reduce the risk of post-exercise nocturnal hypoglycaemia. Based on its long t½, it is unknown whether such adjustments are required or beneficial for insulin degludec.
Identifying blood biomarkers for type 2 diabetes subtyping: a report from the ORIGIN trial
Marie Pigeyre, Hertzel Gerstein, Emma Ahlqvist, Sibylle Hess & Guillaume Paré
doi : 10.1007/s00125-023-05887-7
Individuals with diabetes can be clustered into five subtypes using up to six routinely measured clinical variables. We hypothesised that circulating protein levels might be used to distinguish between these subtypes.
Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study
Yuxia Wei, Tom G. Richardson, Yiqiang Zhan & Sofia Carlsson
doi : 10.1007/s00125-023-05883-x
We investigated whether the impacts of childhood adiposity on adult-onset diabetes differ across proposed diabetes subtypes using a Mendelian randomisation (MR) design.
Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study
Juliette A. de Klerk, Joline W. J. Beulens, Hailiang Mei, Roel Bijkerk, Anton Jan van Zonneveld, Robert W. Koivula, Petra J. M. Elders, Leen M. ’t Hart & Roderick C. Slieker
doi : 10.1007/s00125-023-05886-8
The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). This was to increase our understanding of different molecular mechanisms underlying the five putative clusters of type 2 diabetes.
Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
Najda Rudman, Simranjeet Kaur, Vesna Simunović, Domagoj Kifer, Dinko Šoić, Toma Keser, Tamara Štambuk, Lucija Klarić, Flemming Pociot, Grant Morahan & Olga Gornik
doi : 10.1007/s00125-023-05881-z
We previously demonstrated that N-glycosylation of plasma proteins and IgGs is different in children with recent-onset type 1 diabetes compared with their healthy siblings. To search for genetic variants contributing to these changes, we undertook a genetic association study of the plasma protein and IgG N-glycome in type 1 diabetes.
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
Xinzhi Li, Ying Yang, Zhenzhi Li, Yuqin Wang, Jingting Qiao & Zheng Chen
doi : 10.1007/s00125-023-05900-z
N6-methyladenosine (m6A) mRNA methylation and m6A-related proteins (methyltransferase-like 3 [METTL3], methyltransferase-like 14 [METTL14] and YTH domain containing 1 [YTHDC1]) have been shown to regulate islet beta cell function and the pathogenesis of diabetes.
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Ben Vanderkruk, Nina Maeshima, Daniel J. Pasula, Meilin An, Cassandra L. McDonald, Priya Suresh, Dan S. Luciani, Francis C. Lynn & Brad G. Hoffman
Infant gut microbiome composition correlated with type 1 diabetes acquisition in the general population: the ABIS study
Malin Bélteky, Patricia L. Milletich, Angelica P. Ahrens, Eric W. Triplett & Johnny Ludvigsson
doi : 10.1007/s00125-023-05895-7
While autoantibodies are traditional markers for type 1 diabetes development, we identified gut microbial biomarkers in 1-year-old infants associated with future type 1 diabetes up to 20 years before diagnosis.
The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
Paola S. Apaolaza, Diana Balcacean, Jose Zapardiel-Gonzalo & Teresa Rodriguez-Calvo
doi : 10.1007/s00125-023-05888-6
Insulitis is not present in all islets, and it is elusive in humans. Although earlier studies focused on islets that fulfilled certain criteria (e.g. ≥15 CD45+ cells or ≥6 CD3+ cells), there is a fundamental lack of understanding of the infiltration dynamics in terms of its magnitude (i.e. how much) and extent (i.e. where). Here, we aimed to perform an in-depth characterisation of T cell infiltration by investigating islets with moderate (1–5 CD3+ cells) and high (≥6 CD3+ cells) infiltration in individuals with and without type 1 diabetes.
Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling
Yang Xiao, Yanfei Wang, Jiyoon Ryu, Wei Liu, Hailan Zou, Rong Zhang, Yin Yan, Zhe Dai, Deling Zhang, Lu-Zhe Sun, Feng Liu, Zhiguang Zhou & Lily Q. Dong
doi : 10.1007/s00125-023-05889-5
Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that TGF-β is able to promote hepatic gluconeogenesis in mice. However, the physiological relevance of serum TGF-β levels to human glucose metabolism and the mechanism by which TGF-β enhances gluconeogenesis remain largely unknown.
Drug target Mendelian randomisation: are we really instrumenting drug use?
Emma L. Anderson & Dylan M. Williams
Drug target Mendelian randomisation: are we really instrumenting drug use? Reply to Anderson EL, Williams DM [letter]
Jie Zheng, Tom R. Gaunt, Min Xu, George Davey Smith & Yufang Bi
A large portion of diabetes cases in sub-Saharan African populations with HIV represent drug-induced diabetes
Petr HenebergÂ
Correction to: Sex differences in type 2 diabetes
Alexandra Kautzky-Willer, Michael Leutner & Jürgen Harreiter
