دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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How Crystallographic Orientation-Induced Fibrinogen Conformation Affects Platelet Adhesion and Activation on TiO2 (Adv. Healthcare Mater. 13/2023)
Maja StruczyÅ„ska, Izabela Firkowska-Boden, Nathan Levandovsky, Reinhard Henschler, Nour Kassir, Klaus D. Jandt
doi : 10.1002/adhm.202370065
Volume 12, Issue 13
In Vivo Stable Allogenic Cartilage Regeneration in a Goat Model Based on Immunoisolation Strategy Using Electrospun Semipermeable Membranes (Adv. Healthcare Mater. 13/2023)
Yingying Huo, Baoshuai Bai, Rui Zheng, Yuyan Sun, Yao Yu, Xin Wang, Hong Chen, Yujie Hua, Yixin Zhang, Guangdong Zhou, Xiaoyun Wang
doi : 10.1002/adhm.202370066
Novel Ionizable Lipid Nanoparticles for SARS-CoV-2 Omicron mRNA Delivery (Adv. Healthcare Mater. 13/2023)
Jinrong Long, Changxiao Yu, Honglei Zhang, Yiming Cao, Ye Sang, Haitao Lu, Zhen Zhang, Xin Wang, Huanyu Wang, Gengshen Song, Jing Yang, Shengqi Wang
doi : 10.1002/adhm.202370068
Microneedle Patch Loaded with Exosomes Containing MicroRNA-29b Prevents Cardiac Fibrosis after Myocardial Infarction (Adv. Healthcare Mater. 13/2023)
Jianping Yuan, Hong Yang, Chunxia Liu, Lianbo Shao, Haixin Zhang, Kunyan Lu, Jingjing Wang, Yuanyuan Wang, Qian Yu, Yanxia Zhang, Yunsheng Yu, Zhenya Shen
doi : 10.1002/adhm.202370069
High-Precision Synthesis of RNA-Loaded Lipid Nanoparticles for Biomedical Applications
Hanjin Seo, Leekang Jeon, Jaeyeong Kwon, Hyomin Lee
doi : 10.1002/adhm.202203033
The recent development of RNA-based therapeutics in delivering nucleic acids for gene editing and regulating protein translation has led to the effective treatment of various diseases including cancer, inflammatory and genetic disorder, as well as infectious diseases.
How Crystallographic Orientation-Induced Fibrinogen Conformation Affects Platelet Adhesion and Activation on TiO2
Maja StruczyÅ„ska, Izabela Firkowska-Boden, Nathan Levandovsky, Reinhard Henschler, Nour Kassir, Klaus D. Jandt
doi : 10.1002/adhm.202202508
Control of protein adsorption is essential for successful integration of healthcare materials into the body. Human plasma fibrinogen (HPF), especially its conformation is a key upstream regulator for platelet behavior and thus pathological clot formation at the blood-biomaterial interface.
In Vivo Stable Allogenic Cartilage Regeneration in a Goat Model Based on Immunoisolation Strategy Using Electrospun Semipermeable Membranes
Yingying Huo, Baoshuai Bai, Rui Zheng, Yuyan Sun, Yao Yu, Xin Wang, Hong Chen, Yujie Hua, Yixin Zhang, Guangdong Zhou, Xiaoyun Wang
doi : 10.1002/adhm.202203084
Tissue engineering is a promising strategy for cartilage defect repair. However, autologous cartilage regeneration is limited by additional trauma to the donor site and a long in vitro culture period.
Novel Ionizable Lipid Nanoparticles for SARS-CoV-2 Omicron mRNA Delivery
Jinrong Long, Changxiao Yu, Honglei Zhang, Yiming Cao, Ye Sang, Haitao Lu, Zhen Zhang, Xin Wang, Huanyu Wang, Gengshen Song, Jing Yang, Shengqi Wang
doi : 10.1002/adhm.202202590
mRNA-based therapy has emerged as the most promising nucleic acid therapy in the fight against COVID-19. However, a safe and efficacious systemic delivery remains a challenge for mRNA therapy. Lipid nanoparticles (LNPs) are currently widely used in mRNA delivery vehicles.
Microneedle Patch Loaded with Exosomes Containing MicroRNA-29b Prevents Cardiac Fibrosis after Myocardial Infarction
Jianping Yuan, Hong Yang, Chunxia Liu, Lianbo Shao, Haixin Zhang, Kunyan Lu, Jingjing Wang, Yuanyuan Wang, Qian Yu, Yanxia Zhang, Yunsheng Yu, Zhenya Shen
doi : 10.1002/adhm.202202959
Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a primary contributor to mortality by heart failure.
Design of Nanohydrogels for Targeted Intracellular Drug Transport to the Trans-Golgi Network
Thorsten Keller, Nora Trinks, Jessica Brand, Steffen Trippmacher, Philipp Stahlhut, Krystyna Albrecht, Georg Papastavrou, Hermann Koepsell, Markus Sauer, Jürgen Groll
doi : 10.1002/adhm.202201794
Nanohydrogels combine advantages of hydrogels and nanoparticles. In particular, they represent promising drug delivery systems. Nanogel synthesis by oxidative condensation of polyglycidol prepolymers, that are modified with thiol groups, results in crosslinking by disulfide bonds.
Cell-Laden Scaffolds for Vascular-Innervated Bone Regeneration
Chen Qin, Hongjian Zhang, Lei Chen, Meng Zhang, Jingge Ma, Hui Zhuang, Zhiguang Huan, Yin Xiao, Chengtie Wu
doi : 10.1002/adhm.202201923
For regeneration of highly vascularized and innervated tissues, like bone, simultaneous ingrowth of blood vessels and nerves is essential but largely neglected.
Multisized Photoannealable Microgels Regulate Cell Spreading, Aggregation, and Macrophage Phenotype through Microporous Void Space
Jeremy M. Lowen, Gabriella C. Bond, Katherine H. Griffin, Nathan K. Shimamoto, Victoria L. Thai, J. Kent Leach
doi : 10.1002/adhm.202202239
Microgels are an emerging platform for in vitro models and guiding cell fate due to their inherent porosity and tunability. This work describes a light-based technique for rapidly annealing microgels across a range of diameters. Utilizing 8-arm poly(ethylene)Â glycol-vinyl sulfone, the number of arms available for crosslinking, functionalization, and annealing is stoichiometrically controlled.
Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2Â Antibodies, and Protein Profiling
Federico Ribet, Annika Bendes, Claudia Fredolini, Mikolaj Dobielewski, Michael Böttcher, Olof Beck, Jochen M. Schwenk, Göran Stemme, Niclas Roxhed
doi : 10.1002/adhm.202202564
Blood sampling is a common practice to monitor health, but it entails a series of drawbacks for patients including pain and discomfort. Thus, there is a demand for more convenient ways to obtain samples. Modern analytical techniques enable monitoring of multiple bioanalytes in smaller samples, opening possibilities for new matrices, and microsampling technologies to be adopted.
Nanovaccines Displaying the Influenza Virus Hemagglutinin in an Inverted Orientation Elicit an Enhanced Stalk-Directed Antibody Response
Steven J. Frey, Juan Manuel Carreño, Dominika Bielak, Ammar Arsiwala, Clara G. Altomare, Chad Varner, Tania Rosen-Cheriyan, Goran Bajic, Florian Krammer, Ravi S. Kane
doi : 10.1002/adhm.202202729
Despite the availability of licensed vaccines, influenza causes considerable morbidity and mortality worldwide. Current influenza vaccines elicit an immune response that primarily targets the head domain of the viral glycoprotein hemagglutinin (HA).
Conductive Antifouling Sensing Coating: A Bionic Design Inspired by Natural Cell Membrane
Yi Huang, Haiping Wu, Ning Xie, Xuewen Zhang, Zhenyang Zou, Meng Deng, Wei Cheng, Xiaolan Guo, Shijia Ding, Bin Guo
doi : 10.1002/adhm.202202790
Constructing antifouling coatings for biosensing interfaces is a major hurdle in driving their practical application. Inspired by the excellent antifouling properties of natural cell membranes, a conductive biomimetic antifouling interface coating is proposed, which highly mimics the excellent antifouling properties of biofilms while overcoming the low conductivity defects of conventional coatings.
An Instant Underwater Tissue Adhesive Composed of Catechin-Chondroitin Sulfate and Cholesterol-Polyethyleneimine
Min Jin, Chao Tao, Xu Hu, Bangheng Liu, Cheng Ma, Zhonglian Wu, Hang Yao, Dong-An Wang
doi : 10.1002/adhm.202202814
Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard to apply to in vivo physiological environments and more diverse medical use conditions.
Nanoscale Hafnium Metal–Organic Frameworks Enhance Radiotherapeutic Effects by Upregulation of Type I Interferon and TLR7 Expression
Eunseo Choi, Madeleine Landry, Nathan Pennock, Megan Neufeld, Katherine Weinfurter, Andrea Goforth, Joshua Walker, Conroy Sun
doi : 10.1002/adhm.202202830
Recent preclinical and clinical studies have highlighted the improved outcomes of combination radiotherapy and immunotherapy. Concurrently, the development of high-Z metallic nanoparticles as radiation dose enhancers has been explored to widen the therapeutic window of radiotherapy and potentially enhance immune activation.
Tumor Microenvironment Responsive Hollow Nanoplatform for Triple Amplification of Oxidative Stress to Enhance Cuproptosis-Based Synergistic Cancer Therapy
Weijun Xu, Yaping Wang, Guanghui Hou, Jinlei Wang, Taibing Wang, Junmin Qian, Aili Suo
doi : 10.1002/adhm.202202949
Cuproptosis is a recently discovered form of programmed cell death and shows great potential in cancer treatment. Herein, a copper-dithiocarbamate chelate-doped and artemisinin-loaded hollow nanoplatform (HNP) is developed via a chelation competition-induced hollowing strategy for cuproptosis-based combination therapy.
Near-Infrared Light-Driven Mesoporous SiO2/Au Nanomotors for Eradication of Pseudomonas aeruginosa Biofilm
Tijana Maric, Amalie Løvind, Zhongyang Zhang, Jiayue Geng, Anja Boisen
doi : 10.1002/adhm.202203018
Bacterial biofilms are linked to several diseases and cause resistant and chronic infections in immune-compromised patients. Nanomotors comprise a new field of research showing a great promise within biomedicine but pose challenges in terms of biocompatibility.
Thermodynamic 2D Silicene for Sequential and Multistage Bone Regeneration
Ni Ni, Min Ge, Rui Huang, Dandan Zhang, Han Lin, Yahan Ju, Zhimin Tang, Huiqin Gao, Huifang Zhou, Yu Chen, Ping Gu
doi : 10.1002/adhm.202203107
Bone healing is a multistage process involving the recruitment of cells, revascularization, and osteogenic differentiation, all of which are modulated in the temporal sequence to maximize cascade bone regeneration.
Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces
Lihui Peng, Carlos Matellan, Minerva Bosch-Fortea, Jordi Gonzalez-Molina, Matteo Frigerio, Stefan Salentinig, Armando del Rio Hernandez, Julien E. Gautrot
doi : 10.1002/adhm.202203297
Stem cells are known to sense and respond to the mechanical properties of biomaterials. In turn, cells exert forces on their environment that can lead to striking changes in shape, size and contraction of associated tissues, and may result in mechanical disruption and functional failure.
Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On-Demand Removability for Wound Closure and MRSA-Infected Wound Healing
Xinchang Kang, Pengfei Guan, Cairong Xiao, Can Liu, Youjun Guan, Yeying Lin, Yu Tian, Kunyu Ren, Yanting Huang, Rumin Fu, Chengyun Ning, Lei Fan, Guoxin Tan, Lei Zhou
doi : 10.1002/adhm.202203306
Photothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on-demand removability without additional nanomaterials-based photothermal agents have rarely been reported in the literature.
Glutamine-Based Metabolism Normalization and Oxidative Stress Alleviation by Self-Assembled Bilirubin/V9302 Nanoparticles for Psoriasis Treatment
Xinyu Jiang, Shuqi Huang, Wenjing Cai, Peiqi Wang, Zewei Jiang, Minghui Wang, Linyi Zhang, Pengfei Mao, Lijia Chen, Ruizhen Wang, Tuyue Sun, Yiling Jiang, Qing Yao, Ruijie Chen, Longfa Kou
doi : 10.1002/adhm.202203397
Psoriasis is an immune-mediated chronic inflammatory skin disorder characterized by epidermal hyperplasia and infiltration of inflammatory cells. Even though the pathogenesis remains unclear, T helper 17 (Th17) cells-mediated inflammation and keratinocyte-involved proliferation are considered to play key roles during the occurrence and the development of psoriasis.
Solid-Phase Screening and Synthesis of Molecularly Imprinted Nanoparticles for Selective Recognition and Detection of Brain Natriuretic Peptide
Ziying Zhang, Liang Ma, Hui Yuan, Ziman Chen, Yongqin Lv
doi : 10.1002/adhm.202300146
A new recognition method is explored for the rapid detection of B-type natriuretic peptide (BNP) based on the rational design and solid-phase synthesis of molecularly imprinted nanoparticles (nanoMIP) encapsulated with carbon dots.
