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When Oral Therapy Can Replace Intravenous Antibiotics—Changing Practice as New Data Emerge
Astrid Heppenstall Heger, MD1,2; Rachel Baden, MD3; Brad Spellberg, MD3
doi : 10.1001/jamainternmed.2023.0923
June 2023, Vol 183, No. 6, Pages 504-628
Medicine in the Era of Artificial Intelligence
Teva D. Brender, MD1
Frequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years
Jessica El Halabi, MD, MBI1; Carol A. Burke, MD2; Essa Hariri, MD, MSc1; Maged Rizk, MD2; Carole Macaron, MD2; John McMichael, BS2; Michael B. Rothberg, MD, MPH1,3
doi : 10.1001/jamainternmed.2023.0435
Importance The benefits from colorectal cancer (CRC) screening may take 10 to 15 years to accrue. Therefore, screening is recommended for older adults who are in good health.
Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia
Vincent Labbé, MD1,2,3; Damien Contou, MD4; Nicholas Heming, MD, PhD5,6; Bruno Megarbane, MD, PhD7,8; Keyvan Razazi, MD, PhD3,9; Florence Boissier, MD, PhD10,11; Hafid Ait-Oufella, MD, PhD12; Matthieu Turpin, MD1; Serge Carreira, MD13; Alexandre Robert, MD14,15; Mehran Monchi, MD16; Bertrand Souweine, MD, PhD17; Sebastien Preau, MD, PhD18,19; Denis Doyen, MD20,21; Emmanuel Vivier, MD, PhD22; Noémie Zucman, MD23,24; Martin Dres, MD, PhD25; Mohamed Fejjal, MD26; Elise Noel-Savina, MD27; Marwa Bachir, MD28; Karim Jaffal, MD29; Jean-François Timsit, MD, PhD30,31; Santiago Alberto Picos, MD32; Eric Mariotte, MD33; Nihal Martis, MD34; William Juguet, MD35; Giovanna Melica, MD36; Paul Rondeau, MD37; Etienne Audureau, MD, PhD38,39; Armand Mekontso Dessap, MD, PhD3,9,40; for the ANTICOVID Investigators
doi : 10.1001/jamainternmed.2023.0456
Importance Given the high risk of thrombosis and anticoagulation-related bleeding in patients with hypoxemic COVID-19 pneumonia, identifying the lowest effective dose of anticoagulation therapy for these patients is imperative.
Racial and Ethnic Disparities in Health Care Use and Access Associated With Loss of Medicaid Supplemental Insurance Eligibility Above the Federal Poverty Level
Eric T. Roberts, PhD1; Youngmin Kwon, BA1; Alexandra G. Hames, BA1; J. Michael McWilliams, MD, PhD2; John Z. Ayanian, MD, MPP3; Renuka Tipirneni, MD, MSc3
doi : 10.1001/jamainternmed.2023.0512
Importance Medicaid supplemental insurance covers most cost sharing in Medicare. Among low-income Medicare beneficiaries, the loss of Medicaid eligibility above this program’s income eligibility threshold (100% of federal poverty level [FPL]) may exacerbate racial and ethnic disparities in Medicare beneficiaries’ ability to afford care.
Effect of a Coaching Intervention to Improve Cardiologist Communication
Kathryn I. Pollak, PhD1,2; Maren K. Olsen, PhD3,4; Hongqiu Yang, PhD5; Neil Prose, MD6; Larry R. Jackson II, MD, MHs7; Sandro O. Pinheiro, PhD7; T. Kayla Dunbar, MS1; Kimberly S. Johnson, MD, MHs6,7
doi : 10.1001/jamainternmed.2023.0629
Importance Communication between cardiologists and patients can significantly affect patient comprehension, adherence, and satisfaction. To our knowledge, a coaching intervention to improve cardiologist communication has not been tested.
Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition
Yan Xie, PhD1,2; Taeyoung Choi, MPH1,2; Ziyad Al-Aly, MD1,2,3,4,5
doi : 10.1001/jamainternmed.2023.0743
Importance Post–COVID-19 condition (PCC), also known as long COVID, affects many individuals. Prevention of PCC is an urgent public health priority.
Risk Factors Associated With Post−COVID-19 Condition
Vasiliki Tsampasian, MD, MSc1,2; Hussein Elghazaly, MBBS3; Rahul Chattopadhyay, MBBS, MSc1,4; Maciej Debski, MD, PhD1,2; Thin Kyi Phyu Naing, MBBS1,2; Pankaj Garg, PhD1,2; Allan Clark, PhD2; Eleana Ntatsaki, MD(Res), MA5,6; Vassilios S. Vassiliou, MBBS, PhD1,2
doi : 10.1001/jamainternmed.2023.0750
Importance Post−COVID-19 condition (PCC) is a complex heterogeneous disorder that has affected the lives of millions of people globally. Identification of potential risk factors to better understand who is at risk of developing PCC is important because it would allow for early and appropriate clinical support.
Examining Opportunities to Increase Savings From Medicare Price Negotiations
Marissa B. Reitsma, BS1; Stacie B. Dusetzina, PhD2; Jeromie M. Ballreich, PhD3; Antonio J. Trujillo, PhD3; Michelle M. Mello, JD, PhD1,4
doi : 10.1001/jamainternmed.2023.0763
Importance Allowing the US Centers for Medicare & Medicaid Services to negotiate prescription drug prices for Medicare may improve drug affordability.
Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum
John W. Ayers, PhD, MA1,2; Adam Poliak, PhD3; Mark Dredze, PhD4; Eric C. Leas, PhD, MPH1,5; Zechariah Zhu, BS1; Jessica B. Kelley, MSN6; Dennis J. Faix, MD7; Aaron M. Goodman, MD8,9; Christopher A. Longhurst, MD, MS10; Michael Hogarth, MD10,11; Davey M. Smith, MD, MAS2,11
doi : 10.1001/jamainternmed.2023.1838
Importance The rapid expansion of virtual health care has caused a surge in patient messages concomitant with more work and burnout among health care professionals. Artificial intelligence (AI) assistants could potentially aid in creating answers to patient questions by drafting responses that could be reviewed by clinicians.
Insufficient Evidence for Screening Reinforces Need for Primary Prevention of Skin Cancer
Isabella de Vere Hunt, MD1; Jenna Lester, MD2; Eleni Linos, MD, MPH, DrPH3
Private Equity in US Health Care—Now Cradle to Grave?
Francis J. Crosson, MD1; Isabel R. Ostrer, MD2; Cary P. Gross, MD3
Anticoagulation in Patients With COVID-19 Pneumonia—What Is the Optimal Intensity?
Richard C. Becker, MD1; Thomas L. Ortel, MD, PhD2
How Chatbots and Large Language Model Artificial Intelligence Systems Will Reshape Modern Medicine
Ron Li, MD1,2; Andre Kumar, MD, MEd1; Jonathan H. Chen, MD, PhD1,2,3
Use of Sepsis Clinical Prediction Models to Improve Patient Care
Murtaza Mogri, PhD1; Richard W. Grant, MD, MPH1,2; Vincent X. Liu, MD, MS1,2
While Waiting for a Randomized Clinical Trial of Nirmatrelvir for Prevention of Post–COVID-19 Condition
Mitchell H. Katz, MD1
Use of Active Surveillance vs Definitive Treatment Among Men With Low- and Favorable Intermediate–Risk Prostate Cancer in the US Between 2010 and 2018
Bashir Al Hussein Al Awamlh, MD1; Daniel A. Barocas, MD, MPH1; Alec Zhu, MD2; Jeffrey J. Tosoian, MD, MPH1; Lee Ponsky, MD3; Serban Negoita, MD, DrPH4; Jonathan E. Shoag, MD2,3
Factors Associated With Variability in the Performance of a Proprietary Sepsis Prediction Model Across 9 Networked Hospitals in the US
Patrick G. Lyons, MD, MSc1,2; Mackenzie R. Hofford, MD3; Sean C. Yu, PhD3; Andrew P. Michelson, MD1; Philip R. O. Payne, PhD3; Catherine L. Hough, MD, MSc4; Karandeep Singh, MD, MMSc5
Daratumumab for a Patient With Refractory Antineutrophil Cytoplasmatic Antibody–Associated Vasculitis
Torben M. Rixecker, MD1; Philipp M. Lepper, MD1; Sebastian Mang, MD1; Pascal Espig1; Katharina Brill, MD2; Lorenz Thurner, MD2; Joerg Thomas Bittenbring, MD2
Novel Estimates of Mortality Associated With Poverty in the US
David Brady, PhD1,2; Ulrich Kohler, PhD3; Hui Zheng, PhD4
Internal Medicine Resident Perspectives on Virtual Recruitment
Alec B. O’Connor, MD, MPH1; Kelly McGarry, MD2; Kathleen M. Finn, MD, MPhil3; Linda Harris, AAS4; Aimee K. Zaas, MD, MHS5
Private Equity Acquisition of Oncology Clinics in the US From 2003 to 2022
Kevin Tyan, BA1,2; Miranda B. Lam, MD, MBA3; Michael Milligan, MD, MBA1,3
Chest Pain, Paced Rhythm, and 2 Missed Indications for Emergent Reperfusion
Jesse T. T. McLaren, MD1; H. Pendell Meyers, MD2; Stephen W. Smith, MD3
Chest Pain and Wide QRS Tachycardia
János Tomcsányi, MD, PhD1; Péter Arányi, MD, PhD1
An Unusual Cause of ST-Segment Elevation in the Right Precordial Leads—A Clue From the Humble Waves
Yan Chen, MD1; Gujiang Chen, MD1; Yuan Zhang, MD2
An Unusual Tracing
Sameer Kassem, MD, PhD1; Jochanan E. Naschitz, MD1
Serial Electrocardiograms—An Unsung Hero
Maha Nadir, MBBS1; Muhammad Talha Bin Nazir, MBBS, MRCP (UK), CCDS, CEPS-A1
What Should I Know About Hormones for Symptoms of Menopause?
Grace Y. Zhang, MD1,2; Michael A. Incze, MD, MSEd3
Recommending Higher Valent Pneumococcal Conjugate Vaccine for Older Adults
David S. Fedson, MD1
Recommending Higher Valent Pneumococcal Conjugate Vaccine for Older Adults—Reply
Miwako Kobayashi, MD, MPH1; Tamara Pilishvili, PhD, MPH1; Fernanda C. Lessa, MD, MPH1
Immortal Time and Selection Biases in Study of Direct-Acting Antiviral Treatment and Hepatitis C Outcomes
Laurent Lam, MD1; Fabrice Carrat, MD, PhD1
Immortal Time and Selection Biases in Study of Direct-Acting Antiviral Treatment and Hepatitis C Outcomes—Reply
Eiichi Ogawa, MD, PhD1; Yee Hui Yeo, MD, MSc2; Mindie H. Nguyen, MD, MAS3,4
Reciprocal Changes and Emergent Trips to the Catheterization Laboratory
Mochamad Yusuf Alsagaff, MD, PhD1; Terrence Timothy Evan Lusida, MD1; Muhammad Ramadhan, MD1
Reciprocal Changes and Emergent Trips to the Catheterization Laboratory
Santi Di Pietro, MD1,2; Bruno Barcella, MD1; Stefano Perlini, MD, PhD1
Reciprocal Changes and Emergent Trips to the Catheterization Laboratory
Michael Brouner, MD1; Jamey Hammock, MD2; Harish Doppalapudi, MD3
