دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Architecture-Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration (Adv. Healthcare Mater. 12/2023)
Yu Tang, Zonghan Xu, Jincheng Tang, Yichang Xu, Ziang Li, Wenbo Wang, Liang Wu, Kun Xi, Yong Gu, Liang Chen
doi : 10.1002/adhm.202370058
Volume 12, Issue 12
Cell-Sized Lipid Vesicles as Artificial Antigen-Presenting Cells for Antigen-Specific T Cell Activation (Adv. Healthcare Mater. 12/2023)
Jui-Yi Chen, Sudhanshu Agrawal, Hsiu-Ping Yi, Derek Vallejo, Anshu Agrawal, Abraham P. Lee
doi : 10.1002/adhm.202370059
Intrafibrillar Mineralization and Immunomodulatory for Synergetic Enhancement of Bone Regeneration via Calcium Phosphate Nanocluster Scaffold (Adv. Healthcare Mater. 12/2023)
Yanyan Zhou, Zihe Hu, Wenjing Jin, Haiyan Wu, Minghao Zuo, Changyu Shao, Yanhua Lan, Yang Shi, Ruikang Tang, Zhuo Chen, Zhijian Xie, Jue Shi
doi : 10.1002/adhm.202370063
Endogenous Electric Field-Coupled PD@BP Biomimetic Periosteum Promotes Bone Regeneration through Sensory Nerve via Fanconi Anemia Signaling Pathway (Adv. Healthcare Mater. 12/2023)
Yanlin Su, Lian Zeng, Rongli Deng, Bing Ye, Shuo Tang, Zekang Xiong, Tingfang Sun, Qiuyue Ding, Weijie Su, Xirui Jing, Qing Gao, Xiumei Wang, Zhiye Qiu, Kaifang Chen, Daping Quan, Xiaodong Guo
doi : 10.1002/adhm.202370064
Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy
Kexuan Liu, Lei Huang, Shuangyan Qi, Shuchen Liu, Wangni Xie, Liuyi Du, Jing Cui, Xu Zhang, Boya Zhang, Lijun Liu, Daowei Li, Hongchen Sun
doi : 10.1002/adhm.202203085
Ferroptosis is a non-apoptotic programmed cell death caused by the accumulation of lipid peroxide. System Xc-/glutathione peroxidase 4 (GPX4) axis and iron axis are two main pathways regulating ferroptosis. Simultaneously, multiple pathways are also involved in the ferroptosis regulation.
The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy
Wenyan Yu, Bingbing Liu, Lei Zhou, Enpeng Gong, Chengyuan Che, Jianchao Zhou, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
doi : 10.1002/adhm.202203141
Intracerebral hemorrhage (ICH) is the most devastating form of stroke, which accounts for 10–15% of cases and causes high morbidity and mortality. With the continuous exploration of the pathological mechanism of ICH, extensive research focusing on ICH therapy has been conducted.
Architecture-Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration
Yu Tang, Zonghan Xu, Jincheng Tang, Yichang Xu, Ziang Li, Wenbo Wang, Liang Wu, Kun Xi, Yong Gu, Liang Chen
doi : 10.1002/adhm.202202658
The inflammatory cascade after spinal cord injury (SCI) causes necrotizing apoptosis of local stem cells, which limits nerve regeneration. Therefore, coordinating the inflammatory immune response and neural stem cell (NSC) functions is key to promoting the recovery of central nervous system function.
Cell-Sized Lipid Vesicles as Artificial Antigen-Presenting Cells for Antigen-Specific T Cell Activation
Jui-Yi Chen, Sudhanshu Agrawal, Hsiu-Ping Yi, Derek Vallejo, Anshu Agrawal, Abraham P. Lee
doi : 10.1002/adhm.202203163
In this study, efficient T cell activation is demonstrated using cell-sized artificial antigen-presenting cells (aAPCs) with protein-conjugated bilayer lipid membranes that mimic biological cell membranes.
Intrafibrillar Mineralization and Immunomodulatory for Synergetic Enhancement of Bone Regeneration via Calcium Phosphate Nanocluster Scaffold
Yanyan Zhou, Zihe Hu, Wenjing Jin, Haiyan Wu, Minghao Zuo, Changyu Shao, Yanhua Lan, Yang Shi, Ruikang Tang, Zhuo Chen, Zhijian Xie, Jue Shi
doi : 10.1002/adhm.202201548
Inspired by the bionic mineralization theory, organic–inorganic composites with hydroxyapatite nanorods orderly arranged along collagen fibrils have attracted extensive attention. Planted with an ideal bone scaffold will contribute greatly to the osteogenic microenvironment; however, it remains challenging to develop a biomimetic scaffold with the ability to promote intrafibrillar mineralization and simultaneous regulation of immune microenvironment in situ.
Endogenous Electric Field-Coupled PD@BP Biomimetic Periosteum Promotes Bone Regeneration through Sensory Nerve via Fanconi Anemia Signaling Pathway
Yanlin Su, Lian Zeng, Rongli Deng, Bing Ye, Shuo Tang, Zekang Xiong, Tingfang Sun, Qiuyue Ding, Weijie Su, Xirui Jing, Qing Gao, Xiumei Wang, Zhiye Qiu, Kaifang Chen, Daping Quan, Xiaodong Guo
doi : 10.1002/adhm.202203027
To treat bone defects, repairing the nerve-rich periosteum is critical for repairing the local electric field. In this study, an endogenous electric field is coupled with 2D black phosphorus electroactive periosteum to explore its role in promoting bone regeneration through nerves. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are used to characterize the electrically active biomimetic periosteum.
AIEgens/Mitochondria Nanohybrids as Bioactive Microwave Sensitizers for Non-Thermal Microwave Cancer Therapy (Adv. Healthcare Mater. 12/2023)
Xinghua Yu, Ming Lyu, Xupei Ou, Wenquan Liu, Xing Yang, Xiaoxi Ma, Tianfu Zhang, Longnan Wang, Ying-Chuan Zhang, Sijie Chen, Ryan T. K. Kwok, Zheng Zheng, Hong-Liang Cui, Lintao Cai, Pengfei Zhang, Ben Zhong Tang
doi : 10.1002/adhm.202370061
AIEgens/Mitochondria Nanohybrids as Bioactive Microwave Sensitizers for Non-Thermal Microwave Cancer Therapy
Xinghua Yu, Ming Lyu, Xupei Ou, Wenquan Liu, Xing Yang, Xiaoxi Ma, Tianfu Zhang, Longnan Wang, Ying-Chuan Zhang, Sijie Chen, Ryan T. K. Kwok, Zheng Zheng, Hong-Liang Cui, Lintao Cai, Pengfei Zhang, Ben Zhong Tang
doi : 10.1002/adhm.202202907
Aggregation-induced emission luminogens (AIEgens) are widely used as photosensitizers for image-guided photodynamic therapy (PDT). Due to the limited penetration depth of light in biological tissues, the treatments of deep-seated tumors by visible-light-sensitized aggregation-induced emission (AIE) photosensitizers are severely hampered.
Hierarchical Topography with Tunable Micro- and Nanoarchitectonics for Highly Enhanced Cardiomyocyte Maturation via Multi-Scale Mechanotransduction
Hyunah Ahn, Younghak Cho, Geun-Tae Yun, Kwang Bo Jung, Wonji Jeong, Yesol Kim, Mi-Young Son, Eunjung Lee, Sung Gap Im, Hee-Tae Jung
doi : 10.1002/adhm.202202371
Enhancing cardiomyocyte (CM) maturation by topographical cues is a critical issue in cardiac tissue engineering. Thus far, single-scale topographies with a broad range of feature shapes and dimensions have been utilized including grooves, pillars, and fibers. This study reports for the first time a hierarchical structure composed of nano-pillars (nPs) on micro-wrinkles (µWs) for effective maturation of CMs.
A Self-Reinforcing Nanoplatform for Highly Effective Synergistic Targeted Combinatary Calcium-Overload and Photodynamic Therapy of Cancer
Dongdong Guo, Xiaoyong Dai, Kewei Liu, Yuhong Liu, Jiamin Wu, Kun Wang, Shengwei Jiang, Fen Sun, Lijun Wang, Bing Guo, Dongye Yang, Laiqiang Huang
doi : 10.1002/adhm.202202424
While calcium-overload-mediated therapy (COMT) is a promising but largely untapped therapeutic strategy, combinatory therapy greatly boosts treatment outcomes with integrated merits of different therapies.
Extrafibrillarly Demineralized Dentin Matrix for Bone Regeneration (Adv. Healthcare Mater. 12/2023)
Xiaoyi Wu, Wenan Peng, Gufeng Liu, Shilei Wang, Bo Duan, Jian Yu, Hongye Yang, Cui Huang
doi : 10.1002/adhm.202370062
Extrafibrillarly Demineralized Dentin Matrix for Bone Regeneration
Xiaoyi Wu, Wenan Peng, Gufeng Liu, Shilei Wang, Bo Duan, Jian Yu, Hongye Yang, Cui Huang
doi : 10.1002/adhm.202202611
Dentin is a natural extracellular matrix, but its availability in bone grafting and tissue engineering applications is underestimated due to a lack of proper treatment. In this study, the concept of extrafibrillar demineralization is introduced into the construction of dentin-derived biomaterials for bone regeneration for the first time.
Photomodulated Extrusion as a Localized Endovascular Hydrogel Deposition Method
Yuta Dobashi, Jerry C. Ku, Joel Ramjist, Christopher Pasarikovski, Konrad Walus, John D. W. Madden, Victor X. D. Yang
doi : 10.1002/adhm.202202632
Minimally invasive endovascular embolization is used to treat a wide range of diseases in neurology, oncology, and trauma where the vascular morphologies and corresponding hemodynamics vary greatly.
Amyloid Fibrils Enhance the Topical Bio-Adhesivity of Liquid Crystalline Mesophase-Based Drug Formulations
Francesca Damiani Victorelli, Camila Fernanda Rodero, Viviane Lutz-Bueno, Marlus Chorilli, Raffaele Mezzenga
doi : 10.1002/adhm.202202720
Despite their distinctive secondary structure based on cross β-strands, amyloid fibrils (AF) are stable fibrous protein aggregates with features similar to collagen, one of the main components of the extracellular matrix, and thus constitute a potential scaffold for enhancing cell adhesion for topical applications.
Engineering Multifunctional Polyether Ether Ketone Implant: Mechanics-Adaptability, Biominerialization, Immunoregulation, Anti-Infection, Osteointegration, and Osteogenesis
Hongyun Ma, Hao Han, Xiaoming Zhao, Junping Ma, Xiaoyan Qu, Xiaoxiao Lou, Angxiu Suonan, Bo Lei, Yingang Zhang
doi : 10.1002/adhm.202202799
Polyether ether ketone (PEEK) has become one of the most promising polymer implants in bone orthopedics, due to the biocompatibility, good processability, and radiation resistance. However, the poor mechanics-adaptability/osteointegration/osteogenesis/antiinfection limits the long-term in vivo applications of PEEK implants.
Multivalent Lactobionic Acid and N-Acetylgalactosamine-Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes
Vikas Kumar, Aniket Wahane, Anisha Gupta, José E. Manautou, Raman Bahal
doi : 10.1002/adhm.202202859
Peptide nucleic acids (PNAs) are used/applied in various studies to target genomic DNA and RNA to modulate gene expression. Non-specific targeting and rapid elimination always remain a challenge for PNA-based applications.
Multishell Colloidosome Platform with Sequential Gastrointestinal Resistance for On-Demand Probiotic Delivery
Xin Xie, Qinyuan Li, Lufan Jia, Hao Yuan, Ting Guo, Tao Meng
doi : 10.1002/adhm.202202954
Probiotic-based oral therapy can potentially prevent and treat diseases by regulating the balance of intestinal flora. However, significant loss of viability and bioactivity of probiotics before reaching the colon results in low delivery efficiency and therapeutic effects, which limits their clinical applications.
Electrocatalytic Palladium Nanoclusters as Versatile Indicators of Bioassays: Rapid Electroanalytical Detection of SARS-CoV-2 by Reverse Transcription Loop-Mediated Isothermal Amplification
Alejandro RodrÃÂguez-Penedo, Pablo Rioboó-Legaspi, Andrea González-López, Ana Lores-PadÃÂn, Rosario Pereiro, MarÃÂa del Mar GarcÃÂa-Suárez, MarÃÂa Dolores Cima-Cabal, EstefanÃÂa Costa-Rama, Beatriz Fernández, M. Teresa Fernández-Abedul
doi : 10.1002/adhm.202202972
Quantitative polymerase chain reaction (qPCR) is considered the gold standard for pathogen detection. However, improvement is still required, especially regarding the possibilities of decentralization. Apart from other reasons, infectious diseases demand on-site analysis to avoid pathogen spreading and increase treatment efficacy.
MOF-Immobilized Two-in-One Engineered Enzymes Enhancing Activity of Biocatalytic Cascade for Tumor Therapy
Caiqi Yang, Wen Liu, Shanfeng Chen, Xiaoqing Zong, Pengfei Yuan, Xinjie Chen, Xiaodi Li, Yuchao Li, Wei Xue, Jian Dai
doi : 10.1002/adhm.202203035
Biocatalytic systems based on enzyme cascade reactions have attracted growing interest in the field of biocatalytic medicine. However, it is a major challenge to reasonably construct enzyme cascade reactions with high stability, selectivity, and catalytic efficiency for the in vivo biocatalytic application.
Melatonin-Primed Mesenchymal Stem Cells-Derived Small Extracellular Vesicles Alleviated Neurogenic Erectile Dysfunction by Reversing Phenotypic Modulation
Zehong Chen, Jiancheng Zhai, Jiahui Ma, Peng Chen, Weishun Lin, Weipeng Zhang, Jiaming Xiong, Chaowei Zhang, Hongbo Wei
doi : 10.1002/adhm.202203087
Erectile dysfunction (ED) is an adverse side effect of pelvic surgery with no effective treatment. In this study, it is explored whether melatonin could improve the therapeutic effects of small extracellular vesicles (sEVs), derived from mesenchymal stem cells (MSCs), on cavernous nerve injury (CNI) ED, and the underlying mechanisms are investigated.
Ultralow Background Near-Infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability
Kai Bao, Molly Tully, Kevin Cardenas, Haoran Wang, Surbhi Srinivas, Jiyun Rho, Ok Hwa Jeon, Jason Dinh, Shinya Yokomizo, Rose McDonnell, Atsushi Yamashita, Satoshi Kashiwagi, Homan Kang, Hyun Koo Kim, Hak Soo Choi
doi : 10.1002/adhm.202203134
Two of the most pressing challenges facing bioimaging are nonspecific uptake of intravenously administered contrast agents and incomplete elimination of unbound targeted agents from the body.
Zero-Valence Selenium-Enriched Prussian Blue Nanozymes Reconstruct Intestinal Barrier against Inflammatory Bowel Disease via Inhibiting Ferroptosis and T Cells Differentiation
Dongdong Zhu, Haitao Wu, Kai Jiang, Yifeng Xu, Zhaohua Miao, Hua Wang, Yan Ma
doi : 10.1002/adhm.202203160
The structural disruption of mechanical barrier and dysfunction of immune barrier in intestinal, are important factors, that aggravate inflammatory bowel disease (IBD). To tackle this challenge, a multifunctional nanozyme capable of scavenging reactive oxygen species (ROS) and inhibiting ferroptosis or T cells differentiation for IBD therapy is here reported.
A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy
Cheng Li, Peiwei Gong, Mianran Chao, Juan Li, Liyan Yang, Yan Huang, Dandan Wang, Jianxi Liu, Zhe Liu
doi : 10.1002/adhm.202203245
Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA.
Targeting STING Activation by Antigen-Inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy
Yuan Gu, Subin Lin, Yanxian Wu, Pei Xu, Wen Zhu, Yangyun Wang, Xiaju Cheng, Leshuai W. Zhang, Roland H. Stauber, Yong Wang, Mingyuan Gao
doi : 10.1002/adhm.202300028
Immune checkpoint blockers therapy can improve the radiotherapy-induced immunosuppression by enhancing interferon secretion, but still suffer from low clinical response rate and potential adverse effects. Mn2+-mediated activation of interferon gene stimulator (STING) pathway provides an alternative for combination radioimmunotherapy of tumor.
