دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Emerging immunotherapeutics for immune activation and tolerance
Ryan M. Pearson, Abhinav P. Acharya & James J. Moon
doi : 10.1007/s13346-023-01352-5
Volume 13, issue 7, July 2023
Nanomaterials for antigen-specific immune tolerance therapy
Jinwon Park, Yina Wu, Qiaoyun Li, Jaehyun Choi, Hyemin Ju, Yu Cai, Jaiwoo Lee & Yu-Kyoung Oh
doi : 10.1007/s13346-022-01233-3
Impairment of immune tolerance might cause autologous tissue damage or overactive immune response against non-pathogenic molecules. Although autoimmune disease and allergy have complicated pathologies, the current strategies have mainly focused on symptom amelioration or systemic immunosuppression which can lead to fatal adverse events.
Neutrophils and neutrophil extracellular traps in cancer: promising targets for engineered nanomaterials
Emeka B. Okeke, Cameron Louttit, Caitlin M. Snyder & James J. Moon
doi : 10.1007/s13346-022-01243-1
Neutrophils are the most abundant white blood cells in circulation and constitute up to 60% of circulating leukocytes. Neutrophils play a significant role in host defense against pathogens through various mechanisms, including phagocytosis, production of antimicrobial proteins, and formation of neutrophil extracellular traps (NETs).
Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages
Iago Fernández-Mariño, Clément Anfray, Jose Crecente-Campo, Akihiro Maeda, Aldo Ummarino, Carmen Teijeiro-Valiño, Dario Blanco-Martinez, Francis Mpambani, Laurence Poul, Julie Devalliere, Matthieu Germain, Juan Correa, Marcos Fernandez-Villamarin, Paola Allavena, Eduardo Fernandez-Megia, MarÃa José Alonso & Fernando Torres Andón
doi : 10.1007/s13346-022-01265-9
Tumor-associated macrophages (TAMs), a class of immune cells that play a key role in tumor immunosuppression, are recognized as important targets to improve cancer prognosis and treatment. Consequently, the engineering of drug delivery nanocarriers that can reach TAMs has acquired special relevance.
Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro
David A. McBride, Nicholas C. Dorn, Mina Yao, Wade T. Johnson, Wei Wang, Nunzio Bottini & Nisarg J. Shah
doi : 10.1007/s13346-022-01284-6
Short-chain fatty acids (SCFAs) are major metabolic products of indigestible polysaccharides in the gut and mediate the function of immune cells to facilitate homeostasis. The immunomodulatory effect of SCFAs has been attributed, at least in part, to the epigenetic modulation of immune cells through the inhibition the nucleus-resident enzyme histone deacetylase (HDAC).
Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model
Abhirami Thumsi1 · Srivatsan J. Swaminathan2 · Joslyn L. Mangal1 · Abhirami P. Suresh1 · Abhinav P. Acharya
doi : 10.1007/s13346-023-01333-8
Metabolic reprogramming of immune cells modulates their function and reduces the severity of autoimmune diseases. However, the long-term effects of the metabolically reprogrammed cells, specifically in the case of immune flare-ups, need to be examined.
Nanocarriers for cancer nano-immunotherapy
Isra Rana, Jaeeun Oh, Juwon Baig, Jeong Hyun Moon, Sejin Son & Jutaek Nam
doi : 10.1007/s13346-022-01241-3
The host immune system possesses an intrinsic ability to target and kill cancer cells in a specific and adaptable manner that can be further enhanced by cancer immunotherapy, which aims to train the immune system to boost the antitumor immune response.
Nanoparticle pre-treatment for enhancing the survival and activation of pulmonary macrophage transplant
Bader M. Jarai, Kartik Bomb & Catherine A. Fromen
doi : 10.1007/s13346-023-01319-6
Despite recent clinical successes of chimeric antigen receptor T cell therapies in treating liquid cancers, many lingering challenges stand in the way of therapeutic translation to broader types of malignancies. Macrophages have been proposed as alternatives to T cells given macrophages’ advantages in promoting tumor infiltration, acquiring diverse antigens, and possessing the ability to continuously stimulate adaptive responses.
Nanoassemblies from the aqueous extract of roasted coffee beans modulate the behavioral and molecular effects of smoking withdrawal–induced anxiety in female rats
Alaa M. Hammad, Lujain F. Alzaghari, Malek Alfaraj, Laith Al-Shawaf & Suhair Sunoqrot
doi : 10.1007/s13346-023-01331-w
Antioxidant-rich plant extracts have demonstrated tremendous value as inflammatory modulators and as nanomaterial precursors. Chronic cigarette smoking alters neurotransmitter systems, particularly the glutamatergic system, and produces neuroinflammation.
Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches
Shreya S. Soni, Arielle M. D’Elia & Christopher B. Rodell
doi : 10.1007/s13346-023-01290-2
Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for which heart transplantation remains the only definitive treatment. IHF manifests from myocardial infarction (MI) that initiates tissue remodeling processes, mediated by mechanical changes in the tissue (loss of contractility, softening of the myocardium) that are interdependent with cellular mechanisms (cardiomyocyte death, inflammatory response).
Nanoengineered drug delivery in cancer immunotherapy for overcoming immunosuppressive tumor microenvironment
Sei Hyun Park, Ryounho Eun, Janghun Heo & Yong Taik Lim
doi : 10.1007/s13346-022-01282-8
Almost like a living being in and of itself, tumors actively interact with and modify their environment to escape immune responses. Owing to the pre-formation of cancer-favorable microenvironment prior to anti-cancer treatment, the numerous attempts that followed propose limited efficacy in oncology.
Anti-tumor antibody isotype response can be modified with locally administered immunoadjuvants
Adam A. Walters, Abrar Ali, Julie Tzu-Wen Wang & Khuloud T. Al-Jamal
doi : 10.1007/s13346-022-01258-8
In situ vaccination with immunostimulatory compounds is a demonstrated means to treat tumors preclinically. While these therapeutic effects have been attributed to the actions of T cells or innate immune activation, characterisation of the humoral immune response is seldom performed.
Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy
Sedigheh Shahvali, Niloufar Rahiman, Mahmoud Reza Jaafari & Leila Arabi
doi : 10.1007/s13346-023-01308-9
Fibroblast activation protein (FAP) is a serine protease with dual enzymatic activities overexpressed in cancer-associated fibroblasts (CAFs) in several tumor types, while its expression in healthy adult tissues is scarce.
