دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine (Adv. Healthcare Mater. 15/2023)
Ye Li, Yin-Hsueh Chen, Bing-Yun Liu, Qing Nie, Li-Jun Li, Xu Duan, Lian-Zhi Wu, Gang Chen
doi : 10.1002/adhm.202370075
Selective Photothermal Therapy Based on Lipopolysaccharide Aptamer Functionalized MoS2 Nanosheet-Coated Gold Nanorods for Multidrug-Resistant Pseudomonas aeruginosa Infection (Adv. Healthcare Mater. 15/2023)
Jie Lv, Bo Li, Tingting Luo, Chengtao Nie, Weilun Pan, Xiaoxue Ge, Jinsheng Zheng, Yongyu Rui, Lei Zheng
doi : 10.1002/adhm.202370076
Controlled Cascade-Release and High Selective Sterilization by Core–Shell Nanogels for Microenvironment Regulation of Aerobic Vaginitis (Adv. Healthcare Mater. 15/2023)
Xinxin Wang, Yiting Wang, Mengteng Tang, Xiaoyi Wang, Wei Xue, Xiao Zhang, Yuxia Wang, Wen-Hui Lee, Yingshuai Wang, Tong-Yi Sun, Yuanyuan Gao, Li-Li Li
doi : 10.1002/adhm.202370079
Full-Scale Osteochondral Regeneration by Sole Graft of Tissue-Engineered Hyaline Cartilage without Co-Engraftment of Subchondral Bone Substitute
Xiaolei Nie, Jian Yang, Yon Jin Chuah, Wenzhen Zhu, Yvonne Peck, Pengfei He, Dong-An Wang
doi : 10.1002/adhm.202301333
Polymer-Based mRNA Delivery Strategies for Advanced Therapies
Wenqian Yang, Lucas Mixich, Eger Boonstra, Horacio Cabral
doi : 10.1002/adhm.202202688
Messenger RNA (mRNA)-based therapies offer great promise for the treatment of a variety of diseases. In 2020, two FDA approvals of mRNA-based vaccines have elevated mRNA vaccines to global recognition.
Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine
Ye Li, Yin-Hsueh Chen, Bing-Yun Liu, Qing Nie, Li-Jun Li, Xu Duan, Lian-Zhi Wu, Gang Chen
doi : 10.1002/adhm.202202453
Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) have been considered promising therapeutics for disease treatments. However, MSC-EVs harvested from different tissues present unique biological features reflective of their origins.
Selective Photothermal Therapy Based on Lipopolysaccharide Aptamer Functionalized MoS2 Nanosheet-Coated Gold Nanorods for Multidrug-Resistant Pseudomonas aeruginosa Infection
Jie Lv, Bo Li, Tingting Luo, Chengtao Nie, Weilun Pan, Xiaoxue Ge, Jinsheng Zheng, Yongyu Rui, Lei Zheng
doi : 10.1002/adhm.202202794
Chronic wounds infected by multidrug-resistant gram-negative bacteria have evolved resistance to traditional antibiotic therapy, posing a threat to global public health in recent years. Herein, a selective therapeutic nanorod (MoS2-AuNRs-apt) based on molybdenum disulfide (MoS2) nanosheets coated gold nanorods (AuNRs) targeting lipopolysaccharide (LPS) is presented.
Controlled Cascade-Release and High Selective Sterilization by Core–Shell Nanogels for Microenvironment Regulation of Aerobic Vaginitis
Xinxin Wang, Yiting Wang, Mengteng Tang, Xiaoyi Wang, Wei Xue, Xiao Zhang, Yuxia Wang, Wen-Hui Lee, Yingshuai Wang, Tong-Yi Sun, Yuanyuan Gao, Li-Li Li
doi : 10.1002/adhm.202202432
Aerobic vaginitis (AV) is a gynecological disease associated with vaginal flora imbalance. The nonselective bactericidal nature of antibiotics and low customization rate of probiotic supplementation in existing treatments lead to AV recurrence. Here, a drug delivery strategy is proposed that works with the changing dynamics of the bacterial flora.
Sustained Release of Dicumarol via Novel Grafted Polymer in Electrospun Nanofiber Membrane for Treatment of Peritendinous Adhesion (Adv. Healthcare Mater. 15/2023)
Yanhao Li, Chengfang Hu, Bo Hu, Jian Tian, Gang Zhao, Chuandong Cai, Yuange Li, Zhenyu Sun, Shuo Wang, Sa Pang, Rong Bao, Zaijing Tao, Huajiang Chen, Jinglei Wu, Shen Liu
doi : 10.1002/adhm.202370078
Sustained Release of Dicumarol via Novel Grafted Polymer in Electrospun Nanofiber Membrane for Treatment of Peritendinous Adhesion
Yanhao Li, Chengfang Hu, Bo Hu, Jian Tian, Gang Zhao, Chuandong Cai, Yuange Li, Zhenyu Sun, Shuo Wang, Sa Pang, Rong Bao, Zaijing Tao, Huajiang Chen, Jinglei Wu, Shen Liu
doi : 10.1002/adhm.202203078
The prevention and treatment of post-traumatic peritendinous adhesion (PA) have always been a great difficulty for orthopedic surgeons. Current treatments include resecting surgery, non-steroidal anti-inflammatory drugs (NSAIDs) usage and implantable membranes, often target single disease pathogenic processes, resulting in unfavorable therapeutic outcomes.
Mn3O4 Nanoshell Coated Metal–Organic Frameworks with Microenvironment-Driven O2 Production and GSH Exhaustion Ability for Enhanced Chemodynamic and Photodynamic Cancer Therapies
Wenya Li, Rongtian Li, Qiang Ye, Yiming Zou, Xing Lu, Wenhua Zhang, Jinxiang Chen, Yinghua Zhao
doi : 10.1002/adhm.202202280
Nanomedicine exhibits emerging potentials to deliver advanced therapeutic strategies in the fight against triple-negative breast cancer (TNBC). Nevertheless, it is still difficult to develop a precise codelivery system that integrates highly effective photosensitizers, low toxicity, and hydrophobicity.
Crystalline Antibody-Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of Antibodies
Amir Erfani, Jeremy M. Schieferstein, Paul Reichert, Chakravarthy N. Narasimhan, Cinthia Pastuskovas, Vaishali Parab, Denarra Simmons, Xiaoyu Yang, Apoorv Shanker, Paula Hammond, Patrick S. Doyle
doi : 10.1002/adhm.202202370
Subcutaneous (SC) administration is a desired route for monoclonal antibodies (mAbs). However, formulating mAbs for small injection volumes at high concentrations with suitable stability and injectability is a significant challenge.
Hybrid Extracellular Vesicles-Liposomes Camouflaged Magnetic Vesicles Cooperating with Bioorthogonal Click Chemistry for High-Efficient Melanoma Circulating Tumor Cells Enrichment
Ke Kang, Yujia Zhang, Xiaoxi Zhou, Yue Yu, Nanhang Zhu, Jia Cheng, Qiangying Yi, Yao Wu
doi : 10.1002/adhm.202202825
The capture of melanoma circulating tumor cells (melanoma CTCs, MelCTCs) is of great significance for the early diagnosis and personalized treatment of melanoma. The rarity and heterogeneity of MelCTCs have greatly limited the development of MelCTCs capture methods, especially those based on immune/aptamer-affinity.
Polytonic Drug Release via Multi-Hierarchical Microstructures Enabled by Nano-Metamaterials
Qi Lou, Feng Feng, Junfeng Hui, Peisen Zhang, Shijie Qin, Xiaoping Ouyang, Dazhuan Wu, Xiuyu Wang
doi : 10.1002/adhm.202202826
€³Nano-metamaterials″, rationally designed novel class metamaterials with multilevel microarchitectures and both characteristic sizes and whole sizes at the nanoscale, are introduced into the area of drug delivery system (DDS), and the relationship between release profile and treatment efficacy at the single-cell level is revealed for the first time. Fe3+-core-shell-corona nano-metamaterials (Fe3+-CSCs) are synthesized using a dual-kinetic control strategy.
Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning
Xingcan Huang, Yiming Liu, Wooyoung Park, Jiyu Li, Jie Ma, Chun Ki Yiu, Qiang Zhang, Jian Li, Pengcheng Wu, Jingkun Zhou, Yuyang Zeng, Xinxin He, Jialin Li, Tsz Hung Wong, Kuanming Yao, Ling Zhao, Yuyu Gao, Rui Shi, Hu Li, Meixi Li, Dengfeng Li, Zhao Zhao, Yuhang Li, Heng Li, Xinge Yu
doi : 10.1002/adhm.202202846
Intelligent monitoring human physiological information in real time raises the demand for skin-integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring.
Förster Resonance Energy Transfer Nanobullet for Photoacoustic Imaging and Amplified Photothermal-Photodynamic Therapy of Cancer
Mixiao Tan, Xuemei Li, Hua Zhang, Min Zheng, Jie Xiong, Yang Cao, Guoliang Cao, Zhigang Wang, Haitao Ran
doi : 10.1002/adhm.202202943
Synergistic photodynamic and photothermal therapy (PDT-PTT) has emerged as an appealing effective antitumor approach. However, clinical utilization of PDT-PTT is plagued by aggregation-caused photobleaching, sequential double irradiations, unsatisfying balance between single oxygen (1O2) quantum yield and photothermal conversion efficiency.
Enhancing the Management of Metastatic Tumors by Robust Co-Delivery of 5-Fluorouracil/MicroRNA-10b Inhibitor Using EGFR-Targeted Nanovehicles
Di Wang, Liwei Wang, Liming Zheng, Jiaxin Chen, Wei Zhang, Wei Zhou, Xiaobo Yang, Lifeng Jiang, Xiaoqiang Jin, Xiaohua Yu, Xin Liu, Heng Chen, Jianbin Xu
doi : 10.1002/adhm.202202989
Invasion and metastasis are the leading causes of death of patients with CRC. 5-Fluorouracil is widely used in clinic practice as the basic chemotherapy drug for CRC. However, it is inefficient in inhibiting tumor metastasis.
Antibacterial Collagen-Based Nanocomposite Dressings for Promoting Infected Wound Healing
Weidong Liao, Die Yang, Zhilang Xu, Lei Zhao, Changdao Mu, Defu Li, Liming Ge
doi : 10.1002/adhm.202203054
Pathogenic bacterial infection is the most frequent wound complication, which has become a major clinical and healthcare challenge in wound management worldwide, leading to impaired healing processes, the risk of amputation, and even death.
Tumor-Targeting Near-Infrared Dimeric Heptamethine Cyanine Photosensitizers with an Aromatic Diphenol Linker for Imaging-Guided Cancer Phototherapy
Yang Xu, Jiaying Yu, Jinzhong Hu, Kai Sun, Wenjun Lu, Fenglian Zeng, Jian chen, Min liu, Zhuoer Cai, Xiaofan He, Wanying Wei, Baiwang Sun
doi : 10.1002/adhm.202203080
Phototherapy is considered a promising alternative to conventional tumor treatments due to its noninvasive modality and effective therapeutic effect. However, designing a photosensitizer with satisfactory therapeutic effect and high security remains a considerable challenge.
Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
doi : 10.1002/adhm.202203099
Osteoporosis is a degenerative bone disease resulting from bone homeostasis imbalance regulated by osteoblasts and osteoclasts. Treating osteoporotic bone defects tends to be more difficult due to suppressed osteogenic differentiation, hyperactive osteoclastogenesis, and impaired angiogenesis.
Mitochondrial Calcium Ion Nanogluttons Alleviate Periodontitis via Controlling mPTPs
Ping He, Fengyi Liu, Mingzheng Li, Mingxing Ren, Xu Wang, Yangjia Deng, Xianghao Wu, Yuzhou Li, Sheng Yang, Jinlin Song
doi : 10.1002/adhm.202203106
The mitochondrial permeability transition (mPT) directly affects mitochondrial function in macrophages. Under inflammatory conditions, mitochondrial calcium ion (mitoCa2+) overload triggers the persistent opening of mPT pores (mPTPs), further aggravating Ca2+ overload and increasing reactive oxygen species (ROS) to form an adverse cycle.
A Versatile Design-Enabled Analysis of Circulating Extracellular Vesicles in Disease Diagnosis
Qi Liu, Jianhua Yao, Zichen Huang, Shuning Wang, Jizong Jiang, Ya Cao, Yihua Bei, Jing Zhao
doi : 10.1002/adhm.202203119
Circulating extracellular vesicles (EVs) are considered as potential biomarkers for treatment and diagnosis of many diseases. Most of the existing methods for the EV analysis only have a single function and thus reveal limited information carried by EVs.
Ratio Fluorescent Detecting of Tryptophan and Its Metabolite 5-Hydroxyindole-3-acetic Acid Relevant with Depression via Tb(III) Modified HOFs Hybrids: Further Designing Recyclable Molecular Logic Gate Connected by Back Propagation Neural Network
Kai Zhu, Xin Xu, Bing Yan
doi : 10.1002/adhm.202203292
Exploring intelligent fluorescent materials with high reliability and precision to diagnose diseases is significant but remains a great challenge. Herein, based on coordination post-synthetic modification, a Tb3+ functionalized ME-PA (Tb@1) is prepared, which can emit brilliant green fluorescence through ligand-to-mental charge transfer-assisted energy transfer (LMCT-ET) process from ME-PA to Tb3+ ions.
Influence of Pore Size in Protein G'-Grafted Mesoporous Silica Nanoparticles as a Serum Pretreatment System for In Vitro Allergy Diagnosis
Juan L. Paris, Cristina MonÃÂo, Ana M. Pérez-Moreno, Raquel Jurado-Escobar, Gador Bogas, TahÃÂa D. Fernández, MarÃÂa I. Montañez, Cristobalina Mayorga, MarÃÂa J. Torres
doi : 10.1002/adhm.202203321
Particles with the capacity to bind to immunoglobulin G (IgG) can be used for the purification of IgG or to process clinical samples for diagnostic purposes. For in vitro allergy diagnosis, the high IgG levels in serum can interfere with the detection of allergen-specific IgE, the main diagnostic biomarker.
A One-Stone-Two-Birds Strategy for Osteochondral Regeneration Based on a 3D Printable Biomimetic Scaffold with Kartogenin Biochemical Stimuli Gradient
Wenying Wei, Wenbin Liu, Haifei Kang, Xiangke Zhang, Ran Yu, Jiawei Liu, Kai Huang, Yiqian Zhang, Mingsheng Xie, Yihe Hu, Honglian Dai
doi : 10.1002/adhm.202300108
Osteochondral defect (OCD) regeneration remains challenging because of the hierarchy of the native tissue including both the articular cartilage and the subchondral bone. Constructing an osteochondral scaffold with biomimetic composition, structure, and biological functionality is the key to achieve its high-quality repair.
Biomimetic Periodontal Ligament Transplantation Activated by Gold Nanoparticles Protects Alveolar Bone
Chen Zong, Wannes Van Holm, Annelies Bronckaers, Zuodong Zhao, Stevan Čokić, Merve Kübra Aktan, Ana Belén Castro, Bart Van Meerbeek, Annabel Braem, Guy Willems, Maria Cadenas de Llano-Pérula
doi : 10.1002/adhm.202300328
Stem cell therapy might be a promising method to stimulate alveolar bone regeneration, which is currently a major clinical challenge. However, its therapeutic features largely depend on pretreatment and transplantation preparation.
