دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Silk-in-Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model (Adv. Healthcare Mater. 11/2023)
Lorenz Semmler, Aida Naghilou, Flavia Millesi, Sonja Wolf, Anda Mann, Sarah Stadlmayr, Sascha Mero, Leon Ploszczanski, Lisa Greutter, Adelheid Woehrer, Eva Placheta-Györi, Fritz Vollrath, Tamara Weiss, Christine Radtke
doi : 10.1002/adhm.202370052
Volume 12, Issue 11
Novel Titanium Implant: A 3D Multifunction Architecture with Charge-Trapping and Piezoelectric Self-Stimulation (Adv. Healthcare Mater. 11/2023)
Lei Sun, Xuzhuo Chen, Kun Ma, Ruiguo Chen, Yi Mao, Rui Chao, Hui Wang, Bin Yu, Junfeng Wang, Shanyong Zhang
doi : 10.1002/adhm.202370053
Transcriptomic Changes toward Osteogenic Differentiation of Mesenchymal Stem Cells on 3D-Printed GelMA/CNC Hydrogel under Pulsatile Pressure Environment (Adv. Healthcare Mater. 11/2023)
Keya Ganguly, Sayan Deb Dutta, Aayushi Randhawa, Dinesh K. Patel, Tejal V. Patil, Ki-Taek Lim
doi : 10.1002/adhm.202370056
Suppression of Lung Cancer Malignancy by Micellized siRNA through Cell Cycle Arrest (Adv. Healthcare Mater. 11/2023)
Haejoo Kim, In-ho Jeong, Yeol Kyo Choi, Yeon Kyung Lee, Eunyoung Moon, Yang Hoon Huh, Wonpil Im, Jun-O Jin, Minseok Kwak, Peter Chang-Whan Lee
doi : 10.1002/adhm.202370057
Silk-in-Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model
Lorenz Semmler, Aida Naghilou, Flavia Millesi, Sonja Wolf, Anda Mann, Sarah Stadlmayr, Sascha Mero, Leon Ploszczanski, Lisa Greutter, Adelheid Woehrer, Eva Placheta-Györi, Fritz Vollrath, Tamara Weiss, Christine Radtke
doi : 10.1002/adhm.202203237
Advanced nerve guidance conduits can provide an off-the-shelf alternative to autografts for the rehabilitation of segmental peripheral nerve injuries. In this study, the excellent processing ability of silk fibroin and the outstanding cell adhesion quality of spider dragline silk are combined to generate a silk-in-silk conduit for nerve repair.
Novel Titanium Implant: A 3D Multifunction Architecture with Charge-Trapping and Piezoelectric Self-Stimulation
Lei Sun, Xuzhuo Chen, Kun Ma, Ruiguo Chen, Yi Mao, Rui Chao, Hui Wang, Bin Yu, Junfeng Wang, Shanyong Zhang
doi : 10.1002/adhm.202202620
Implant-associated infection and inflammation are the main causes of implant failure, causing irreversible damage and significantly increasing clinical risks and economic losses. In this study, a 3D multifunctional architecture is constructed that consisted of hierarchical TiO2 nanotubes (NTs) and electrospun polyvinylidene fluoride nanofiber layers on the surface of a titanium implant.
Transcriptomic Changes toward Osteogenic Differentiation of Mesenchymal Stem Cells on 3D-Printed GelMA/CNC Hydrogel under Pulsatile Pressure Environment
Keya Ganguly, Sayan Deb Dutta, Aayushi Randhawa, Dinesh K. Patel, Tejal V. Patil, Ki-Taek Lim
doi : 10.1002/adhm.202202163
Biomimetic soft hydrogels used in bone tissue engineering frequently produce unsatisfactory outcomes. Here, it is investigated how human bone-marrow-derived mesenchymal stem cells (hBMSCs) differentiated into early osteoblasts on remarkably soft 3D hydrogel (70 ± 0.00049 Pa).
Suppression of Lung Cancer Malignancy by Micellized siRNA through Cell Cycle Arrest
Haejoo Kim, In-ho Jeong, Yeol Kyo Choi, Yeon Kyung Lee, Eunyoung Moon, Yang Hoon Huh, Wonpil Im, Jun-O Jin, Minseok Kwak, Peter Chang-Whan Lee
doi : 10.1002/adhm.202202358
UBA6-specific E2 conjugation enzyme 1 (USE1) is frequently overexpressed in lung cancer patients. Moreover, the critical role of USE1 in the progression of human lung cancer is also indicated. As the next step, the authors aim to develop USE1-targeted therapeutic agents based on RNA interference (RNAi).
Engineering of an Osteoinductive and Growth Factor-Free Injectable Bone-Like Microgel for Bone Regeneration (Adv. Healthcare Mater. 11/2023)
Ramesh Subbiah, Edith Y. Lin, Avathamsa Athirasala, Genevieve E. Romanowicz, Angela S. P. Lin, Joseph V. Califano, Robert E. Guldberg, Luiz E. Bertassoni
doi : 10.1002/adhm.202370055
Engineering of an Osteoinductive and Growth Factor-Free Injectable Bone-Like Microgel for Bone Regeneration
Ramesh Subbiah, Edith Y. Lin, Avathamsa Athirasala, Genevieve E. Romanowicz, Angela S. P. Lin, Joseph V. Califano, Robert E. Guldberg, Luiz E. Bertassoni
doi : 10.1002/adhm.202200976
Bone autografts remain the gold standard for bone grafting surgeries despite having increased donor site morbidity and limited availability. Bone morphogenetic protein-loaded grafts represent another successful commercial alternative.
Efficiently Inhibiting Systemic Inflammatory Cascades by Fullerenes for Retarding HFD-Fueled Atherosclerosis
Sheng'e Su, Mingming Zhen, Chen Zhou, Xinran Cao, Zihao Sun, Yuan Xu, Lei Li, Wang Jia, Zhanfeng Wu, Chunru Wang
doi : 10.1002/adhm.202202161
Atherosclerosis accounts for major mortality of cardiac-cerebral vascular diseases worldwide. Pathologically, persistent inflammation dominates the progression of atherosclerosis, which can be accelerated by a high-fat diet (HFD), possibly through triggering local intestinal oxidative stress and ensuing gut barrier dysfunction.
CD44-Targeting Drug Delivery System of Exosomes Loading Forsythiaside A Combats Liver Fibrosis via Regulating NLRP3-Mediated Pyroptosis
Lihong Gong, Honglin Zhou, Shenglin Zhang, Cheng Wang, Ke Fu, Cheng Ma, Yafang Zhang, Cheng Peng, Yunxia Li
doi : 10.1002/adhm.202202228
Liver fibrosis is a progressive pathological process induced by various stimuli and may progress to liver cirrhosis and cancer. Forsythiaside A (FA) is an active ingredient extracted from traditional Chinese medicine Forsythiae Fructus and has prominent hepatoprotective activities.
In Vitro Properties and Pharmacokinetics of Temporarily PEGylated Onc72 Prodrugs
Gubran Khalil Mohammed, Roland Böttger, Andor Krizsan, Daniela Volke, Marina Mötzing, Shyh-Dar Li, Daniel Knappe, Ralf Hoffmann
doi : 10.1002/adhm.202202368
The favorable properties of antimicrobial peptides (AMPs) to rapidly kill pathogens are often limited by unfavorable pharmacokinetics due to fast degradation and renal clearance rates. Here, a prodrug strategy linking proline-rich AMP Onc72 to polyethylene glycol (PEGs) with average molecular weights of 5 and 20Â kDa via a peptide linker containing a protease cleavage site is tested for the first time in vivo.
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation
Lu Liu, Fei Yu, Lei Chen, Lunguo Xia, Chengtie Wu, Bing Fang
doi : 10.1002/adhm.202202390
The repair of damaged cartilage still remains a great challenge in clinic. It is demonstrated that bone marrow stromal cells (BMSCs)-chondrocytes communication is of great significance for cartilage repair.
“Cluster Bomb� Based Bismuth Nano-in-Micro Spheres Formed Dry Powder Inhalation for Thermo-Radio Sensitization Effects of Lung Metastatic Breast Cancer
Qiyue Wang, Ji Liu, Daquan Chen, Si Miao, Jing Wen, Chang Liu, Shushu Xue, Yang Liu, Qingjie Zhang, Yan Shen
doi : 10.1002/adhm.202202622
Lung metastatic breast cancer (LMBC) is mainly diagnosed through CT imaging and radiotherapy could be the most common method in the clinic to inhibit tumor proliferation. While the sensitivity of radiotherapy is always limited due to the hypoxic tumor microenvironment and high doses of irradiation easily induce systemic cytotoxicity.
Stable and Dynamic Multiparameter Monitoring on Chests Using Flexible Skin Patches with Self-Adhesive Electrodes and a Synchronous Correlation Peak Extraction Algorithm
Ziyue Wu, Xueting Li, Zhijie Feng, Chunxue Wan, Ya Li, Tianyu Li, Qing Yang, Xinyu Liu, Miaoning Ren, Jiameng Li, Xue Shang, Xiangyu Zhang, Xian Huang
doi : 10.1002/adhm.202202629
Advances in wearable bioelectronics interfacing directly with skin offer important tools for non-invasive measurements of physiological parameters. However, wearable monitoring devices majorly conduct static sensing to avoid signal disturbance and unreliable contact with the skin.
Labeling Assembly of Hydrophilic Methionine into Nanoparticle for Mild-Heat Mediated Immunometabolic Therapy
Xiao Zheng, Ying Liu, Tingting Zhang, Yuge Zhao, Yiqiong Liu, Jie Zang, Gaowei Chong, Yan Li, Yushan Yang, Yan Yang, Jingjing Gu, Ruiqing He, Bingbing Liu, Weimin Yin, Haiqing Dong, Yongyong Li
doi : 10.1002/adhm.202202695
Methionine metabolism has a significant impact on T cells’ survival and activation even in comparison to arginine, a well-documented amino acid in metabolic therapy. However, hydrophilic methionine is hardly delivered into TME due to difficult loading and rapid diffusion.
Radial Sponges Facilitate Wound Healing by Promoting Cell Migration and Angiogenesis
Jiawen Li, Lingfei Xiao, Shijie Gao, Huayi Huang, Qingjian Lei, Yan Chen, Zhe Chen, Longjian Xue, Feifei Yan, Lin Cai
doi : 10.1002/adhm.202202737
The topographic cues of wound dressings play important roles in regulating cellular behaviors, such as cellular migration and morphology, and are capable of providing a prolonged stimulus for promoting wound healing.
A Novel Tri-Functional Liposome Re-Educates “Cold Tumor� and Abrogates Tumor Growth by Synergizing Autophagy Inhibition and PD-L1 Blockade
Fei Zhou, Xiaojiaoyang Li, Xiaoyong Xue, Shuo Li, Guifang Fan, Yajie Cai, Zihao Chang, Jiaorong Qu, Runping Liu
doi : 10.1002/adhm.202202757
Immunotherapy has been regarded as a breakthrough in cancer treatment and achieved great success. However, the poor response rate is still a formidable challenge of current immunotherapies, especially in solid tumors without sufficient infiltration of immune cells, also known as “cold tumor.
Design and Development of Extracellular Matrix Protein-Based Microcapsules as Tools for Bacteria Investigation
Sadaf Pashapour, Senne Seneca, Martin Schröter, Friedrich Frischknecht, Ilia Platzman, Joachim Spatz
doi : 10.1002/adhm.202202789
The extracellular matrix (ECM) plays an immense role in the homeostasis of tissues and organs, can function as a barrier for infectious agents, but is also exploited by pathogens during infection.
Phototheranostic Agents Based on Nonionic Heptamethine Cyanine for Realizing Synergistic Cancer Phototherapy
Tianguang Liu, Yanli Chen, Huizhe Wang, Mengyuan Cui, Jiaqi Zhang, Wancun Zhang, Peng Wang
doi : 10.1002/adhm.202202817
Asymmetrical heptamethine cyanine with near-infrared (NIR) absorption is used for photothermal therapy (PTT) of cancer. Aiming to overcome the drawbacks caused by the high temperature of PTT, the development of asymmetrical heptamethine cyanine with photothermal and photodynamic properties is still an attractive strategy.
Preparation of 2D Polyaniline/MoO3−x Superlattice Nanosheets via Intercalation-Induced Morphological Transformation for Efficient Chemodynamic Therapy
Tingting Hu, Baoli Xue, Fanqi Meng, Lu Ma, Yonghua Du, Shilong Yu, Ruquan Ye, Hai Li, Qinghua Zhang, Lin Gu, Zhan Zhou, Ruizheng Liang, Chaoliang Tan
doi : 10.1002/adhm.202202911
Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of 2D organic/inorganic superlattice nanosheets remains a big challenge.
Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy
Chenghu Wu, Wenjuan He, Yue Chen, Jie Cai, Fanjun Zeng, Zidong Lu, Jilong Wang
doi : 10.1002/adhm.202203026
Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage–Myofibroblast Transition in Bladder Remodeling
Wei Wang, Dexuan Xiao, Lede Lin, Xiaoshuai Gao, Liao Peng, Jiawei Chen, Kaiwen Xiao, Shiyu Zhu, Jixiang Chen, Fuxun Zhang, Yang Xiong, Huiling Chen, Banghua Liao, Liang Zhou, Yunfeng Lin
doi : 10.1002/adhm.202203076
Bladder outlet obstruction (BOO) is a prevalent condition arising from urethral stricture, posterior urethral valves, and benign prostatic hyperplasia. Long-term obstruction can lead to bladder remodeling, which is characterized by inflammatory cell infiltration, detrusor hypertrophy, and fibrosis.
Optimization of Lactoferrin-Derived Amyloid Coating for Enhancing Soft Tissue Seal and Antibacterial Activity of Titanium Implants
Wan-rong Wang, Jing Li, Jun-ting Gu, Bo-wen Hu, Wen Qin, Yi-na Zhu, Zhen-xing Guo, Yu-Xuan Ma, Franklin Tay, Kai Jiao, Lina Niu
doi : 10.1002/adhm.202203086
A poor seal of the titanium implant–soft tissue interface provokes bacterial invasion, aggravates inflammation, and ultimately results in implant failure. To ensure the long-term success of titanium implants, lactoferrin-derived amyloid is coated on the titanium surface to increase the expression of cell integrins and hemidesmosomes, with the goal of promoting soft tissue seal and imparting antibacterial activity to the implants.
Engineering of M2 Macrophages-Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair
Junkai Zeng, Changjiang Gu, Yanqing Sun, Xiongsheng Chen
doi : 10.1002/adhm.202203391
Spinal cord injury (SCI) is one of the most common causes of death and disability. The effective modulation of complicated microenvironment, regeneration of injured spinal cord tissue, and the functional recovery after SCI are still clinical challenges.
