دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Nanoparticles labeled with gamma-emitting radioisotopes: an attractive approach for in vivo tracking using SPECT imaging
Mahnaz Ahmadi, Marjan Emzhik & Mona Mosayebnia
doi : 10.1007/s13346-023-01291-1
Providing accurate molecular imaging of the body and biological process is critical for diagnosing disease and personalizing treatment with the minimum side effects. Recently, diagnostic radiopharmaceuticals have gained more attention in precise molecular imaging due to their high sensitivity and appropriate tissue penetration depth.
Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology—a systematic review
Vazula Zulfra Bekkers, Liora Bik, Johanna Catharina van Huijstee, Albert Wolkerstorfer, Errol Prospero Prens & Martijn Bastiaan Adriaan van Doorn
doi : 10.1007/s13346-023-01295-x
Needle-free jet injectors are used for the intralesional treatment of various dermatological indications. However, a systematic review that evaluates the efficacy and safety of these treatments has not been published. The objectives of this study are to evaluate the efficacy and safety of needle-free jet injections for dermatological indications and to provide evidence-based treatment recommendations.
Microneedle-mediated treatment for superficial tumors by combining multiple strategies
Meng Wang, Xiaodan Li, Wenzhen Du, Minge Sun, Guixia Ling & Peng Zhang
doi : 10.1007/s13346-023-01297-9
Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion.
Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer
Mayur Aalhate, Srushti Mahajan, Hoshiyar Singh, Santosh Kumar Guru & Pankaj Kumar Singh
doi : 10.1007/s13346-023-01299-7
Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide. Almost 70–80% of cases of BC are curable at the early non-metastatic stage. BC is a heterogeneous disease with different molecular subtypes. Around 70% of breast tumors exhibit estrogen-receptor (ER) expression and endocrine therapy is used for the treatment of these patients.
Studies on spray dried topical ophthalmic emulsions containing cyclosporin A (0.05% w/w): systematic optimization, in vitro preclinical toxicity and in vivo assessments
Syed Nazrin Ruhina Rahman, Neha Agarwal, Abhinab Goswami, Amoolya Sree, Aishwarya Jala, Animith Venuganti, Apurba Deka, Roshan M. Borkar, Vivek Singh, Dipankar Das & Tamilvanan Shunmugaperumal
doi : 10.1007/s13346-022-01271-x
Cyclosporin A (CsA, 0.05% w/w)–loaded positively charged emulsions were prepared based on castor oil, chitosan, poloxamer 188, glycerin and double-distilled water. To augment the shelf/storage-stability of original emulsions, the solid-dry powder for reconstitution was made by spray drying technique.
Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy
Shibani Supe, Archana Upadhya, Santosh Tripathi, Vikas Dighe & Kavita Singh
doi : 10.1007/s13346-022-01281-9
Diabetic retinopathy (DR) is a vision-impairing complication of diabetes, damaging the retinal microcirculatory system. Overexpression of VEGF (vascular endothelial growth factor) is implicated in the pathogenesis of DR. Human antigen R (HuR) is an RNA-binding protein that favorably regulates VEGF protein expression by binding to VEGF-encoding mRNA.
Functionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides
Fatima Hameedat, Soraia Pinto, Joana Marques, Sofia Dias & Bruno Sarmento
doi : 10.1007/s13346-022-01286-4
Peptides have a distinguished therapeutic potential for several chronic conditions, and more than 80 peptides exist in the global market. However, most of these marketed peptide drugs are currently delivered intravenously or subcutaneously due to their fast degradation and limited absorption through non-invasive routes.
Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages
Sajedeh Maghrebi, Nicky Thomas, Clive A. Prestidge & Paul Joyce
doi : 10.1007/s13346-022-01287-3
Intracellular bacteria serve as a problematic source of infection due to their ability to evade biological immune responses and the inability for conventional antibiotics to efficiently penetrate cellular membranes. Subsequently, new treatment approaches are urgently required to effectively eradicate intracellular pathogens residing within immune cells (e.g. macrophages).
Development of hyaluronic acid–anchored polycaprolactone nanoparticles for efficient delivery of PLK1 siRNA to breast cancer
Dolly Jain & Awesh K. Yadav
doi : 10.1007/s13346-022-01288-2
PlK1 has a significant role in the development of breast cancer. Thus, silencing of PlK1 gene may arrest the growth of breast cancer. However, the in vivo stability of PlK1 siRNA after injection remains a challenge to target the specific site. The delivery of siPlK1 RNA via viral vector and amine group–terminated dendrimer is associated with immune reaction and cellular cytotoxicity.
Sleeping Beauty transposon system for GDNF overexpression of entrapped stem cells in fibrin hydrogel in a rat model of Parkinson’s disease
Laura Stahn, Justyna Rasińska, Tilo Dehne, Stefanie Schreyer, Aileen Hakus, Manfred Gossen, Barbara Steiner & Shabnam Hemmati-Sadeghi
doi : 10.1007/s13346-023-01289-9
There is currently no causal treatment available for Parkinson’s disease (PD). However, the use of glial cell line–derived neurotrophic factor (GDNF) to provide regenerative effects for neurons is promising. Such approaches require translational delivery systems that are functional in diseased tissue.
Fabrication and characterization of bilayer scaffolds made of decellularized dermis/nanofibrous collagen for healing of full-thickness wounds
Naser Amini, Ahmad Hivechi, Shiva Asadpour, Kaveh Ebrahimzadeh, Saeid Kargozar, Mazaher Gholipourmalekabadi, Ahvan Nasrolahi, Melina Ghasemian, Amir Shafaat, Masoud Mozafari, Peiman Brouki Milan & Alireza Rezapour
doi : 10.1007/s13346-023-01292-0
Skin tissue engineering has progressed from simple wound dressings to biocompatible materials with desired physico-chemical properties that can deliver regenerative biomolecules. This study describes using a novel biomimetic hybrid scaffold of decellularized dermis/collagen fibers that can continuously deliver stromal cell-derived factor-1 alpha (SDF-1α) for skin regeneration.
Assessment of formulation variables of poor water soluble diacerein for its improved loading and anti-inflammatory activity
Maryam Shabbir, Kashif Barkat, Muhammad Umer Ashraf, Uzair Nagra & Syed Nisar Hussain Shah
doi : 10.1007/s13346-023-01293-z
Dissolving microneedles have become a popular method for percutaneous administrationof drugs. However, loading poorly soluble drugs into water-based dissolving microneedles remains a challenge. In view of this, we aimed to improve Diacerein (DCN) solubility formulating dissolving microneedles.
Towards the personalization of gelatin-based 3D patches: a tunable porous carrier for topical applications
Ricardo Ribeiro, Sara Bom, Ana M. Martins, Helena M. Ribeiro, Catarina Santos & Joana Marto
doi : 10.1007/s13346-023-01294-y
Cell-free based therapies, for example, the use of the cell secretome, have emerged as a promising alternative to conventional skin therapies using bioactive and, when combined with 3D printing technologies, allow the development of personalized dosage forms.
Design, analysis and fabrication of solid polymer microneedle patch using CO2 laser and polymer molding
Gowthami Anbazhagan, Sreeja Balakrishnapillai Suseela & Radha Sankararajan
doi : 10.1007/s13346-023-01296-w
Microneedle-based transdermal drug delivery into the skin has gained attraction for the past few years. An affordable and effective fabrication methodology is required for the development of micron size needle. Manufacturing cost-effective microneedle patches in batch production is a challenging process.
Sustained antigens delivery using composite microneedles for effective epicutaneous immunotherapy
Erkang Zhang, Binghui Zeng, Ruolin Song, Lu Yao & Huilian Che
doi : 10.1007/s13346-023-01298-8
Allergen-specific immunotherapy (SIT) is a desirable way of therapy for various allergic diseases such as food allergy (FA). However, frequent visits for more than 3 years and potential adverse effects often hinder patient compliance.
Targeting reactive astrocytes by pH-responsive ligand-bonded polymeric nanoparticles in spinal cord injury
Parinaz Sabourian, Masoud Frounchi, Sahar Kiani, Shohreh Mashayekhan, Masoumeh Zarei Kheirabadi, Yasaman Heydari & Seyed Sajad Ashraf
doi : 10.1007/s13346-023-01300-3
In spinal cord injuries, axonal regeneration decreases with the activation of astrocytes followed by glial scar formation. Targeting reactive astrocytes has been recently performed by unsafe viral vectors to inhibit gliosis.
